EKS-HOS-00210
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00210
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/RCK513.57.2E-1544284281
StatusReviewed
Ensembl ProteinENSP00000442250
UniProt AccessionP20794; F1T0K6; G1FL29; Q547D0; Q9NUH7;
Protein NameSerine/threonine-protein kinase MAK
Protein Synonyms/Alias Male germ cell-associated kinase;
Gene NameMAK
Gene Synonyms/Alias MAK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000111837ENSP00000346484ENST00000354489
ENSG00000111837ENSP00000442221ENST00000536370
ENSG00000111837ENSP00000313021ENST00000313243
ENSG00000111837ENSP00000442250ENST00000538030
OrganismHomo sapiens
Functional DescriptionEssential for the regulation of ciliary length andrequired for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
Protein Length457
Protein Sequence
(FASTA)
MNRYTTMRQL GDGTYGSVLM GKSNESGELV AIKRMKRKFY SWDECMNLRE VKSLKKLNHA 60
NVIKLKEVIR ENDHLYFIFE YMKENLYQLM KDRNKLFPES VIRNIMYQIL QGLAFIHKHG 120
FFHRDMKPEN LLCMGPELVK IADFGLAREL RSQPPYTDYV STRWYRAPEV LLRSSVYSSP 180
IDVWAVGSIM AELYMLRPLF PGTSEVDEIF KICQVLGTPK KSDWPEGYQL ASSMNFRFPQ 240
CVPINLKTLI PNASNEAIQL MTEMLNWDPK KRPTASQALK HPYFQVGQVL GPSSNHLESK 300
QSLNKQLQPL ESKPSLVEVE PKPLPDIIDQ VVGQPQPKTS QQPLQPIQPP QNLSVQQPPK 360
QQSQEKPPQT LFPSIVKNMP TKPNGTLSHK SGRRRWGQTI FKSGDSWEEL EDYDFGASHS 420
KKPSMGVFKE KRKKDSPFRQ QVKMAVISLS AHQFPTL 457
Nucleotide Sequence
(FASTA)
ATGAACCGAT ACACAACCAT GAGACAGTTG GGGGACGGCA CGTATGGGAG TGTGCTTATG 60
GGCAAGAGTA ATGAATCCGG GGAGCTGGTG GCCATCAAAA GGATGAAGAG AAAGTTCTAT 120
TCTTGGGATG AATGCATGAA CTTGAGAGAA GTTAAGTCTC TGAAGAAACT TAATCATGCC 180
AATGTTATTA AATTGAAAGA AGTTATCAGA GAAAATGACC ATCTTTATTT TATATTTGAA 240
TATATGAAAG AAAACCTCTA TCAATTAATG AAAGACAGAA ACAAGTTGTT CCCTGAATCA 300
GTCATCAGAA ATATTATGTA TCAAATATTG CAAGGGCTGG CTTTTATCCA TAAACATGGC 360
TTTTTTCATA GGGACATGAA ACCAGAAAAC TTGCTTTGTA TGGGTCCAGA GCTTGTGAAA 420
ATTGCTGATT TTGGACTTGC AAGAGAATTA AGGTCACAGC CACCATACAC TGATTATGTA 480
TCTACCAGAT GGTATCGTGC CCCTGAAGTT TTACTGAGAT CTTCAGTTTA TAGTTCTCCC 540
ATTGATGTGT GGGCTGTTGG AAGTATCATG GCTGAACTCT ATATGTTAAG GCCACTTTTC 600
CCAGGGACAA GTGAGGTCGA TGAAATCTTT AAAATTTGCC AAGTTTTAGG GACTCCCAAA 660
AAAAGTGACT GGCCAGAAGG ATACCAGCTG GCATCCTCTA TGAACTTCCG TTTTCCCCAG 720
TGTGTTCCTA TAAACTTAAA AACTCTTATT CCCAATGCCA GTAATGAAGC TATTCAGCTC 780
ATGACCGAAA TGTTGAATTG GGATCCAAAG AAACGACCGA CAGCAAGCCA GGCATTGAAA 840
CACCCATATT TTCAAGTTGG TCAGGTATTA GGCCCTTCGT CAAATCATCT GGAATCAAAA 900
CAGTCTTTAA ATAAGCAGCT GCAACCATTA GAATCAAAGC CATCTTTAGT TGAGGTAGAG 960
CCTAAGCCTC TGCCGGATAT AATCGATCAG GTTGTTGGAC AACCCCAGCC AAAAACTAGC 1020
CAGCAGCCAC TGCAGCCCAT TCAGCCGCCA CAGAACCTGA GCGTCCAGCA ACCTCCAAAG 1080
CAACAGAGTC AGGAGAAACC GCCACAAACG CTATTCCCGA GCATCGTCAA AAACATGCCA 1140
ACTAAGCCAA ATGGCACACT GAGTCATAAA AGTGGTAGGA GGCGTTGGGG TCAGACTATC 1200
TTCAAGTCTG GAGATAGCTG GGAAGAGTTG GAGGACTATG ATTTCGGAGC CTCCCATTCC 1260
AAGAAGCCAA GCATGGGTGT TTTTAAAGAA AAAAGGAAAA AAGATTCTCC ATTTCGTCAA 1320
CAGGTGAAGA TGGCTGTTAT TTCCCTCTCA GCACACCAGT TTCCCACGTT ATGA 1374
Domain Profile
S: 1     yklikklGdGtfgevllakslktgelvaikkmkrkfesleevtnlrevkslkklnahdni  60
         y+++++lGdGt+g+vl++ks+++gelvaik+mkrkf+s++e++nlrevkslkkln h+n+
Q: 4     YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-HANV  62
         99*****************************************************.****
S: 61    iklkeviidrendslylvlelmeenlyqlikdrrkllsesklksilyqilkglafihkhg  120
         iklkevi  rend+ly+++e+m+enlyql+kdr+kl++es++++i+yqil+glafihkhg
Q: 63    IKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG  120
         *******..***************************************************
S: 121   ffhrdlkPenilikgselvkladfGlarevrsknPytdyvstrwyraPevllrsgvyssp  180
         ffhrd+kPen+l++g+elvk+adfGlare+rs++PytdyvstrwyraPevllrs+vyssp
Q: 121   FFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSP  180
         ************************************************************
S: 181   ldlwavGcvlaevavlrplfPGaseidqifkilevlGtPkkkewdeayklasalnlkfpq  240
         +d+wavG+++ae+++lrplfPG+se+d+ifki++vlGtPkk++w+e+y+las++n++fpq
Q: 181   IDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQ  240
         ************************************************************
S: 241   vegsslktlvsnaskealellkdllaydPderataqqalkypyf  284
         +++++lktl++nas+ea++l++++l++dP++r+ta+qalk+pyf
Q: 241   CVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF  284
         *******************************************9
Domain Sequence
(FASTA)
YTTMRQLGDG TYGSVLMGKS NESGELVAIK RMKRKFYSWD ECMNLREVKS LKKLNHANVI 60
KLKEVIREND HLYFIFEYMK ENLYQLMKDR NKLFPESVIR NIMYQILQGL AFIHKHGFFH 120
RDMKPENLLC MGPELVKIAD FGLARELRSQ PPYTDYVSTR WYRAPEVLLR SSVYSSPIDV 180
WAVGSIMAEL YMLRPLFPGT SEVDEIFKIC QVLGTPKKSD WPEGYQLASS MNFRFPQCVP 240
INLKTLIPNA SNEAIQLMTE MLNWDPKKRP TASQALKHPY F 281
KeywordAlternative splicing; ATP-binding; Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Disease mutation; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Retinitis pigmentosa; Serine/threonine-protein kinase; Spermatogenesis; Transcription; Transcription regulation; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00186
EKS-ANC-00198
EKS-BOT-00204
EKS-CAJ-00210
EKS-CAF-00205
EKS-CAP-00228
EKS-DAR-00504
EKS-EQC-00198
EKS-FEC-00186
EKS-GAM-00115
EKS-GAG-00174
EKS-GAA-00252
EKS-GOG-00200
EKS-ICT-00195
EKS-LAC-00214
EKS-LOA-00201
EKS-MAM-00205
EKS-MEG-00153
EKS-MOD-00202
EKS-MUM-00202
EKS-MUP-00201
EKS-MYL-00201
EKS-NOL-00187
EKS-OCP-00132
EKS-ORN-00255
EKS-ORA-00175
EKS-ORC-00182
EKS-OTG-00204
EKS-PAT-00190
EKS-PES-00175
EKS-PEM-00105
EKS-POA-00198
EKS-RAN-00193
EKS-SAH-00192
EKS-SUS-00172
EKS-TAG-00223
EKS-TUT-00190
EKS-XET-00230
EKS-XIM-00249
Gene Ontology
GO:0005813; C:centrosome
GO:0030496; C:midbody
GO:0072686; C:mitotic spindle
GO:0005634; C:nucleus
GO:0001917; C:photoreceptor inner segment
GO:0001750; C:photoreceptor outer segment
GO:0005524; F:ATP binding
GO:0004693; F:cyclin-dependent protein kinase activity
GO:0004672; F:protein kinase activity
GO:0003713; F:transcription coactivator activity
GO:0007049; P:cell cycle
GO:0030154; P:cell differentiation
GO:0007275; P:multicellular organismal development
GO:0045494; P:photoreceptor cell maintenance
GO:0046777; P:protein autophosphorylation
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0007283; P:spermatogenesis
GO:0006351; P:transcription, DNA-dependent
KEGG
hsa:4117;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013