| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00378 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| TK/Src | 425.0 | 4.5E-127 | 92 | 345 | 254 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000443075 |
| UniProt Accession | P42685; Q13128; Q9NTR5; |
| Protein Name | Tyrosine-protein kinase FRK |
| Protein Synonyms/Alias | FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; |
| Gene Name | FRK |
| Gene Synonyms/Alias | FRK; PTK5, RAK; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Non-receptor tyrosine-protein kinase that negativelyregulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
| Protein Length | 363 |
Protein Sequence
(FASTA) | | MDSTSLLPNP WIRVLDGAVV KHYRIKRLDE GGFFLTRRRI FSTLNEFVSH YTKTSDGLCV 60 | | KLGKPCLKIQ VPAPFDLSYK TVDQWEIDRN SIQLLKRLGS GQFGEVWEGL WNNTTPVAVK 120 | | TLKPGSMDPN DFLREAQIMK NLRHPKLIQL YAVCTLEDPI YIITELMRHG SLQEYLQNDT 180 | | GSKIHLTQQV DMAAQVASGM AYLESRNYIH RDLAARNVLV GEHNIYKVAD FGLARVFKVD 240 | | NEDIYESRHE IKLPVKWTAP EAIRSNKFSI KSDVWSFGIL LYEIITYGKM PYSGMTGAQV 300 | | IQMLAQNYRL PQPSNCPQQF YNIMLECWNA EPKERPTFET LRWKLEDYFE TDSSYSDANN 360 | | FIR 363 |
|
Nucleotide Sequence
(FASTA) | | ATGGATTCAA CTTCACTACT ACCTAATCCA TGGATAAGAG TTTTAGATGG AGCAGTTGTA 60 | | AAACACTACA GAATTAAAAG ACTGGATGAA GGGGGATTTT TTCTCACGCG AAGAAGAATC 120 | | TTTTCAACAC TGAACGAATT TGTGAGCCAC TACACCAAGA CAAGTGACGG CCTGTGTGTC 180 | | AAGCTGGGGA AACCATGCTT AAAGATCCAG GTCCCAGCTC CATTTGATTT GTCGTATAAA 240 | | ACCGTGGACC AATGGGAGAT AGACCGCAAC TCCATACAGC TTCTGAAGCG ATTGGGATCT 300 | | GGTCAGTTTG GCGAAGTATG GGAAGGTCTG TGGAACAATA CCACTCCAGT AGCAGTGAAA 360 | | ACATTAAAAC CAGGTTCAAT GGATCCAAAT GACTTCCTGA GGGAGGCACA GATAATGAAG 420 | | AACCTAAGAC ATCCAAAGCT TATCCAGCTT TATGCTGTTT GCACTTTAGA AGATCCAATT 480 | | TATATTATTA CAGAGTTGAT GAGACATGGA AGTCTGCAAG AATATCTCCA AAATGACACT 540 | | GGATCAAAAA TCCATCTGAC TCAACAGGTA GACATGGCGG CACAGGTTGC CTCTGGAATG 600 | | GCCTATCTGG AGTCTCGGAA CTACATTCAC AGAGATCTGG CTGCCAGAAA TGTCCTCGTT 660 | | GGTGAACATA ATATCTACAA AGTAGCAGAT TTTGGACTTG CCAGAGTTTT TAAGGTAGAT 720 | | AATGAAGACA TCTATGAATC TAGACACGAA ATAAAGCTGC CGGTGAAGTG GACTGCGCCC 780 | | GAAGCCATTC GTAGTAATAA ATTCAGCATT AAGTCCGATG TATGGTCATT TGGAATCCTT 840 | | CTTTATGAAA TCATTACTTA TGGCAAAATG CCTTACAGTG GTATGACAGG TGCCCAGGTA 900 | | ATCCAGATGT TGGCTCAAAA CTATAGACTT CCGCAACCAT CCAACTGTCC ACAGCAATTT 960 | | TACAACATCA TGTTGGAGTG CTGGAATGCA GAGCCTAAGG AACGACCTAC ATTTGAGACA 1020 | | CTGCGTTGGA AACTTGAAGA CTATTTTGAA ACAGACTCTT CATATTCAGA TGCAAATAAC 1080 | | TTCATAAGAT GA 1092 |
|
| Domain Profile | S: 1 lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly 60 | ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly | Q: 92 IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLY 151 | 6899******************************************************** |
| S: 61 avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr 120 | av++ e+Piyi+telm++Gsl+++l++++g+k++l+++vd+aaqva+Gmayle++n+ihr | Q: 152 AVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHR 211 | ************************************************************ |
| S: 121 dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik 177 | dlaarnvlvge++++kvadfGlar+++ +d+y+++++ klP+kWtaPeai+ +kf+ik | Q: 212 DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESRHEIKLPVKWTAPEAIRSNKFSIK 271 | ************************998878999*************************** |
| S: 178 sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd 237 | sdvWsfGill+ei+t+Gk+Py+Gmt ++v++++ ++yrlp+p++cp+++y+++lecw+++ | Q: 272 SDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAE 331 | ************************************************************ |
| S: 238 peerPtfetlqevl 251 | p+erPtfetl+++l | Q: 332 PKERPTFETLRWKL 345 | **********9986 |
|
Domain Sequence
(FASTA) | | IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKN LRHPKLIQLY 60 | | AVCTLEDPIY IITELMRHGS LQEYLQNDTG SKIHLTQQVD MAAQVASGMA YLESRNYIHR 120 | | DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESRHEI KLPVKWTAPE AIRSNKFSIK 180 | | SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLAQNYRLP QPSNCPQQFY NIMLECWNAE 240 | | PKERPTFETL RWKL 254 |
|
| Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; SH3 domain; Transferase; Tumor suppressor; Tyrosine-protein kinase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |