Tag | Content |
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EKPD ID | EKS-HOS-00288 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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TKL/STKR | 420.6 | 1.6E-125 | 84 | 370 | 287 |
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Status | Reviewed |
Ensembl Protein | ENSP00000439988 |
UniProt Accession | P27037; B2RAB8; D3DP85; Q53TH4; Q6NWV2; Q92474; |
Protein Name | Activin receptor type-2A |
Protein Synonyms/Alias | Activin receptor type IIA; ACTR-IIA; ACTRIIA; |
Gene Name | ACVR2A |
Gene Synonyms/Alias | ACVR2A; ACVR2; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. |
Protein Length | 405 |
Protein Sequence (FASTA) | MCNEKFSYFP EMEVTQPTSN PVTPKPPYYN ILLYSLVPLM LIAGIVICAF WVYRHHKMAY 60 | PPVLVPTQDP GPPPPSPLLG LKPLQLLEVK ARGRFGCVWK AQLLNEYVAV KIFPIQDKQS 120 | WQNEYEVYSL PGMKHENILQ FIGAEKRGTS VDVDLWLITA FHEKGSLSDF LKANVVSWNE 180 | LCHIAETMAR GLAYLHEDIP GLKDGHKPAI SHRDIKSKNV LLKNNLTACI ADFGLALKFE 240 | AGKSAGDTHG QVGTRRYMAP EVLEGAINFQ RDAFLRIDMY AMGLVLWELA SRCTAADGPV 300 | DEYMLPFEEE IGQHPSLEDM QEVVVHKKKR PVLRDYWQKH AGMAMLCETI EECWDHDAEA 360 | RLSAGCVGER ITQMQRLTNI ITTEDIVTVV TMVTNVDFPP KESSL 405 |
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Nucleotide Sequence (FASTA) | ATGTGTAATG AAAAGTTTTC TTATTTTCCG GAGATGGAAG TCACACAGCC CACTTCAAAT 60 | CCAGTTACAC CTAAGCCACC CTATTACAAC ATCCTGCTCT ATTCCTTGGT GCCACTTATG 120 | TTAATTGCGG GGATTGTCAT TTGTGCATTT TGGGTGTACA GGCATCACAA GATGGCCTAC 180 | CCTCCTGTAC TTGTTCCAAC TCAAGACCCA GGACCACCCC CACCTTCTCC ATTACTAGGT 240 | TTGAAACCAC TGCAGTTATT AGAAGTGAAA GCAAGGGGAA GATTTGGTTG TGTCTGGAAA 300 | GCCCAGTTGC TTAACGAATA TGTGGCTGTC AAAATATTTC CAATACAGGA CAAACAGTCA 360 | TGGCAAAATG AATACGAAGT CTACAGTTTG CCTGGAATGA AGCATGAGAA CATATTACAG 420 | TTCATTGGTG CAGAAAAACG AGGCACCAGT GTTGATGTGG ATCTTTGGCT GATCACAGCA 480 | TTTCATGAAA AGGGTTCACT ATCAGACTTT CTTAAGGCTA ATGTGGTCTC TTGGAATGAA 540 | CTGTGTCATA TTGCAGAAAC CATGGCTAGA GGATTGGCAT ATTTACATGA GGATATACCT 600 | GGCCTAAAAG ATGGCCACAA ACCTGCCATA TCTCACAGGG ACATCAAAAG TAAAAATGTG 660 | CTGTTGAAAA ACAACCTGAC AGCTTGCATT GCTGACTTTG GGTTGGCCTT AAAATTTGAG 720 | GCTGGCAAGT CTGCAGGCGA TACCCATGGA CAGGTTGGTA CCCGGAGGTA CATGGCTCCA 780 | GAGGTATTAG AGGGTGCTAT AAACTTCCAA AGGGATGCAT TTTTGAGGAT AGATATGTAT 840 | GCCATGGGAT TAGTCCTATG GGAACTGGCT TCTCGCTGTA CTGCTGCAGA TGGACCTGTA 900 | GATGAATACA TGTTGCCATT TGAGGAGGAA ATTGGCCAGC ATCCATCTCT TGAAGACATG 960 | CAGGAAGTTG TTGTGCATAA AAAAAAGAGG CCTGTTTTAA GAGATTATTG GCAGAAACAT 1020 | GCTGGAATGG CAATGCTCTG TGAAACCATT GAAGAATGTT GGGATCACGA CGCAGAAGCC 1080 | AGGTTATCAG CTGGATGTGT AGGTGAAAGA ATTACCCAGA TGCAGAGACT AACAAATATT 1140 | ATTACCACAG AGGACATTGT AACAGTGGTC ACAATGGTGA CAAATGTTGA CTTTCCTCCC 1200 | AAAGAATCTA GTCTATGA 1218 |
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Domain Profile | S: 1 lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia 60 | l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+ | Q: 84 LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG 143 | 6899******************************************************** |
| S: 61 adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk 120 | a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k | Q: 144 AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK 203 | ************************************************************ |
| S: 121 gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE 180 | + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d ++ qvGt+RYmaPE | Q: 204 DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE 261 | *****************************************888..79************ |
| S: 181 vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem 240 | vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m | Q: 262 VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM 320 | *********9.9************************************************ |
| S: 241 kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr 290 | +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r | Q: 321 QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER 370 | ***********************************************987 |
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Domain Sequence (FASTA) | LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60 | AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120 | DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180 | EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240 | VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287 |
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Keyword | 3D-structure; ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |