EKS-HOS-00014
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00014
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph383.61.7E-114393637245
StatusReviewed
Ensembl ProteinENSP00000409061
UniProt AccessionO15197; A4D2I7; A8CDT5; D3DXD3; Q2TB23; Q2TB24;
Protein NameEphrin type-B receptor 6
Protein Synonyms/Alias HEP; Tyrosine-protein kinase-defective receptor EPH-6;
Gene NameEPHB6
Gene Synonyms/Alias EPHB6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000106123ENSP00000410789ENST00000442129
ENSG00000106123ENSP00000376684ENST00000392957
ENSG00000106123ENSP00000409061ENST00000411471
ENSG00000106123ENSP00000411175ENST00000425995
ENSG00000106123ENSP00000404786ENST00000422643
OrganismHomo sapiens
Functional DescriptionKinase-defective receptor for members of the ephrin-Bfamily. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Protein Length744
Protein Sequence
(FASTA)
MATEGAAQLG NRVAGMVSVG GCRCQPGYQP ARGDKACQAC PRGLYKSSAG NAPCSPCPAR 60
SHAPNPAAPV CPCLEGFYRA SSDPPEAPCT GPPSAPQELW FEVQGSALML HWRLPRELGG 120
RGDLLFNVVC KECEGRQEPA SGGGGTCHRC RDEVHFDPRQ RGLTESRVLV GGLRAHVPYI 180
LEVQAVNGVS ELSPDPPQAA AINVSTSHEV PSAVPVVHQV SRASNSITVS WPQPDQTNGN 240
ILDYQLRYYD QAEDESHSFT LTSETNTATV TQLSPGHIYG FQVRARTAAG HGPYGGKVYF 300
QTLPQGELSS QLPERLSLVI GSILGALAFL LLAAITVLAV VFQRKRRGTG YTEQLQQYSS 360
PGLGVKYYID PSTYEDPCQA IRELAREVDP AYIKIEEVIG TGSFGEVRQG RLQPRGRREQ 420
TVAIQALWAG GAESLQMTFL GRAAVLGQFQ HPNILRLEGV VTKSRPLMVL TEFMELGPLD 480
SFLRQREGQF SSLQLVAMQR GVAAAMQYLS SFAFVHRSLS AHSVLVNSHL VCKVARLGHS 540
PQGPSCLLRW AAPEVIAHGK HTTSSDVWSF GILMWEVMSY GERPYWDMSE QEVLNAIEQE 600
FRLPPPPGCP PGLHLLMLDT WQKDRARRPH FDQLVAAFDK MIRKPDTLQA GGDPGERPSQ 660
ALLTPVALDF PCLDSPQAWL SAIGLECYQD NFSKFGLCTF SDVAQLSLED LPALGITLAG 720
HQKKLLHHIQ LLQQHLRQQG SVEV 744
Nucleotide Sequence
(FASTA)
ATGGCTACTG AAGGGGCTGC CCAGTTAGGG AACAGAGTGG CGGGCATGGT GTCTGTCGGG 60
GGCTGCCGCT GCCAGCCTGG ATACCAACCA GCACGAGGAG ACAAGGCCTG CCAAGCCTGC 120
CCACGGGGGC TCTATAAGTC TTCTGCTGGG AATGCTCCCT GCTCACCATG CCCTGCCCGC 180
AGTCACGCTC CCAACCCAGC AGCCCCCGTT TGCCCCTGCC TGGAGGGCTT CTACCGGGCC 240
AGTTCCGACC CACCAGAGGC CCCCTGCACT GGTCCTCCAT CGGCTCCCCA GGAGCTTTGG 300
TTTGAGGTGC AAGGCTCAGC ACTCATGCTA CACTGGCGCC TGCCTCGGGA GCTGGGGGGT 360
CGAGGGGACC TGCTCTTCAA TGTCGTGTGC AAGGAGTGTG AAGGCCGCCA GGAACCTGCC 420
AGCGGTGGTG GGGGCACTTG TCACCGCTGC AGGGATGAGG TCCACTTCGA CCCTCGCCAG 480
AGAGGCCTGA CTGAGAGCCG AGTGTTAGTG GGGGGACTCC GGGCACACGT ACCCTACATC 540
TTAGAGGTGC AGGCTGTTAA TGGGGTGTCT GAGCTCAGCC CTGACCCTCC TCAGGCTGCA 600
GCCATCAATG TCAGCACCAG CCATGAAGTG CCCTCTGCTG TCCCTGTGGT GCACCAGGTG 660
AGCCGGGCAT CCAACAGCAT CACGGTGTCC TGGCCGCAGC CCGACCAGAC CAATGGGAAC 720
ATCCTGGACT ATCAGCTCCG CTACTATGAC CAGGCAGAAG ACGAATCCCA CTCCTTCACC 780
CTGACCAGCG AGACCAACAC TGCCACCGTG ACACAGCTGA GCCCTGGCCA CATCTATGGT 840
TTCCAGGTGC GGGCCCGGAC TGCTGCCGGC CACGGCCCCT ACGGGGGCAA AGTCTATTTC 900
CAGACACTTC CTCAAGGGGA GCTGTCTTCC CAGCTTCCGG AAAGACTCTC CTTGGTGATC 960
GGCTCCATCC TGGGGGCTTT GGCCTTCCTC CTGCTGGCAG CCATCACCGT GCTGGCGGTC 1020
GTCTTCCAGC GGAAGCGGCG TGGGACTGGC TACACGGAGC AGCTGCAGCA ATACAGCAGC 1080
CCAGGACTCG GGGTGAAGTA TTACATCGAC CCCTCCACCT ACGAGGACCC CTGTCAGGCC 1140
ATCCGAGAAC TTGCCCGGGA AGTCGATCCT GCTTATATCA AGATTGAGGA GGTCATTGGG 1200
ACAGGCTCTT TTGGAGAAGT GCGCCAGGGC CGCCTGCAGC CACGGGGACG GAGGGAGCAG 1260
ACTGTGGCCA TCCAGGCCCT GTGGGCCGGG GGCGCCGAAA GCCTGCAGAT GACCTTCCTG 1320
GGCCGGGCCG CAGTGCTGGG TCAGTTCCAG CACCCCAACA TCCTGCGGCT GGAGGGCGTG 1380
GTCACCAAGA GCCGACCCCT CATGGTGCTG ACGGAGTTCA TGGAGCTTGG CCCCCTGGAC 1440
AGCTTCCTCA GGCAGCGGGA GGGCCAGTTC AGCAGCCTGC AGCTGGTGGC CATGCAGCGG 1500
GGAGTGGCTG CTGCCATGCA GTACCTGTCC AGCTTTGCCT TCGTCCATCG CTCGCTGTCT 1560
GCCCACAGCG TGCTGGTGAA TAGCCACTTG GTGTGCAAGG TGGCCCGTCT TGGCCACAGT 1620
CCTCAGGGCC CAAGTTGTTT GCTTCGCTGG GCAGCCCCAG AGGTCATTGC ACATGGAAAG 1680
CATACAACAT CCAGTGATGT CTGGAGCTTT GGGATACTCA TGTGGGAAGT GATGAGTTAT 1740
GGAGAACGGC CTTACTGGGA CATGAGTGAG CAGGAGGTAC TAAATGCAAT AGAGCAGGAG 1800
TTCCGGCTGC CCCCGCCTCC AGGCTGTCCT CCTGGATTAC ATCTACTTAT GTTGGACACT 1860
TGGCAGAAGG ACCGTGCCCG GCGGCCTCAT TTTGACCAGC TGGTGGCTGC ATTTGACAAG 1920
ATGATCCGCA AGCCAGATAC CCTGCAGGCT GGCGGGGACC CAGGGGAAAG GCCTTCCCAG 1980
GCCCTTCTGA CCCCTGTGGC CCTGGACTTT CCTTGTCTGG ACTCACCCCA GGCCTGGCTT 2040
TCAGCCATTG GACTGGAGTG CTACCAGGAC AACTTCTCCA AGTTTGGCCT CTGTACCTTC 2100
AGTGATGTGG CTCAGCTCAG CCTAGAAGAC CTGCCTGCCC TGGGCATCAC CCTGGCTGGC 2160
CACCAGAAGA AGCTGCTGCA CCACATCCAG CTCCTTCAGC AACACCTGAG GCAGCAGGGC 2220
TCAGTGGAGG TCTGA 2235
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kie+viG+G+fGev++Grl+ +g+re++vai++l+ag +e+ +++fl +a++lGqf+hp
Q: 393   IKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHP  452
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         ni+rleGvvtks+p+m++te+me g ldsflr+++gqf+++qlv+m+rG+a++m+yls++
Q: 453   NILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSF  512
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         ++vhr+l+a+++lvns+lvckv+++G+s++            g ++ +rw+ape+ia++k
Q: 513   AFVHRSLSAHSVLVNSHLVCKVARLGHSPQ------------GPSCLLRWAAPEVIAHGK  560
         ****************************98............999***************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         +t++sdvws+Gi++wev+syGerpywdms+q+v++aie+++rlppp +cp +l+ lmld+
Q: 561   HTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDT  620
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         wqkdra+rp+f+q+v++
Q: 621   WQKDRARRPHFDQLVAA  637
         **************986
Domain Sequence
(FASTA)
IKIEEVIGTG SFGEVRQGRL QPRGRREQTV AIQALWAGGA ESLQMTFLGR AAVLGQFQHP 60
NILRLEGVVT KSRPLMVLTE FMELGPLDSF LRQREGQFSS LQLVAMQRGV AAAMQYLSSF 120
AFVHRSLSAH SVLVNSHLVC KVARLGHSPQ GPSCLLRWAA PEVIAHGKHT TSSDVWSFGI 180
LMWEVMSYGE RPYWDMSEQE VLNAIEQEFR LPPPPGCPPG LHLLMLDTWQ KDRARRPHFD 240
QLVAA 245
KeywordAlternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Nucleotide-binding; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00013
EKS-CAJ-00013
EKS-CAF-00013
EKS-CAP-00012
EKS-EQC-00013
EKS-FEC-00010
EKS-GOG-00014
EKS-ICT-00014
EKS-MAM-00012
EKS-MOD-00012
EKS-MUM-00013
EKS-MUP-00014
EKS-NOL-00013
EKS-ORC-00013
EKS-OTG-00014
EKS-PAT-00011
EKS-POA-00012
EKS-RAN-00013
EKS-SAH-00012
EKS-SUS-00012
Gene Ontology
GO:0005576; C:extracellular region
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0055074; P:calcium ion homeostasis
GO:0035898; P:parathyroid hormone secretion
KEGG
hsa:2051;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013