EKS-HOS-00457

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00457

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PDHK	189.7	1.0E-55	264	400	137

Status

Reviewed

Ensembl Protein

ENSP00000219794

UniProt Accession

O14874; Q6FGL4; Q96IN5;

Protein Name

[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

Protein Synonyms/Alias

Branched-chain alpha-ketoacid dehydrogenase kinase; BCKD-kinase; BCKDHKIN;

Gene Name

BCKDK

Gene Synonyms/Alias

BCKDK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000103507	ENSP00000455866	ENST00000561755
ENSG00000103507	ENSP00000454947	ENST00000567676
ENSG00000103507	ENSP00000219794	ENST00000219794
ENSG00000103507	ENSP00000287507	ENST00000287507
ENSG00000103507	ENSP00000457821	ENST00000567682
ENSG00000103507	ENSP00000378405	ENST00000394951
ENSG00000103507	ENSP00000457226	ENST00000484226
ENSG00000103507	ENSP00000378404	ENST00000394950
ENSG00000103507	ENSP00000456479	ENST00000567530

Organism

Homo sapiens

Functional Description

Catalyzes the phosphorylation and inactivation of thebranched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex (By similarity).

Protein Length

412

Protein Sequence
(FASTA)

MILASVLRSG PGGGLPLRPL LGPALALRAR STSATDTHHV EMARERSKTV TSFYNQSAID 60

AAAEKPSVRL TPTMMLYAGR SQDGSHLLKS ARYLQQELPV RIAHRIKGFR CLPFIIGCNP 120

TILHVHELYI RAFQKLTDFP PIKDQADEAQ YCQLVRQLLD DHKDVVTLLA EGLRESRKHI 180

EDEKLVRYFL DKTLTSRLGI RMLATHHLAL HEDKPDFVGI ICTRLSPKKI IEKWVDFARR 240

LCEHKYGNAP RVRINGHVAA RFPFIPMPLD YILPELLKNA MRATMESHLD TPYNVPDVVI 300

TIANNDVDLI IRISDRGGGI AHKDLDRVMD YHFTTAEAST QDPRISPLFG HLDMHSGAQS 360

GPMHGFGFGL PTSRAYAEYL GGSLQLQSLQ GIGTDVYLRL RHIDGREESF RI 412

Nucleotide Sequence
(FASTA)

ATGATCCTGG CGTCGGTGCT GAGGAGCGGT CCCGGGGGCG GGCTTCCGCT CCGGCCCCTC 60

CTGGGACCCG CACTCGCGCT CCGGGCCCGC TCGACGTCGG CCACCGACAC ACACCACGTG 120

GAGATGGCTC GGGAGCGCTC CAAGACCGTC ACCTCCTTTT ACAACCAGTC GGCCATCGAC 180

GCGGCAGCGG AGAAGCCCTC AGTCCGCCTA ACGCCCACCA TGATGCTCTA CGCTGGCCGC 240

TCTCAGGACG GCAGCCACCT TCTGAAAAGT GCTCGGTACC TGCAGCAAGA ACTTCCAGTG 300

AGGATTGCTC ACCGCATCAA GGGCTTCCGC TGCCTTCCTT TCATCATTGG CTGCAACCCC 360

ACCATACTGC ACGTGCATGA GCTATATATC CGTGCCTTCC AGAAGCTGAC AGACTTCCCT 420

CCGATCAAGG ACCAGGCGGA CGAGGCCCAG TACTGCCAGC TGGTGCGACA GCTGCTGGAT 480

GACCACAAGG ATGTGGTGAC CCTCTTGGCA GAGGGCCTAC GTGAGAGCCG GAAGCACATA 540

GAGGATGAAA AGCTCGTCCG CTACTTCTTG GACAAGACGC TGACTTCGAG GCTTGGAATC 600

CGCATGTTGG CCACGCATCA CCTGGCGCTG CATGAGGACA AGCCTGACTT TGTCGGCATC 660

ATCTGTACTC GTCTCTCACC AAAGAAGATT ATTGAGAAGT GGGTGGACTT TGCCAGACGC 720

CTGTGTGAGC ACAAGTATGG CAATGCGCCC CGTGTCCGCA TCAATGGCCA TGTGGCTGCC 780

CGGTTCCCCT TCATCCCTAT GCCACTGGAC TACATCCTGC CGGAGCTGCT CAAGAATGCC 840

ATGAGAGCCA CAATGGAGAG TCACCTAGAC ACTCCCTACA ATGTCCCAGA TGTGGTCATC 900

ACCATCGCCA ACAATGATGT CGATCTGATC ATCAGGATCT CAGACCGTGG TGGAGGAATC 960

GCTCACAAAG ATCTGGACCG GGTCATGGAC TACCACTTCA CTACTGCTGA GGCCAGCACA 1020

CAGGACCCCC GGATCAGCCC CCTCTTTGGC CATCTGGACA TGCATAGTGG CGCCCAGTCA 1080

GGACCCATGC ACGGCTTTGG CTTCGGGTTG CCCACGTCAC GGGCCTACGC GGAGTACCTC 1140

GGTGGGTCTC TGCAGCTGCA GTCCCTGCAG GGCATTGGCA CGGACGTCTA CCTGCGGCTC 1200

CGCCACATCG ATGGCCGGGA GGAAAGCTTC CGGATCTGA 1239

Domain Profile

S: 1     yvpshlyyllfellknamratveshedkkv.lpdvkvlvalgkedliikisdrGGGvplr  59

         ++p++l+y+l+ellknamrat+esh d+++ +pdv++++a++++dlii+isdrGGG++++

Q: 264   FIPMPLDYILPELLKNAMRATMESHLDTPYnVPDVVITIANNDVDLIIRISDRGGGIAHK  323

         8*****************************9*****************************

S: 60    kidrlldymystapapskdd..............araaplaGfGyGlpisrlyakylqGd  105

         ++dr++dy+++ta+a+++d+              a+++p++GfG+Glp+sr+ya+yl+G+

Q: 324   DLDRVMDYHFTTAEASTQDPrisplfghldmhsgAQSGPMHGFGFGLPTSRAYAEYLGGS  383

         ************************************************************

S: 106   lkllsleGiGtdaviylka  124

         l+l+sl+GiGtd+  yl++

Q: 384   LQLQSLQGIGTDV--YLRL  400

         ************9..8886

Domain Sequence
(FASTA)

FIPMPLDYIL PELLKNAMRA TMESHLDTPY NVPDVVITIA NNDVDLIIRI SDRGGGIAHK 60

DLDRVMDYHF TTAEASTQDP RISPLFGHLD MHSGAQSGPM HGFGFGLPTS RAYAEYLGGS 120

LQLQSLQGIG TDVYLRL 137

Keyword

Acetylation; ATP-binding; Complete proteome; Kinase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005947	; C:mitochondrial alpha-ketoglutarate dehydrogenase complex
GO:0047323	; F:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009083	; P:branched-chain amino acid catabolic process

KEGG

hsa:10295

;

InterPros

IPR003594	; ATPase-like_ATP-bd.
IPR018955	; BCDHK/PDK_N.
IPR004358	; Sig_transdc_His_kin-like_C.
IPR005467	; Sig_transdc_His_kinase_core.

Pfam

PF10436	; BCDHK_Adom3; 1.
PF02518	; HATPase_c; 1.

SMARTs

SM00387

; HATPase_c; 1.

Prosites

PS50109

; HIS_KIN; 1.

Prints

PR00344

; BCTRLSENSOR.

Created Date

20-Feb-2013