| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00473 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/MAPK | 416.6 | 2.4E-124 | 26 | 321 | 296 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000378595 |
| UniProt Accession | P53779; A6NFS3; A6NG28; B3KQ94; Q15707; Q49AP1; |
| Protein Name | Mitogen-activated protein kinase 10 |
| Protein Synonyms/Alias | MAP kinase 10; MAPK 10; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; |
| Gene Name | MAPK10 |
| Gene Synonyms/Alias | MAPK10; JNK3, JNK3A, PRKM10, SAPK1B; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Serine/threonine-protein kinase involved in variousprocesses such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. |
| Protein Length | 426 |
Protein Sequence
(FASTA) | | MSKSKVDNQF YSVEVGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAVLDR NVAIKKLSRP 60 | | FQNQTHAKRA YRELVLMKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIQ 120 | | MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180 | | MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMVR HKILFPGRDY IDQWNKVIEQ 240 | | LGTPCPEFMK KLQPTVRNYV ENRPKYAGLT FPKLFPDSLF PADSEHNKLK ASQARDLLSK 300 | | MLVIDPAKRI SVDDALQHPY INVWYDPAEV EAPPPQIYDK QLDEREHTIE EWKELIYKEV 360 | | MNSEEKTKNG VVKGQPSPSG AAVNSSESLP PSSSVNDISS MSTDQTLASD TDSSLEASAG 420 | | PLGCCR 426 |
|
Nucleotide Sequence
(FASTA) | | ATGAGCAAAA GCAAAGTTGA CAACCAGTTC TACAGTGTGG AAGTGGGAGA CTCAACCTTC 60 | | ACAGTTCTCA AGCGCTACCA GAATCTAAAG CCTATTGGCT CTGGGGCTCA GGGCATAGTT 120 | | TGTGCCGCGT ATGATGCTGT CCTTGACAGA AATGTGGCCA TTAAGAAGCT CAGCAGACCC 180 | | TTTCAGAACC AAACACATGC CAAGAGAGCG TACCGGGAGC TGGTCCTCAT GAAGTGTGTG 240 | | AACCATAAAA ACATTATTAG TTTATTAAAT GTCTTCACAC CCCAGAAAAC GCTGGAGGAG 300 | | TTCCAAGATG TTTACTTAGT AATGGAACTG ATGGATGCCA ACTTATGTCA AGTGATTCAG 360 | | ATGGAATTAG ACCATGAGCG AATGTCTTAC CTGCTGTACC AAATGTTGTG TGGCATTAAG 420 | | CACCTCCATT CTGCTGGAAT TATTCACAGG GATTTAAAAC CAAGTAACAT TGTAGTCAAG 480 | | TCTGATTGCA CATTGAAAAT CCTGGACTTT GGACTGGCCA GGACAGCAGG CACAAGCTTC 540 | | ATGATGACTC CATATGTGGT GACACGTTAT TACAGAGCCC CTGAGGTCAT CCTGGGGATG 600 | | GGCTACAAGG AGAACGTGGA TATATGGTCT GTGGGATGCA TTATGGGAGA AATGGTTCGC 660 | | CACAAAATCC TCTTTCCAGG AAGGGACTAT ATTGACCAGT GGAATAAGGT AATTGAACAA 720 | | CTAGGAACAC CATGTCCAGA ATTCATGAAG AAATTGCAAC CCACAGTAAG AAACTATGTG 780 | | GAGAATCGGC CCAAGTATGC GGGACTCACC TTCCCCAAAC TCTTCCCAGA TTCCCTCTTC 840 | | CCAGCGGACT CCGAGCACAA TAAACTCAAA GCCAGCCAAG CCAGGGACTT GTTGTCAAAG 900 | | ATGCTAGTGA TTGACCCAGC AAAAAGAATA TCAGTGGACG ACGCCTTACA GCATCCCTAC 960 | | ATCAACGTCT GGTATGACCC AGCCGAAGTG GAGGCGCCTC CACCTCAGAT ATATGACAAG 1020 | | CAGTTGGATG AAAGAGAACA CACAATTGAA GAATGGAAAG AACTTATCTA CAAGGAAGTA 1080 | | ATGAATTCAG AAGAAAAGAC TAAAAATGGT GTAGTAAAAG GACAGCCTTC TCCTTCAGGT 1140 | | GCAGCAGTGA ACAGCAGTGA GAGTCTCCCT CCATCCTCGT CTGTCAATGA CATCTCCTCC 1200 | | ATGTCCACCG ACCAGACCCT GGCATCTGAC ACTGACAGCA GCCTGGAAGC CTCGGCAGGA 1260 | | CCCCTGGGTT GTTGCAGGTG A 1281 |
|
| Domain Profile | S: 1 yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi 60 | y++lkp+g+Ga+g+v++a+d+ +++vaikklsrpfq++t+akr++REl l+k+++h+Ni | Q: 26 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 85 | 899********************************************************* |
| S: 61 iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs 120 | i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs | Q: 86 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS 144 | ************************************9.********************** |
| S: 121 anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke 180 | a++iHrDlKPsN++v++dc+lkildFGlar+a ++ + +t+yv+tr+YraPe++l + | Q: 145 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG 201 | **********************************976..*****************9.99 |
| S: 181 ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi 240 | y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp ef+kk++ ++rny+ | Q: 202 YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV 260 | *****************************************************.5***** |
| S: 241 kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY 288 | +++pk++ +f +lfp+ + ++a+dLl+k+Lv+dp kRisv++aL+hpY | Q: 261 ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY 320 | *****************************99***************************** |
| S: 289 l 289 | + | Q: 321 I 321 | 7 |
|
Domain Sequence
(FASTA) | | YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60 | | ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120 | | GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180 | | VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240 | | YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296 |
|
| Keyword | 3D-structure; Alternative splicing; ATP-binding; Chromosomal rearrangement; Complete proteome; Cytoplasm; Direct protein sequencing; Epilepsy; Kinase; Lipoprotein; Membrane; Mental retardation; Nucleotide-binding; Nucleus; Palmitate; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |