| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00434 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| AGC/SGK | 534.5 | 2.5E-160 | 162 | 419 | 258 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000262211 |
| UniProt Accession | Q96BR1; A8K5W3; B3KQC2; Q9P1Q7; Q9UKG5; |
| Protein Name | Serine/threonine-protein kinase Sgk3 |
| Protein Synonyms/Alias | Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like; |
| Gene Name | SGK3 |
| Gene Synonyms/Alias | SGK3; CISK, SGKL; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Serine/threonine-protein kinase which is involved in theregulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. |
| Protein Length | 496 |
Protein Sequence
(FASTA) | | MQRDHTMDYK ESCPSVSIPS SDEHREKKKR FTVYKVLVSV GRSEWFVFRR YAEFDKLYNT 60 | | LKKQFPAMAL KIPAKRIFGD NFDPDFIKQR RAGLNEFIQN LVRYPELYNH PDVRAFLQMD 120 | | SPKHQSDPSE DEDERSSQKL HSTSQNINLG PSGNPHAKPT DFDFLKVIGK GSFGKVLLAK 180 | | RKLDGKFYAV KVLQKKIVLN RKEQKHIMAE RNVLLKNVKH PFLVGLHYSF QTTEKLYFVL 240 | | DFVNGGELFF HLQRERSFPE HRARFYAAEI ASALGYLHSI KIVYRDLKPE NILLDSVGHV 300 | | VLTDFGLCKE GIAISDTTTT FCGTPEYLAP EVIRKQPYDN TVDWWCLGAV LYEMLYGLPP 360 | | FYCRDVAEMY DNILHKPLSL RPGVSLTAWS ILEELLEKDR QNRLGAKEDF LEIQNHPFFE 420 | | SLSWADLVQK KIPPPFNPNV AGPDDIRNFD TAFTEETVPY SVCVSSDYSI VNASVLEADD 480 | | AFVGFSYAPP SEDLFL 496 |
|
Nucleotide Sequence
(FASTA) | | ATGCAAAGAG ATCACACCAT GGACTACAAG GAAAGCTGCC CAAGTGTAAG CATTCCCAGC 60 | | TCCGATGAAC ACAGAGAGAA AAAGAAGAGG TTTACTGTTT ATAAAGTTCT GGTTTCAGTG 120 | | GGAAGAAGTG AATGGTTTGT CTTCAGGAGA TATGCAGAGT TTGATAAACT TTATAACACT 180 | | TTAAAAAAAC AGTTTCCTGC TATGGCCCTG AAGATTCCTG CCAAGAGAAT ATTTGGTGAT 240 | | AATTTTGATC CAGATTTTAT TAAACAAAGA CGAGCAGGAC TAAACGAATT CATTCAGAAC 300 | | CTAGTTAGGT ATCCAGAACT TTATAACCAT CCAGATGTCA GAGCATTCCT TCAAATGGAC 360 | | AGTCCAAAAC ACCAGTCAGA TCCATCTGAA GATGAGGATG AAAGAAGTTC TCAGAAGCTA 420 | | CACTCTACCT CACAGAACAT CAACCTGGGA CCGTCTGGAA ATCCTCATGC CAAACCAACT 480 | | GACTTTGATT TCTTAAAAGT TATTGGAAAA GGCAGCTTTG GCAAGGTTCT TCTTGCAAAA 540 | | CGGAAACTGG ATGGAAAATT TTATGCTGTC AAAGTGTTAC AGAAAAAAAT AGTTCTCAAC 600 | | AGAAAAGAGC AAAAACATAT TATGGCTGAA CGTAATGTGC TCTTGAAAAA TGTGAAACAT 660 | | CCGTTTTTGG TTGGATTGCA TTATTCCTTC CAAACAACTG AAAAGCTTTA TTTTGTTCTG 720 | | GATTTTGTTA ATGGAGGGGA GCTTTTTTTC CACTTACAAA GAGAACGGTC CTTTCCTGAG 780 | | CACAGAGCTA GGTTTTACGC TGCTGAAATT GCTAGTGCAT TGGGTTACTT ACATTCCATC 840 | | AAAATAGTAT ACAGAGACTT GAAACCAGAA AATATTCTTT TGGATTCAGT AGGACATGTT 900 | | GTCTTAACAG ATTTTGGGCT TTGTAAAGAA GGAATTGCTA TTTCTGACAC CACTACCACA 960 | | TTTTGTGGGA CACCAGAGTA TCTTGCACCT GAAGTAATTA GAAAACAGCC CTATGACAAT 1020 | | ACTGTAGATT GGTGGTGCCT TGGGGCTGTT CTGTATGAAA TGCTGTATGG ATTGCCTCCT 1080 | | TTTTATTGCC GAGATGTTGC TGAAATGTAT GACAATATCC TTCACAAACC CCTAAGTTTG 1140 | | AGGCCAGGAG TGAGTCTTAC AGCCTGGTCC ATTCTGGAAG AACTCCTAGA AAAAGACAGG 1200 | | CAAAATCGAC TTGGTGCCAA GGAAGACTTT CTTGAAATTC AGAATCATCC TTTTTTTGAA 1260 | | TCACTCAGCT GGGCTGACCT TGTACAAAAG AAGATTCCAC CACCATTTAA TCCTAATGTG 1320 | | GCTGGACCAG ATGATATCAG AAACTTTGAC ACAGCATTTA CAGAAGAAAC AGTTCCATAT 1380 | | TCTGTGTGTG TATCTTCTGA CTATTCTATA GTGAATGCCA GTGTATTGGA GGCAGATGAT 1440 | | GCATTCGTTG GTTTCTCTTA TGCACCTCCT TCAGAAGACT TATTTTTGTG A 1491 |
|
| Domain Profile | S: 1 fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp 60 | fdflkvigkgsfgkvllakrk d+kfyavkvlqkk++l++ke+khimaernvllknvkhp | Q: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221 | 9*********************************************************** |
| S: 61 flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln 120 | flvglhysfqt+eklyfvld+vnggelffhlqrersf+e+rarfyaaeiasalgylhs++ | Q: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281 | ************************************************************ |
| S: 121 ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt 180 | ivyrdlkpenillds ghvvltdfglcke+i+++dtt+tfcgtpeylapev+rk+pyd+t | Q: 282 IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341 | ************************************************************ |
| S: 181 vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk 240 | vdwwclgavlyemlyglppfy+rdvaemydnil+kpl+l+pg+s++a+++leellekdr+ | Q: 342 VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQ 401 | ************************************************************ |
| S: 241 krlgakedfleiknhvff 258 | +rlgakedflei+nh+ff | Q: 402 NRLGAKEDFLEIQNHPFF 419 | *****************9 |
|
Domain Sequence
(FASTA) | | FDFLKVIGKG SFGKVLLAKR KLDGKFYAVK VLQKKIVLNR KEQKHIMAER NVLLKNVKHP 60 | | FLVGLHYSFQ TTEKLYFVLD FVNGGELFFH LQRERSFPEH RARFYAAEIA SALGYLHSIK 120 | | IVYRDLKPEN ILLDSVGHVV LTDFGLCKEG IAISDTTTTF CGTPEYLAPE VIRKQPYDNT 180 | | VDWWCLGAVL YEMLYGLPPF YCRDVAEMYD NILHKPLSLR PGVSLTAWSI LEELLEKDRQ 240 | | NRLGAKEDFL EIQNHPFF 258 |
|
| Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasmic vesicle; Endosome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |