| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00458 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CK1/CK1 | 503.3 | 6.2E-151 | 17 | 277 | 261 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000261798 |
| UniProt Accession | P48729; D3DQG0; D3DQG1; Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q96HD2; Q9UDK3; |
| Protein Name | Casein kinase I isoform alpha |
| Protein Synonyms/Alias | CKI-alpha; CK1; |
| Gene Name | CSNK1A1 |
| Gene Synonyms/Alias | CSNK1A1; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis. |
| Protein Length | 325 |
Protein Sequence
(FASTA) | | MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE 60 | | SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM 120 | | ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKN 180 | | LTGTARYASI NAHLGIEQSR RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK 240 | | MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM 300 | | LKQKAAQQAA SSSGQGQQAQ TPTGF 325 |
|
Nucleotide Sequence
(FASTA) | | ATGGCGAGTA GCAGCGGCTC CAAGGCTGAA TTCATTGTCG GAGGGAAATA TAAACTGGTA 60 | | CGGAAGATCG GGTCTGGCTC CTTCGGGGAC ATCTATTTGG CGATCAACAT CACCAACGGC 120 | | GAGGAAGTGG CAGTGAAGCT AGAATCTCAG AAGGCCAGGC ATCCCCAGTT GCTGTACGAG 180 | | AGCAAGCTCT ATAAGATTCT TCAAGGTGGG GTTGGCATCC CCCACATACG GTGGTATGGT 240 | | CAGGAAAAAG ACTACAATGT ACTAGTCATG GATCTTCTGG GACCTAGCCT CGAAGACCTC 300 | | TTCAATTTCT GTTCAAGAAG GTTCACAATG AAAACTGTAC TTATGTTAGC TGACCAGATG 360 | | ATCAGTAGAA TTGAATATGT GCATACAAAG AATTTTATAC ACAGAGACAT TAAACCAGAT 420 | | AACTTCCTAA TGGGTATTGG GCGTCACTGT AATAAGTTAT TCCTTATTGA TTTTGGTTTG 480 | | GCCAAAAAGT ACAGAGACAA CAGGACAAGG CAACACATAC CATACAGAGA AGATAAAAAC 540 | | CTCACTGGCA CTGCCCGATA TGCTAGCATC AATGCACATC TTGGTATTGA GCAGAGTCGC 600 | | CGAGATGACA TGGAATCATT AGGATATGTT TTGATGTATT TTAATAGAAC CAGCCTGCCA 660 | | TGGCAAGGGC TAAAGGCTGC AACAAAGAAA CAAAAATATG AAAAGATTAG TGAAAAGAAG 720 | | ATGTCCACGC CTGTTGAAGT TTTATGTAAG GGGTTTCCTG CAGAATTTGC GATGTACTTA 780 | | AACTATTGTC GTGGGCTACG CTTTGAGGAA GCCCCAGATT ACATGTATCT GAGGCAGCTA 840 | | TTCCGCATTC TTTTCAGGAC CCTGAACCAT CAATATGACT ACACATTTGA TTGGACAATG 900 | | TTAAAGCAGA AAGCAGCACA GCAGGCAGCC TCTTCCAGTG GGCAGGGTCA GCAGGCCCAA 960 | | ACCCCCACAG GTTTCTAA 978 |
|
| Domain Profile | S: 1 yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev 60 | y++v+kiGsGsfGdiyl++n+++geeva+kles+k+++pql +es++ykilqggvgiP++ | Q: 17 YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHI 76 | 89********************************************************** |
| S: 61 ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd 120 | r++g+ek+ynvlv+dllGpsledlf++c+r+f++ktvl+ladq+isrieyvh+k++i+rd | Q: 77 RWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRD 136 | ************************************************************ |
| S: 121 ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk 180 | ikPdnfl+gigr+++k++lidfGlakkyrd++t++hipyre+k+ltGtaryasin+hlg+ | Q: 137 IKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGI 196 | ************************************************************ |
| S: 181 eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef 240 | eqsrrdd+eslgyvl+yf+r+slPWqglkaatkkqkyekisekk+st++evlc+gfP+ef | Q: 197 EQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEF 256 | ************************************************************ |
| S: 241 atylkyvrklkfeekPdyeyl 261 | a+yl+y+r l+fee+Pdy+yl | Q: 257 AMYLNYCRGLRFEEAPDYMYL 277 | *******************97 |
|
Domain Sequence
(FASTA) | | YKLVRKIGSG SFGDIYLAIN ITNGEEVAVK LESQKARHPQ LLYESKLYKI LQGGVGIPHI 60 | | RWYGQEKDYN VLVMDLLGPS LEDLFNFCSR RFTMKTVLML ADQMISRIEY VHTKNFIHRD 120 | | IKPDNFLMGI GRHCNKLFLI DFGLAKKYRD NRTRQHIPYR EDKNLTGTAR YASINAHLGI 180 | | EQSRRDDMES LGYVLMYFNR TSLPWQGLKA ATKKQKYEKI SEKKMSTPVE VLCKGFPAEF 240 | | AMYLNYCRGL RFEEAPDYMY L 261 |
|
| Keyword | Acetylation; Alternative splicing; ATP-binding; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinase; Kinetochore; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |