EPS-HOS-00134
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-HOS-00134
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
PPP/PP2B430.15.7E-1297207201
StatusReviewed
Ensembl ProteinENSP00000439876
UniProt AccessionP16298; P16299; Q5F2F9; Q8N1F0; Q8N3W4;
Protein NameSerine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Protein Synonyms/Alias CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit beta isoform;
Gene NamePPP3CB
Gene Synonyms/Alias PPP3CB; CALNA2, CALNB, CNA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000107758ENSP00000378306ENST00000394829
ENSG00000107758ENSP00000378305ENST00000394828
ENSG00000107758ENSP00000378299ENST00000394822
ENSG00000107758ENSP00000437596ENST00000544628
ENSG00000107758ENSP00000343147ENST00000342558
ENSG00000107758ENSP00000398022ENST00000430762
ENSG00000107758ENSP00000439876ENST00000545874
ENSG00000107758ENSP00000353881ENST00000360663
OrganismHomo sapiens
Functional DescriptionCalcium-dependent, calmodulin-stimulated proteinphosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
Protein Length411
Protein Sequence
(FASTA)
MIEVEAPITV CGDIHGQFFD LMKLFEVGGS PANTRYLFLG DYVDRGYFSI ECVLYLWVLK 60
ILYPSTLFLL RGNHECRHLT EYFTFKQECK IKYSERVYEA CMEAFDSLPL AALLNQQFLC 120
VHGGLSPEIH TLDDIRRLDR FKEPPAFGPM CDLLWSDPSE DFGNEKSQEH FSHNTVRGCS 180
YFYNYPAVCE FLQNNNLLSI IRAHEAQDAG YRMYRKSQTT GFPSLITIFS APNYLDVYNN 240
KAAVLKYENN VMNIRQFNCS PHPYWLPNFM DVFTWSLPFV GEKVTEMLVN VLSICSDDEL 300
MTEGEDQFDV GSAAARKEII RNKIRAIGKM ARVFSVLREE SESVLTLKGL TPTGMLPSGV 360
LAGGRQTLQS GNDVMQLAVP QMDWGTPHSF ANNSHNACRE FLLFFSSCLS S 411
Nucleotide Sequence
(FASTA)
ATGATAGAAG TAGAAGCTCC AATCACAGTG TGTGGTGACA TCCATGGCCA ATTTTTTGAT 60
CTGATGAAAC TTTTTGAAGT AGGAGGATCA CCTGCTAATA CACGATACCT TTTTCTTGGC 120
GATTATGTGG ACAGAGGTTA TTTTAGTATA GAGTGTGTCT TATATTTATG GGTTCTGAAG 180
ATTCTATACC CAAGCACATT ATTTCTTCTG AGAGGCAACC ATGAATGCAG ACACCTTACT 240
GAATATTTTA CCTTTAAGCA GGAATGTAAA ATTAAGTATT CGGAAAGAGT CTATGAAGCT 300
TGTATGGAAG CTTTTGATAG TTTGCCTCTT GCTGCACTTT TAAACCAACA GTTTCTTTGT 360
GTTCATGGTG GACTTTCACC AGAAATACAC ACACTGGATG ATATTAGGAG ATTAGATAGA 420
TTCAAAGAGC CACCTGCATT TGGACCAATG TGTGACTTGT TATGGTCCGA TCCTTCTGAA 480
GATTTTGGAA ATGAAAAATC ACAGGAACAT TTTAGTCACA ATACAGTTCG AGGATGTTCT 540
TATTTTTATA ACTATCCAGC AGTGTGTGAA TTTTTGCAAA ACAATAATTT GTTATCGATT 600
ATTAGAGCTC ATGAAGCTCA AGATGCAGGC TATAGAATGT ACAGAAAAAG TCAAACTACA 660
GGGTTCCCTT CATTAATAAC AATTTTTTCG GCACCTAATT ACTTAGATGT CTACAATAAT 720
AAAGCTGCTG TATTAAAGTA TGAAAATAAT GTGATGAATA TTCGACAGTT TAACTGTTCT 780
CCACATCCTT ACTGGTTGCC TAATTTTATG GATGTCTTCA CGTGGTCTTT ACCGTTTGTT 840
GGAGAAAAAG TGACAGAAAT GTTGGTAAAT GTTCTGAGTA TTTGCTCTGA TGATGAACTA 900
ATGACTGAAG GTGAAGACCA GTTTGATGTA GGTTCAGCTG CAGCCCGGAA AGAAATCATA 960
AGAAACAAAA TTCGAGCAAT TGGCAAGATG GCAAGAGTCT TCTCTGTTCT CAGGGAGGAG 1020
AGTGAAAGTG TGCTGACACT CAAGGGCCTG ACTCCCACAG GGATGTTGCC TAGTGGAGTG 1080
TTAGCTGGAG GACGGCAGAC CCTGCAAAGT GGTAATGATG TTATGCAACT TGCTGTGCCT 1140
CAGATGGACT GGGGCACACC TCACTCTTTT GCTAACAATT CACATAATGC ATGCAGGGAA 1200
TTCCTTCTGT TTTTTAGTTC CTGTCTCAGC AGCTGA 1236
Domain Profile
S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60
         p+tvcgdihgqffdl+klfevggspantrylflgdyvdrgyfsiecvlyl++lkilyp+t
Q: 7     PITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPST  66
         9***********************************************************
S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120
         lfllrgnhecrhlteyftfkqe+kikyservy+ac+eafd+lplaallnqqflcvhggls
Q: 67    LFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLS  126
         ************************************************************
S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgnekseeefvhnsvrgcsyfysyk  180
         pe++tlddir+ldrfkeppa+g+mcdllwsdp edfgneks+e+f+hn+vrgcsyfy+y+
Q: 127   PEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYP  186
         ************************************************************
S: 181   avceflqennllsiiraheaq  201
         avceflq+nnllsiiraheaq
Q: 187   AVCEFLQNNNLLSIIRAHEAQ  207
         ********************8
Domain Sequence
(FASTA)
PITVCGDIHG QFFDLMKLFE VGGSPANTRY LFLGDYVDRG YFSIECVLYL WVLKILYPST 60
LFLLRGNHEC RHLTEYFTFK QECKIKYSER VYEACMEAFD SLPLAALLNQ QFLCVHGGLS 120
PEIHTLDDIR RLDRFKEPPA FGPMCDLLWS DPSEDFGNEK SQEHFSHNTV RGCSYFYNYP 180
AVCEFLQNNN LLSIIRAHEA Q 201
KeywordAcetylation; Alternative splicing; Calmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding; Protein phosphatase; Reference proteome; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EPS-AIM-00124
EPS-CAE-00092
EPS-CAP-00107
EPS-CHH-00026
EPS-CIS-00023
EPS-DAR-00113
EPS-EQC-00127
EPS-FEC-00128
EPS-GAM-00060
EPS-LOA-00112
EPS-MIM-00035
EPS-MOD-00136
EPS-MUM-00111
EPS-MUP-00124
EPS-MYL-00105
EPS-ORA-00069
EPS-ORC-00107
EPS-PES-00076
EPS-POA-00079
EPS-SAH-00101
EPS-SUS-00108
EPS-XET-00075
EPS-SAC-00018
EPS-SCP-00018
Gene Ontology
GO:0005955; C:calcineurin complex
GO:0005829; C:cytosol
GO:0005886; C:plasma membrane
GO:0005509; F:calcium ion binding
GO:0005516; F:calmodulin binding
GO:0033192; F:calmodulin-dependent protein phosphatase activity
GO:0008144; F:drug binding
GO:0030346; F:protein phosphatase 2B binding
GO:0048675; P:axon extension
GO:0017156; P:calcium ion-dependent exocytosis
GO:0035690; P:cellular response to drug
GO:0007507; P:heart development
GO:0007612; P:learning
GO:0007613; P:memory
GO:0046716; P:muscle cell homeostasis
GO:0001915; P:negative regulation of T cell mediated cytotoxicity
GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0006470; P:protein dephosphorylation
GO:0006468; P:protein phosphorylation
GO:0048167; P:regulation of synaptic plasticity
GO:0001975; P:response to amphetamine
GO:0034097; P:response to cytokine stimulus
GO:0007165; P:signal transduction
GO:0035176; P:social behavior
GO:0030217; P:T cell differentiation
GO:0043029; P:T cell homeostasis
GO:0042098; P:T cell proliferation
KEGG
hsa:5532;
InterPros
IPR004843; Metallo_PEstase_dom.
IPR006186; Ser/Thr-sp_prot-phosphatase.
Pfam
PF00149; Metallophos; 1.
SMARTs
SM00156; PP2Ac; 1.
Prosites
PS00125; SER_THR_PHOSPHATASE; 1.
Prints
PR00114; STPHPHTASE.
Created Date20-Feb-2013