EKS-HOS-00284

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00284

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.3	1.7E-135	208	495	288

Status

Reviewed

Ensembl Protein

ENSP00000263640

UniProt Accession

Q04771;

Protein Name

Activin receptor type-1

Protein Synonyms/Alias

Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I;

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1; ACVRLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000115170	ENSP00000387273	ENST00000409283
ENSG00000115170	ENSP00000400767	ENST00000424669
ENSG00000115170	ENSP00000399322	ENST00000413751
ENSG00000115170	ENSP00000401189	ENST00000440523
ENSG00000115170	ENSP00000403006	ENST00000412025
ENSG00000115170	ENSP00000405004	ENST00000434821
ENSG00000115170	ENSP00000387127	ENST00000410057
ENSG00000115170	ENSP00000440091	ENST00000539637
ENSG00000115170	ENSP00000263640	ENST00000263640

Organism

Homo sapiens

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).

Protein Length

509

Protein Sequence
(FASTA)

MVDGVMILPV LIMIALPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN 60

DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 120

HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 180

ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 240

DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300

DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM 360

HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 420

NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 480

NPSARLTALR IKKTLTKIDN SLDKLKTDC 509

Nucleotide Sequence
(FASTA)

ATGGTAGATG GAGTGATGAT TCTTCCTGTG CTTATCATGA TTGCTCTCCC CTCCCCTAGT 60

ATGGAAGATG AGAAGCCCAA GGTCAACCCC AAACTCTACA TGTGTGTGTG TGAAGGTCTC 120

TCCTGCGGTA ATGAGGACCA CTGTGAAGGC CAGCAGTGCT TTTCCTCACT GAGCATCAAC 180

GATGGCTTCC ACGTCTACCA GAAAGGCTGC TTCCAGGTTT ATGAGCAGGG AAAGATGACC 240

TGTAAGACCC CGCCGTCCCC TGGCCAAGCC GTGGAGTGCT GCCAAGGGGA CTGGTGTAAC 300

AGGAACATCA CGGCCCAGCT GCCCACTAAA GGAAAATCCT TCCCTGGAAC ACAGAATTTC 360

CACTTGGAGG TTGGCCTCAT TATTCTCTCT GTAGTGTTCG CAGTATGTCT TTTAGCCTGC 420

CTGCTGGGAG TTGCTCTCCG AAAATTTAAA AGGCGCAACC AAGAACGCCT CAATCCCCGA 480

GACGTGGAGT ATGGCACTAT CGAAGGGCTC ATCACCACCA ATGTTGGAGA CAGCACTTTA 540

GCAGATTTAT TGGATCATTC GTGTACATCA GGAAGTGGCT CTGGTCTTCC TTTTCTGGTA 600

CAAAGAACAG TGGCTCGCCA GATTACACTG TTGGAGTGTG TCGGGAAAGG CAGGTATGGT 660

GAGGTGTGGA GGGGCAGCTG GCAAGGGGAG AATGTTGCCG TGAAGATCTT CTCCTCCCGT 720

GATGAGAAGT CATGGTTCAG GGAAACGGAA TTGTACAACA CTGTGATGCT GAGGCATGAA 780

AATATCTTAG GTTTCATTGC TTCAGACATG ACATCAAGAC ACTCCAGTAC CCAGCTGTGG 840

TTAATTACAC ATTATCATGA AATGGGATCG TTGTACGACT ATCTTCAGCT TACTACTCTG 900

GATACAGTTA GCTGCCTTCG AATAGTGCTG TCCATAGCTA GTGGTCTTGC ACATTTGCAC 960

ATAGAGATAT TTGGGACCCA AGGGAAACCA GCCATTGCCC ATCGAGATTT AAAGAGCAAA 1020

AATATTCTGG TTAAGAAGAA TGGACAGTGT TGCATAGCAG ATTTGGGCCT GGCAGTCATG 1080

CATTCCCAGA GCACCAATCA GCTTGATGTG GGGAACAATC CCCGTGTGGG CACCAAGCGC 1140

TACATGGCCC CCGAAGTTCT AGATGAAACC ATCCAGGTGG ATTGTTTCGA TTCTTATAAA 1200

AGGGTCGATA TTTGGGCCTT TGGACTTGTT TTGTGGGAAG TGGCCAGGCG GATGGTGAGC 1260

AATGGTATAG TGGAGGATTA CAAGCCACCG TTCTACGATG TGGTTCCCAA TGACCCAAGT 1320

TTTGAAGATA TGAGGAAGGT AGTCTGTGTG GATCAACAAA GGCCAAACAT ACCCAACAGA 1380

TGGTTCTCAG ACCCGACATT AACCTCTCTG GCCAAGCTAA TGAAAGAATG CTGGTATCAA 1440

AATCCATCCG CAAGACTCAC AGCACTGCGT ATCAAAAAGA CTTTGACCAA AATTGATAAT 1500

TCCCTCGACA AATTGAAAAC TGACTGTTGA 1530

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia

Q: 208   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  267

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 268   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  327

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 328   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  385

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 386   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  444

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 445   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  495

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

3D-structure; ATP-binding; Complete proteome; Disease mutation; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0045177	; C:apical part of cell
GO:0048185	; F:activin binding
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0017046	; F:peptide hormone binding
GO:0042803	; F:protein homodimerization activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0046332	; F:SMAD binding
GO:0050431	; F:transforming growth factor beta binding
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0032924	; P:activin receptor signaling pathway
GO:0002526	; P:acute inflammatory response
GO:0003289	; P:atrial septum primum morphogenesis
GO:0030509	; P:BMP signaling pathway
GO:0060923	; P:cardiac muscle cell fate commitment
GO:0071385	; P:cellular response to glucocorticoid stimulus
GO:0007368	; P:determination of left/right symmetry
GO:0003143	; P:embryonic heart tube morphogenesis
GO:0061445	; P:endocardial cushion cell fate commitment
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001702	; P:gastrulation with mouth forming second
GO:0007281	; P:germ cell development
GO:0001701	; P:in utero embryonic development
GO:0001707	; P:mesoderm formation
GO:0003183	; P:mitral valve morphogenesis
GO:0032926	; P:negative regulation of activin receptor signaling pathway
GO:0043066	; P:negative regulation of apoptotic process
GO:0001755	; P:neural crest cell migration
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0060037	; P:pharyngeal system development
GO:0030501	; P:positive regulation of bone mineralization
GO:2000017	; P:positive regulation of determination of dorsal identity
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0048641	; P:regulation of skeletal muscle tissue development
GO:0023014	; P:signal transduction by phosphorylation
GO:0051145	; P:smooth muscle cell differentiation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0001655	; P:urogenital system development

KEGG

hsa:90

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013