EKS-HOS-00497

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00497

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/CCK4	544.5	2.2E-163	666	931	266

Status

Reviewed

Ensembl Protein

ENSP00000325462

UniProt Accession

Q13308; A8K974; B7Z477; E9PFZ5; Q13417; Q5T650; Q6IQ54; Q8NFA5; Q8NFA6; Q8NFA7; Q8NFA8;

Protein Name

Inactive tyrosine-protein kinase 7

Protein Synonyms/Alias

Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7;

Gene Name

PTK7

Gene Synonyms/Alias

PTK7; CCK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000112655	ENSP00000325992	ENST00000345201
ENSG00000112655	ENSP00000418462	ENST00000497957
ENSG00000112655	ENSP00000418545	ENST00000461100
ENSG00000112655	ENSP00000419096	ENST00000494146
ENSG00000112655	ENSP00000418386	ENST00000461389
ENSG00000112655	ENSP00000230418	ENST00000230418
ENSG00000112655	ENSP00000230419	ENST00000230419
ENSG00000112655	ENSP00000326029	ENST00000352931
ENSG00000112655	ENSP00000325462	ENST00000349241
ENSG00000112655	ENSP00000420165	ENST00000481946
ENSG00000112655	ENSP00000420322	ENST00000470019
ENSG00000112655	ENSP00000420765	ENST00000489707
ENSG00000112655	ENSP00000417607	ENST00000476760
ENSG00000112655	ENSP00000419037	ENST00000471863
ENSG00000112655	ENSP00000420186	ENST00000473339
ENSG00000112655	ENSP00000418754	ENST00000481273

Organism

Homo sapiens

Functional Description

Inactive tyrosine kinase involved in Wnt signalingpathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Protein Length

940

Protein Sequence
(FASTA)

MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 60

VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 120

IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 180

KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE 240

EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 300

CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 360

VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAN GSSLPEWVTD 420

NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER TTVYQGHTAL 480

LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG RYTCIAGNSC 540

NIKHTEAPLY VVDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL GLMFYCKKRC 600

KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPAATN KRHSTSDKMH 660

FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ LDFRRELEMF 720

GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ PLSTKQKVAL 780

CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY YHFRQAWVPL 840

RWMSPEAILE GDFSTKSDVW AFGVLMWEVF THGEMPHGGQ ADDEVLADLQ AGKARLPQPE 900

GCPSKLYRLM QRCWALSPKD RPSFSEIASA LGDSTVDSKP 940

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CGCGGGGATC CCCGGCCAGA CCCCGCCGGT TGCCTCTGCT CAGCGTCCTG 60

CTGCTGCCGC TGCTGGGCGG TACCCAGACA GCCATTGTCT TCATCAAGCA GCCGTCCTCC 120

CAGGATGCAC TGCAGGGGCG CCGGGCGCTG CTTCGCTGTG AGGTTGAGGC TCCGGGCCCG 180

GTACATGTGT ACTGGCTGCT CGATGGGGCC CCTGTCCAGG ACACGGAGCG GCGTTTCGCC 240

CAGGGCAGCA GCCTGAGCTT TGCAGCTGTG GACCGGCTGC AGGACTCTGG CACCTTCCAG 300

TGTGTGGCTC GGGATGATGT CACTGGAGAA GAAGCCCGCA GTGCCAACGC CTCCTTCAAC 360

ATCAAATGGA TTGAGGCAGG TCCTGTGGTC CTGAAGCATC CAGCCTCGGA AGCTGAGATC 420

CAGCCACAGA CCCAGGTCAC ACTTCGTTGC CACATTGATG GGCACCCTCG GCCCACCTAC 480

CAATGGTTCC GAGATGGGAC CCCCCTTTCT GATGGTCAGA GCAACCACAC AGTCAGCAGC 540

AAGGAGCGGA ACCTGACGCT CCGGCCAGCT GGTCCTGAGC ATAGTGGGCT GTATTCCTGC 600

TGCGCCCACA GTGCTTTTGG CCAGGCTTGC AGCAGCCAGA ACTTCACCTT GAGCATTGCT 660

GATGAAAGCT TTGCCAGGGT GGTGCTGGCA CCCCAGGACG TGGTAGTAGC GAGGTATGAG 720

GAGGCCATGT TCCATTGCCA GTTCTCAGCC CAGCCACCCC CGAGCCTGCA GTGGCTCTTT 780

GAGGATGAGA CTCCCATCAC TAACCGCAGT CGCCCCCCAC ACCTCCGCAG AGCCACAGTG 840

TTTGCCAACG GGTCTCTGCT GCTGACCCAG GTCCGGCCAC GCAATGCAGG GATCTACCGC 900

TGCATTGGCC AGGGGCAGAG GGGCCCACCC ATCATCCTGG AAGCCACACT TCACCTAGCA 960

GAGATTGAAG ACATGCCGCT ATTTGAGCCA CGGGTGTTTA CAGCTGGCAG CGAGGAGCGT 1020

GTGACCTGCC TTCCCCCCAA GGGTCTGCCA GAGCCCAGCG TGTGGTGGGA GCACGCGGGA 1080

GTCCGGCTGC CCACCCATGG CAGGGTCTAC CAGAAGGGCC ACGAGCTGGT GTTGGCCAAT 1140

ATTGCTGAAA GTGATGCTGG TGTCTACACC TGCCACGCGG CCAACCTGGC TGGTCAGCGG 1200

AGACAGGATG TCAACATCAC TGTGGCCAAT GGGAGCAGCC TCCCAGAGTG GGTGACAGAC 1260

AACGCTGGGA CCCTGCATTT TGCCCGGGTG ACTCGAGATG ACGCTGGCAA CTACACTTGC 1320

ATTGCCTCCA ACGGGCCGCA GGGCCAGATT CGTGCCCATG TCCAGCTCAC TGTGGCAGTT 1380

TTTATCACCT TCAAAGTGGA ACCAGAGCGT ACGACTGTGT ACCAGGGCCA CACAGCCCTA 1440

CTGCAGTGCG AGGCCCAGGG GGACCCCAAG CCGCTGATTC AGTGGAAAGG CAAGGACCGC 1500

ATCCTGGACC CCACCAAGCT GGGACCCAGG ATGCACATCT TCCAGAATGG CTCCCTGGTG 1560

ATCCATGACG TGGCCCCTGA GGACTCAGGC CGCTACACCT GCATTGCAGG CAACAGCTGC 1620

AACATCAAGC ACACGGAGGC CCCCCTCTAT GTCGTGGACA AGCCTGTGCC GGAGGAGTCG 1680

GAGGGCCCTG GCAGCCCTCC CCCCTACAAG ATGATCCAGA CCATTGGGTT GTCGGTGGGT 1740

GCCGCTGTGG CCTACATCAT TGCCGTGCTG GGCCTCATGT TCTACTGCAA GAAGCGCTGC 1800

AAAGCCAAGC GGCTGCAGAA GCAGCCCGAG GGCGAGGAGC CAGAGATGGA ATGCCTCAAC 1860

GGTGGGCCTT TGCAGAACGG GCAGCCCTCA GCAGAGATCC AAGAAGAAGT GGCCTTGACC 1920

AGCTTGGGCT CCGGCCCCGC GGCCACCAAC AAACGCCACA GCACAAGTGA TAAGATGCAC 1980

TTCCCACGGT CTAGCCTGCA GCCCATCACC ACGCTGGGGA AGAGTGAGTT TGGGGAGGTG 2040

TTCCTGGCAA AGGCTCAGGG CTTGGAGGAG GGAGTGGCAG AGACCCTGGT ACTTGTGAAG 2100

AGCCTGCAGA GCAAGGATGA GCAGCAGCAG CTGGACTTCC GGAGGGAGTT GGAGATGTTT 2160

GGGAAGCTGA ACCACGCCAA CGTGGTGCGG CTCCTGGGGC TGTGCCGGGA GGCTGAGCCC 2220

CACTACATGG TGCTGGAATA TGTGGATCTG GGAGACCTCA AGCAGTTCCT GAGGATTTCC 2280

AAGAGCAAGG ATGAAAAATT GAAGTCACAG CCCCTCAGCA CCAAGCAGAA GGTGGCCCTA 2340

TGCACCCAGG TAGCCCTGGG CATGGAGCAC CTGTCCAACA ACCGCTTTGT GCATAAGGAC 2400

TTGGCTGCGC GTAACTGCCT GGTCAGTGCC CAGAGACAAG TGAAGGTGTC TGCCCTGGGC 2460

CTCAGCAAGG ATGTGTACAA CAGTGAGTAC TACCACTTCC GCCAGGCCTG GGTGCCGCTG 2520

CGCTGGATGT CCCCCGAGGC CATCCTGGAG GGTGACTTCT CTACCAAGTC TGATGTCTGG 2580

GCCTTCGGTG TGCTGATGTG GGAAGTGTTT ACACATGGAG AGATGCCCCA TGGTGGGCAG 2640

GCAGATGATG AAGTACTGGC AGATTTGCAG GCTGGGAAGG CTAGACTTCC TCAGCCCGAG 2700

GGCTGCCCTT CCAAACTCTA TCGGCTGATG CAGCGCTGCT GGGCCCTCAG CCCCAAGGAC 2760

CGGCCCTCCT TCAGTGAGAT TGCCAGCGCC CTGGGAGACA GCACCGTGGA CAGCAAGCCG 2820

TGA 2823

Domain Profile

S: 1     lqelitlgksefgevflaklkgleegatetlvlvkslqkkdeqaqldfrrelellgklnh  60

         lq+++tlgksefgevflak++gleeg++etlvlvkslq+kdeq+qldfrrele++gklnh

Q: 666   LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNH  725

         79**********************************************************

S: 61    anvvrllglcreaephymvleyvdlgdlkqflkiskakdeklksqplstkqkvalasqva  120

         anvvrllglcreaephymvleyvdlgdlkqfl+isk+kdeklksqplstkqkval++qva

Q: 726   ANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVA  785

         ************************************************************

S: 121   lgmealsrarfvhkdlaarnclisaerqvkvsalalskdvynseyykfrqalvplrwlsp  180

         lgme+ls++rfvhkdlaarncl+sa+rqvkvsal+lskdvynseyy+frqa+vplrw+sp

Q: 786   LGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSP  845

         ************************************************************

S: 181   eaileddfstksdvfafgvlvwevftqaelpheeladdevladlqagklrlsqaeatpsk  240

         eaile+dfstksdv+afgvl+wevft++e+ph+++addevladlqagk+rl+q+e++psk

Q: 846   EAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSK  905

         ************************************************************

S: 241   lyrlllrcwasnpkdrpsfselasal  266

         lyrl++rcwa++pkdrpsfse+asal

Q: 906   LYRLMQRCWALSPKDRPSFSEIASAL  931

         ************************97

Domain Sequence
(FASTA)

LQPITTLGKS EFGEVFLAKA QGLEEGVAET LVLVKSLQSK DEQQQLDFRR ELEMFGKLNH 60

ANVVRLLGLC REAEPHYMVL EYVDLGDLKQ FLRISKSKDE KLKSQPLSTK QKVALCTQVA 120

LGMEHLSNNR FVHKDLAARN CLVSAQRQVK VSALGLSKDV YNSEYYHFRQ AWVPLRWMSP 180

EAILEGDFST KSDVWAFGVL MWEVFTHGEM PHGGQADDEV LADLQAGKAR LPQPEGCPSK 240

LYRLMQRCWA LSPKDRPSFS EIASAL 266

Keyword

Alternative splicing; Cell adhesion; Cell junction; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005911	; C:cell-cell junction
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0003401	; P:axis elongation
GO:0060070	; P:canonical Wnt receptor signaling pathway
GO:0007155	; P:cell adhesion
GO:0016477	; P:cell migration
GO:0071300	; P:cellular response to retinoic acid
GO:0090103	; P:cochlea morphogenesis
GO:0060026	; P:convergent extension
GO:0045198	; P:establishment of epithelial cell apical/basal polarity
GO:0001736	; P:establishment of planar polarity
GO:0060484	; P:lung-associated mesenchyme development
GO:0001843	; P:neural tube closure
GO:0090179	; P:planar cell polarity pathway involved in neural tube closure
GO:0010976	; P:positive regulation of neuron projection development
GO:0042060	; P:wound healing

KEGG

hsa:5754

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 6.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 2.
SM00408	; IGc2; 5.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 7.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; FALSE_NEG.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013