EKS-HOS-00309
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00309
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/Alpha329.74.0E-98591809219
StatusReviewed
Ensembl ProteinENSP00000366067
UniProt AccessionQ9BX84; Q6VPR8; Q6VPR9; Q6VPS0; Q6VPS1; Q6VPS2;
Protein NameTransient receptor potential cation channel subfamily M member 6
Protein Synonyms/Alias Channel kinase 2; Melastatin-related TRP cation channel 6;
Gene NameTRPM6
Gene Synonyms/Alias TRPM6; CHAK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000119121ENSP00000366068ENST00000376872
ENSG00000119121ENSP00000351942ENST00000359047
ENSG00000119121ENSP00000366067ENST00000376871
ENSG00000119121ENSP00000354006ENST00000360774
ENSG00000119121ENSP00000354962ENST00000361255
ENSG00000119121ENSP00000396672ENST00000449912
ENSG00000119121ENSP00000366060ENST00000376864
ENSG00000119121ENSP00000309693ENST00000312449
ENSG00000119121ENSP00000407341ENST00000451710
OrganismHomo sapiens
Functional DescriptionEssential ion channel and serine/threonine-proteinkinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
Protein Length859
Protein Sequence
(FASTA)
MKEQPVLERL QSQKSWIKGV FDKRECSTII PSSKNPHRCT PVCQVCQNLI RCYCGRLIGD 60
HAGIDYSWTI SAAKGKESEQ WSVEKHTTKS PTDTFGTINF QDGEHTHHAK YIRTSYDTKL 120
DHLLHLMLKE WKMELPKLVI SVHGGIQNFT MPSKFKEIFS QGLVKAAETT GAWIITEGIN 180
TGVSKHVGDA LKSHSSHSLR KIWTVGIPPW GVIENQRDLI GKDVVCLYQT LDNPLSKLTT 240
LNSMHSHFIL SDDGTVGKYG NEMKLRRNLE KYLSLQKIHC RSRQGVPVVG LVVEGGPNVI 300
LSVWETVKDK DPVVVCEGTG RAADLLAFTH KHLADEGMLR PQVKEEIICM IQNTFNFSLK 360
QSKHLFQILM ECMVHRDCIT IFDADSEEQQ DLDLAILTAL LKGTNLSASE QLNLAMAWDR 420
VDIAKKHILI YEQHWKPDAL EQAMSDALVM DRVDFVKLLI EYGVNLHRFL TIPRLEELYN 480
TKQGPTNTLL HHLVQDVKQD LSKNSLWNSR STNLNRNSLH VIKMPISSLI SEISASLKSP 540
QEPHHHYSAI ERNNLMRLSQ TIPFTPVQLF AGEEITVYRL EESSPLNLDK SMSSWSQRGR 600
AAMIQVLSRE EMDGGLRKAM RVVSTWSEDD ILKPGQVFIV KSFLPEVVRT WHKIFQESTV 660
LHLCLREIQQ QRAAQKLIYT FNQVKPQTIP YTPRFLEVFL IYCHSANQWL TIEKYMTGEF 720
RKYNNNNGDE ITPTNTLEEL MLAFSHWTYE YTRGELLVLD LQGVGENLTD PSVIKPEVKQ 780
SRGMVFGPAN LGEDAIRNFI AKHHCNSCCR KLKLPDLKRN DYSPERINST FGLEIKIESA 840
EEPPARETGR NSPEDDMQL 859
Nucleotide Sequence
(FASTA)
ATGAAAGAAC AACCTGTCTT GGAGCGCTTG CAGTCCCAGA AATCCTGGAT TAAAGGAGTA 60
TTTGACAAGA GAGAATGTAG CACAATCATA CCCAGCTCAA AAAATCCTCA CAGATGTACT 120
CCAGTATGCC AAGTCTGCCA GAATTTAATC AGGTGTTACT GTGGCCGACT GATTGGAGAC 180
CATGCTGGGA TAGATTATTC CTGGACCATC TCAGCTGCCA AGGGTAAAGA AAGTGAACAA 240
TGGTCTGTTG AAAAGCACAC AACGAAAAGC CCAACAGATA CTTTTGGCAC GATTAATTTC 300
CAAGATGGAG AGCACACCCA TCATGCCAAG TATATTAGAA CTTCTTATGA TACAAAACTG 360
GATCATCTGT TACATTTAAT GTTGAAAGAG TGGAAAATGG AACTGCCCAA GCTTGTGATC 420
TCAGTCCATG GGGGCATCCA GAACTTTACT ATGCCCTCTA AATTTAAAGA GATTTTCAGC 480
CAAGGTTTGG TTAAAGCTGC AGAGACAACA GGAGCGTGGA TAATAACTGA AGGCATCAAT 540
ACAGGAGTGT CCAAGCATGT TGGGGATGCC TTGAAATCCC ATTCCTCTCA TTCCTTGAGA 600
AAAATCTGGA CAGTTGGAAT CCCTCCTTGG GGTGTCATTG AGAACCAGAG AGACCTTATT 660
GGAAAAGATG TGGTGTGCCT GTACCAGACT CTGGATAACC CCCTCAGCAA GCTCACAACA 720
CTCAACAGCA TGCACTCGCA CTTCATCCTG TCTGATGATG GGACCGTGGG CAAGTATGGA 780
AATGAAATGA AGCTCAGAAG GAACCTGGAG AAGTACCTCT CTCTGCAGAA AATACACTGC 840
CGCTCAAGAC AAGGCGTGCC GGTCGTGGGG CTGGTGGTGG AAGGCGGTCC CAACGTCATC 900
CTGTCAGTGT GGGAGACTGT CAAGGACAAG GACCCAGTGG TGGTGTGTGA GGGCACAGGT 960
AGGGCGGCTG ACCTCCTGGC CTTCACACAC AAACACCTGG CAGATGAAGG GATGCTGCGA 1020
CCTCAGGTGA AAGAGGAGAT CATCTGCATG ATTCAGAACA CTTTCAACTT TAGTCTTAAA 1080
CAGTCCAAGC ACCTTTTCCA AATTCTAATG GAGTGTATGG TTCACAGGGA TTGTATTACC 1140
ATATTTGATG CTGACTCTGA AGAGCAGCAA GACCTGGACT TAGCAATCCT AACAGCTTTG 1200
CTGAAGGGCA CAAATTTATC AGCGTCAGAG CAATTAAATC TGGCAATGGC TTGGGACAGG 1260
GTGGACATTG CCAAGAAACA TATCCTAATT TATGAACAAC ACTGGAAGCC TGATGCCCTG 1320
GAACAAGCAA TGTCAGATGC TTTAGTGATG GATCGGGTGG ATTTTGTGAA GCTCTTAATA 1380
GAATATGGAG TGAACCTCCA TCGCTTTCTT ACCATCCCTC GACTGGAAGA GCTCTACAAT 1440
ACAAAACAAG GACCTACTAA TACACTCTTG CATCATCTCG TCCAAGATGT GAAACAGGAT 1500
CTCAGCAAAA ACTCTTTGTG GAATTCCAGG AGCACCAACC TCAATAGGAA CTCCCTCCAT 1560
GTAATTAAAA TGCCAATCTC CTCTCTAATT TCAGAGATCT CAGCCTCCTT AAAAAGCCCT 1620
CAAGAGCCTC ACCATCATTA TTCAGCCATT GAAAGGAATA ATTTAATGAG GCTTTCTCAG 1680
ACCATACCAT TTACACCAGT CCAACTGTTT GCAGGAGAAG AAATAACTGT CTACAGGTTG 1740
GAGGAGAGTT CCCCTTTAAA CCTTGATAAA AGCATGTCCT CTTGGTCTCA GCGTGGGAGA 1800
GCGGCAATGA TCCAGGTATT GTCCCGAGAG GAGATGGATG GGGGCCTCCG TAAAGCTATG 1860
AGAGTCGTCA GCACTTGGTC TGAGGATGAC ATTCTCAAGC CGGGACAAGT TTTCATTGTC 1920
AAGTCCTTTC TTCCTGAGGT TGTGCGGACA TGGCATAAAA TCTTCCAGGA GAGCACTGTG 1980
CTTCATCTTT GCCTCAGGGA AATTCAACAA CAAAGAGCTG CTCAAAAATT GATCTATACC 2040
TTCAACCAAG TGAAACCACA AACCATACCC TACACACCAA GGTTCCTGGA AGTTTTCTTA 2100
ATCTACTGCC ATTCAGCCAA CCAGTGGTTG ACCATTGAGA AGTATATGAC AGGGGAGTTC 2160
CGGAAGTATA ACAACAACAA TGGTGATGAA ATCACCCCCA CCAACACCCT GGAGGAGCTG 2220
ATGTTGGCTT TCTCTCACTG GACCTATGAG TACACTCGGG GAGAGCTGCT GGTTTTAGAT 2280
TTGCAAGGTG TTGGAGAAAA TTTGACAGAT CCATCTGTTA TAAAACCTGA AGTCAAACAA 2340
TCAAGAGGAA TGGTGTTTGG ACCGGCCAAT TTGGGGGAAG ATGCAATTAG AAACTTCATT 2400
GCAAAACATC ATTGTAACTC CTGCTGCCGG AAGCTCAAAC TCCCGGATTT AAAAAGAAAT 2460
GACTATTCCC CTGAAAGGAT AAATTCCACC TTTGGACTTG AGATAAAAAT AGAATCAGCT 2520
GAGGAGCCTC CAGCAAGGGA GACGGGTAGA AATTCCCCAG AAGATGATAT GCAACTATAA 2580
Domain Profile
S: 1     ssesWsqqetivlikvlskeekkGalRkalrv..........kkgslflvkeelkevvry  50
         s++sWsq++++++i+vls+ee++G+lRka+rv          k+g++f+vk++l+evvr+
Q: 591   SMSSWSQRGRAAMIQVLSREEMDGGLRKAMRVvstwseddilKPGQVFIVKSFLPEVVRT  650
         699*********************************************************
S: 51    vakiykeqkvlhlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqll  110
         ++ki++e++vlhl+lr++++qraaqkl+++fnqvkP++i+y+pr++evfL++++s+nq+l
Q: 651   WHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVFLIYCHSANQWL  710
         ************************************************************
S: 111   tvEeyllGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTD  170
         t+E+y++Gef+Kynnnngdei+++n+leelmlafsH+tyeyt+gellV+DlqGvge+lTD
Q: 711   TIEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTD  770
         ************************************************************
S: 171   pqiat....ksrgtkfgkanlgeraiknFfakhhCNeiC  205
         p++++    +srg++fg+anlge+ai+nF+akhhCN++C
Q: 771   PSVIKpevkQSRGMVFGPANLGEDAIRNFIAKHHCNSCC  809
         *****9999******************************
Domain Sequence
(FASTA)
SMSSWSQRGR AAMIQVLSRE EMDGGLRKAM RVVSTWSEDD ILKPGQVFIV KSFLPEVVRT 60
WHKIFQESTV LHLCLREIQQ QRAAQKLIYT FNQVKPQTIP YTPRFLEVFL IYCHSANQWL 120
TIEKYMTGEF RKYNNNNGDE ITPTNTLEEL MLAFSHWTYE YTRGELLVLD LQGVGENLTD 180
PSVIKPEVKQ SRGMVFGPAN LGEDAIRNFI AKHHCNSCC 219
KeywordAlternative splicing; ATP-binding; Calcium; Calcium channel; Calcium transport; Complete proteome; Disease mutation; Ion transport; Ionic channel; Kinase; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Primary hypomagnesemia; Reference proteome; Serine/threonine-protein kinase; Transferase; Transmembrane; Transmembrane helix; Transport; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Loxodonta africana"; ?>Macaca mulatta"; ?>Oryctolagus cuniculus"; ?>
EKS-LOA-00311
EKS-MAM-00306
EKS-ORC-00286
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0031526; C:brush border membrane
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005262; F:calcium channel activity
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0009636; P:response to toxin
KEGG
hsa:140803;
InterPros
IPR005821; Ion_trans_dom.
IPR011009; Kinase-like_dom.
IPR004166; MHCK_EF2_kinase.
Pfam
PF02816; Alpha_kinase; 1.
PF00520; Ion_trans; 1.
SMARTs
SM00811; Alpha_kinase; 1.
Prosites
PS51158; ALPHA_KINASE; 1.
Prints
Created Date20-Feb-2013