| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00150 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| TK/Csk | 472.4 | 1.2E-141 | 195 | 440 | 246 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000220003 |
| UniProt Accession | P41240; Q2M3N2; Q6FGZ6; |
| Protein Name | Tyrosine-protein kinase CSK |
| Protein Synonyms/Alias | C-Src kinase; Protein-tyrosine kinase CYL; |
| Gene Name | CSK |
| Gene Synonyms/Alias | CSK; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Non-receptor tyrosine-protein kinase that plays animportant role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. |
| Protein Length | 450 |
Protein Sequence
(FASTA) | | MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60 | | PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120 | | SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 180 | | DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240 | | TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300 | | AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360 | | KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 420 | | NCWHLDAAMR PSFLQLREQL EHIKTHELHL 450 |
|
Nucleotide Sequence
(FASTA) | | ATGTCAGCAA TACAGGCCGC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 60 | | CACGGCACTG CCGAGCAGGA CCTGCCCTTC TGCAAAGGAG ACGTGCTCAC CATTGTGGCC 120 | | GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAGG TGGGCCGTGA GGGCATCATC 180 | | CCAGCCAACT ACGTCCAGAA GCGGGAGGGC GTGAAGGCGG GTACCAAACT CAGCCTCATG 240 | | CCTTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCTGAGC GGCTTCTGTA CCCGCCGGAG 300 | | ACAGGCCTGT TCCTGGTGCG GGAGAGCACC AACTACCCCG GAGACTACAC GCTGTGCGTG 360 | | AGCTGCGACG GCAAGGTGGA GCACTACCGC ATCATGTACC ATGCCAGCAA GCTCAGCATC 420 | | GACGAGGAGG TGTACTTTGA GAACCTCATG CAGCTGGTGG AGCACTACAC CTCAGACGCA 480 | | GATGGACTCT GTACGCGCCT CATTAAACCA AAGGTCATGG AGGGCACAGT GGCGGCCCAG 540 | | GATGAGTTCT ACCGCAGCGG CTGGGCCCTG AACATGAAGG AGCTGAAGCT GCTGCAGACC 600 | | ATCGGGAAGG GGGAGTTCGG AGACGTGATG CTGGGCGATT ACCGAGGGAA CAAAGTCGCC 660 | | GTCAAGTGCA TTAAGAACGA CGCCACTGCC CAGGCCTTCC TGGCTGAAGC CTCAGTCATG 720 | | ACGCAACTGC GGCATAGCAA CCTGGTGCAG CTCCTGGGCG TGATCGTGGA GGAGAAGGGC 780 | | GGGCTCTACA TCGTCACTGA GTACATGGCC AAGGGGAGCC TTGTGGACTA CCTGCGGTCT 840 | | AGGGGTCGGT CAGTGCTGGG CGGAGACTGT CTCCTCAAGT TCTCGCTAGA TGTCTGCGAG 900 | | GCCATGGAAT ACCTGGAGGG CAACAATTTC GTGCATCGAG ACCTGGCTGC CCGCAATGTG 960 | | CTGGTGTCTG AGGACAACGT GGCCAAGGTC AGCGACTTTG GTCTCACCAA GGAGGCGTCC 1020 | | AGCACCCAGG ACACGGGCAA GCTGCCAGTC AAGTGGACAG CCCCTGAGGC CCTGAGAGAG 1080 | | AAGAAATTCT CCACTAAGTC TGACGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAC 1140 | | TCCTTTGGGC GAGTGCCTTA TCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAG 1200 | | AAGGGCTACA AGATGGATGC CCCCGACGGC TGCCCGCCCG CAGTCTATGA AGTCATGAAG 1260 | | AACTGCTGGC ACCTGGACGC CGCCATGCGG CCCTCCTTCC TACAGCTCCG AGAGCAGCTT 1320 | | GAGCACATCA AAACCCACGA GCTGCACCTG TGA 1353 |
|
| Domain Profile | S: 1 lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv 60 | lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv | Q: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 | 6899******************************************************** |
| S: 61 ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd 119 | i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd | Q: 255 IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 | *****99***************************************************** |
| S: 120 laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi 179 | laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi | Q: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI 374 | ************************************************************ |
| S: 180 llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa 239 | llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vye+mk++w+l+aa+rpsf | Q: 375 LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFL 434 | ************************************************************ |
| S: 240 klkekl 245 | +l+e+l | Q: 435 QLREQL 440 | ***997 |
|
Domain Sequence
(FASTA) | | LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60 | | IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120 | | LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180 | | LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYEVMKNCWH LDAAMRPSFL 240 | | QLREQL 246 |
|
| Keyword | 3D-structure; Adaptive immunity; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Immunity; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |