| Tag | Content |
|---|
| EKPD ID | EPS-HOS-00015 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| DSP/aDSP | 59.7 | 1.4E-15 | 106 | 185 | 80 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000325958 |
| UniProt Accession | Q8WUK0; Q7Z557; Q96CR2; Q9BXV8; |
| Protein Name | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
| Protein Synonyms/Alias | PTEN-like phosphatase; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1; |
| Gene Name | PTPMT1 |
| Gene Synonyms/Alias | PTPMT1; MOSP, PLIP; PNAS-129; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Lipid phosphatase which dephosphorylatesphosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). |
| Protein Length | 201 |
Protein Sequence
(FASTA) | | MAATALLEAG LARVLFYPTL LYTLFRGKVP GRAHRDWYHR IDPTVLLGAL PLRSLTRQLV 60 | | QDENVRGVIT MNEEYETRFL CNSSQEWKRL GVEQLRLSTV DMTGIPTLDN LQKGVQFALK 120 | | YQSLGQCVYV HCKAGRSRSA TMVAAYLIQV HKWSPEEAVR AIAKIRSYIH IRPGQLDVLK 180 | | EFHKQITARA TKDGTFVISK T 201 |
|
Nucleotide Sequence
(FASTA) | | ATGGCGGCCA CCGCGCTGCT GGAGGCCGGC CTGGCGCGGG TGCTCTTCTA CCCGACGCTG 60 | | CTCTACACCC TGTTCCGCGG GAAGGTGCCG GGTCGGGCGC ACCGGGACTG GTACCACCGC 120 | | ATCGACCCCA CCGTGCTGCT GGGCGCGCTG CCGTTGCGGA GCTTGACGCG CCAGCTGGTA 180 | | CAGGACGAGA ACGTGCGCGG GGTGATCACC ATGAACGAGG AGTACGAGAC GAGGTTCCTG 240 | | TGCAACTCTT CACAGGAGTG GAAGAGACTA GGAGTCGAGC AGCTGCGGCT CAGCACAGTA 300 | | GACATGACTG GGATCCCCAC CTTGGACAAC CTCCAGAAGG GAGTCCAATT TGCTCTCAAG 360 | | TACCAGTCGC TGGGCCAGTG TGTTTACGTG CATTGTAAGG CTGGGCGCTC CAGGAGTGCC 420 | | ACTATGGTGG CAGCATACCT GATTCAGGTG CACAAATGGA GTCCAGAGGA GGCTGTAAGA 480 | | GCCATCGCCA AGATCCGGTC ATACATCCAC ATCAGGCCTG GCCAGCTGGA TGTTCTTAAA 540 | | GAGTTCCACA AGCAGATTAC TGCACGGGCA ACAAAGGATG GGACTTTTGT CATTTCAAAG 600 | | ACATGA 606 |
|
| Domain Profile | S: 67 dllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieavkrk 126 | l+ +++ ++f + ++ g+ v+vHC+aG sRSat+v aYL++v+++s ++A++a+ + | Q: 106 PTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKI 165 | 4555566677777777889999************************************** |
| S: 127 rpsiepnegfleQLlelekk 146 | r+ i + g+l L e+ k+ | Q: 166 RSYIHIRPGQLDVLKEFHKQ 185 | *****************998 |
|
Domain Sequence
(FASTA) | | PTLDNLQKGV QFALKYQSLG QCVYVHCKAG RSRSATMVAA YLIQVHKWSP EEAVRAIAKI 60 | | RSYIHIRPGQ LDVLKEFHKQ 80 |
|
| Keyword | Alternative splicing; Complete proteome; Hydrolase; Lipid biosynthesis; Lipid metabolism; Membrane; Mitochondrion; Mitochondrion inner membrane; Phospholipid biosynthesis; Phospholipid metabolism; Protein phosphatase; Reference proteome; Transit peptide. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | | GO:0005743 | ; C:mitochondrial inner membrane | | GO:0005739 | ; C:mitochondrion | | GO:0008962 | ; F:phosphatidylglycerophosphatase activity | | GO:0004439 | ; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | | GO:0004725 | ; F:protein tyrosine phosphatase activity | | GO:0008138 | ; F:protein tyrosine/serine/threonine phosphatase activity | | GO:0032049 | ; P:cardiolipin biosynthetic process | | GO:0046855 | ; P:inositol phosphate dephosphorylation | | GO:0035335 | ; P:peptidyl-tyrosine dephosphorylation |
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| KEGG | |
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| Pfam | |
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| Prints | |
| Created Date | 20-Feb-2013 |