EPS-HOS-00072
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-HOS-00072
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
PPP/PP2A419.58.2E-12651243193
StatusReviewed
Ensembl ProteinENSP00000418447
UniProt AccessionP67775; P05323; P13197;
Protein NameSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Protein Synonyms/Alias PP2A-alpha; Replication protein C; RP-C;
Gene NamePPP2CA
Gene Synonyms/Alias PPP2CA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000113575ENSP00000430869ENST00000522385
ENSG00000113575ENSP00000428816ENST00000523082
ENSG00000113575ENSP00000418447ENST00000481195
OrganismHomo sapiens
Functional DescriptionPP2A is the major phosphatase for microtubule-associatedproteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Protein Length309
Protein Sequence
(FASTA)
MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120
RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180
RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240
HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300
TRRTPDYFL 309
Nucleotide Sequence
(FASTA)
ATGGACGAGA AGGTGTTCAC CAAGGAGCTG GACCAGTGGA TCGAGCAGCT GAACGAGTGC 60
AAGCAGCTGT CCGAGTCCCA GGTCAAGAGC CTCTGCGAGA AGGCTAAAGA AATCCTGACA 120
AAAGAATCCA ACGTGCAAGA GGTTCGATGT CCAGTTACTG TCTGTGGAGA TGTGCATGGG 180
CAATTTCATG ATCTCATGGA ACTGTTTAGA ATTGGTGGCA AATCACCAGA TACAAATTAC 240
TTGTTTATGG GAGATTATGT TGACAGAGGA TATTATTCAG TTGAAACAGT TACACTGCTT 300
GTAGCTCTTA AGGTTCGTTA CCGTGAACGC ATCACCATTC TTCGAGGGAA TCATGAGAGC 360
AGACAGATCA CACAAGTTTA TGGTTTCTAT GATGAATGTT TAAGAAAATA TGGAAATGCA 420
AATGTTTGGA AATATTTTAC AGATCTTTTT GACTATCTTC CTCTCACTGC CTTGGTGGAT 480
GGGCAGATCT TCTGTCTACA TGGTGGTCTC TCGCCATCTA TAGATACACT GGATCATATC 540
AGAGCACTTG ATCGCCTACA AGAAGTTCCC CATGAGGGTC CAATGTGTGA CTTGCTGTGG 600
TCAGATCCAG ATGACCGTGG TGGTTGGGGT ATATCTCCTC GAGGAGCTGG TTACACCTTT 660
GGGCAAGATA TTTCTGAGAC ATTTAATCAT GCCAATGGCC TCACGTTGGT GTCTAGAGCT 720
CACCAGCTAG TGATGGAGGG ATATAACTGG TGCCATGACC GGAATGTAGT AACGATTTTC 780
AGTGCTCCAA ACTATTGTTA TCGTTGTGGT AACCAAGCTG CAATCATGGA ACTTGACGAT 840
ACTCTAAAAT ACTCTTTCTT GCAGTTTGAC CCAGCACCTC GTAGAGGCGA GCCACATGTT 900
ACTCGTCGTA CCCCAGACTA CTTCCTGTAA 930
Domain Profile
S: 1     pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer  60
         pvtvcgdvhgqfhdl+elfriggkspdtnylf+gdyvdrgyysvetvtllvalkvryrer
Q: 51    PVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRER  110
         9***********************************************************
S: 61    itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl  120
         itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdg+ifclhggl
Q: 111   ITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGL  170
         ************************************************************
S: 121   spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh  180
         spsidtld+iraldrlqevphegp+cdllwsdpddr+gwgisprgagytfgqdise+fnh
Q: 171   SPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNH  230
         ************************************************************
S: 181   angleliarahql  193
         angl+l++rahql
Q: 231   ANGLTLVSRAHQL  243
         ************8
Domain Sequence
(FASTA)
PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER 60
ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL 120
SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH 180
ANGLTLVSRA HQL 193
Keyword3D-structure; Acetylation; Alternative splicing; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydrolase; Iron; Manganese; Meiosis; Metal-binding; Methylation; Nucleus; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EPS-AIM-00090
EPS-ANC-00092
EPS-BOT-00072
EPS-CAJ-00073
EPS-CAF-00094
EPS-CAP-00068
EPS-CII-00040
EPS-CIS-00031
EPS-DAR-00132
EPS-DAN-00001
EPS-DRM-00038
EPS-ECT-00005
EPS-FEC-00090
EPS-GAM-00073
EPS-GAG-00077
EPS-GOG-00092
EPS-ICT-00068
EPS-LAC-00093
EPS-LOA-00069
EPS-MAM-00077
EPS-MEG-00083
EPS-MOD-00073
EPS-MUM-00072
EPS-MUP-00065
EPS-MYL-00069
EPS-NOL-00084
EPS-OCP-00037
EPS-ORN-00097
EPS-ORA-00081
EPS-ORC-00071
EPS-ORL-00110
EPS-OTG-00071
EPS-PAT-00068
EPS-PES-00087
EPS-PEM-00054
EPS-RAN-00076
EPS-SAH-00070
EPS-TAG-00087
EPS-TAR-00116
EPS-TAS-00025
EPS-TEN-00089
EPS-TUB-00022
EPS-TUT-00051
EPS-XET-00090
EPS-XIM-00132
EPS-SCP-00025
Gene Ontology
GO:0000775; C:chromosome, centromeric region
GO:0005829; C:cytosol
GO:0016020; C:membrane
GO:0015630; C:microtubule cytoskeleton
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0000159; C:protein phosphatase type 2A complex
GO:0000922; C:spindle pole
GO:0046872; F:metal ion binding
GO:0004721; F:phosphoprotein phosphatase activity
GO:0006672; P:ceramide metabolic process
GO:0008543; P:fibroblast growth factor receptor signaling pathway
GO:0000188; P:inactivation of MAPK activity
GO:0006917; P:induction of apoptosis
GO:0007126; P:meiosis
GO:0007498; P:mesoderm development
GO:0030308; P:negative regulation of cell growth
GO:0010719; P:negative regulation of epithelial to mesenchymal transition
GO:0042518; P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0006470; P:protein dephosphorylation
GO:0070208; P:protein heterotrimerization
GO:0030155; P:regulation of cell adhesion
GO:0006275; P:regulation of DNA replication
GO:0031952; P:regulation of protein autophosphorylation
GO:0042176; P:regulation of protein catabolic process
GO:0010469; P:regulation of receptor activity
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0030111; P:regulation of Wnt receptor signaling pathway
GO:0008380; P:RNA splicing
GO:0019932; P:second-messenger-mediated signaling
KEGG
hsa:5515;
InterPros
IPR004843; Metallo_PEstase_dom.
IPR006186; Ser/Thr-sp_prot-phosphatase.
Pfam
PF00149; Metallophos; 1.
SMARTs
SM00156; PP2Ac; 1.
Prosites
PS00125; SER_THR_PHOSPHATASE; 1.
Prints
PR00114; STPHPHTASE.
Created Date20-Feb-2013