EKS-HOS-00199
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00199
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LISK422.62.9E-12657311255
StatusReviewed
Ensembl ProteinENSP00000338127
UniProt AccessionQ15569; Q8IXZ8;
Protein NameDual specificity testis-specific protein kinase 1
Protein Synonyms/Alias Testicular protein kinase 1;
Gene NameTESK1
Gene Synonyms/Alias TESK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000107140ENSP00000338127ENST00000336395
OrganismHomo sapiens
Functional DescriptionDual specificity protein kinase activity catalyzingautophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).
Protein Length626
Protein Sequence
(FASTA)
MAGERPPLRG PGPGPGEVPG EGPPGPGGTG GGPGRGRPSS YRALRSAVSS LARVDDFHCA 60
EKIGAGFFSE VYKVRHRQSG QVMVLKMNKL PSNRGNTLRE VQLMNRLRHP NILRFMGVCV 120
HQGQLHALTE YMNGGTLEQL LSSPEPLSWP VRLHLALDIA RGLRYLHSKG VFHRDLTSKN 180
CLVRREDRGF TAVVGDFGLA EKIPVYREGA RKEPLAVVGS PYWMAPEVLR GELYDEKADV 240
FAFGIVLCEL IARVPADPDY LPRTEDFGLD VPAFRTLVGD DCPLPFLLLA IHCCNLEPST 300
RAPFTEITQH LEWILEQLPE PAPLTRTALT HNQGSVARGG PSATLPRPDP RLSRSRSDLF 360
LPPSPESPPN WGDNLTRVNP FSLREDLRGG KIKLLDTPSK PVLPLVPPSP FPSTQLPLVT 420
TPETLVQPGT PARRCRSLPS SPELPRRMET ALPGPGPPAV GPSAEEKMEC EGSSPEPEPP 480
GPAPQLPLAV ATDNFISTCS SASQPWSPRS GPVLNNNPPA VVVNSPQGWA GEPWNRAQHS 540
LPRAAALERT EPSPPPSAPR EPDEGLPCPG CCLGPFSFGF LSMCPRPTPA VARYRNLNCE 600
AGSLLCHRGH HAKPPTPSLQ LPGARS 626
Nucleotide Sequence
(FASTA)
ATGGCCGGGG AACGGCCCCC ACTGCGGGGC CCTGGGCCCG GGCCTGGAGA GGTGCCGGGG 60
GAGGGGCCCC CGGGGCCGGG GGGCACGGGC GGAGGCCCGG GCCGGGGCCG CCCCTCCTCC 120
TACCGGGCTC TCCGCAGCGC CGTGTCTAGC CTGGCGCGTG TGGACGATTT TCACTGCGCG 180
GAGAAGATCG GGGCCGGCTT CTTCTCTGAG GTCTACAAGG TTCGGCACCG ACAGTCAGGG 240
CAAGTCATGG TGCTGAAGAT GAACAAGCTC CCCAGTAACC GGGGCAACAC ACTACGGGAA 300
GTGCAGCTGA TGAACCGGCT CAGGCACCCC AACATCCTAA GGTTCATGGG AGTCTGTGTG 360
CACCAGGGAC AGCTGCACGC TCTTACAGAG TATATGAATG GGGGGACATT GGAACAGCTG 420
CTCAGCTCCC CTGAACCCCT GTCCTGGCCG GTCAGGCTCC ACCTGGCCCT GGACATTGCC 480
CGAGGCCTGC GGTACCTGCA CTCCAAAGGT GTATTTCACC GCGACCTCAC ATCCAAGAAC 540
TGTCTAGTCC GACGGGAAGA TCGAGGCTTC ACCGCTGTCG TGGGTGACTT CGGGCTGGCC 600
GAAAAGATTC CTGTGTATAG GGAGGGGGCA AGGAAGGAGC CATTGGCCGT GGTGGGCTCC 660
CCATACTGGA TGGCTCCAGA GGTGTTACGG GGTGAGCTGT ATGATGAGAA GGCTGATGTC 720
TTTGCCTTCG GGATTGTCCT CTGTGAGCTC ATCGCCCGAG TACCTGCAGA CCCTGACTAC 780
CTACCACGCA CTGAGGACTT TGGCCTGGAT GTGCCTGCTT TCCGAACTCT GGTGGGGGAT 840
GACTGCCCAC TGCCTTTCTT GCTCCTGGCC ATCCACTGCT GCAACCTGGA ACCCAGCACC 900
CGTGCCCCCT TCACCGAAAT TACCCAGCAC CTGGAATGGA TCCTGGAGCA GCTGCCTGAG 960
CCAGCCCCAC TCACCAGGAC CGCCCTGACA CACAATCAGG GCTCTGTTGC AAGAGGGGGT 1020
CCCTCTGCCA CGCTTCCCAG GCCAGATCCC CGGCTTTCCC GAAGCCGGTC AGACCTCTTC 1080
CTGCCCCCAT CACCAGAATC ACCCCCCAAC TGGGGGGACA ATCTGACTCG AGTCAACCCC 1140
TTCTCACTAC GGGAAGACCT CAGGGGTGGC AAGATCAAGC TCTTAGACAC ACCCAGCAAG 1200
CCAGTCCTGC CTCTTGTGCC ACCATCACCA TTCCCATCCA CTCAGCTGCC CTTGGTGACC 1260
ACTCCGGAGA CCCTGGTCCA GCCTGGGACA CCTGCCCGCC GCTGCCGCTC ACTACCCTCA 1320
TCCCCCGAGC TCCCCCGCCG TATGGAGACA GCACTGCCAG GTCCTGGCCC TCCCGCTGTG 1380
GGCCCCTCGG CTGAAGAGAA GATGGAGTGC GAGGGCAGCA GCCCTGAGCC GGAACCTCCA 1440
GGGCCAGCGC CCCAGCTGCC TCTGGCTGTG GCCACAGACA ACTTCATCAG CACCTGTTCC 1500
TCGGCCTCCC AACCCTGGTC CCCTAGATCA GGACCCGTCC TCAATAACAA TCCCCCAGCT 1560
GTGGTGGTGA ACTCCCCACA AGGCTGGGCT GGGGAGCCCT GGAACCGGGC CCAGCATAGC 1620
CTGCCCCGGG CGGCAGCCCT GGAGCGGACA GAACCCTCGC CACCCCCTTC AGCTCCCCGG 1680
GAGCCCGATG AGGGGCTGCC CTGTCCTGGC TGCTGCCTCG GCCCCTTCAG CTTTGGCTTC 1740
CTGTCCATGT GCCCCCGCCC CACACCAGCT GTTGCCCGCT ACCGCAACCT GAACTGTGAG 1800
GCGGGCAGTC TCCTCTGCCA CCGAGGGCAC CACGCCAAGC CACCCACACC CAGCCTGCAG 1860
CTGCCTGGGG CACGCTCTTA G 1881
Domain Profile
S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60
         ++++ek+G+Gffsev+kv+hr+sG+vmvlk  ++++ +nr n+l+ev+l+++l+hpn+l+
Q: 57    FHCAEKIGAGFFSEVYKVRHRQSGQVMVLK--MNKLPSNRGNTLREVQLMNRLRHPNILR  114
         689***************************..****************************
S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120
         f+Gv+v++++lh+ltey++gGtl++ll+s+e+l+w++r++la dia+Gl+ylhskg++hr
Q: 115   FMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHR  174
         ************************************************************
S: 121   dlnsknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywm  177
         dl+sknclvr+   ++++vv+dfGla          ek++++++++rk+ l+vvGsPywm
Q: 175   DLTSKNCLVRRedrGFTAVVGDFGLA----------EKIPVYREGARKEPLAVVGSPYWM  224
         **********988889**********..........9***********************
S: 178   aPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcP  237
         aPevl+g+ ydek+dvf+fGivlce+iarv adPdylPrtedfgldv afr+ lv++dcP
Q: 225   APEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRT-LVGDDCP  283
         ****************************************************.*******
S: 238   eaflklavvccdldpesrpsfeelekkl  265
          +fl la++cc+l+p++r++f+e++++l
Q: 284   LPFLLLAIHCCNLEPSTRAPFTEITQHL  311
         *************************987
Domain Sequence
(FASTA)
FHCAEKIGAG FFSEVYKVRH RQSGQVMVLK MNKLPSNRGN TLREVQLMNR LRHPNILRFM 60
GVCVHQGQLH ALTEYMNGGT LEQLLSSPEP LSWPVRLHLA LDIARGLRYL HSKGVFHRDL 120
TSKNCLVRRE DRGFTAVVGD FGLAEKIPVY REGARKEPLA VVGSPYWMAP EVLRGELYDE 180
KADVFAFGIV LCELIARVPA DPDYLPRTED FGLDVPAFRT LVGDDCPLPF LLLAIHCCNL 240
EPSTRAPFTE ITQHL 255
KeywordATP-binding; Complete proteome; Kinase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00181
EKS-ANC-00187
EKS-BOT-00193
EKS-CAJ-00199
EKS-CAF-00200
EKS-CAP-00218
EKS-DIO-00099
EKS-DRM-00102
EKS-ECT-00069
EKS-EQC-00189
EKS-GAM-00110
EKS-GAA-00237
EKS-GOG-00187
EKS-LAC-00204
EKS-LOA-00190
EKS-MAM-00193
EKS-MIM-00090
EKS-MOD-00191
EKS-MUM-00196
EKS-MUP-00196
EKS-NOL-00182
EKS-ORN-00246
EKS-ORA-00172
EKS-ORC-00176
EKS-ORL-00231
EKS-OTG-00200
EKS-PAT-00184
EKS-PEM-00101
EKS-POA-00186
EKS-PRC-00066
EKS-RAN-00187
EKS-SAH-00185
EKS-SUS-00167
Gene Ontology
GO:0005829; C:cytosol
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004712; F:protein serine/threonine/tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0034329; P:cell junction assembly
GO:0007283; P:spermatogenesis
KEGG
hsa:7016;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR015782; Testis-specific_kinase_1.
IPR008266; Tyr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013