EKS-HOS-00279

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00279

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	402.6	6.3E-120	267	583	317

Status

Reviewed

Ensembl Protein

ENSP00000433714

UniProt Accession

Q13523; A8K5C9; Q5D0F6; Q5TAY8; Q8IVC3; Q8TDP2; Q96QT7; Q9UEE6;

Protein Name

Serine/threonine-protein kinase PRP4 homolog

Protein Synonyms/Alias

PRP4 kinase; PRP4 pre-mRNA-processing factor 4 homolog;

Gene Name

PRPF4B

Gene Synonyms/Alias

PRPF4B; KIAA0536, PRP4, PRP4H, PRP4K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000112739	ENSP00000435540	ENST00000463634
ENSG00000112739	ENSP00000337194	ENST00000337659
ENSG00000112739	ENSP00000433547	ENST00000480058
ENSG00000112739	ENSP00000433714	ENST00000481109
ENSG00000112739	ENSP00000439331	ENST00000538861

Organism

Homo sapiens

Functional Description

Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

Protein Length

587

Protein Sequence
(FASTA)

LSRRERSKDA SPINRWSPTR RRSRSPIRRR SRSPLRRSRS PRRRSRSPRR RDRGRRSRSR 60

LRRRSRSRGG RRRRSRSKVK EDKFKGSLSE GMKVEQESSS DDNLEDFDVE EEDEEALIEQ 120

RRIQRQAIVQ KYKYLAEDSN MSVPSEPSSP QSSTRTRSPS PDDILERVAA DVKEYERENV 180

DTFEASVKAK HNLMTVEQNN GSSQKKLLAP DMFTESDDMF AAYFDSARLR AAGIGKDFKE 240

NPNLRDNWTD AEGYYRVNIG EVLDKRYNVY GYTGQGVFSN VVRARDNARA NQEVAVKIIR 300

NNELMQKTGL KELEFLKKLN DADPDDKFHC LRLFRHFYHK QHLCLVFEPL SMNLREVLKK 360

YGKDVGLHIK AVRSYSQQLF LALKLLKRCN ILHADIKPDN ILVNESKTIL KLCDFGSASH 420

VADNDITPYL VSRFYRAPEI IIGKSYDYGI DMWSVGCTLY ELYTGKILFP GKTNNHMLKL 480

AMDLKGKMPN KMIRKGVFKD QHFDQNLNFM YIEVDKVTER EKVTVMSTIN PTKDLLADLI 540

GCQRLPEDQR KKVHQLKDLL DQILMLDPAK RISINQALQH AFIQEKI 587

Nucleotide Sequence
(FASTA)

CTCAGTAGAC GTGAAAGATC AAAAGATGCC AGCCCCATCA ATAGATGGTC TCCAACCCGA 60

AGAAGAAGTA GATCTCCCAT TAGAAGGAGG TCTCGTTCCC CACTCAGACG TAGCAGGTCT 120

CCAAGAAGAA GAAGCAGATC TCCTCGGAGA AGGGACAGAG GTCGGAGGAG CAGATCACGC 180

TTGCGAAGGC GGTCTCGATC ACGCGGTGGT CGTAGACGAA GGAGCAGAAG CAAAGTAAAG 240

GAAGATAAAT TTAAAGGAAG TCTTTCTGAA GGAATGAAAG TTGAGCAGGA ATCTTCGTCT 300

GATGATAACC TTGAAGACTT TGATGTAGAG GAAGAAGATG AAGAAGCCCT AATAGAACAG 360

AGAAGAATCC AAAGGCAGGC AATTGTTCAG AAATATAAAT ACCTTGCTGA AGATAGCAAC 420

ATGTCTGTGC CATCTGAACC AAGCAGCCCC CAGAGCAGTA CGAGAACACG ATCACCATCT 480

CCAGATGACA TTCTGGAGCG AGTAGCTGCT GATGTTAAAG AGTATGAACG GGAAAATGTT 540

GATACATTTG AGGCCTCAGT GAAAGCCAAG CATAATCTAA TGACAGTTGA ACAGAATAAT 600

GGTTCATCTC AGAAGAAGTT GTTGGCACCT GATATGTTTA CAGAATCTGA TGATATGTTT 660

GCTGCGTATT TTGATAGTGC TCGTCTTCGG GCCGCTGGCA TTGGAAAAGA TTTCAAAGAG 720

AATCCCAACC TCAGAGATAA CTGGACCGAT GCAGAAGGCT ATTATCGTGT GAACATAGGT 780

GAAGTCCTAG ATAAACGTTA CAATGTGTAT GGCTACACTG GGCAAGGTGT ATTCAGTAAT 840

GTTGTACGAG CCAGAGATAA TGCAAGAGCC AACCAAGAAG TGGCTGTAAA GATCATCAGA 900

AACAATGAGC TCATGCAAAA GACTGGTTTA AAAGAATTAG AGTTCTTGAA AAAACTTAAT 960

GATGCTGATC CTGATGACAA ATTTCATTGT CTGAGACTCT TCAGGCACTT CTATCACAAG 1020

CAGCATCTTT GTCTGGTATT CGAGCCTCTC AGCATGAACT TACGAGAGGT GTTAAAAAAA 1080

TATGGTAAAG ATGTTGGTCT TCATATTAAA GCTGTAAGAT CCTATAGTCA GCAGTTGTTC 1140

CTGGCATTGA AACTCCTTAA AAGATGCAAT ATCCTACATG CAGATATCAA GCCAGACAAT 1200

ATCCTGGTTA ATGAATCCAA AACTATTTTA AAGCTTTGCG ATTTTGGGTC GGCTTCACAT 1260

GTTGCGGATA ATGACATAAC ACCTTATCTT GTCAGTAGAT TTTATCGTGC TCCTGAAATC 1320

ATTATAGGTA AAAGCTATGA CTATGGTATA GATATGTGGT CTGTAGGTTG CACCTTATAC 1380

GAACTCTATA CTGGAAAAAT TTTATTCCCT GGCAAAACCA ATAACCATAT GCTGAAGCTT 1440

GCAATGGATC TCAAAGGAAA GATGCCAAAT AAGATGATTC GAAAAGGTGT GTTCAAAGAT 1500

CAGCATTTTG ATCAAAATCT CAACTTCATG TACATAGAAG TTGATAAAGT AACAGAGAGG 1560

GAGAAAGTTA CTGTTATGAG CACCATTAAT CCAACTAAGG ACCTGTTGGC TGACTTGATT 1620

GGGTGCCAGA GACTTCCTGA AGACCAACGT AAGAAAGTAC ACCAGCTAAA GGACTTGTTG 1680

GACCAGATTC TGATGTTGGA CCCAGCTAAA CGAATTAGCA TCAACCAGGC CCTACAGCAC 1740

GCCTTCATCC AGGAAAAAAT TTAA 1764

Domain Profile

S: 1     yevlevigkGsfgqVvkaldk.ktkeivaikiiknkkrfarqaqeEveiLeklnkkdkee  59

         y+v+ ++g+G+f++Vv+a+d+ +++++va+kii+n++ +++++ +E+e+L+kln++d+++

Q: 267   YNVYGYTGQGVFSNVVRARDNaRANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDD  326

         99******************9889************************************

S: 60    kynvvrllelfvfrnhlclvfellsqnLyellkknkfs.glslklvrklaqqilkaLklL  118

         k++++rl+++f++++hlclvfe ls+nL+e+lkk++++ gl++k+vr+++qq++ aLklL

Q: 327   KFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDvGLHIKAVRSYSQQLFLALKLL  386

         ************************************999*********************

S: 119   kelkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

         k+++i+HaD+KP+Nil++e+k+  +k++DFGs+s+v++++i++y++srfYraPEii+g++

Q: 387   KRCNILHADIKPDNILVNESKTI-LKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKS  445

         *********************99.************************************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd+ iDmWS+Gc+l+El+tGk+LfpG++++++l+l ++++g++p+k+++k+  ++++f++

Q: 446   YDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQ  505

         ************************************************************

S: 239   keapkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedkl.fkdllkrmle  297

         + +++yi ++k+++r+k++v+++++ +k+  a+l  +++ +++++++ + +kdll+++l+

Q: 506   NLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHqLKDLLDQILM  565

         ***********************************************999**********

S: 298   ldpakRitpkealkhpfv  315

         ldpakRi++++al+h f+

Q: 566   LDPAKRISINQALQHAFI  583

         *****************7

Domain Sequence
(FASTA)

YNVYGYTGQG VFSNVVRARD NARANQEVAV KIIRNNELMQ KTGLKELEFL KKLNDADPDD 60

KFHCLRLFRH FYHKQHLCLV FEPLSMNLRE VLKKYGKDVG LHIKAVRSYS QQLFLALKLL 120

KRCNILHADI KPDNILVNES KTILKLCDFG SASHVADNDI TPYLVSRFYR APEIIIGKSY 180

DYGIDMWSVG CTLYELYTGK ILFPGKTNNH MLKLAMDLKG KMPNKMIRKG VFKDQHFDQN 240

LNFMYIEVDK VTEREKVTVM STINPTKDLL ADLIGCQRLP EDQRKKVHQL KDLLDQILML 300

DPAKRISINQ ALQHAFI 317

Keyword

Acetylation; ATP-binding; Complete proteome; Kinase; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Spliceosome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0071013	; C:catalytic step 2 spliceosome
GO:0005694	; C:chromosome
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000398	; P:mRNA splicing, via spliceosome

KEGG

hsa:8899

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013