EKS-HOS-00265
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00265
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CAMKL251.05.6E-7449309261
StatusReviewed
Ensembl ProteinENSP00000324856
UniProt AccessionQ15831; B2RBX7; E7EW76;
Protein NameSerine/threonine-protein kinase STK11
Protein Synonyms/Alias Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19;
Gene NameSTK11
Gene Synonyms/Alias STK11; LKB1, PJS;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000118046ENSP00000466610ENST00000593219
ENSG00000118046ENSP00000467912ENST00000585851
ENSG00000118046ENSP00000467240ENST00000586243
ENSG00000118046ENSP00000324856ENST00000326873
OrganismHomo sapiens
Functional DescriptionTumor suppressor serine/threonine-protein kinase thatcontrols the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2: it thereby regulates inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neurons polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1 Also acts as a mediator p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways.
Protein Length433
Protein Sequence
(FASTA)
MEVVDPQQLG MFTEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY 60
GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHKNV IQLVDVLYNE 120
EKQKMYMVME YCVCGMQEML DSVPEKRFPV CQAHGYFCQL IDGLEYLHSQ GIVHKDIKPG 180
NLLLTTGGTL KISDLGVAEA LHPFAADDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS 240
AGVTLYNITT GLYPFEGDNI YKLFENIGKG SYAIPGDCGP PLSDLLKGML EYEPAKRFSI 300
RQIRQHSWFR KKHPPAEAPV PIPPSPDTKD RWRSMTVVPY LEDLHGADED EDLFDIEDDI 360
IYTQDFTVPG QVPEEEASHN GQRRGLPKAV CMNGTEAAQL STKSRAEGRA PNPARKACSA 420
SSKIRRLSAC KQQ 433
Nucleotide Sequence
(FASTA)
ATGGAGGTGG TGGACCCGCA GCAGCTGGGC ATGTTCACGG AGGGCGAGCT GATGTCGGTG 60
GGTATGGACA CGTTCATCCA CCGCATCGAC TCCACCGAGG TCATCTACCA GCCGCGCCGC 120
AAGCGGGCCA AGCTCATCGG CAAGTACCTG ATGGGGGACC TGCTGGGGGA AGGCTCTTAC 180
GGCAAGGTGA AGGAGGTGCT GGACTCGGAG ACGCTGTGCA GGAGGGCCGT CAAGATCCTC 240
AAGAAGAAGA AGTTGCGAAG GATCCCCAAC GGGGAGGCCA ACGTGAAGAA GGAAATTCAA 300
CTACTGAGGA GGTTACGGCA CAAAAATGTC ATCCAGCTGG TGGATGTGTT ATACAACGAA 360
GAGAAGCAGA AAATGTATAT GGTGATGGAG TACTGCGTGT GTGGCATGCA GGAAATGCTG 420
GACAGCGTGC CGGAGAAGCG TTTCCCAGTG TGCCAGGCCC ACGGGTACTT CTGTCAGCTG 480
ATTGACGGCC TGGAGTACCT GCATAGCCAG GGCATTGTGC ACAAGGACAT CAAGCCGGGG 540
AACCTGCTGC TCACCACCGG TGGCACCCTC AAAATCTCCG ACCTGGGCGT GGCCGAGGCA 600
CTGCACCCGT TCGCGGCGGA CGACACCTGC CGGACCAGCC AGGGCTCCCC GGCTTTCCAG 660
CCGCCCGAGA TTGCCAACGG CCTGGACACC TTCTCCGGCT TCAAGGTGGA CATCTGGTCG 720
GCTGGGGTCA CCCTCTACAA CATCACCACG GGTCTGTACC CCTTCGAAGG GGACAACATC 780
TACAAGTTGT TTGAGAACAT CGGGAAGGGG AGCTACGCCA TCCCGGGCGA CTGTGGCCCC 840
CCGCTCTCTG ACCTGCTGAA AGGGATGCTT GAGTACGAAC CGGCCAAGAG GTTCTCCATC 900
CGGCAGATCC GGCAGCACAG CTGGTTCCGG AAGAAACATC CTCCGGCTGA AGCACCAGTG 960
CCCATCCCAC CGAGCCCAGA CACCAAGGAC CGGTGGCGCA GCATGACTGT GGTGCCGTAC 1020
TTGGAGGACC TGCACGGCGC GGACGAGGAC GAGGACCTCT TCGACATCGA GGATGACATC 1080
ATCTACACTC AGGACTTCAC GGTGCCCGGA CAGGTCCCAG AAGAGGAGGC CAGTCACAAT 1140
GGACAGCGCC GGGGCCTCCC CAAGGCCGTG TGTATGAACG GCACAGAGGC GGCGCAGCTG 1200
AGCACCAAAT CCAGGGCGGA GGGCCGGGCC CCCAACCCTG CCCGCAAGGC CTGCTCCGCC 1260
AGCAGCAAGA TCCGCCGGCT GTCGGCCTGC AAGCAGCAGT GA 1302
Domain Profile
S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhp  58
         y +++ lGegs+gkVk++ ++et  + avKi+kkkkl    +   ++k+Ei++l++l+h+
Q: 49    YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLrrIPNGEANVKKEIQLLRRLRHK  108
         778999******************************965334567***************
S: 59    niikllevi..etkkklylvleyasgg..eLfdyieekgrlkekearklfkqlvsavkYl  114
         n+i+l++v+  e+k+k+y+v+ey+  g  e++d +  ++r++  +a+ +f ql+++++Yl
Q: 109   NVIQLVDVLynEEKQKMYMVMEYCVCGmqEMLDSV-PEKRFPVCQAHGYFCQLIDGLEYL  167
         ********9888999********998888*****6.8899********************
S: 115   hskgivHrDlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPellkg  171
         hs+givH+D+Kp Nlll++ +++ki+D+G+a+    f  +++++t++Gsp++++Pe+ +g
Q: 168   HSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEalhPFAADDTCRTSQGSPAFQPPEIANG  227
         *******************************955556778******************99
S: 172   .kkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlr  230
          ++++g kvD+Ws+Gv+Ly++ tg +Pf+++n+ +l+e+i kg++ ip  + + l++Ll+
Q: 228   lDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLK  287
         899*********************************************************
S: 231   klLvvdpekRatieeilkhewl  252
          +L+ +p+kR++i++i++h+w+
Q: 288   GMLEYEPAKRFSIRQIRQHSWF  309
         *********************7
Domain Sequence
(FASTA)
YLMGDLLGEG SYGKVKEVLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHK 60
NVIQLVDVLY NEEKQKMYMV MEYCVCGMQE MLDSVPEKRF PVCQAHGYFC QLIDGLEYLH 120
SQGIVHKDIK PGNLLLTTGG TLKISDLGVA EALHPFAADD TCRTSQGSPA FQPPEIANGL 180
DTFSGFKVDI WSAGVTLYNI TTGLYPFEGD NIYKLFENIG KGSYAIPGDC GPPLSDLLKG 240
MLEYEPAKRF SIRQIRQHSW F 261
Keyword3D-structure; Alternative splicing; Apoptosis; ATP-binding; Autophagy; Cell cycle; Complete proteome; Cytoplasm; Disease mutation; DNA damage; Kinase; Lipoprotein; Magnesium; Manganese; Membrane; Metal-binding; Mitochondrion; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Prenylation; Reference proteome; Serine/threonine-protein kinase; Transferase; Tumor suppressor.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00236
EKS-ANC-00248
EKS-BOT-00255
EKS-CAE-00230
EKS-CAF-00264
EKS-CAP-00292
EKS-CII-00153
EKS-CIS-00029
EKS-DAR-00584
EKS-DIO-00016
EKS-DRM-00132
EKS-EQC-00250
EKS-FEC-00240
EKS-GAM-00158
EKS-GAG-00215
EKS-GAA-00316
EKS-GOG-00253
EKS-ICT-00242
EKS-LAC-00269
EKS-LOA-00259
EKS-MAM-00257
EKS-MEG-00200
EKS-MOD-00254
EKS-MUM-00286
EKS-MUP-00254
EKS-MYL-00257
EKS-NOL-00237
EKS-ORN-00333
EKS-ORA-00224
EKS-OTG-00262
EKS-PAT-00243
EKS-PES-00226
EKS-PEM-00131
EKS-POA-00250
EKS-PTV-00024
EKS-RAN-00267
EKS-SAH-00242
EKS-SUS-00218
EKS-TAG-00272
EKS-TAR-00329
EKS-TEN-00324
EKS-XET-00334
EKS-XIM-00325
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005829; C:cytosol
GO:0016020; C:membrane
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0043234; C:protein complex
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0002039; F:p53 binding
GO:0030295; F:protein kinase activator activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0043276; P:anoikis
GO:0006914; P:autophagy
GO:0007409; P:axonogenesis
GO:0060070; P:canonical Wnt receptor signaling pathway
GO:0007050; P:cell cycle arrest
GO:0006112; P:energy reserve metabolic process
GO:0030010; P:establishment of cell polarity
GO:0042593; P:glucose homeostasis
GO:0051645; P:Golgi localization
GO:0008286; P:insulin receptor signaling pathway
GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0030308; P:negative regulation of cell growth
GO:0008285; P:negative regulation of cell proliferation
GO:0060770; P:negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0050772; P:positive regulation of axonogenesis
GO:0045722; P:positive regulation of gluconeogenesis
GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0051291; P:protein heterooligomerization
GO:0042304; P:regulation of fatty acid biosynthetic process
GO:0046320; P:regulation of fatty acid oxidation
GO:0051896; P:regulation of protein kinase B signaling cascade
GO:0030111; P:regulation of Wnt receptor signaling pathway
GO:0006974; P:response to DNA damage stimulus
GO:0033762; P:response to glucagon stimulus
GO:0010212; P:response to ionizing radiation
GO:0033993; P:response to lipid
GO:0044281; P:small molecule metabolic process
GO:0007286; P:spermatid development
GO:0001894; P:tissue homeostasis
GO:0001944; P:vasculature development
KEGG
hsa:6794;
InterPros
IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013