| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00144 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| AGC/Akt | 504.9 | 2.4E-151 | 148 | 405 | 258 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000336943 |
| UniProt Accession | Q9Y243; Q0VAA6; Q5VTI1; Q5VTI2; Q96QV3; Q9UFP5; |
| Protein Name | RAC-gamma serine/threonine-protein kinase |
| Protein Synonyms/Alias | Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2; |
| Gene Name | AKT3 |
| Gene Synonyms/Alias | AKT3; PKBG; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. |
| Protein Length | 465 |
Protein Sequence
(FASTA) | | MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 60 | | LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 120 | | PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 180 | | KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 240 | | RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 300 | | ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 360 | | EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFSGVNW QDVYDKKLVP 420 | | PFKPQVTSET DTRYFDEEFT AQTITITPPE KCQQSDCGML GNWKK 465 |
|
Nucleotide Sequence
(FASTA) | | ATGAGCGATG TTACCATTGT GAAAGAAGGT TGGGTTCAGA AGAGGGGAGA ATATATAAAA 60 | | AACTGGAGGC CAAGATACTT CCTTTTGAAG ACAGATGGCT CATTCATAGG ATATAAAGAG 120 | | AAACCTCAAG ATGTGGATTT ACCTTATCCC CTCAACAACT TTTCAGTGGC AAAATGCCAG 180 | | TTAATGAAAA CAGAACGACC AAAGCCAAAC ACATTTATAA TCAGATGTCT CCAGTGGACT 240 | | ACTGTTATAG AGAGAACATT TCATGTAGAT ACTCCAGAGG AAAGGGAAGA ATGGACAGAA 300 | | GCTATCCAGG CTGTAGCAGA CAGACTGCAG AGGCAAGAAG AGGAGAGAAT GAATTGTAGT 360 | | CCAACTTCAC AAATTGATAA TATAGGAGAG GAAGAGATGG ATGCCTCTAC AACCCATCAT 420 | | AAAAGAAAGA CAATGAATGA TTTTGACTAT TTGAAACTAC TAGGTAAAGG CACTTTTGGG 480 | | AAAGTTATTT TGGTTCGAGA GAAGGCAAGT GGAAAATACT ATGCTATGAA GATTCTGAAG 540 | | AAAGAAGTCA TTATTGCAAA GGATGAAGTG GCACACACTC TAACTGAAAG CAGAGTATTA 600 | | AAGAACACTA GACATCCCTT TTTAACATCC TTGAAATATT CCTTCCAGAC AAAAGACCGT 660 | | TTGTGTTTTG TGATGGAATA TGTTAATGGG GGCGAGCTGT TTTTCCATTT GTCGAGAGAG 720 | | CGGGTGTTCT CTGAGGACCG CACACGTTTC TATGGTGCAG AAATTGTCTC TGCCTTGGAC 780 | | TATCTACATT CCGGAAAGAT TGTGTACCGT GATCTCAAGT TGGAGAATCT AATGCTGGAC 840 | | AAAGATGGCC ACATAAAAAT TACAGATTTT GGACTTTGCA AAGAAGGGAT CACAGATGCA 900 | | GCCACCATGA AGACATTCTG TGGCACTCCA GAATATCTGG CACCAGAGGT GTTAGAAGAT 960 | | AATGACTATG GCCGAGCAGT AGACTGGTGG GGCCTAGGGG TTGTCATGTA TGAAATGATG 1020 | | TGTGGGAGGT TACCTTTCTA CAACCAGGAC CATGAGAAAC TTTTTGAATT AATATTAATG 1080 | | GAAGACATTA AATTTCCTCG AACACTCTCT TCAGATGCAA AATCATTGCT TTCAGGGCTC 1140 | | TTGATAAAGG ATCCAAATAA ACGCCTTGGT GGAGGACCAG ATGATGCAAA AGAAATTATG 1200 | | AGACACAGTT TCTTCTCTGG AGTAAACTGG CAAGATGTAT ATGATAAAAA GCTTGTACCT 1260 | | CCTTTTAAAC CTCAAGTAAC ATCTGAGACA GATACTAGAT ATTTTGATGA AGAATTTACA 1320 | | GCTCAGACTA TTACAATAAC ACCACCTGAA AAATGTCAGC AATCAGATTG TGGCATGCTG 1380 | | GGTAACTGGA AAAAATAA 1398 |
|
| Domain Profile | S: 1 fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf 60 | fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf | Q: 148 FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF 207 | 9*********************************************************** |
| S: 61 lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv 120 | l++lkysfqtk++lc+v+eyvnGGelffhls+ervfsedr+rfygaeivsaldylhs ++ | Q: 208 LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI 267 | ************************************************************ |
| S: 121 vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav 180 | vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av | Q: 268 VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV 327 | ************************************************************ |
| S: 181 dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk 240 | dwwglGvv+yem+cGrlpfyn+dheklfelil+e++kfpr+ls++aksllsGll kdp+k | Q: 328 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNK 387 | ************************************************************ |
| S: 241 rlGggkddakeireheff 258 | rlGgg+ddakei++h+ff | Q: 388 RLGGGPDDAKEIMRHSFF 405 | *****************9 |
|
Domain Sequence
(FASTA) | | FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60 | | LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEDR TRFYGAEIVS ALDYLHSGKI 120 | | VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180 | | DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEDIKFPR TLSSDAKSLL SGLLIKDPNK 240 | | RLGGGPDDAK EIMRHSFF 258 |
|
| Keyword | 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Disease mutation; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |