EPS-HOS-00017
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-HOS-00017
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/aDSP37.41.1E-810217372
StatusReviewed
Ensembl ProteinENSP00000358487
UniProt AccessionO60942; E1P513; E1P514; O43483; O60257; O60351; Q5TCW8; Q8WUM8;
Protein NamemRNA guanylyltransferase
Protein Synonyms/Alias HCAP1; HCE; mRNA 5'-triphosphatase; TPase; GTP--RNA guanylyltransferase; GTase;
Gene NameRNGTT
Gene Synonyms/Alias RNGTT; CAP1A;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000111880ENSP00000358487ENST00000369475
ENSG00000111880ENSP00000265607ENST00000265607
ENSG00000111880ENSP00000358497ENST00000369485
ENSG00000111880ENSP00000442609ENST00000538899
OrganismHomo sapiens
Functional DescriptionBifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
Protein Length541
Protein Sequence
(FASTA)
MAHNKIPPRW LNCPRRGQPV AGRFLPLKTM LGPRYDSQVA EENRFHPSML SNYLKSLKVK 60
MGLLVDLTNT SRFYDRNDIE KEGIKYIKLQ CKGHGECPTT ENTETFIRLC ERFNERNPPE 120
LIGVHCTHGF NRTGFLICAF LVEKMDWSIE AAVATFAQAR PPGIYKGDYL KELFRRYGDI 180
EEAPPPPLLP DWCFEDDEDE DEDEDGKKES EPGSSASFGK RRKERLKLGA IFLEGVTVKG 240
VTQVTTQPKL GEVQQKCHQF CGWEGSGFPG AQPVSMDKQN IKLLDLKPYK VSWKADGTRY 300
MMLIDGTNEV FMIDRDNSVF HVSNLEFPFR KDLRMHLSNT LLDGEMIIDR VNGQAVPRYL 360
IYDIIKFNSQ PVGDCDFNVR LQCIEREIIS PRHEKMKTGL IDKTQEPFSV RNKPFFDICT 420
SRKLLEGNFA KEVSHEMDGL IFQPTGKYKP GRCDDILKWK PPSLNSVDFR LKITRMGGEG 480
LLPQNVGLLY VGGYERPFAQ IKVCLFIFSV LFLDVLLSRI HQNLANNNQH IKISCSSTLG 540
G 541
Nucleotide Sequence
(FASTA)
ATGGCTCACA ACAAGATCCC GCCGCGGTGG CTGAACTGTC CCCGGCGCGG CCAGCCGGTG 60
GCAGGAAGAT TCTTACCTCT GAAGACAATG TTAGGACCAA GATATGATAG TCAAGTTGCT 120
GAAGAAAATC GGTTCCATCC CAGCATGCTC TCAAATTACC TAAAGAGCCT AAAGGTTAAA 180
ATGGGCTTGT TGGTGGACCT GACAAATACT TCAAGGTTCT ATGACCGAAA TGACATAGAA 240
AAAGAAGGAA TCAAATATAT AAAACTTCAG TGTAAAGGAC ATGGTGAGTG CCCTACCACT 300
GAGAATACTG AGACCTTTAT TCGTCTGTGT GAGCGGTTTA ATGAAAGAAA TCCACCTGAA 360
CTTATAGGTG TTCATTGTAC TCATGGCTTC AATCGCACTG GTTTCCTCAT ATGTGCCTTT 420
TTGGTGGAGA AAATGGATTG GAGTATCGAA GCAGCAGTTG CTACTTTTGC CCAAGCCAGA 480
CCACCAGGAA TCTACAAGGG TGATTATTTG AAGGAACTTT TTCGTCGGTA TGGTGACATA 540
GAGGAAGCAC CACCCCCACC TCTATTGCCA GATTGGTGTT TTGAGGATGA TGAAGACGAA 600
GATGAGGATG AGGATGGAAA GAAGGAATCA GAACCCGGGT CAAGTGCTTC TTTTGGCAAA 660
AGGAGAAAAG AACGGTTAAA ACTGGGCGCT ATTTTCTTGG AAGGTGTTAC TGTTAAAGGT 720
GTAACTCAAG TAACAACACA ACCAAAGTTA GGAGAGGTAC AGCAGAAGTG TCATCAATTC 780
TGTGGCTGGG AAGGGTCTGG ATTCCCTGGA GCACAGCCTG TTTCCATGGA CAAGCAAAAT 840
ATTAAACTTT TAGACCTGAA GCCATACAAA GTAAGCTGGA AAGCAGATGG TACTCGGTAC 900
ATGATGTTGA TTGATGGCAC AAATGAAGTT TTTATGATTG ATAGAGACAA TTCAGTATTT 960
CATGTTTCAA ATCTGGAATT TCCATTTCGT AAAGATCTTC GTATGCATTT ATCAAATACT 1020
CTCTTGGATG GCGAGATGAT TATTGACAGA GTAAATGGAC AGGCTGTTCC TAGATATTTG 1080
ATATATGACA TAATTAAATT CAATTCACAG CCCGTTGGAG ATTGTGATTT TAATGTTCGT 1140
CTGCAGTGTA TAGAACGAGA AATTATAAGT CCTCGACACG AAAAAATGAA GACTGGGCTC 1200
ATTGACAAAA CACAGGAACC ATTTAGCGTC AGAAATAAGC CGTTTTTTGA CATCTGTACT 1260
TCAAGAAAGC TACTTGAAGG AAATTTTGCC AAAGAAGTGA GCCATGAAAT GGATGGACTT 1320
ATTTTTCAGC CTACTGGAAA ATACAAACCT GGTCGATGTG ATGATATTTT GAAATGGAAG 1380
CCTCCCAGTC TGAATTCTGT GGATTTTCGT CTAAAAATAA CAAGAATGGG AGGAGAAGGG 1440
TTACTTCCTC AGAATGTTGG CCTCCTGTAT GTTGGAGGTT ATGAAAGACC CTTTGCACAA 1500
ATCAAGGTAT GTTTGTTCAT TTTCAGTGTA CTTTTCCTGG ATGTTCTCTT ATCTAGAATC 1560
CATCAAAACC TTGCTAATAA TAATCAACAT ATAAAAATAT CGTGTTCCAG CACTTTGGGA 1620
GGCTAA 1626
Domain Profile
S: 74    eaaefidea.....kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieavkrkrp  128
         ++  fi  +     +++ + + vHC++G++R++ l++a+L++ +++s++ A+ ++ + rp
Q: 102   NTETFIRLCerfneRNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARP  161
         45556666666677788899***************************************9
S: 129   siepnegfleQL  140
           + + ++l+ L
Q: 162   PGIYKGDYLKEL  173
         877777777666
Domain Sequence
(FASTA)
NTETFIRLCE RFNERNPPEL IGVHCTHGFN RTGFLICAFL VEKMDWSIEA AVATFAQARP 60
PGIYKGDYLK EL 72
Keyword3D-structure; Alternative splicing; Complete proteome; GTP-binding; Host-virus interaction; Hydrolase; mRNA capping; mRNA processing; Multifunctional enzyme; Nucleotide-binding; Nucleotidyltransferase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EPS-AIM-00022
EPS-BOT-00017
EPS-CAJ-00018
EPS-CAF-00025
EPS-CAP-00017
EPS-CII-00008
EPS-DAR-00044
EPS-ECT-00014
EPS-FEC-00023
EPS-GAA-00032
EPS-ICT-00019
EPS-MAM-00017
EPS-MOD-00018
EPS-MYL-00021
EPS-ORN-00025
EPS-ORA-00018
EPS-ORC-00019
EPS-OTG-00019
EPS-PES-00025
EPS-PEM-00015
EPS-POA-00025
EPS-SAH-00019
EPS-TAG-00021
EPS-TAR-00033
EPS-TEN-00025
EPS-XET-00022
EPS-XIM-00040
Gene Ontology
GO:0005654; C:nucleoplasm
GO:0005525; F:GTP binding
GO:0004484; F:mRNA guanylyltransferase activity
GO:0004651; F:polynucleotide 5'-phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006370; P:7-methylguanosine mRNA capping
GO:0035335; P:peptidyl-tyrosine dephosphorylation
GO:0006366; P:transcription from RNA polymerase II promoter
GO:0016032; P:viral reproduction
GO:0019048; P:virus-host interaction
KEGG
hsa:8732;
InterPros
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR017074; mRNA_cap_enz_bifunc.
IPR001339; mRNA_cap_enzyme.
IPR013846; mRNA_cap_enzyme_C.
IPR012340; NA-bd_OB-fold.
IPR016027; NA-bd_OB-fold-like.
IPR000387; Tyr/Dual-specificity_Pase.
IPR016130; Tyr_Pase_AS.
Pfam
PF00782; DSPc; 1.
PF03919; mRNA_cap_C; 1.
PF01331; mRNA_cap_enzyme; 1.
SMARTs
Prosites
PS00383; TYR_PHOSPHATASE_1; 1.
PS50056; TYR_PHOSPHATASE_2; 1.
Prints
Created Date20-Feb-2013