EPS-HOS-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	169.4	6.3E-49	309	502	194

Status

Reviewed

Ensembl Protein

ENSP00000264714

UniProt Accession

O15355;

Protein Name

Protein phosphatase 1G

Protein Synonyms/Alias

Protein phosphatase 1C; Protein phosphatase 2C isoform gamma; PP2C-gamma; Protein phosphatase magnesium-dependent 1 gamma;

Gene Name

PPM1G

Gene Synonyms/Alias

PPM1G; PPM1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000115241	ENSP00000342778	ENST00000344034
ENSG00000115241	ENSP00000264714	ENST00000350803

Organism

Homo sapiens

Functional Description

Protein Length

546

Protein Sequence
(FASTA)

MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD 60

GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 120

PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGGGTGEE 180

PGSQGLNGEA GPEDSTRETP SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS 240

CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300

AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR CVVSEAGKAL 360

DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI GDHFYKRNKN LPPEEQMISA 420

LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ EVVDFIQSKI SQRDENGELR LLSSIVEELL 480

DQCLAPDTSG DGTGCDNMTC IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK 540

KKAKRD 546

Nucleotide Sequence
(FASTA)

ATGGGTGCCT ACCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 60

CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG 120

GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT 180

GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA 240

GATCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC CTTCTTGGCT 300

ATTGACGCCA AATTGACCAC TGAAGAAGTC ATTAAAGAGC TGGCACAGAT TGCAGGGCGA 360

CCCACTGAGG ATGAAGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG 420

GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC 480

GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGGTGGGAC AGGCGAGGAA 540

CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACTCAACTAG GGAAACTCCT 600

TCACAAGAAA ATGGCCCCAC AGCCAAGGCC TACACAGGCT TTTCCTCCAA CTCGGAACGT 660

GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCATTCCCA CTGGTGAGGC TGGGCCTTCC 720

TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 780

GAGGATGAGT CAGATGAGGC GGAGGAAGAA GAGGAAGACA GTGAGGAATG CAGCGAGGAA 840

GAGGATGGCT ACAGCAGTGA GGAGGCAGAG AATGAGGAAG ATGAGGATGA CACCGAGGAG 900

GCTGAAGAGG ACGATGAAGA AGAAGAAGAA GAGATGATGG TGCCAGGGAT GGAAGGCAAA 960

GAGGAGCCTG GCTCTGACAG TGGTACAACA GCGGTGGTGG CCCTGATACG AGGGAAGCAG 1020

TTGATTGTAG CCAACGCAGG AGACTCTCGC TGTGTGGTAT CTGAGGCTGG CAAAGCTTTA 1080

GACATGTCCT ATGATCACAA ACCAGAGGAT GAAGTAGAAC TAGCACGCAT CAAGAATGCT 1140

GGTGGCAAGG TCACCATGGA TGGGCGAGTC AACGGGGGCC TCAACCTCTC CAGAGCCATT 1200

GGGGACCACT TCTATAAGAG AAACAAGAAC CTGCCACCTG AGGAACAGAT GATTTCAGCC 1260

CTTCCTGACA TCAAGGTGCT GACTCTCACT GACGACCATG AATTCATGGT CATTGCCTGT 1320

GATGGCATCT GGAATGTGAT GAGCAGCCAG GAAGTTGTAG ATTTCATTCA ATCAAAGATC 1380

AGCCAGCGTG ATGAAAATGG GGAGCTTCGG TTATTGTCAT CCATTGTGGA AGAGCTGCTG 1440

GATCAGTGCC TGGCACCAGA CACTTCTGGG GATGGTACAG GGTGTGACAA CATGACCTGC 1500

ATCATCATTT GCTTCAAGCC CCGAAACACA GCAGAGCTCC AGCCAGAGAG TGGCAAGCGA 1560

AAACTAGAGG AGGTGCTCTC TACTGAGGGG GCTGAAGAAA ATGGCAACAG CGACAAGAAG 1620

AAGAAGGCCA AGCGAGACTA G 1641

Domain Profile

S: 87    deel..kvleeksldidksGstavvalikdsklyvanvGdSravLcrngkavelssdHkp  144

         +ee+    +e k++  + sG+tavvali++++l+van+GdSr+v +  gka+ +s dHkp

Q: 309   EEEMmvPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKP  368

         344413234444445566******************************************

S: 145   sredEleRieeaggsvilkdgaRvlGvLavsRalGdlylk.........pyvtpePevts  195

         + e El+Ri++agg+v+ +   Rv+G L++sRa+Gd ++k         +++++ P++ +

Q: 369   EDEVELARIKNAGGKVTMDG--RVNGGLNLSRAIGDHFYKrnknlppeeQMISALPDIKV  426

         *******************9..**************************************

S: 196   hrltsedefliLasDGlwdvvsneeavslvrdvle......kkeaeqeaakkLvklalar  249

          +lt ++ef+++a+DG+w+v+s++e+v+++++ ++      + + ++++ ++L++++la

Q: 427   LTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISqrdengELRLLSSIVEELLDQCLAP  486

         ********************************9998877666667788999999999999

S: 250   gsk......dnvsaiv  259

          ++      dn++ i+

Q: 487   DTSgdgtgcDNMTCII  502

         9987777777777766

Domain Sequence
(FASTA)

EEEMMVPGME GKEEPGSDSG TTAVVALIRG KQLIVANAGD SRCVVSEAGK ALDMSYDHKP 60

EDEVELARIK NAGGKVTMDG RVNGGLNLSR AIGDHFYKRN KNLPPEEQMI SALPDIKVLT 120

LTDDHEFMVI ACDGIWNVMS SQEVVDFIQS KISQRDENGE LRLLSSIVEE LLDQCLAPDT 180

SGDGTGCDNM TCII 194

Keyword

Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

hsa:5496

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 2.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013