| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00437 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Other/Aur | 467.1 | 5.5E-140 | 9 | 259 | 251 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000406798 |
| UniProt Accession | Q9UQB9; O60681; O75442; Q6AZY8; Q6DLZ0; Q9UPK5; |
| Protein Name | Aurora kinase C |
| Protein Synonyms/Alias | Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; |
| Gene Name | AURKC |
| Gene Synonyms/Alias | AURKC; AIE2, AIK3, AIRK3, ARK3, STK13; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Serine/threonine-protein kinase component of thechromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
| Protein Length | 275 |
Protein Sequence
(FASTA) | | MRRLTVDDFE IGRPLGKGKF GNVYLARLKE SHFIVALKVL FKSQIEKEGL EHQLRREIEI 60 | | QAHLQHPNIL RLYNYFHDAR RVYLILEYAP RGELYKELQK SEKLDEQRTA TIIEELADAL 120 | | TYCHDKKVIH RDIKPENLLL GFRGEVKIAD FGWSVHTPSL RRKTMCGTLD YLPPEMIEGR 180 | | TYDEKVDLWC IGVLCYELLV GYPPFESASH SETYRRILKV DVRFPLSMPL GARDLISRLL 240 | | RYQPLERLPL AQILKHPWVQ AHSRRVLPPC AQMAS 275 |
|
Nucleotide Sequence
(FASTA) | | ATGCGGCGCC TCACAGTCGA TGACTTTGAA ATCGGGCGTC CCCTGGGCAA GGGGAAATTT 60 | | GGGAATGTGT ACCTGGCTCG GCTCAAGGAA AGCCATTTCA TTGTGGCCCT GAAGGTTCTC 120 | | TTCAAGTCGC AGATAGAGAA GGAAGGACTG GAGCACCAGC TGCGCCGGGA AATTGAGATC 180 | | CAGGCTCATC TACAACACCC CAATATCCTG CGCCTGTATA ACTATTTCCA TGATGCACGC 240 | | CGGGTGTACC TGATTCTGGA ATATGCTCCA AGGGGTGAGC TCTACAAGGA GCTGCAGAAA 300 | | AGCGAGAAAT TAGATGAACA GCGCACAGCC ACGATAATAG AGGAGTTGGC AGATGCCCTG 360 | | ACCTACTGCC ATGACAAGAA AGTGATTCAC AGAGATATTA AGCCAGAGAA CCTGCTGCTG 420 | | GGGTTCAGGG GTGAGGTGAA GATTGCAGAT TTTGGCTGGT CTGTGCACAC CCCCTCCCTG 480 | | AGGAGGAAGA CAATGTGTGG GACACTGGAC TACTTGCCGC CAGAAATGAT TGAGGGGAGA 540 | | ACATATGATG AAAAGGTGGA TTTGTGGTGC ATTGGAGTGC TCTGCTATGA GCTGCTGGTG 600 | | GGATATCCAC CCTTTGAGAG CGCCTCCCAC AGTGAGACTT ACAGACGCAT CCTCAAGGTA 660 | | GATGTGAGGT TTCCACTATC AATGCCTCTG GGGGCCCGGG ACTTGATTTC CAGGCTTCTC 720 | | AGATACCAGC CCTTGGAGAG ACTGCCCCTG GCCCAGATCC TGAAGCACCC CTGGGTTCAG 780 | | GCCCACTCCC GAAGGGTGCT GCCTCCCTGT GCTCAGATGG CTTCCTGA 828 |
|
| Domain Profile | S: 1 feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn 60 | feiGr+lGkGkfGnvylar k+s+fivalkvlfk+q+ekeg+e+qlrreieiq+hl+hpn | Q: 9 FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 68 | 9*********************************************************** |
| S: 61 ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv 120 | ilrly+yfhd++rvylileyaprGelykelqks+kldeqr+a++ieeladal+y+h+kkv | Q: 69 ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKV 128 | ************************************************************ |
| S: 121 ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl 180 | ihrdikpenlllg++ge+k+adfGwsvh+ps +rkt+cGtldylppem+egr+ydekvdl | Q: 129 IHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDL 188 | ************************************************************ |
| S: 181 walGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepkerl 240 | w++GvlcyellvG+ppfes+s++ety+ri kvd+++p s++ ga+dlis+ll+++p erl | Q: 189 WCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERL 248 | ************************************************************ |
| S: 241 tladvlahpwi 251 | +la++l+hpw+ | Q: 249 PLAQILKHPWV 259 | **********8 |
|
Domain Sequence
(FASTA) | | FEIGRPLGKG KFGNVYLARL KESHFIVALK VLFKSQIEKE GLEHQLRREI EIQAHLQHPN 60 | | ILRLYNYFHD ARRVYLILEY APRGELYKEL QKSEKLDEQR TATIIEELAD ALTYCHDKKV 120 | | IHRDIKPENL LLGFRGEVKI ADFGWSVHTP SLRRKTMCGT LDYLPPEMIE GRTYDEKVDL 180 | | WCIGVLCYEL LVGYPPFESA SHSETYRRIL KVDVRFPLSM PLGARDLISR LLRYQPLERL 240 | | PLAQILKHPW V 251 |
|
| Keyword | Alternative splicing; ATP-binding; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Meiosis; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |