EKS-HOS-00286

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00286

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	446.9	1.5E-133	234	521	288

Status

Reviewed

Ensembl Protein

ENSP00000224764

UniProt Accession

P36894; A8K6U9; Q8NEN8;

Protein Name

Bone morphogenetic protein receptor type-1A

Protein Synonyms/Alias

BMP type-1A receptor; BMPR-1A; Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5;

Gene Name

BMPR1A

Gene Synonyms/Alias

BMPR1A; ACVRLK3, ALK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000107779	ENSP00000224764	ENST00000224764
ENSG00000107779	ENSP00000361107	ENST00000372037

Organism

Homo sapiens

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

Protein Length

532

Protein Sequence
(FASTA)

MPQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSD QKKSENGVTL APEDTLPFLK 60

CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR 120

TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVLLISM AVCIIAMIIF SSCFCYKHYC 180

KSISSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240

GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300

SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360

RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN 420

HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 480

PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532

Nucleotide Sequence
(FASTA)

ATGCCTCAGC TATACATTTA CATCAGATTA TTGGGAGCCT ATTTGTTCAT CATTTCTCGT 60

GTTCAAGGAC AGAATCTGGA TAGTATGCTT CATGGCACTG GGATGAAATC AGACTCCGAC 120

CAGAAAAAGT CAGAAAATGG AGTAACCTTA GCACCAGAGG ATACCTTGCC TTTTTTAAAG 180

TGCTATTGCT CAGGGCACTG TCCAGATGAT GCTATTAATA ACACATGCAT AACTAATGGA 240

CATTGCTTTG CCATCATAGA AGAAGATGAC CAGGGAGAAA CCACATTAGC TTCAGGGTGT 300

ATGAAATATG AAGGATCTGA TTTTCAGTGC AAAGATTCTC CAAAAGCCCA GCTACGCCGG 360

ACAATAGAAT GTTGTCGGAC CAATTTATGT AACCAGTATT TGCAACCCAC ACTGCCCCCT 420

GTTGTCATAG GTCCGTTTTT TGATGGCAGC ATTCGATGGC TGGTTTTGCT CATTTCTATG 480

GCTGTCTGCA TAATTGCTAT GATCATCTTC TCCAGCTGCT TTTGTTACAA ACATTATTGC 540

AAGAGCATCT CAAGCAGACG TCGTTACAAT CGTGATTTGG AACAGGATGA AGCATTTATT 600

CCAGTTGGAG AATCACTAAA AGACCTTATT GACCAGTCAC AAAGTTCTGG TAGTGGGTCT 660

GGACTACCTT TATTGGTTCA GCGAACTATT GCCAAACAGA TTCAGATGGT CCGGCAAGTT 720

GGTAAAGGCC GATATGGAGA AGTATGGATG GGCAAATGGC GTGGCGAAAA AGTGGCGGTG 780

AAAGTATTCT TTACCACTGA AGAAGCCAGC TGGTTTCGAG AAACAGAAAT CTACCAAACT 840

GTGCTAATGC GCCATGAAAA CATACTTGGT TTCATAGCGG CAGACATTAA AGGTACAGGT 900

TCCTGGACTC AGCTCTATTT GATTACTGAT TACCATGAAA ATGGATCTCT CTATGACTTC 960

CTGAAATGTG CTACACTGGA CACCAGAGCC CTGCTTAAAT TGGCTTATTC AGCTGCCTGT 1020

GGTCTGTGCC ACCTGCACAC AGAAATTTAT GGCACCCAAG GAAAGCCCGC AATTGCTCAT 1080

CGAGACCTAA AGAGCAAAAA CATCCTCATC AAGAAAAATG GGAGTTGCTG CATTGCTGAC 1140

CTGGGCCTTG CTGTTAAATT CAACAGTGAC ACAAATGAAG TTGATGTGCC CTTGAATACC 1200

AGGGTGGGCA CCAAACGCTA CATGGCTCCC GAAGTGCTGG ACGAAAGCCT GAACAAAAAC 1260

CACTTCCAGC CCTACATCAT GGCTGACATC TACAGCTTCG GCCTAATCAT TTGGGAGATG 1320

GCTCGTCGTT GTATCACAGG AGGGATCGTG GAAGAATACC AATTGCCATA TTACAACATG 1380

GTACCGAGTG ATCCGTCATA CGAAGATATG CGTGAGGTTG TGTGTGTCAA ACGTTTGCGG 1440

CCAATTGTGT CTAATCGGTG GAACAGTGAT GAATGTCTAC GAGCAGTTTT GAAGCTAATG 1500

TCAGAATGCT GGGCCCACAA TCCAGCCTCC AGACTCACAG CATTGAGAAT TAAGAAGACG 1560

CTTGCCAAGA TGGTTGAATC CCAAGATGTA AAAATCTGA 1599

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         +++++++gkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 234   IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  293

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+d+Lk  tld++ ll+la+s+a+Gl+hLH+ei gt+

Q: 294   ADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQ  353

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNil+kk+++cciaDlGLa+k++++++e+d+  n++vGtkRYmaPE

Q: 354   G--KPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPE  411

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+ + +aD+Ys+gL++WE+a+Rc + +++veey+lp++++v+sdPs+e+m

Q: 412   VLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT-GGIVEEYQLPYYNMVPSDPSYEDM  470

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv++k+lrP ++++w+++e+l+++ kl++ecW+++p++Rltalr+kk+l

Q: 471   REVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL  521

         *************************************************97

Domain Sequence
(FASTA)

IQMVRQVGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDFLKC ATLDTRALLK LAYSAACGLC HLHTEIYGTQ 120

GKPAIAHRDL KSKNILIKKN GSCCIADLGL AVKFNSDTNE VDVPLNTRVG TKRYMAPEVL 180

DESLNKNHFQ PYIMADIYSF GLIIWEMARR CITGGIVEEY QLPYYNMVPS DPSYEDMREV 240

VCVKRLRPIV SNRWNSDECL RAVLKLMSEC WAHNPASRLT ALRIKKTL 288

Keyword

3D-structure; ATP-binding; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0030425	; C:dendrite
GO:0016021	; C:integral to membrane
GO:0043025	; C:neuronal cell body
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0042803	; F:protein homodimerization activity
GO:0000981	; F:sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0046332	; F:SMAD binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0004675	; F:transmembrane receptor protein serine/threonine kinase activity
GO:0030509	; P:BMP signaling pathway
GO:0051216	; P:cartilage development
GO:0048589	; P:developmental growth
GO:0009950	; P:dorsal/ventral axis specification
GO:0007398	; P:ectoderm development
GO:0042733	; P:embryonic digit morphogenesis
GO:0048568	; P:embryonic organ development
GO:0003272	; P:endocardial cushion formation
GO:0060914	; P:heart formation
GO:0035137	; P:hindlimb morphogenesis
GO:0006955	; P:immune response
GO:0001701	; P:in utero embryonic development
GO:0048368	; P:lateral mesoderm development
GO:0030324	; P:lung development
GO:0048382	; P:mesendoderm development
GO:0001707	; P:mesoderm formation
GO:0001880	; P:Mullerian duct regression
GO:0050768	; P:negative regulation of neurogenesis
GO:0014032	; P:neural crest cell development
GO:0021998	; P:neural plate mediolateral regionalization
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0060021	; P:palate development
GO:0048352	; P:paraxial mesoderm structural organization
GO:0021983	; P:pituitary gland development
GO:0030501	; P:positive regulation of bone mineralization
GO:0050679	; P:positive regulation of epithelial cell proliferation
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0001756	; P:somitogenesis
GO:0019827	; P:stem cell maintenance
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

hsa:657

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013