EKS-HOS-00033

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00033

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	331.3	2.5E-98	712	982	271

Status

Reviewed

Ensembl Protein

ENSP00000433203

UniProt Accession

P29597; Q6QB10; Q96CH0;

Protein Name

Non-receptor tyrosine-protein kinase TYK2

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000105397	ENSP00000465291	ENST00000530560
ENSG00000105397	ENSP00000436155	ENST00000529739
ENSG00000105397	ENSP00000466340	ENST00000527481
ENSG00000105397	ENSP00000431885	ENST00000525621
ENSG00000105397	ENSP00000434931	ENST00000525220
ENSG00000105397	ENSP00000433203	ENST00000524462
ENSG00000105397	ENSP00000436175	ENST00000531836
ENSG00000105397	ENSP00000432728	ENST00000529370
ENSG00000105397	ENSP00000467288	ENST00000525824
ENSG00000105397	ENSP00000264818	ENST00000264818
ENSG00000105397	ENSP00000432320	ENST00000533334
ENSG00000105397	ENSP00000436826	ENST00000530829
ENSG00000105397	ENSP00000434831	ENST00000525976

Organism

Homo sapiens

Functional Description

Probably involved in intracellular signal transductionby being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Protein Length

1002

Protein Sequence
(FASTA)

MAFLHLCHLA LRHGIPLEEV AKKTSFKDCI PRSFRRHIRQ HSALTRLRLR NVFRRFLRDF 60

QPGRLSQQMV MVKYLATLER LAPRFGTERV PVCHLRLLAQ AEGEPCYIRD SGVAPTDPGP 120

ESAAGPPTHE VLVTGTGGIQ WWPVEEEVNK EEGSSGSSGR NPQASLFGKK AKAHKAVGQP 180

ADRPREPLWA YFCDFRDITH VVLKEHCVSI HRQDNKCLEL SLPSRAAALS FVSLVDGYFR 240

LTADSSHYLC HEVAPPRLVM SIRDGIHGPL LEPFVQAKLR PEDGLYLIHW STSHPYRLIL 300

TVAQRSQAPD GMQSLRLRKF PIEQQDGAFV LEGWGRSFPS VRELGAALQG CLLRAGDDCF 360

SLRRCCLPQP GETSNLIIMR GARASPRTLN LSQLSFHRVD QKEITQLSHL GQGTRTNVYE 420

GRLRVEGSGD PEEGKMDDED PLVPGRDRGQ ELRVVLKVLD PSHHDIALAF YETASLMSQV 480

SHTHLAFVHG VCVRGPENIM VTEYVEHGPL DVWLRRERGH VPMAWKMVVA QQLASALSYL 540

ENKNLVHGNV CGRNILLARL GLAEGTSPFI KLSDPGVGLG ALSREERVER IPWLAPECLP 600

GGANSLSTAM DKWGFGATLL EICFDGEAPL QSRSPSEKEH FYQRQHRLPE PSCPQLATLT 660

SQCLTYEPTQ RPSFRTILRD LTRLQPHNLA DVLTVNPDSP ASDPTVFHKR YLKKIRDLGE 720

GHFGKVSLYC YDPTNDGTGE MVAVKALKAD CGPQHRSGWK QEIDILRTLY HEHIIKYKGC 780

CEDQGEKSLQ LVMEYVPLGS LRDYLPRHSI GLAQLLLFAQ QICEGMAYLH AQHYIHRDLA 840

ARNVLLDNDR LVKIGDFGLA KAVPEGHEYY RVREDGDSPV FWYAPECLKE YKFYYASDVW 900

SFGVTLYELL THCDSSQSPP TKFLELIGIA QGQMTVLRLT ELLERGERLP RPDKCPCEVY 960

HLMKNCWETE ASFRPTFENL IPILKTVHEK YQGQAPSVFS VC 1002

Nucleotide Sequence
(FASTA)

ATGGCCTTTC TGCACCTCTG TCACCTCGCT CTCCGCCATG GCATCCCCCT GGAGGAGGTG 60

GCCAAGAAGA CCAGCTTCAA GGACTGCATC CCGCGCTCCT TCCGCCGGCA TATCCGGCAG 120

CACAGCGCCC TGACCCGGCT GCGCCTTCGG AACGTCTTCC GCAGGTTCCT GCGGGACTTC 180

CAGCCGGGCC GACTCTCCCA GCAGATGGTC ATGGTCAAAT ACCTAGCCAC ACTCGAGCGG 240

CTGGCACCCC GCTTCGGCAC AGAGCGTGTG CCCGTGTGCC ACCTGAGGCT GCTGGCCCAG 300

GCCGAGGGGG AGCCCTGCTA CATCCGGGAC AGTGGGGTGG CCCCTACAGA CCCTGGCCCT 360

GAGTCTGCTG CTGGGCCCCC AACCCACGAG GTGCTGGTGA CAGGCACTGG TGGCATCCAG 420

TGGTGGCCAG TAGAGGAGGA GGTGAACAAG GAGGAGGGTT CTAGTGGCAG CAGTGGCAGG 480

AACCCCCAAG CCAGCCTGTT TGGGAAGAAG GCCAAGGCTC ACAAGGCAGT CGGCCAGCCG 540

GCAGACAGGC CGCGGGAGCC ACTGTGGGCC TACTTCTGTG ACTTCCGGGA CATCACCCAC 600

GTGGTGCTGA AAGAGCACTG TGTCAGCATC CACCGGCAGG ACAACAAGTG CCTGGAGCTG 660

AGCTTGCCTT CCCGGGCTGC GGCGCTGTCC TTCGTGTCGC TGGTGGACGG CTATTTCCGC 720

CTGACGGCCG ACTCCAGCCA CTACCTGTGC CACGAGGTGG CTCCCCCACG GCTGGTGATG 780

AGCATCCGGG ATGGGATCCA CGGACCCCTG CTGGAGCCAT TTGTGCAGGC CAAGCTGCGG 840

CCCGAGGACG GCCTGTACCT CATTCACTGG AGCACCAGCC ACCCCTACCG CCTGATCCTC 900

ACAGTGGCCC AGCGTAGCCA GGCACCAGAC GGCATGCAGA GCTTGCGGCT CCGAAAGTTC 960

CCCATTGAGC AGCAGGACGG GGCCTTCGTG CTGGAGGGCT GGGGCCGGTC CTTCCCCAGC 1020

GTTCGGGAAC TTGGGGCTGC CTTGCAGGGC TGCTTGCTGA GGGCCGGGGA TGACTGCTTC 1080

TCTCTGCGTC GCTGTTGCCT GCCCCAACCA GGAGAAACCT CCAATCTCAT CATCATGCGG 1140

GGGGCTCGGG CCAGCCCCAG GACACTCAAC CTCAGCCAGC TCAGCTTCCA CCGGGTTGAC 1200

CAGAAGGAGA TCACCCAGCT GTCCCACTTG GGCCAGGGCA CAAGGACCAA CGTGTATGAG 1260

GGCCGCCTGC GAGTGGAGGG CAGCGGGGAC CCTGAGGAGG GCAAGATGGA TGACGAGGAC 1320

CCCCTCGTGC CTGGCAGGGA CCGTGGGCAG GAGCTACGAG TGGTGCTCAA AGTGCTGGAC 1380

CCTAGTCACC ATGACATCGC CCTGGCCTTC TACGAGACAG CCAGCCTCAT GAGCCAGGTC 1440

TCCCACACGC ACCTGGCCTT CGTGCATGGC GTCTGTGTGC GCGGCCCTGA AAATATCATG 1500

GTGACAGAGT ACGTGGAGCA CGGACCCCTG GATGTGTGGC TGCGGAGGGA GCGGGGCCAT 1560

GTGCCCATGG CTTGGAAGAT GGTGGTGGCC CAGCAGCTGG CCAGCGCCCT CAGCTACCTG 1620

GAGAACAAGA ACCTGGTTCA TGGTAATGTG TGTGGCCGGA ACATCCTGCT GGCCCGGCTG 1680

GGGTTGGCAG AGGGCACCAG CCCCTTCATC AAGCTGAGTG ATCCTGGCGT GGGCCTGGGC 1740

GCCCTCTCCA GGGAGGAGCG GGTGGAGAGG ATCCCCTGGC TGGCCCCCGA ATGCCTACCA 1800

GGTGGGGCCA ACAGCCTAAG CACCGCCATG GACAAGTGGG GGTTTGGCGC CACCCTCCTG 1860

GAGATCTGCT TTGACGGAGA GGCCCCTCTG CAGAGCCGCA GTCCCTCCGA GAAGGAGCAT 1920

TTCTACCAGA GGCAGCACCG GCTGCCCGAG CCCTCCTGCC CACAGCTGGC CACACTCACC 1980

AGCCAGTGTC TGACCTATGA GCCAACCCAG AGGCCATCAT TCCGCACCAT CCTGCGTGAC 2040

CTCACCCGGC TGCAGCCCCA CAATCTTGCT GACGTCTTGA CTGTGAACCC GGACTCACCG 2100

GCGTCGGACC CTACGGTTTT CCACAAGCGC TATTTGAAAA AGATCCGAGA TCTGGGCGAG 2160

GGTCACTTCG GCAAGGTCAG CTTGTACTGC TACGATCCGA CCAACGACGG CACTGGCGAG 2220

ATGGTGGCGG TGAAAGCCCT CAAGGCAGAC TGCGGCCCCC AGCACCGCTC GGGCTGGAAG 2280

CAGGAGATTG ACATTCTGCG CACGCTCTAC CACGAGCACA TCATCAAGTA CAAGGGCTGC 2340

TGCGAGGACC AAGGCGAGAA GTCGCTGCAG CTGGTCATGG AGTACGTGCC CCTGGGCAGC 2400

CTCCGAGACT ACCTGCCCCG GCACAGCATC GGGCTGGCCC AGCTGCTGCT CTTCGCCCAG 2460

CAGATCTGCG AGGGCATGGC CTATCTGCAC GCGCAGCACT ACATCCACCG AGACCTAGCC 2520

GCGCGCAACG TGCTGCTGGA CAACGACAGG CTGGTCAAGA TCGGGGACTT TGGCCTAGCC 2580

AAGGCCGTGC CCGAAGGCCA CGAGTACTAC CGCGTGCGCG AGGATGGGGA CAGCCCCGTG 2640

TTCTGGTATG CCCCAGAGTG CCTGAAGGAG TATAAGTTCT ACTATGCGTC AGATGTCTGG 2700

TCCTTCGGGG TGACCCTGTA TGAGCTGCTG ACGCACTGTG ACTCCAGCCA GAGCCCCCCC 2760

ACGAAATTCC TTGAGCTCAT AGGCATTGCT CAGGGTCAGA TGACAGTTCT GAGACTCACT 2820

GAGTTGCTGG AACGAGGGGA GAGGCTGCCA CGGCCCGACA AATGTCCCTG TGAGGTCTAT 2880

CATCTCATGA AGAACTGCTG GGAGACAGAG GCGTCCTTTC GCCCAACCTT CGAGAACCTC 2940

ATACCCATTC TGAAGACAGT CCATGAGAAG TACCAAGGCC AGGCCCCTTC AGTGTTCAGC 3000

GTGTGCTGA 3009

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k+Lk ++g+++++++k+e++il++l+h

Q: 712   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKaDCGPQHRSGWKQEIDILRTLYH  771

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         ehi+k+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL

Q: 772   EHIIKYKGCCEDQGEKslQLVMEYVPLGSLRDYLPRH--SIGLAQLLLFAQQICEGMAYL  829

         ****************9********************..*********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++++++hrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+

Q: 830   HAQHYIHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYRVREDGDSPVFWY  883

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+e+k +++asdvWsFgvtlyellt c++++sp    l+ ++++       r++el

Q: 884   APECLKEYK-FYYASDVWSFGVTLYELLThCDSSQSPptkfLELIGIAqgqmtvlRLTEL  942

         *********.****************************99966666667778899*****

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         le++erlp+p+ cp+e+++lm+nc+++e+s+rp+F++++

Q: 943   LERGERLPRPDkCPCEVYHLMKNCWETEASFRPTFENLIP  982

         ************************************9975

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKALKADC GPQHRSGWKQ EIDILRTLYH 60

EHIIKYKGCC EDQGEKSLQL VMEYVPLGSL RDYLPRHSIG LAQLLLFAQQ ICEGMAYLHA 120

QHYIHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYR VREDGDSPVF WYAPECLKEY 180

KFYYASDVWS FGVTLYELLT HCDSSQSPPT KFLELIGIAQ GQMTVLRLTE LLERGERLPR 240

PDKCPCEVYH LMKNCWETEA SFRPTFENLI P 271

Keyword

3D-structure; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0005829	; C:cytosol
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0060338	; P:regulation of type I interferon-mediated signaling pathway
GO:0060337	; P:type I interferon-mediated signaling pathway

KEGG

hsa:7297

;

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS00660	; FERM_1; FALSE_NEG.
PS00661	; FERM_2; FALSE_NEG.
PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; FALSE_NEG.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013