EKS-HOS-00288
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00288
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR420.61.6E-12584370287
StatusReviewed
Ensembl ProteinENSP00000439988
UniProt AccessionP27037; B2RAB8; D3DP85; Q53TH4; Q6NWV2; Q92474;
Protein NameActivin receptor type-2A
Protein Synonyms/Alias Activin receptor type IIA; ACTR-IIA; ACTRIIA;
Gene NameACVR2A
Gene Synonyms/Alias ACVR2A; ACVR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000121989ENSP00000439988ENST00000535787
ENSG00000121989ENSP00000384338ENST00000404590
ENSG00000121989ENSP00000241416ENST00000241416
OrganismHomo sapiens
Functional DescriptionOn ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Protein Length405
Protein Sequence
(FASTA)
MCNEKFSYFP EMEVTQPTSN PVTPKPPYYN ILLYSLVPLM LIAGIVICAF WVYRHHKMAY 60
PPVLVPTQDP GPPPPSPLLG LKPLQLLEVK ARGRFGCVWK AQLLNEYVAV KIFPIQDKQS 120
WQNEYEVYSL PGMKHENILQ FIGAEKRGTS VDVDLWLITA FHEKGSLSDF LKANVVSWNE 180
LCHIAETMAR GLAYLHEDIP GLKDGHKPAI SHRDIKSKNV LLKNNLTACI ADFGLALKFE 240
AGKSAGDTHG QVGTRRYMAP EVLEGAINFQ RDAFLRIDMY AMGLVLWELA SRCTAADGPV 300
DEYMLPFEEE IGQHPSLEDM QEVVVHKKKR PVLRDYWQKH AGMAMLCETI EECWDHDAEA 360
RLSAGCVGER ITQMQRLTNI ITTEDIVTVV TMVTNVDFPP KESSL 405
Nucleotide Sequence
(FASTA)
ATGTGTAATG AAAAGTTTTC TTATTTTCCG GAGATGGAAG TCACACAGCC CACTTCAAAT 60
CCAGTTACAC CTAAGCCACC CTATTACAAC ATCCTGCTCT ATTCCTTGGT GCCACTTATG 120
TTAATTGCGG GGATTGTCAT TTGTGCATTT TGGGTGTACA GGCATCACAA GATGGCCTAC 180
CCTCCTGTAC TTGTTCCAAC TCAAGACCCA GGACCACCCC CACCTTCTCC ATTACTAGGT 240
TTGAAACCAC TGCAGTTATT AGAAGTGAAA GCAAGGGGAA GATTTGGTTG TGTCTGGAAA 300
GCCCAGTTGC TTAACGAATA TGTGGCTGTC AAAATATTTC CAATACAGGA CAAACAGTCA 360
TGGCAAAATG AATACGAAGT CTACAGTTTG CCTGGAATGA AGCATGAGAA CATATTACAG 420
TTCATTGGTG CAGAAAAACG AGGCACCAGT GTTGATGTGG ATCTTTGGCT GATCACAGCA 480
TTTCATGAAA AGGGTTCACT ATCAGACTTT CTTAAGGCTA ATGTGGTCTC TTGGAATGAA 540
CTGTGTCATA TTGCAGAAAC CATGGCTAGA GGATTGGCAT ATTTACATGA GGATATACCT 600
GGCCTAAAAG ATGGCCACAA ACCTGCCATA TCTCACAGGG ACATCAAAAG TAAAAATGTG 660
CTGTTGAAAA ACAACCTGAC AGCTTGCATT GCTGACTTTG GGTTGGCCTT AAAATTTGAG 720
GCTGGCAAGT CTGCAGGCGA TACCCATGGA CAGGTTGGTA CCCGGAGGTA CATGGCTCCA 780
GAGGTATTAG AGGGTGCTAT AAACTTCCAA AGGGATGCAT TTTTGAGGAT AGATATGTAT 840
GCCATGGGAT TAGTCCTATG GGAACTGGCT TCTCGCTGTA CTGCTGCAGA TGGACCTGTA 900
GATGAATACA TGTTGCCATT TGAGGAGGAA ATTGGCCAGC ATCCATCTCT TGAAGACATG 960
CAGGAAGTTG TTGTGCATAA AAAAAAGAGG CCTGTTTTAA GAGATTATTG GCAGAAACAT 1020
GCTGGAATGG CAATGCTCTG TGAAACCATT GAAGAATGTT GGGATCACGA CGCAGAAGCC 1080
AGGTTATCAG CTGGATGTGT AGGTGAAAGA ATTACCCAGA TGCAGAGACT AACAAATATT 1140
ATTACCACAG AGGACATTGT AACAGTGGTC ACAATGGTGA CAAATGTTGA CTTTCCTCCC 1200
AAAGAATCTA GTCTATGA 1218
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+
Q: 84    LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  143
         6899********************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k
Q: 144   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  203
         ************************************************************
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180
         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE
Q: 204   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  261
         *****************************************888..79************
S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240
         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m
Q: 262   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  320
         *********9.9************************************************
S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290
         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r
Q: 321   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  370
         ***********************************************987
Domain Sequence
(FASTA)
LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60
AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120
DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180
EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240
VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287
Keyword3D-structure; ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00264
EKS-BOT-00282
EKS-CAJ-00288
EKS-CAF-00288
EKS-CAP-00317
EKS-CHH-00018
EKS-EQC-00274
EKS-ERE-00021
EKS-FEC-00268
EKS-GAG-00235
EKS-GOG-00281
EKS-ICT-00266
EKS-LOA-00292
EKS-MAM-00284
EKS-MOD-00277
EKS-MUM-00313
EKS-MUP-00277
EKS-MYL-00285
EKS-NOL-00260
EKS-ORC-00265
EKS-OTG-00287
EKS-PAT-00266
EKS-POA-00273
EKS-RAN-00298
EKS-SAH-00264
EKS-SOA-00025
EKS-SUS-00248
EKS-TAS-00019
EKS-TUB-00023
EKS-TUT-00039
EKS-VIP-00018
Gene Ontology
GO:0009986; C:cell surface
GO:0005737; C:cytoplasm
GO:0034673; C:inhibin-betaglycan-ActRII complex
GO:0005887; C:integral to plasma membrane
GO:0016362; F:activin receptor activity, type II
GO:0005524; F:ATP binding
GO:0015026; F:coreceptor activity
GO:0046872; F:metal ion binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity
GO:0009952; P:anterior/posterior pattern specification
GO:0030509; P:BMP signaling pathway
GO:0007368; P:determination of left/right symmetry
GO:0048706; P:embryonic skeletal system development
GO:0001702; P:gastrulation with mouth forming second
GO:0007498; P:mesoderm development
GO:0043084; P:penile erection
GO:0032927; P:positive regulation of activin receptor signaling pathway
GO:0030501; P:positive regulation of bone mineralization
GO:0045648; P:positive regulation of erythrocyte differentiation
GO:0046881; P:positive regulation of follicle-stimulating hormone secretion
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030510; P:regulation of BMP signaling pathway
GO:0050999; P:regulation of nitric-oxide synthase activity
GO:0010033; P:response to organic substance
GO:0060011; P:Sertoli cell proliferation
GO:0023014; P:signal transduction by phosphorylation
GO:0042713; P:sperm ejaculation
GO:0007283; P:spermatogenesis
KEGG
hsa:92;
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR015768; Activin_II_recpt.
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013