EKS-HOS-00390

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00390

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	294.7	3.0E-87	463	719	257

Status

Reviewed

Ensembl Protein

ENSP00000322251

UniProt Accession

Q59H18; Q17RN0; Q49AR1; Q6MZS9; Q9Y2V6;

Protein Name

Serine/threonine-protein kinase TNNI3K

Protein Synonyms/Alias

Cardiac ankyrin repeat kinase; Cardiac troponin I-interacting kinase; TNNI3-interacting kinase;

Gene Name

TNNI3K

Gene Synonyms/Alias

TNNI3K; CARK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000116783	ENSP00000359930	ENST00000370893
ENSG00000116783	ENSP00000434975	ENST00000534020
ENSG00000116783	ENSP00000359928	ENST00000370891
ENSG00000116783	ENSP00000431465	ENST00000526236
ENSG00000116783	ENSP00000322251	ENST00000326637
ENSG00000116783	ENSP00000433550	ENST00000525480

Organism

Homo sapiens

Functional Description

May play a role in cardiac physiology.

Protein Length

835

Protein Sequence
(FASTA)

MGNYKSRPTQ TCTDEWKKKV SESYVITIER LEDDLQIKEK ELTELRNIFG SDEAFSKVNL 60

NYRTENGLSL LHLCCICGGK KSHIRTLMLK GLRPSRLTRN GFTALHLAVY KDNAELITSL 120

LHSGADIQQV GYGGLTALHI ATIAGHLEAA DVLLQHGANV NIQDAVFFTP LHIAAYYGHE 180

QVTRLLLKFG ADVNVSGEVG DRPLHLASAK GFLNIAKLLM EEGSKADVNA QDNEDHVPLH 240

FCSRFGHHDI VKYLLQSDLE VQPHVVNIYG DTPLHLACYN GKFEVAKEII QISGTESLTK 300

ENIFSETAFH SACTYGKSID LVKFLLDQNV ININHQGRDG HTGLHSACYH GHIRLVQFLL 360

DNGADMNLVA CDPSRSSGEK DEQTCLMWAY EKGHDAIVTL LKHYKRPQDE LPCNEYSQPG 420

GDGSYVSVPS PLGKIKSMTK EKADILLLRA GLPSHFHLQL SEIEFHEIIG SGSFGKVYKG 480

RCRNKIVAIK RYRANTYCSK SDVDMFCREV SILCQLNHPC VIQFVGACLN DPSQFAIVTQ 540

YISGGSLFSL LHEQKRILDL QSKLIIAVDV AKGMEYLHNL TQPIIHRDLN SHNILLYEDG 600

HAVVADFGES RFLQSLDEDN MTKQPGNLRW MAPEVFTQCT RYTIKADVFS YALCLWEILT 660

GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPISSLLIR GWNACPEGRP EFSEVVMKLE 720

ECLCNIELMS PASSNSSGSL SPSSSSDCLV NRGGPGRSHV AALRSRFELE YALNARSYAA 780

LSQSAGQYSS QGLSLEEMKR SLQYTPIDKY GYVSDPMSSM HFHSCRNSSS FEDSS 835

Nucleotide Sequence
(FASTA)

ATGGGAAATT ATAAATCTAG ACCAACCCAA ACTTGTACTG ATGAATGGAA GAAAAAAGTC 60

AGTGAATCAT ATGTTATCAC AATAGAAAGA TTAGAAGATG ACCTGCAGAT CAAGGAAAAA 120

GAACTGACAG AACTAAGGAA TATATTTGGC TCTGATGAAG CCTTCAGTAA AGTCAATTTA 180

AATTACCGCA CTGAAAATGG GCTGTCTCTA CTTCATTTAT GTTGCATTTG TGGAGGCAAG 240

AAATCACATA TTCGAACTCT TATGTTGAAA GGGCTCCGCC CATCTCGACT GACAAGAAAT 300

GGATTTACAG CCTTGCATTT AGCAGTTTAC AAGGATAATG CAGAATTGAT CACTTCTCTG 360

CTTCACAGTG GAGCTGATAT ACAGCAGGTT GGATACGGTG GCCTCACTGC CCTCCATATT 420

GCTACAATAG CTGGCCACCT AGAGGCTGCT GATGTGCTGT TGCAACATGG AGCTAATGTC 480

AATATTCAAG ATGCAGTTTT TTTCACTCCA TTGCATATTG CAGCGTACTA TGGACATGAA 540

CAGGTAACTC GCCTTCTTTT GAAATTTGGT GCTGATGTAA ATGTAAGTGG TGAAGTTGGA 600

GATAGACCCC TCCACCTAGC ATCTGCAAAA GGATTCTTGA ATATTGCAAA ACTCTTGATG 660

GAAGAAGGCA GCAAAGCAGA TGTGAATGCT CAAGATAATG AAGACCATGT CCCACTCCAT 720

TTCTGTTCTC GATTTGGACA CCATGATATA GTTAAGTATC TGCTGCAAAG TGATTTGGAA 780

GTTCAACCTC ATGTTGTTAA TATCTATGGA GATACCCCCT TACACCTGGC ATGCTACAAT 840

GGCAAATTTG AAGTTGCCAA GGAAATCATC CAAATATCAG GAACAGAAAG TCTGACTAAG 900

GAAAACATCT TCAGTGAAAC AGCTTTTCAT AGTGCTTGTA CCTATGGCAA GAGCATTGAC 960

CTAGTCAAAT TTCTTCTTGA TCAGAATGTC ATAAACATCA ACCACCAAGG AAGGGATGGG 1020

CACACTGGAT TACACTCTGC TTGCTACCAC GGTCACATTC GCCTGGTTCA GTTCTTACTG 1080

GATAATGGAG CTGATATGAA TCTAGTGGCT TGTGATCCCA GCAGGTCTAG TGGTGAAAAA 1140

GATGAGCAGA CATGTTTGAT GTGGGCTTAT GAAAAAGGGC ATGATGCCAT TGTCACACTC 1200

CTGAAGCATT ATAAGAGACC ACAAGATGAA TTGCCCTGTA ATGAATATTC TCAGCCTGGA 1260

GGAGATGGCT CCTATGTGTC TGTTCCATCA CCCTTGGGGA AGATTAAAAG CATGACAAAA 1320

GAGAAGGCAG ATATTCTCCT CCTAAGAGCT GGATTGCCTT CACATTTCCA TCTTCAGCTC 1380

TCAGAAATTG AGTTCCATGA GATTATTGGC TCAGGTTCTT TTGGGAAAGT ATATAAAGGA 1440

CGATGCAGAA ATAAAATAGT GGCTATAAAA CGTTATCGAG CCAATACCTA CTGCTCCAAG 1500

TCAGATGTGG ATATGTTTTG CCGAGAGGTG TCCATTCTCT GCCAGCTCAA TCATCCCTGC 1560

GTAATTCAGT TTGTGGGTGC TTGCTTGAAT GATCCCAGCC AGTTTGCCAT TGTCACTCAA 1620

TACATATCAG GGGGTTCTCT GTTCTCCCTC CTTCATGAGC AGAAGAGGAT TCTTGATTTG 1680

CAGTCTAAAT TAATTATTGC AGTAGATGTT GCCAAAGGCA TGGAGTACCT TCACAACCTG 1740

ACACAGCCAA TTATACATCG TGACTTGAAC AGTCACAATA TTCTTCTCTA TGAGGATGGG 1800

CATGCTGTGG TGGCAGATTT TGGAGAATCA AGATTTCTAC AGTCTCTGGA TGAAGACAAC 1860

ATGACAAAAC AACCTGGGAA CCTCCGTTGG ATGGCTCCTG AGGTGTTCAC GCAGTGCACT 1920

CGGTACACCA TCAAAGCAGA TGTCTTCAGC TATGCTCTGT GTCTGTGGGA AATTCTCACT 1980

GGCGAAATTC CATTCGCTCA TCTCAAGCCA GCGGCTGCGG CAGCAGACAT GGCTTACCAC 2040

CACATCAGAC CTCCCATTGG CTATTCCATT CCCAAGCCCA TATCATCTCT GCTGATACGA 2100

GGGTGGAACG CATGTCCTGA AGGAAGACCC GAATTTTCTG AAGTTGTCAT GAAGTTAGAA 2160

GAGTGTCTCT GCAACATTGA GCTGATGTCT CCTGCATCAA GTAACAGCAG TGGGTCTCTC 2220

TCACCTTCTT CTTCTTCTGA TTGCCTGGTG AACCGGGGAG GACCTGGCCG GAGTCATGTG 2280

GCAGCATTAA GAAGTCGTTT CGAATTGGAA TATGCTCTAA ATGCAAGGTC CTATGCTGCT 2340

TTGTCCCAAA GTGCTGGACA ATATTCCTCT CAAGGTCTGT CTTTGGAGGA GATGAAAAGA 2400

AGTCTTCAAT ACACACCCAT TGACAAATAT GGCTATGTAT CCGATCCCAT GAGCTCAATG 2460

CATTTTCATT CTTGCCGAAA TAGTAGCAGC TTTGAGGACA GCAGCTGA 2508

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp++i

Q: 463   IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCsKSDVDMFCREVSILCQLNHPCVI  522

         5899****************************99998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+++lhe +kr +dl+  + +a+++A+Gm+YLh+ +

Q: 523   QFVGACLNDPSqFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHNLT  581

         ***********99******************.99*************************6

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

         + +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l++  +++m+++ g+l+wmaPEv+ ++

Q: 582   Q-PIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSldEDNMTKQpGNLRWMAPEVFtQC  639

         6.9*************.9*****************99877777777**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWe+lt+e+P+++l+++a+a+++a++++r+pi+ s+p+++++L+

Q: 640   TRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLI  699

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn++pe Rp+fse+v++l

Q: 700   RGWNACPEGRPEFSEVVMKL  719

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKIVAIKRY RANTYCSKSD VDMFCREVSI LCQLNHPCVI 60

QFVGACLNDP SQFAIVTQYI SGGSLFSLLH EQKRILDLQS KLIIAVDVAK GMEYLHNLTQ 120

PIIHRDLNSH NILLYEDGHA VVADFGESRF LQSLDEDNMT KQPGNLRWMA PEVFTQCTRY 180

TIKADVFSYA LCLWEILTGE IPFAHLKPAA AAADMAYHHI RPPIGYSIPK PISSLLIRGW 240

NACPEGRPEF SEVVMKL 257

Keyword

Alternative splicing; ANK repeat; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

hsa:100526835	;
hsa:51086	;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 6.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013