| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00122 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Other/NAK | 331.5 | 2.0E-98 | 22 | 290 | 269 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000379964 |
| UniProt Accession | O75716; A8K9H9; Q5U0F8; Q96KI2; Q9BUH4; Q9UEN3; Q9UP78; |
| Protein Name | Serine/threonine-protein kinase 16 |
| Protein Synonyms/Alias | Myristoylated and palmitoylated serine/threonine-protein kinase; MPSK; Protein kinase PKL12; TGF-beta-stimulated factor 1; TSF-1; Tyrosine-protein kinase STK16; hPSK; |
| Gene Name | STK16 |
| Gene Synonyms/Alias | STK16; MPSK1, PKL12, TSF1; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Membrane-associated protein kinase that phosphorylateson serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. |
| Protein Length | 305 |
Protein Sequence
(FASTA) | | MGHALCVCSR GTVIIDNKRY LFIQKLGEGG FSYVDLVEGL HDGHFYALKR ILCHEQQDRE 60 | | EAQREADMHR LFNHPNILRL VAYCLRERGA KHEAWLLLPF FKRGTLWNEI ERLKDKGNFL 120 | | TEDQILWLLL GICRGLEAIH AKGYAHRDLK PTNILLGDEG QPVLMDLGSM NQACIHVEGS 180 | | RQALTLQDWA AQRCTISYRA PELFSVQSHC VIDERTDVWS LGCVLYAMMF GEGPYDMVFQ 240 | | KGDSVALAVQ NQLSIPQSPR HSSALRQLLN SMMTVDPHQR PHIPLLLSQL EALQPPAPGQ 300 | | HTTQI 305 |
|
Nucleotide Sequence
(FASTA) | | ATGGGCCACG CGCTGTGTGT CTGCTCTCGG GGAACTGTCA TCATTGACAA TAAGCGCTAC 60 | | CTCTTCATCC AGAAACTGGG GGAGGGTGGG TTCAGCTATG TGGACCTAGT GGAAGGGTTA 120 | | CATGATGGAC ACTTCTACGC CCTGAAGCGA ATCCTGTGTC ACGAGCAGCA GGACCGGGAG 180 | | GAGGCCCAGC GAGAAGCCGA CATGCATCGC CTCTTCAATC ACCCCAACAT CCTTCGCCTC 240 | | GTGGCTTACT GTCTGAGGGA ACGGGGTGCT AAGCATGAGG CCTGGCTGCT GCTACCATTC 300 | | TTCAAGAGAG GTACGCTGTG GAATGAGATA GAAAGGCTGA AGGACAAAGG CAACTTCCTG 360 | | ACCGAGGATC AAATCCTTTG GCTGCTGCTG GGGATCTGCA GAGGCCTTGA GGCCATTCAT 420 | | GCCAAGGGTT ATGCCCACAG AGACTTGAAG CCCACCAATA TATTGCTTGG AGATGAGGGG 480 | | CAGCCAGTTT TAATGGACTT GGGTTCCATG AATCAAGCAT GCATCCATGT GGAGGGCTCC 540 | | CGCCAGGCTC TGACCCTGCA GGACTGGGCA GCCCAGCGGT GCACCATCTC CTACCGAGCC 600 | | CCAGAGCTCT TCTCTGTGCA GAGTCACTGT GTCATCGATG AGCGGACTGA TGTCTGGTCC 660 | | CTAGGCTGCG TGCTATATGC CATGATGTTT GGGGAAGGCC CTTATGACAT GGTGTTCCAA 720 | | AAGGGTGACA GTGTGGCCCT TGCTGTGCAG AACCAACTCA GCATCCCACA AAGCCCCAGG 780 | | CATTCTTCAG CATTGCGGCA GCTCCTGAAC TCGATGATGA CCGTGGACCC GCATCAGCGT 840 | | CCTCACATTC CTCTCCTCCT CAGTCAGCTG GAGGCGCTTC AGCCCCCAGC TCCTGGCCAA 900 | | CATACTACCC AAATCTGA 918 |
|
| Domain Profile | S: 3 iekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivkl 62 | + ++l+eGGf++v+l+e++++g+ yalKril++e++d ee++rE+++++ ++ h+ni++l | Q: 22 FIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFN-HPNILRL 80 | 6799***********************************************9.******* |
| S: 63 vdssvkeekdngskevlllleyckkgslvdllnkrlekge.lseaeilkilldvtravaa 121 | v+++++e+ + ++e++lll+++k+g+l++ +++ ++kg+ l+e++il++ll+++r+++a | Q: 81 VAYCLRERGA--KHEAWLLLPFFKRGTLWNEIERLKDKGNfLTEDQILWLLLGICRGLEA 138 | ********99..9*********************************************** |
| S: 122 lHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeieknttl 181 | +H +++++HRDlk++Nill deg++vl+DlGS+++a+++ve+++++ +lq+++++++t+ | Q: 139 IH--AKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTI 196 | **..99****************************************************** |
| S: 182 syrsPElidlysnlvideksDiWaLGcllYklcffesPf......eesvklailngkysi 235 | syr+PEl++++s++vide++D+W+LGc+lY+++f+e P+ ++sv+la++n ++si | Q: 197 SYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYdmvfqkGDSVALAVQN-QLSI 255 | *******************************************************.**** |
| S: 236 PensryseklkslikkmlevdpeeRptiaqvlell 270 | P+++r+s++l++l+++m++vdp++Rp+i +l++l | Q: 256 PQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQL 290 | ****************************9998875 |
|
Domain Sequence
(FASTA) | | FIQKLGEGGF SYVDLVEGLH DGHFYALKRI LCHEQQDREE AQREADMHRL FNHPNILRLV 60 | | AYCLRERGAK HEAWLLLPFF KRGTLWNEIE RLKDKGNFLT EDQILWLLLG ICRGLEAIHA 120 | | KGYAHRDLKP TNILLGDEGQ PVLMDLGSMN QACIHVEGSR QALTLQDWAA QRCTISYRAP 180 | | ELFSVQSHCV IDERTDVWSL GCVLYAMMFG EGPYDMVFQK GDSVALAVQN QLSIPQSPRH 240 | | SSALRQLLNS MMTVDPHQRP HIPLLLSQL 269 |
|
| Keyword | 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |