EKS-HOS-00330
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00330
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20333.06.2E-9925313289
StatusReviewed
Ensembl ProteinENSP00000438378
UniProt AccessionQ7Z2Y5; Q32ND6; Q5H9K2; Q6ZMP2;
Protein NameNik-related protein kinase
Protein Synonyms/Alias
Gene NameNRK
Gene Synonyms/Alias NRK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000123572ENSP00000438785ENST00000536164
ENSG00000123572ENSP00000438148ENST00000540278
ENSG00000123572ENSP00000438378ENST00000428173
ENSG00000123572ENSP00000434830ENST00000243300
OrganismHomo sapiens
Functional DescriptionMay phosphorylate cofilin-1 and induce actinpolymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).
Protein Length1583
Protein Sequence
(FASTA)
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF TAVKVMNARK 60
TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVSFY GAFFKLSPPG 120
QRHQLWMVME LCAAGSVTDV VRMTSNQSLK EDWIAYICRE ILQGLAHLHA HRVIHRDIKG 180
QNVLLTHNAE VKLVDFGVSA QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV 240
WSVGITAIEM AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF 300
RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK KGIPLIFERE EAIKEQYTVR 360
RFRGPSCTHE LLRLPTSSRC RPLRVLHGEP SQPRWLPDRE EPQVQALQQL QGAARVFMPL 420
QALDSAPKPL KGQAQAPQRL QGAARVFMPL QAQVKAKASK PLQMQIKAPP RLRRAARVLM 480
PLQAQVRAPR LLQVQSQVSK KQQAQTQTSE PQDLDQVPEE FQGQDQVPEQ QRQGQAPEQQ 540
QRHNQVPEQE LEQNQAPEQP EVQEQAAEPA QAETEAEEPE SLRVNAQVFL PLLSQDHHVL 600
LPLHLDTQVL IPVEGQTEGS PQAQAWTLEP PQAIGSVQAL IEGLSRDLLR APNSNNSKPL 660
GPLQTLMENL SSNRFYSQPE QAREKKSKVS TLRQALAKRL SPKRFRAKSS WRPEKLELSD 720
LEARRQRRQR RWEDIFNQHE EELRQVDKDK EDESSDNDEV FHSIQAEVQI EPLKPYISNP 780
KKIEVQERSP SVPNNQDHAH HVKFSSSVPQ RSLLEQAQKP IDIRQRSSQN RQNWLAASES 840
SSEEESPVTG RRSQSSPPYS TIDQKLLVDI HVPDGFKVGK ISPPVYLTNE WVGYNALSEI 900
FRNDWLTPAP VIQPPEEDGD YVELYDASAD TDGDDDDESN DTFEDTYDHA NGNDDLDNQV 960
DQANDVCKDH DDDNNKFVDD VNNNYYEAPS CPRASYGRDG SCKQDGYDGS RGKEEAYRGY 1020
GSHTANRSHG GSAASEDNAA IGDQEEHAAN IGSERRGSEG DGGKGVVRTS EESGALGLNG 1080
EENCSETDGP GLKRPASQDF EYLQEEPGGG NEASNAIDSG AAPSAPDHES DNKDISESST 1140
QSDFSANHSS PSKGSGMSAD ANFASAILYA GFVEVPEESP KQPSEVNVNP LYVSPACKKP 1200
LIHMYEKEFT SEICCGSLWG VNLLLGTRSN LYLMDRSGKA DITKLIRRRP FRQIQVLEPL 1260
NLLITISGHK NRLRVYHLTW LRNKILNNDP ESKRRQEEML KTEEACKAID KLTGCEHFSV 1320
LQHEETTYIA IALKSSIHLY AWAPKSFDES TAIKVCIDQS ADSEGDYMSY QAYIRILAKI 1380
QAADPVNRFK RPDELLHLLK LKVFPTLDHK PVTVDLAIGS EKRLKIFFSS ADGYHLIDAE 1440
SEVMSDVTLP KNPLEIIIPQ NIIILPDCLG IGMMLTFNAE ALSVEANEQL FKKILEMWKD 1500
IPSSIAFECT QRTTGWGQKA IEVRSLQSRV LESELKRRSI KKLRFLCTRG DKLFFTSTLR 1560
NHHSRVYFMT LGKLEELQSN YDV 1583
Nucleotide Sequence
(FASTA)
ATGGCGGGAC CTGGGGGCTG GAGGGACAGG GAGGTCACGG ATCTGGGCCA CCTGCCGGAT 60
CCAACTGGAA TATTCTCACT AGATAAAACC ATTGGCCTTG GTACTTATGG CAGAATCTAT 120
TTGGGACTTC ATGAGAAGAC TGGTGCATTT ACAGCTGTTA AAGTGATGAA CGCTCGTAAG 180
ACCCCTTTAC CTGAAATAGG AAGGCGAGTG AGAGTGAATA AATATCAAAA ATCTGTTGGG 240
TGGAGATACA GTGATGAGGA AGAGGATCTC AGGACTGAAC TCAACCTTCT GAGGAAGTAC 300
TCTTTCCACA AAAACATTGT GTCCTTCTAT GGAGCATTTT TCAAGCTGAG TCCCCCTGGT 360
CAGCGGCACC AACTTTGGAT GGTGATGGAG TTATGTGCAG CAGGTTCGGT CACTGATGTA 420
GTGAGAATGA CCAGTAATCA GAGTTTAAAA GAAGATTGGA TTGCTTATAT CTGCCGAGAA 480
ATCCTTCAGG GCTTAGCTCA CCTTCACGCA CACCGAGTAA TTCACCGGGA CATCAAAGGT 540
CAGAATGTGC TGCTGACTCA TAATGCTGAA GTAAAACTGG TTGATTTTGG AGTGAGTGCC 600
CAGGTGAGCA GAACTAATGG AAGAAGGAAT AGTTTCATTG GGACACCATA CTGGATGGCA 660
CCTGAGGTGA TTGACTGTGA TGAGGACCCA AGACGCTCCT ATGATTACAG AAGTGATGTG 720
TGGTCTGTGG GAATTACTGC CATTGAAATG GCTGAAGGAG CCCCTCCTCT GTGTAACCTT 780
CAACCCTTGG AAGCTCTCTT CGTTATTTTG CGGGAATCTG CTCCCACAGT CAAATCCAGC 840
GGATGGTCCC GTAAGTTCCA CAATTTCATG GAAAAGTGTA CGATAAAAAA TTTCCTGTTT 900
CGTCCTACTT CTGCAAACAT GCTTCAACAC CCATTTGTTC GGGATATAAA AAATGAACGA 960
CATGTTGTTG AGTCATTAAC AAGGCATCTT ACTGGAATCA TTAAAAAAAG ACAGAAAAAA 1020
AAAGGAATAC CTTTGATCTT TGAAAGAGAA GAAGCTATTA AGGAACAGTA CACCGTGAGA 1080
AGATTCAGAG GACCCTCTTG CACTCACGAG CTTCTGAGAT TGCCAACCAG CAGCAGATGC 1140
AGACCACTTA GAGTCCTGCA TGGGGAACCC TCTCAGCCAA GGTGGCTACC TGATCGAGAA 1200
GAGCCACAGG TCCAGGCACT TCAGCAGCTA CAGGGAGCAG CCAGGGTATT CATGCCACTG 1260
CAGGCTCTGG ACAGTGCACC TAAGCCTCTA AAGGGGCAGG CTCAGGCACC TCAACGACTA 1320
CAAGGGGCAG CTCGGGTGTT CATGCCACTA CAGGCTCAGG TGAAGGCTAA AGCCTCTAAA 1380
CCTCTACAAA TGCAGATTAA GGCACCTCCA CGACTACGGA GGGCAGCCAG GGTGCTCATG 1440
CCACTACAGG CACAGGTTAG GGCACCTAGG CTTCTGCAGG TACAGTCCCA GGTATCCAAA 1500
AAGCAGCAGG CCCAGACCCA GACATCAGAA CCACAAGATT TGGACCAGGT ACCAGAGGAA 1560
TTTCAGGGTC AAGATCAGGT ACCCGAACAA CAAAGGCAGG GCCAGGCCCC TGAACAACAG 1620
CAGAGGCACA ACCAGGTGCC TGAACAAGAG CTGGAGCAGA ACCAGGCACC TGAACAGCCA 1680
GAGGTACAGG AACAGGCTGC CGAGCCTGCA CAGGCAGAGA CTGAGGCAGA GGAACCTGAG 1740
TCATTACGAG TAAATGCCCA GGTATTTCTG CCCCTGCTAT CACAAGATCA CCATGTGCTG 1800
TTGCCACTAC ATTTGGATAC TCAGGTGCTC ATTCCAGTAG AGGGGCAAAC TGAAGGATCA 1860
CCTCAGGCAC AGGCTTGGAC ACTAGAACCC CCACAGGCAA TTGGCTCAGT TCAAGCACTG 1920
ATAGAGGGAC TATCAAGAGA CTTGCTTCGG GCACCAAACT CAAATAACTC AAAGCCACTT 1980
GGTCCGTTGC AAACCCTGAT GGAAAATCTG TCATCAAATA GGTTTTACTC ACAACCAGAA 2040
CAGGCACGGG AGAAAAAATC AAAAGTTTCT ACTCTGAGGC AAGCACTGGC AAAAAGACTA 2100
TCACCAAAGA GGTTCAGGGC AAAGTCATCA TGGAGACCTG AAAAGCTTGA ACTCTCGGAT 2160
TTAGAAGCCC GCAGGCAAAG GCGCCAACGC AGATGGGAAG ATATCTTTAA TCAGCATGAG 2220
GAAGAATTGA GACAAGTTGA TAAAGACAAA GAAGATGAAT CATCAGACAA TGATGAAGTA 2280
TTTCATTCGA TTCAGGCTGA AGTCCAGATA GAGCCATTGA AGCCATACAT TTCAAATCCT 2340
AAAAAAATTG AGGTTCAAGA GAGATCTCCT TCTGTGCCTA ACAACCAGGA TCATGCACAT 2400
CATGTCAAGT TCTCTTCAAG CGTTCCTCAG CGGTCTCTTT TGGAACAAGC TCAGAAGCCC 2460
ATTGACATCA GACAAAGGAG TTCGCAAAAT CGTCAAAATT GGCTGGCAGC ATCAGAATCT 2520
TCTTCTGAGG AAGAAAGTCC TGTGACTGGA AGGAGGTCTC AGTCATCACC ACCTTATTCT 2580
ACTATTGATC AGAAGTTGCT GGTTGACATC CATGTTCCAG ATGGATTTAA AGTAGGAAAA 2640
ATATCACCCC CTGTATACTT GACAAACGAA TGGGTAGGCT ATAATGCACT CTCTGAAATC 2700
TTCCGGAATG ATTGGTTAAC TCCGGCACCT GTCATTCAGC CACCTGAAGA GGATGGTGAT 2760
TATGTTGAAC TCTATGATGC CAGTGCTGAT ACTGATGGTG ATGATGATGA TGAGTCTAAT 2820
GATACTTTTG AAGATACCTA TGATCATGCC AATGGCAATG ATGACTTGGA TAACCAGGTT 2880
GATCAGGCTA ATGATGTTTG TAAAGACCAT GATGATGACA ACAATAAGTT TGTTGATGAT 2940
GTAAATAATA ATTATTATGA GGCGCCTAGT TGTCCAAGGG CAAGCTATGG CAGAGATGGA 3000
AGCTGCAAGC AAGATGGTTA TGATGGAAGT CGTGGAAAAG AGGAAGCCTA CAGAGGCTAT 3060
GGAAGCCATA CAGCCAATAG AAGCCATGGA GGAAGTGCAG CCAGTGAGGA CAATGCAGCC 3120
ATTGGAGATC AGGAAGAACA TGCAGCCAAT ATAGGCAGTG AAAGAAGAGG CAGTGAGGGT 3180
GATGGAGGTA AGGGAGTCGT TCGAACCAGT GAAGAGAGTG GAGCCCTTGG ACTCAATGGA 3240
GAAGAAAATT GCTCAGAGAC AGATGGTCCA GGATTGAAGA GACCTGCGTC TCAGGACTTT 3300
GAATATCTAC AGGAGGAGCC AGGTGGTGGA AATGAGGCCT CAAATGCCAT TGACTCAGGT 3360
GCTGCACCGT CAGCACCTGA TCATGAGAGT GACAATAAGG ACATATCAGA ATCATCAACA 3420
CAATCAGATT TTTCTGCCAA TCACTCATCT CCTTCCAAAG GTTCTGGGAT GTCTGCTGAT 3480
GCTAACTTTG CCAGTGCCAT CTTATACGCT GGATTCGTAG AAGTACCTGA GGAATCACCT 3540
AAGCAACCCT CTGAAGTCAA TGTTAACCCA CTCTATGTCT CTCCTGCATG TAAAAAACCA 3600
CTAATCCACA TGTATGAAAA GGAGTTCACT TCTGAGATCT GCTGTGGTTC TTTGTGGGGA 3660
GTCAATTTGC TGTTGGGAAC CCGATCTAAT CTATATCTGA TGGACAGAAG TGGAAAGGCT 3720
GACATTACTA AACTTATAAG GCGAAGACCA TTCCGCCAGA TTCAAGTCTT AGAGCCACTC 3780
AATTTGCTGA TTACCATCTC AGGTCATAAG AACAGACTTC GGGTGTATCA TCTGACCTGG 3840
TTGAGGAACA AGATTTTGAA TAATGATCCA GAAAGTAAAA GAAGGCAAGA AGAAATGCTG 3900
AAGACAGAGG AAGCCTGCAA AGCTATTGAT AAGTTAACAG GCTGTGAACA CTTCAGTGTC 3960
CTCCAACATG AAGAAACAAC ATATATTGCA ATTGCTTTGA AATCATCAAT TCACCTTTAT 4020
GCATGGGCAC CAAAGTCCTT TGATGAAAGC ACTGCTATTA AAGTATGCAT TGATCAATCA 4080
GCAGACTCTG AAGGAGACTA CATGTCCTAT CAAGCCTATA TACGAATACT GGCAAAAATA 4140
CAGGCAGCTG ATCCAGTGAA CCGGTTTAAG AGACCAGATG AGCTCCTTCA TTTGCTGAAG 4200
CTCAAGGTAT TTCCAACACT TGATCATAAG CCAGTGACAG TTGACCTGGC TATTGGTTCT 4260
GAAAAAAGAC TAAAGATTTT CTTCAGCTCA GCAGATGGAT ATCACCTCAT CGATGCAGAA 4320
TCTGAGGTTA TGTCTGATGT GACCCTGCCA AAGAATCCCC TGGAAATCAT TATACCACAG 4380
AATATCATCA TTTTACCTGA TTGCTTGGGA ATTGGCATGA TGCTCACCTT CAATGCTGAA 4440
GCCCTCTCTG TGGAAGCAAA TGAACAACTC TTCAAGAAGA TCCTTGAAAT GTGGAAAGAC 4500
ATACCATCTT CTATAGCTTT TGAATGTACA CAGCGAACCA CAGGATGGGG CCAAAAGGCC 4560
ATTGAAGTGC GCTCTTTGCA ATCCAGGGTT CTGGAAAGTG AGCTGAAGCG CAGGTCAATT 4620
AAGAAGCTGA GATTCCTGTG CACCCGGGGT GACAAGCTGT TCTTTACCTC TACCCTGCGC 4680
AATCACCACA GCCGGGTTTA CTTCATGACA CTTGGAAAAC TTGAAGAGCT CCAAAGCAAT 4740
TATGATGTCT AA 4752
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.......................  37
         ++l ++ig G++g++yl+ ++ktg+++a+k++n++k+                       
Q: 25    FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTplpeigrrvrvnkyqksvgwrys  84
         78999*******************************************************
S: 38    ekleelqkeisvlkklkh.pniveylesflk......eeelwlvmeylagGslsdlvkee  90
         +++e+l++e+++l+k++  +niv+++++f+k      +++lw+vme++a+Gs++d+v+++
Q: 85    DEEEDLRTELNLLRKYSFhKNIVSFYGAFFKlsppgqRHQLWMVMELCAAGSVTDVVRMT  144
         ****************966*****************99**********************
S: 91    lkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlek  150
         ++++lkE++iayi+re+l++L++lH+++viHrdik++n+Llt+++eVkL+dfgv+aq+++
Q: 145   SNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSR  204
         ************************************************************
S: 151   trkkrktvvgtpywmAPEviaqe...ekgYdekaDiwslGItaielaegepPfkdleplk  207
         t+ +r++++gtpywmAPEvi+++   +++Yd+++D+ws+GItaie+aeg+pP+++l+pl+
Q: 205   TNGRRNSFIGTPYWMAPEVIDCDedpRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLE  264
         ***********************99999********************************
S: 208   allkilkneppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257
         al+ il++++p++ks+  +s++f++f+ekc  kn+ +Rp+++++l+h+F+
Q: 265   ALFVILRESAPTVKSS-GWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV  313
         *************888.********************************7
Domain Sequence
(FASTA)
FSLDKTIGLG TYGRIYLGLH EKTGAFTAVK VMNARKTPLP EIGRRVRVNK YQKSVGWRYS 60
DEEEDLRTEL NLLRKYSFHK NIVSFYGAFF KLSPPGQRHQ LWMVMELCAA GSVTDVVRMT 120
SNQSLKEDWI AYICREILQG LAHLHAHRVI HRDIKGQNVL LTHNAEVKLV DFGVSAQVSR 180
TNGRRNSFIG TPYWMAPEVI DCDEDPRRSY DYRSDVWSVG ITAIEMAEGA PPLCNLQPLE 240
ALFVILRESA PTVKSSGWSR KFHNFMEKCT IKNFLFRPTS ANMLQHPFV 289
KeywordAlternative splicing; ATP-binding; Coiled coil; Complete proteome; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>
EKS-AIM-00306
EKS-CAJ-00328
EKS-CAF-00336
EKS-CAP-00368
EKS-EQC-00328
EKS-FEC-00318
EKS-GOG-00318
EKS-ICT-00310
EKS-LOA-00340
EKS-MAM-00323
EKS-MUM-00355
EKS-MUP-00314
EKS-MYL-00326
EKS-NOL-00295
EKS-ORC-00312
EKS-OTG-00334
EKS-PAT-00305
EKS-POA-00312
EKS-RAN-00351
EKS-SUS-00289
EKS-TAS-00031
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
hsa:203447;
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013