Tag | Content |
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EKPD ID | EPS-HOS-00072 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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PPP/PP2A | 419.5 | 8.2E-126 | 51 | 243 | 193 |
|
Status | Reviewed |
Ensembl Protein | ENSP00000418447 |
UniProt Accession | P67775; P05323; P13197; |
Protein Name | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
Protein Synonyms/Alias | PP2A-alpha; Replication protein C; RP-C; |
Gene Name | PPP2CA |
Gene Synonyms/Alias | PPP2CA; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | PP2A is the major phosphatase for microtubule-associatedproteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. |
Protein Length | 309 |
Protein Sequence (FASTA) | MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60 | QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120 | RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180 | RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240 | HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300 | TRRTPDYFL 309 |
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Nucleotide Sequence (FASTA) | ATGGACGAGA AGGTGTTCAC CAAGGAGCTG GACCAGTGGA TCGAGCAGCT GAACGAGTGC 60 | AAGCAGCTGT CCGAGTCCCA GGTCAAGAGC CTCTGCGAGA AGGCTAAAGA AATCCTGACA 120 | AAAGAATCCA ACGTGCAAGA GGTTCGATGT CCAGTTACTG TCTGTGGAGA TGTGCATGGG 180 | CAATTTCATG ATCTCATGGA ACTGTTTAGA ATTGGTGGCA AATCACCAGA TACAAATTAC 240 | TTGTTTATGG GAGATTATGT TGACAGAGGA TATTATTCAG TTGAAACAGT TACACTGCTT 300 | GTAGCTCTTA AGGTTCGTTA CCGTGAACGC ATCACCATTC TTCGAGGGAA TCATGAGAGC 360 | AGACAGATCA CACAAGTTTA TGGTTTCTAT GATGAATGTT TAAGAAAATA TGGAAATGCA 420 | AATGTTTGGA AATATTTTAC AGATCTTTTT GACTATCTTC CTCTCACTGC CTTGGTGGAT 480 | GGGCAGATCT TCTGTCTACA TGGTGGTCTC TCGCCATCTA TAGATACACT GGATCATATC 540 | AGAGCACTTG ATCGCCTACA AGAAGTTCCC CATGAGGGTC CAATGTGTGA CTTGCTGTGG 600 | TCAGATCCAG ATGACCGTGG TGGTTGGGGT ATATCTCCTC GAGGAGCTGG TTACACCTTT 660 | GGGCAAGATA TTTCTGAGAC ATTTAATCAT GCCAATGGCC TCACGTTGGT GTCTAGAGCT 720 | CACCAGCTAG TGATGGAGGG ATATAACTGG TGCCATGACC GGAATGTAGT AACGATTTTC 780 | AGTGCTCCAA ACTATTGTTA TCGTTGTGGT AACCAAGCTG CAATCATGGA ACTTGACGAT 840 | ACTCTAAAAT ACTCTTTCTT GCAGTTTGAC CCAGCACCTC GTAGAGGCGA GCCACATGTT 900 | ACTCGTCGTA CCCCAGACTA CTTCCTGTAA 930 |
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Domain Profile | S: 1 pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer 60 | pvtvcgdvhgqfhdl+elfriggkspdtnylf+gdyvdrgyysvetvtllvalkvryrer | Q: 51 PVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRER 110 | 9*********************************************************** |
| S: 61 itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl 120 | itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdg+ifclhggl | Q: 111 ITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGL 170 | ************************************************************ |
| S: 121 spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh 180 | spsidtld+iraldrlqevphegp+cdllwsdpddr+gwgisprgagytfgqdise+fnh | Q: 171 SPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNH 230 | ************************************************************ |
| S: 181 angleliarahql 193 | angl+l++rahql | Q: 231 ANGLTLVSRAHQL 243 | ************8 |
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Domain Sequence (FASTA) | PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER 60 | ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL 120 | SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH 180 | ANGLTLVSRA HQL 193 |
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Keyword | 3D-structure; Acetylation; Alternative splicing; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydrolase; Iron; Manganese; Meiosis; Metal-binding; Methylation; Nucleus; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |