Tag | Content |
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EKPD ID | EPS-HOS-00129 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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PPP/PP6 | 417.6 | 3.1E-125 | 47 | 239 | 193 |
|
Status | Reviewed |
Ensembl Protein | ENSP00000362648 |
UniProt Accession | O00743; B2R5V6; B7Z2W9; B7Z5K9; Q5U0A2; Q9UIC9; |
Protein Name | Serine/threonine-protein phosphatase 6 catalytic subunit |
Protein Synonyms/Alias | PP6C; |
Gene Name | PPP6C |
Gene Synonyms/Alias | PPP6C; PPP6; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Catalytic subunit of protein phosphatase 6 (PP6). PP6 isa component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. |
Protein Length | 305 |
Protein Sequence (FASTA) | MAPLDLDKYV EIARLCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV CGDIHGQFYD 60 | LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK AKWPDRITLL RGNHESRQIT 120 | QVYGFYDECQ TKYGNANAWR YCTKVFDMLT VAALIDEQIL CVHGGLSPDI KTLDQIRTIE 180 | RNQEIPHKGA FCDLVWSDPE DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV 240 | HEGYKFMFDE KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT 300 | TPYFL 305 |
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Nucleotide Sequence (FASTA) | ATGGCGCCGC TAGACCTGGA CAAGTATGTG GAAATAGCGC GGCTGTGCAA GTACCTGCCA 60 | GAGAACGACC TGAAGCGGCT ATGTGACTAC GTTTGTGACC TCCTCTTAGA AGAGTCAAAT 120 | GTTCAGCCAG TATCAACACC AGTAACAGTG TGTGGAGATA TCCATGGACA GTTTTATGAC 180 | CTTTGTGAAC TGTTCAGAAC TGGAGGTCAG GTTCCTGACA CAAACTACAT ATTTATGGGT 240 | GATTTTGTAG ACAGAGGTTA CTATAGTTTG GAGACCTTCA CTTACCTTCT TGCATTAAAG 300 | GCTAAATGGC CTGATCGTAT TACACTTTTG CGAGGAAATC ATGAGAGTAG ACAGATAACA 360 | CAGGTCTATG GATTTTATGA TGAGTGCCAA ACCAAATATG GAAATGCTAA TGCCTGGAGA 420 | TACTGTACCA AAGTTTTTGA CATGCTCACA GTAGCAGCTT TAATAGATGA GCAGATTTTG 480 | TGTGTCCATG GTGGTTTATC TCCTGATATC AAAACACTGG ATCAAATTCG AACCATCGAA 540 | CGGAATCAGG AAATTCCTCA TAAAGGAGCA TTTTGTGATC TGGTTTGGTC AGATCCTGAA 600 | GATGTGGATA CCTGGGCTAT CAGTCCCCGA GGAGCAGGTT GGCTTTTTGG AGCAAAGGTC 660 | ACAAATGAGT TTGTTCATAT CAACAACTTA AAACTCATCT GCAGAGCACA TCAACTAGTG 720 | CACGAAGGCT ATAAATTTAT GTTTGATGAG AAGCTGGTGA CAGTATGGTC TGCTCCTAAT 780 | TACTGCTATC GTTGTGGAAA TATTGCTTCG ATCATGGTCT TCAAAGATGT AAATACAAGA 840 | GAACCAAAGT TATTCCGGGC AGTTCCAGAT TCAGAACGTG TTATTCCTCC CAGAACGACA 900 | ACGCCATATT TCCTTTGA 918 |
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Domain Profile | S: 1 pvtvcgdihgqfydllklfrtggqvpdtnyiflgdfvdrgyyslevftlllllkakypak 60 | pvtvcgdihgqfydl++lfrtggqvpdtnyif+gdfvdrgyysle+ft+ll+lkak+p++ | Q: 47 PVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDR 106 | 9*********************************************************** |
| S: 61 itllrgnhesrqitqvygfydeclrkygnanawkyctkvfdlltlaaiidekvlcvhggl 120 | itllrgnhesrqitqvygfydec++kygnanaw+yctkvfd+lt+aa+ide++lcvhggl | Q: 107 ITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGL 166 | ************************************************************ |
| S: 121 spdirtldqirliernqeiphegafcdllwsdpedvetwavsprgagwlfgskvtkefnh 180 | spdi+tldqir+iernqeiph+gafcdl+wsdpedv+twa+sprgagwlfg+kvt+ef+h | Q: 167 SPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVH 226 | ************************************************************ |
| S: 181 innldlicrahql 193 | innl+licrahql | Q: 227 INNLKLICRAHQL 239 | ************7 |
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Domain Sequence (FASTA) | PVTVCGDIHG QFYDLCELFR TGGQVPDTNY IFMGDFVDRG YYSLETFTYL LALKAKWPDR 60 | ITLLRGNHES RQITQVYGFY DECQTKYGNA NAWRYCTKVF DMLTVAALID EQILCVHGGL 120 | SPDIKTLDQI RTIERNQEIP HKGAFCDLVW SDPEDVDTWA ISPRGAGWLF GAKVTNEFVH 180 | INNLKLICRA HQL 193 |
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Keyword | Alternative splicing; Cell cycle; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Iron; Manganese; Metal-binding; Protein phosphatase; Reference proteome. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |