EKS-HOS-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	517.4	5.2E-155	89	382	294

Status

Reviewed

Ensembl Protein

ENSP00000229812

UniProt Accession

Q15208; Q503A1;

Protein Name

Serine/threonine-protein kinase 38

Protein Synonyms/Alias

NDR1 protein kinase; Nuclear Dbf2-related kinase 1;

Gene Name

STK38

Gene Synonyms/Alias

STK38; NDR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000112079	ENSP00000229812	ENST00000229812

Organism

Homo sapiens

Functional Description

Negative regulator of MAP3K1/2 signaling. ConvertsMAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Protein Length

465

Protein Sequence
(FASTA)

MAMTGSTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLKDE 60

EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 120

RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK 180

KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA 240

HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN 300

KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS EKAKDLILRF 360

CCEWEHRIGA PGVEEIKSNS FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK 420

PTVATSNHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKAAK 465

Nucleotide Sequence
(FASTA)

ATGGCAATGA CAGGCTCAAC ACCTTGCTCA TCCATGAGTA ACCACACAAA GGAAAGGGTG 60

ACAATGACCA AAGTGACACT GGAGAATTTT TATAGCAACC TTATCGCTCA ACATGAAGAA 120

CGAGAAATGA GACAAAAGAA GTTAGAAAAG GTGATGGAAG AAGAAGGCCT AAAAGATGAG 180

GAGAAACGAC TCCGGAGATC AGCACATGCT CGGAAGGAAA CAGAGTTTCT TCGTTTGAAG 240

AGAACAAGAC TTGGATTGGA AGATTTTGAG TCCTTAAAAG TAATAGGCAG AGGAGCATTT 300

GGTGAGGTAC GGCTTGTTCA GAAGAAAGAT ACGGGACATG TGTATGCAAT GAAAATACTC 360

CGTAAAGCAG ATATGCTTGA AAAAGAGCAG GTTGGCCACA TTCGTGCGGA GCGTGACATT 420

CTAGTGGAGG CAGACAGTTT GTGGGTTGTG AAAATGTTCT ATAGTTTTCA GGATAAGCTA 480

AACCTCTACC TAATCATGGA GTTCCTGCCT GGAGGGGACA TGATGACCTT GTTGATGAAA 540

AAAGACACTC TGACAGAAGA GGAGACTCAG TTTTATATAG CAGAAACAGT ATTAGCCATA 600

GACTCTATTC ACCAACTTGG ATTCATCCAC AGAGACATCA AACCAGACAA CCTTCTTTTG 660

GACAGCAAGG GCCATGTGAA ACTTTCTGAC TTTGGTCTTT GCACAGGACT GAAAAAAGCA 720

CATAGGACAG AATTTTATAG GAATCTGAAC CACAGCCTCC CCAGTGATTT CACTTTCCAG 780

AACATGAATT CCAAAAGGAA AGCAGAAACC TGGAAAAGAA ATAGACGTCA GCTAGCCTTC 840

TCCACAGTAG GCACTCCTGA CTACATTGCT CCTGAGGTGT TCATGCAGAC CGGGTACAAC 900

AAGCTCTGTG ATTGGTGGTC GCTTGGGGTG ATCATGTATG AGATGCTCAT CGGCTACCCA 960

CCTTTCTGTT CTGAGACCCC TCAAGAGACA TATAAGAAGG TGATGAACTG GAAAGAAACT 1020

TTGACTTTTC CTCCAGAAGT TCCCATCTCT GAGAAAGCCA AGGATCTAAT TTTGAGGTTC 1080

TGCTGTGAAT GGGAACATAG AATTGGAGCT CCTGGAGTTG AGGAAATAAA AAGTAACTCT 1140

TTTTTTGAAG GCGTTGACTG GGAACATATC AGAGAGAGAC CTGCTGCAAT ATCTATTGAA 1200

ATCAAAAGCA TTGATGATAC CTCAAACTTC GATGAGTTTC CAGAATCTGA TATTCTTAAG 1260

CCAACAGTGG CCACAAGTAA TCATCCTGAG ACTGACTACA AGAACAAAGA CTGGGTCTTC 1320

ATCAATTACA CGTACAAGCG CTTTGAGGGC CTGACTGCAA GGGGGGCAAT ACCTTCCTAC 1380

ATGAAAGCAG CAAAATAG 1398

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt++vya+kilrk+d+l+k+qv h++aerdil+eads w

Q: 89    FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW  148

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk nlyl+me+lPGGd+mtll+kk++l+ee+++fyiae+vla++s+h+lGf

Q: 149   VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF  208

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+d+kGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+ ++    ++++

Q: 209   IHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ----NMNS  264

         *************************************************555....5555

S: 181   rkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfla  236

         ++k    k+nrr+la+s+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++

Q: 265   KRKaetwKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS  324

         5544556*****************************************************

S: 237   etpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         etpqetykkv+nwketl+fp+ev++se+akdli r+++++e+r+g+ Gv+eik+++ff

Q: 325   ETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFF  382

         *********************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHVYAMK ILRKADMLEK EQVGHIRAER DILVEADSLW 60

VVKMFYSFQD KLNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYIAETVL AIDSIHQLGF 120

IHRDIKPDNL LLDSKGHVKL SDFGLCTGLK KAHRTEFYRN LNHSLPSDFT FQNMNSKRKA 180

ETWKRNRRQL AFSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240

ETYKKVMNWK ETLTFPPEVP ISEKAKDLIL RFCCEWEHRI GAPGVEEIKS NSFF 294

Keyword

3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043407	; P:negative regulation of MAP kinase activity

KEGG

hsa:11329

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013