EKS-HOS-00062

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00062

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	382.2	7.3E-114	144	425	282

Status

Reviewed

Ensembl Protein

ENSP00000353176

UniProt Accession

Q07002; Q5VXQ2; Q6V3A2; Q6V3A3; Q96F90;

Protein Name

Cyclin-dependent kinase 18

Protein Synonyms/Alias

Cell division protein kinase 18; PCTAIRE-motif protein kinase 3; Serine/threonine-protein kinase PCTAIRE-3;

Gene Name

CDK18

Gene Synonyms/Alias

CDK18; PCTK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000117266	ENSP00000391324	ENST00000419301
ENSG00000117266	ENSP00000422470	ENST00000512922
ENSG00000117266	ENSP00000422842	ENST00000462976
ENSG00000117266	ENSP00000426368	ENST00000506215
ENSG00000117266	ENSP00000423408	ENST00000478560
ENSG00000117266	ENSP00000425177	ENST00000515494
ENSG00000117266	ENSP00000397831	ENST00000443813
ENSG00000117266	ENSP00000353176	ENST00000360066
ENSG00000117266	ENSP00000399082	ENST00000429964
ENSG00000117266	ENSP00000423665	ENST00000506784
ENSG00000117266	ENSP00000425036	ENST00000504648

Organism

Homo sapiens

Functional Description

May play a role in signal transduction cascades interminally differentiated cells.

Protein Length

474

Protein Sequence
(FASTA)

MIMNKMKNFK RRFSLSVPRT ETIEESLAEF TEQFNQLHNR RNENLQLGPL GRDPPQECST 60

FSPTDSGEEP GQLSPGVQFQ RRQNQRRFSM EDVSKRLSLP MDIRLPQEFL QKLQMESPDL 120

PKPLSRMSRR ASLSDIGFGK LETYVKLDKL GEGTYATVFK GRSKLTENLV ALKEIRLEHE 180

EGAPCTAIRE VSLLKNLKHA NIVTLHDLIH TDRSLTLVFE YLDSDLKQYL DHCGNLMSMH 240

NVKIFMFQLL RGLAYCHHRK ILHRDLKPQN LLINERGELK LADFGLARAK SVPTKTYSNE 300

VVTLWYRPPD VLLGSTEYST PIDMWGVGCI HYEMATGRPL FPGSTVKEEL HLIFRLLGTP 360

TEETWPGVTA FSEFRTYSFP CYLPQPLINH APRLDTDGIH LLSSLLLYES KSRMSAEAAL 420

SHSYFRSLGE RVHQLEDTAS IFSLKEIQLQ KDPGYRGLAF QQPGRGKNRR QSIF 474

Nucleotide Sequence
(FASTA)

ATGATCATGA ACAAGATGAA GAACTTTAAG CGCCGTTTCT CCCTGTCAGT GCCCCGCACT 60

GAGACCATTG AAGAATCCTT GGCTGAATTC ACGGAGCAAT TCAACCAGCT CCACAACCGG 120

CGGAATGAGA ACTTGCAGCT CGGTCCTCTT GGCAGAGACC CCCCGCAGGA GTGCAGCACC 180

TTCTCCCCAA CAGACAGCGG GGAGGAGCCG GGGCAGCTCT CCCCTGGCGT GCAGTTCCAG 240

CGGCGGCAGA ACCAGCGCCG CTTCTCCATG GAGGACGTCA GCAAGAGGCT CTCTCTGCCC 300

ATGGATATCC GCCTGCCCCA GGAATTCCTA CAGAAGCTAC AGATGGAGAG CCCAGATCTG 360

CCCAAGCCGC TCAGCCGCAT GTCCCGCCGG GCCTCCCTGT CAGACATTGG CTTTGGGAAA 420

CTGGAAACAT ACGTGAAACT GGACAAACTG GGAGAGGGCA CCTATGCCAC AGTCTTCAAA 480

GGGCGCAGCA AACTGACGGA GAACCTTGTG GCCCTGAAAG AGATCCGGCT GGAGCACGAG 540

GAGGGAGCGC CCTGCACTGC CATCCGAGAG GTGTCTCTGC TGAAGAACCT GAAGCACGCC 600

AATATTGTGA CCCTGCATGA CCTCATCCAC ACAGATCGGT CCCTCACCCT GGTGTTTGAG 660

TACCTGGACA GTGACCTGAA GCAGTATCTG GACCACTGTG GGAACCTCAT GAGCATGCAC 720

AACGTCAAGA TTTTCATGTT CCAGCTGCTC CGGGGCCTCG CCTACTGTCA CCACCGCAAG 780

ATCCTGCACC GGGACCTGAA GCCCCAGAAC CTGCTCATCA ACGAGAGGGG GGAGCTGAAG 840

CTGGCCGACT TTGGACTGGC CAGGGCCAAG TCAGTGCCCA CAAAGACTTA CTCCAATGAG 900

GTGGTGACCC TGTGGTACAG GCCCCCCGAT GTGCTGCTGG GATCCACAGA GTACTCCACC 960

CCCATTGATA TGTGGGGCGT GGGCTGCATC CACTACGAGA TGGCCACAGG GAGGCCCCTC 1020

TTCCCGGGCT CCACAGTCAA GGAGGAGCTG CACCTCATCT TTCGCCTCCT CGGGACCCCC 1080

ACAGAAGAGA CGTGGCCCGG CGTGACCGCC TTCTCTGAGT TCCGCACCTA CAGCTTCCCC 1140

TGCTACCTCC CGCAGCCGCT CATCAACCAC GCGCCCAGGT TGGATACGGA TGGCATCCAC 1200

CTCCTGAGCA GCCTGCTCCT GTATGAATCC AAGAGTCGCA TGTCAGCAGA GGCTGCCCTG 1260

AGTCACTCCT ACTTCCGGTC TCTGGGAGAG CGTGTGCACC AGCTTGAAGA CACTGCCTCC 1320

ATCTTCTCCC TGAAGGAGAT CCAGCTCCAG AAGGACCCAG GCTACCGAGG CTTGGCCTTC 1380

CAGCAGCCAG GACGAGGGAA GAACAGGCGG CAGAGCATCT TCTGA 1425

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 144   YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANI  202

         7899********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++++l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+glay+H++k

Q: 203   VTLHDLIH-TDRSLTLVFEYLDSDLKQYLDHCGN-LMSMHNVKIFMFQLLRGLAYCHHRK  260

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 261   ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  320

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

          +D+W+vgci  e++t +plf+g++ +++l+ if+llgtp+e++wp+v+ ++e++ +sfp

Q: 321   PIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRtYSFP  380

         *******************************************************89***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

          + ++ l ++ ++l++++++ll++ll ++ k+R+sa++al+h+yf

Q: 381   CYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF  425

         ********************************************9

Domain Sequence
(FASTA)

YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKNLKHANIV 60

TLHDLIHTDR SLTLVFEYLD SDLKQYLDHC GNLMSMHNVK IFMFQLLRGL AYCHHRKILH 120

RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180

MWGVGCIHYE MATGRPLFPG STVKEELHLI FRLLGTPTEE TWPGVTAFSE FRTYSFPCYL 240

PQPLINHAPR LDTDGIHLLS SLLLYESKSR MSAEAALSHS YF 282

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0007049	; P:cell cycle

KEGG

hsa:5129

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013