| Tag | Content |
|---|
| EKPD ID | EPS-HOS-00010 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| DSP/aDSP | 147.3 | 1.5E-42 | 5 | 141 | 137 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000345281 |
| UniProt Accession | Q9NRW4; B4DK56; Q59GW2; Q5VWR2; Q96AR1; |
| Protein Name | Dual specificity protein phosphatase 22 |
| Protein Synonyms/Alias | JNK-stimulatory phosphatase-1; JSP-1; Low molecular weight dual specificity phosphatase 2; LMW-DSP2; Mitogen-activated protein kinase phosphatase x; MAP kinase phosphatase x; MKP-x; |
| Gene Name | DUSP22 |
| Gene Synonyms/Alias | DUSP22; JSP1, LMWDSP2, MKPX; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Activates the Jnk signaling pathway. Dephosphorylatesand deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity). |
| Protein Length | 184 |
Protein Sequence
(FASTA) | | MGNGMNKILP GLYIGNFKDA RDAEQLSKNK VTHILSVHDS ARPMLEGVKY LCIPAADSPS 60 | | QNLTRHFKES IKFIHECRLR GESCLVHCLA GVSRSVTLVI AYIMTVTDFG WEDALHTVRA 120 | | GRSCANPNVG FQRQLQEFEK HEVHQYRQWL KEEYGESPLQ DAEEAKNILA APGILKFWAF 180 | | LRRL 184 |
|
Nucleotide Sequence
(FASTA) | | ATGGGGAATG GGATGAACAA GATCCTGCCC GGCCTGTACA TCGGCAACTT CAAAGATGCC 60 | | AGAGACGCGG AACAATTGAG CAAGAACAAG GTGACACATA TTCTGTCTGT CCACGATAGT 120 | | GCCAGGCCTA TGTTGGAGGG AGTTAAATAC CTGTGCATCC CAGCAGCGGA TTCACCATCT 180 | | CAAAACCTGA CAAGACATTT CAAAGAAAGT ATTAAATTCA TTCACGAGTG CCGGCTCCGC 240 | | GGTGAGAGCT GCCTTGTACA CTGCCTGGCC GGGGTCTCCA GGAGCGTGAC ACTGGTGATC 300 | | GCATACATCA TGACCGTCAC TGACTTTGGC TGGGAGGATG CCCTGCACAC CGTGCGTGCT 360 | | GGGAGATCCT GTGCCAACCC CAACGTGGGC TTCCAGAGAC AGCTCCAGGA GTTTGAGAAG 420 | | CATGAGGTCC ATCAGTATCG GCAGTGGCTG AAGGAAGAAT ATGGAGAGAG CCCTTTGCAG 480 | | GATGCAGAAG AAGCCAAAAA CATTCTGGCC GCTCCGGGAA TTCTGAAGTT CTGGGCCTTT 540 | | CTCAGAAGAC TGTAA 555 |
|
| Domain Profile | S: 2 vteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvd 61 | +++ilpgly+g+ ++a d +Lsk+++t+++ + s + +g++y+ ip+ | Q: 5 MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARP--------MLEGVKYLCIPAA 56 | 689*************************99987666554........569********** |
| S: 62 DsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAie 121 | Ds++++l ++f+e ++fi+e++ +g+++lvHC aGvsRS+tlv+aY+m+v+++ ++dA++ | Q: 57 DSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALH 116 | ************************************************************ |
| S: 122 avkrkrpsiepnegfleQLlelekk 146 | +v++ r++++pn gf +QL e+ek+ | Q: 117 TVRAGRSCANPNVGFQRQLQEFEKH 141 | ***********************96 |
|
Domain Sequence
(FASTA) | | MNKILPGLYI GNFKDARDAE QLSKNKVTHI LSVHDSARPM LEGVKYLCIP AADSPSQNLT 60 | | RHFKESIKFI HECRLRGESC LVHCLAGVSR SVTLVIAYIM TVTDFGWEDA LHTVRAGRSC 120 | | ANPNVGFQRQ LQEFEKH 137 |
|
| Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Lipoprotein; Myristate; Nucleus; Polymorphism; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |