EKS-HOS-00410

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00410

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	584.9	3.2E-175	610	943	334

Status

Reviewed

Ensembl Protein

ENSP00000241453

UniProt Accession

P36888; A0AVG9; B7ZLT7; B7ZLT8; F5H0A0; Q13414;

Protein Name

Receptor-type tyrosine-protein kinase FLT3

Protein Synonyms/Alias

FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1;

Gene Name

FLT3

Gene Synonyms/Alias

FLT3; CD135, FLK2, STK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000122025	ENSP00000370369	ENST00000380982
ENSG00000122025	ENSP00000438139	ENST00000537084
ENSG00000122025	ENSP00000241453	ENST00000241453
ENSG00000122025	ENSP00000370374	ENST00000380987

Organism

Homo sapiens

Functional Description

Tyrosine-protein kinase that acts as cell-surfacereceptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Protein Length

993

Protein Sequence
(FASTA)

MPALARDGGQ LPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS SSYPMVSESP 60

EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN ISCLWVFKHS SLNCQPHFDL 120

QNRGVVSMVI LKMTETQAGE YLLFIQSEAT NYTILFTVSI RNTLLYTLRR PYFRKMENQD 180

ALVCISESVP EPIVEWVLCD SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE 240

CTRLFTIDLN QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM 300

STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVEKGFI NATNSSEDYE 360

IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG YSISKFCNHK HQPGEYIFHA 420

ENDDAQFTKM FTLNIRRKPQ VLAEASASQA SCFSDGYPLP SWTWKKCSDK SPNCTEEITE 480

GVWNRKANRK VFGQWVSSST LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD 540

NISFYATIGV CLLFIVVLTL LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFREYEYD 600

LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA DSSEREALMS 660

ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL NYLRSKREKF HRTWTEIFKE 720

HNFSFYPTFQ SHPNSSMPGS REVQIHPDSD QISGLHGNSF HSEDEIEYEN QKRLEEEEDL 780

NVLTFEDLLC FAYQVAKGME FLEFKSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS 840

NYVVRGNARL PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK 900

LIQNGFKMDQ PFYATEEIYI IMQSCWAFDS RKRPSFPNLT SFLGCQLADA EEAMYQNVDG 960

RVSECPHTYQ NRRPFSREMD LGLLSPQAQV EDS 993

Nucleotide Sequence
(FASTA)

ATGCCGGCGT TGGCGCGCGA CGGCGGCCAG CTGCCGCTGC TCGTTGTTTT TTCTGCAATG 60

ATATTTGGGA CTATTACAAA TCAAGATCTG CCTGTGATCA AGTGTGTTTT AATCAATCAT 120

AAGAACAATG ATTCATCAGT GGGGAAGTCA TCATCATATC CCATGGTATC AGAATCCCCG 180

GAAGACCTCG GGTGTGCGTT GAGACCCCAG AGCTCAGGGA CAGTGTACGA AGCTGCCGCT 240

GTGGAAGTGG ATGTATCTGC TTCCATCACA CTGCAAGTGC TGGTCGACGC CCCAGGGAAC 300

ATTTCCTGTC TCTGGGTCTT TAAGCACAGC TCCCTGAATT GCCAGCCACA TTTTGATTTA 360

CAAAACAGAG GAGTTGTTTC CATGGTCATT TTGAAAATGA CAGAAACCCA AGCTGGAGAA 420

TACCTACTTT TTATTCAGAG TGAAGCTACC AATTACACAA TATTGTTTAC AGTGAGTATA 480

AGAAATACCC TGCTTTACAC ATTAAGAAGA CCTTACTTTA GAAAAATGGA AAACCAGGAC 540

GCCCTGGTCT GCATATCTGA GAGCGTTCCA GAGCCGATCG TGGAATGGGT GCTTTGCGAT 600

TCACAGGGGG AAAGCTGTAA AGAAGAAAGT CCAGCTGTTG TTAAAAAGGA GGAAAAAGTG 660

CTTCATGAAT TATTTGGGAC GGACATAAGG TGCTGTGCCA GAAATGAACT GGGCAGGGAA 720

TGCACCAGGC TGTTCACAAT AGATCTAAAT CAAACTCCTC AGACCACATT GCCACAATTA 780

TTTCTTAAAG TAGGGGAACC CTTATGGATA AGGTGCAAAG CTGTTCATGT GAACCATGGA 840

TTCGGGCTCA CCTGGGAATT AGAAAACAAA GCACTCGAGG AGGGCAACTA CTTTGAGATG 900

AGTACCTATT CAACAAACAG AACTATGATA CGGATTCTGT TTGCTTTTGT ATCATCAGTG 960

GCAAGAAACG ACACCGGATA CTACACTTGT TCCTCTTCAA AGCATCCCAG TCAATCAGCT 1020

TTGGTTACCA TCGTAGAAAA GGGATTTATA AATGCTACCA ATTCAAGTGA AGATTATGAA 1080

ATTGACCAAT ATGAAGAGTT TTGTTTTTCT GTCAGGTTTA AAGCCTACCC ACAAATCAGA 1140

TGTACGTGGA CCTTCTCTCG AAAATCATTT CCTTGTGAGC AAAAGGGTCT TGATAACGGA 1200

TACAGCATAT CCAAGTTTTG CAATCATAAG CACCAGCCAG GAGAATATAT ATTCCATGCA 1260

GAAAATGATG ATGCCCAATT TACCAAAATG TTCACGCTGA ATATAAGAAG GAAACCTCAA 1320

GTGCTCGCAG AAGCATCGGC AAGTCAGGCG TCCTGTTTCT CGGATGGATA CCCATTACCA 1380

TCTTGGACCT GGAAGAAGTG TTCAGACAAG TCTCCCAACT GCACAGAAGA GATCACAGAA 1440

GGAGTCTGGA ATAGAAAGGC TAACAGAAAA GTGTTTGGAC AGTGGGTGTC GAGCAGTACT 1500

CTAAACATGA GTGAAGCCAT AAAAGGGTTC CTGGTCAAGT GCTGTGCATA CAATTCCCTT 1560

GGCACATCTT GTGAGACGAT CCTTTTAAAC TCTCCAGGCC CCTTCCCTTT CATCCAAGAC 1620

AACATCTCAT TCTATGCAAC AATTGGTGTT TGTCTCCTCT TCATTGTCGT TTTAACCCTG 1680

CTAATTTGTC ACAAGTACAA AAAGCAATTT AGGTATGAAA GCCAGCTACA GATGGTACAG 1740

GTGACCGGCT CCTCAGATAA TGAGTACTTC TACGTTGATT TCAGAGAATA TGAATATGAT 1800

CTCAAATGGG AGTTTCCAAG AGAAAATTTA GAGTTTGGGA AGGTACTAGG ATCAGGTGCT 1860

TTTGGAAAAG TGATGAACGC AACAGCTTAT GGAATTAGCA AAACAGGAGT CTCAATCCAG 1920

GTTGCCGTCA AAATGCTGAA AGAAAAAGCA GACAGCTCTG AAAGAGAGGC ACTCATGTCA 1980

GAACTCAAGA TGATGACCCA GCTGGGAAGC CACGAGAATA TTGTGAACCT GCTGGGGGCG 2040

TGCACACTGT CAGGACCAAT TTACTTGATT TTTGAATACT GTTGCTATGG TGATCTTCTC 2100

AACTATCTAA GAAGTAAAAG AGAAAAATTT CACAGGACTT GGACAGAGAT TTTCAAGGAA 2160

CACAATTTCA GTTTTTACCC CACTTTCCAA TCACATCCAA ATTCCAGCAT GCCTGGTTCA 2220

AGAGAAGTTC AGATACACCC GGACTCGGAT CAAATCTCAG GGCTTCATGG GAATTCATTT 2280

CACTCTGAAG ATGAAATTGA ATATGAAAAC CAAAAAAGGC TGGAAGAAGA GGAGGACTTG 2340

AATGTGCTTA CATTTGAAGA TCTTCTTTGC TTTGCATATC AAGTTGCCAA AGGAATGGAA 2400

TTTCTGGAAT TTAAGTCGTG TGTTCACAGA GACCTGGCCG CCAGGAACGT GCTTGTCACC 2460

CACGGGAAAG TGGTGAAGAT ATGTGACTTT GGATTGGCTC GAGATATCAT GAGTGATTCC 2520

AACTATGTTG TCAGGGGCAA TGCCCGTCTG CCTGTAAAAT GGATGGCCCC CGAAAGCCTG 2580

TTTGAAGGCA TCTACACCAT TAAGAGTGAT GTCTGGTCAT ATGGAATATT ACTGTGGGAA 2640

ATCTTCTCAC TTGGTGTGAA TCCTTACCCT GGCATTCCGG TTGATGCTAA CTTCTACAAA 2700

CTGATTCAAA ATGGATTTAA AATGGATCAG CCATTTTATG CTACAGAAGA AATATACATT 2760

ATAATGCAAT CCTGCTGGGC TTTTGACTCA AGGAAACGGC CATCCTTCCC TAATTTGACT 2820

TCGTTTTTAG GATGTCAGCT GGCAGATGCA GAAGAAGCGA TGTATCAGAA TGTGGATGGC 2880

CGTGTTTCGG AATGTCCTCA CACCTACCAA AACAGGCGAC CTTTCAGCAG AGAGATGGAT 2940

TTGGGGCTAC TCTCTCCGCA GGCTCAGGTC GAAGATTCGT AG 2982

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk++++lG

Q: 610   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLG  669

         79**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ +

Q: 670   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  728

         *********************************************************99.

S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180

               ++s+ ++s+++s+e v++++d++++s  + ++++se++ +++++++   +eeed

Q: 729   ------FQSHPNSSMPGSRE-VQIHPDSDQISGLHGNSFHSEDEIEYENQKRL--EEEED  779

         ......9*************.**************************999877..78999

S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240

          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+GkvvkicdfGlardim+d

Q: 780   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD  839

         ************************************************************

S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300

         snyvv+Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy

Q: 840   SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  899

         ************************************************************

S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l

Q: 900   KLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL  943

         ****************************************9986

Domain Sequence
(FASTA)

LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMMTQLG 60

SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120

QSHPNSSMPG SREVQIHPDS DQISGLHGNS FHSEDEIEYE NQKRLEEEED LNVLTFEDLL 180

CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKVVKICD FGLARDIMSD SNYVVRGNAR 240

LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIQNGFKMD 300

QPFYATEEIY IIMQSCWAFD SRKRPSFPNL TSFL 334

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; Disease mutation; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Proto-oncogene; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005788	; C:endoplasmic reticulum lumen
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0004896	; F:cytokine receptor activity
GO:0042803	; F:protein homodimerization activity
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0030183	; P:B cell differentiation
GO:0035726	; P:common myeloid progenitor cell proliferation
GO:0097028	; P:dendritic cell differentiation
GO:0001776	; P:leukocyte homeostasis
GO:0046651	; P:lymphocyte proliferation
GO:0002318	; P:myeloid progenitor cell differentiation
GO:0045578	; P:negative regulation of B cell differentiation
GO:0008285	; P:negative regulation of cell proliferation
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0008284	; P:positive regulation of cell proliferation
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0043410	; P:positive regulation of MAPK cascade
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068	; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0042531	; P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0002328	; P:pro-B cell differentiation
GO:0002572	; P:pro-T cell differentiation
GO:0046777	; P:protein autophosphorylation
GO:0042981	; P:regulation of apoptotic process

KEGG

hsa:2322

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013