EPS-HOS-00006

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00006

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	157.6	9.3E-46	31	177	147

Status

Reviewed

Ensembl Protein

ENSP00000226004

UniProt Accession

P51452; D3DX45; Q5U0J1;

Protein Name

Dual specificity protein phosphatase 3

Protein Synonyms/Alias

Dual specificity protein phosphatase VHR; Vaccinia H1-related phosphatase; VHR;

Gene Name

DUSP3

Gene Synonyms/Alias

DUSP3; VHR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000108861	ENSP00000467424	ENST00000590342
ENSG00000108861	ENSP00000443014	ENST00000397937
ENSG00000108861	ENSP00000226004	ENST00000226004
ENSG00000108861	ENSP00000468604	ENST00000590935
ENSG00000108861	ENSP00000466069	ENST00000590753

Organism

Homo sapiens

Functional Description

Shows activity both for tyrosine-protein phosphate andserine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Protein Length

185

Protein Sequence
(FASTA)

MSGSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVTPRIYVG NASVAQDIPK LQKLGITHVL 60

NAAEGRSFMH VNTNANFYKD SGITYLGIKA NDTQEFNLSA YFERAADFID QALAQKNGRV 120

LVHCREGYSR SPTLVIAYLM MRQKMDVKSA LSIVRQNREI GPNDGFLAQL CQLNDRLAKE 180

GKLKP 185

Nucleotide Sequence
(FASTA)

ATGTCGGGCT CGTTCGAGCT CTCGGTGCAG GATCTCAACG ACCTGCTCTC GGACGGCAGC 60

GGCTGCTACA GCCTCCCGAG CCAGCCCTGC AACGAGGTCA CCCCGCGGAT CTACGTGGGC 120

AACGCGTCTG TGGCTCAGGA CATCCCCAAG CTGCAGAAAC TAGGCATCAC CCATGTGCTG 180

AACGCGGCTG AGGGCAGGTC CTTCATGCAC GTCAACACCA ATGCCAACTT CTACAAGGAC 240

TCCGGCATCA CATACCTGGG CATCAAGGCC AACGACACAC AGGAGTTCAA CCTCAGCGCT 300

TACTTTGAAA GGGCTGCCGA CTTCATTGAC CAGGCTTTGG CTCAAAAGAA TGGCCGGGTG 360

CTCGTCCACT GCCGGGAAGG TTATAGCCGC TCCCCAACGC TAGTTATCGC CTACCTCATG 420

ATGCGGCAGA AGATGGACGT CAAGTCTGCC CTGAGCATCG TGAGGCAGAA CCGTGAGATC 480

GGCCCCAACG ATGGCTTCCT GGCCCAGCTC TGCCAGCTCA ATGACAGACT AGCCAAGGAG 540

GGGAAGTTGA AACCCTAG 558

Domain Profile

S: 3     teilpglylgdqataldrreLsklgitvvinaslsv..ikvqviPeylikkgityknipv  60

         +e++p++y+g++ +a d  +L+klgit+v+na+ ++  ++v++  +++ ++gity++i++

Q: 31    NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRsfMHVNTNANFYKDSGITYLGIKA  90

         79******************************9754227889999***************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         +D+++++l+ yf++aa+fid+a  +k+g+vlvHC+ G+sRS+tlv+aYLm+++++ +++A

Q: 91    NDTQEFNLSAYFERAADFIDQAlAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSA  150

         **********************9999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         ++ v+++r +i pn+gfl+QL++l+ +l

Q: 151   LSIVRQNR-EIGPNDGFLAQLCQLNDRL  177

         ********.***************9876

Domain Sequence
(FASTA)

NEVTPRIYVG NASVAQDIPK LQKLGITHVL NAAEGRSFMH VNTNANFYKD SGITYLGIKA 60

NDTQEFNLSA YFERAADFID QALAQKNGRV LVHCREGYSR SPTLVIAYLM MRQKMDVKSA 120

LSIVRQNREI GPNDGFLAQL CQLNDRL 147

Keyword

3D-structure; Complete proteome; Hydrolase; Nucleus; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0001772	; C:immunological synapse
GO:0005654	; C:nucleoplasm
GO:0033549	; F:MAP kinase phosphatase activity
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0001701	; P:in utero embryonic development
GO:0045087	; P:innate immune response
GO:0002755	; P:MyD88-dependent toll-like receptor signaling pathway
GO:0070373	; P:negative regulation of ERK1 and ERK2 cascade
GO:0046329	; P:negative regulation of JNK cascade
GO:0050868	; P:negative regulation of T cell activation
GO:0050860	; P:negative regulation of T cell receptor signaling pathway
GO:0048011	; P:nerve growth factor receptor signaling pathway
GO:0045931	; P:positive regulation of mitotic cell cycle
GO:0051403	; P:stress-activated MAPK cascade
GO:0008063	; P:Toll signaling pathway
GO:0034130	; P:toll-like receptor 1 signaling pathway
GO:0034134	; P:toll-like receptor 2 signaling pathway
GO:0034138	; P:toll-like receptor 3 signaling pathway
GO:0034142	; P:toll-like receptor 4 signaling pathway
GO:0035666	; P:TRIF-dependent toll-like receptor signaling pathway

KEGG

hsa:1845

;

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR016130	; Tyr_Pase_AS.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS00383	; TYR_PHOSPHATASE_1; 1.
PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013