EKS-HOS-00283
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00283
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR453.91.1E-135115402288
StatusReviewed
Ensembl ProteinENSP00000335178
UniProt AccessionQ8NER5; Q4ZFZ8; Q86UL1; Q86UL2; Q8TBG2;
Protein NameActivin receptor type-1C
Protein Synonyms/Alias Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7;
Gene NameACVR1C
Gene Synonyms/Alias ACVR1C; ALK7;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000123612ENSP00000335139ENST00000348328
ENSG00000123612ENSP00000335178ENST00000335450
ENSG00000123612ENSP00000387168ENST00000409680
ENSG00000123612ENSP00000243349ENST00000243349
OrganismHomo sapiens
Functional DescriptionSerine/threonine protein kinase which forms a receptorcomplex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Protein Length413
Protein Sequence
(FASTA)
MTRALCSALR QALLLLAAAA ELSPGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVI 60
KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TGLPLLVQRT IARTIVLQEI 120
VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL GFIAADNKDN 180
GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMIKLALSIA SGLAHLHMEI VGTQGKPAIA 240
HRDIKSKNIL VKKCETCAIA DLGLAVKHDS ILNTIDIPQN PKVGTKRYMA PEMLDDTMNV 300
NIFESFKRAD IYSVGLVYWE IARRCSVGGI VEEYQLPYYD MVPSDPSIEE MRKVVCDQKF 360
RPSIPNQWQS CEALRVMGRI MRECWYANGA ARLTALRIKK TISQLCVKED CKA 413
Nucleotide Sequence
(FASTA)
ATGACCCGGG CGCTCTGCTC AGCGCTCCGC CAGGCTCTCC TGCTGCTCGC AGCGGCCGCC 60
GAGCTCTCGC CAGGACTGAA GTGTGTATGT CTTTTGTGTG ATTCTTCAAA CTTCACCTGC 120
CAAACAGAAG GAGCATGTTG GGCATCAGTC ATGCTAACCA ATGGAAAAGA GCAGGTGATC 180
AAATCCTGTG TCTCCCTTCC AGAACTGAAT GCTCAAGTCT TCTGTCATAG TTCCAACAAT 240
GTTACCAAAA CCGAATGCTG CTTCACAGAT TTTTGCAACA ACATAACACT GCACCTTCCA 300
ACAGGTCTAC CTCTGTTGGT TCAAAGGACA ATTGCAAGGA CGATTGTGCT TCAGGAAATA 360
GTAGGAAAAG GTAGATTTGG TGAGGTGTGG CATGGAAGAT GGTGTGGGGA AGATGTGGCT 420
GTGAAAATAT TCTCCTCCAG AGATGAAAGA TCTTGGTTTC GTGAGGCAGA AATTTACCAG 480
ACGGTCATGC TGCGACATGA AAACATCCTT GGTTTCATTG CTGCTGACAA CAAAGATAAT 540
GGAACTTGGA CTCAACTTTG GCTGGTATCT GAATATCATG AACAGGGCTC CTTATATGAC 600
TATTTGAATA GAAATATAGT GACCGTGGCT GGAATGATCA AGCTGGCGCT CTCAATTGCT 660
AGTGGTCTGG CACACCTTCA TATGGAGATT GTTGGTACAC AAGGTAAACC TGCTATTGCT 720
CATCGAGACA TAAAATCAAA GAATATCTTA GTGAAAAAGT GTGAAACTTG TGCCATAGCG 780
GACTTAGGGT TGGCTGTGAA GCATGATTCA ATACTGAACA CTATCGACAT ACCTCAGAAT 840
CCTAAAGTGG GAACCAAGAG GTATATGGCT CCTGAAATGC TTGATGATAC AATGAATGTG 900
AATATCTTTG AGTCCTTCAA ACGAGCTGAC ATCTATTCTG TTGGTCTGGT TTACTGGGAA 960
ATAGCCCGGA GGTGTTCAGT CGGAGGAATT GTTGAGGAGT ACCAATTGCC TTATTATGAC 1020
ATGGTGCCTT CAGATCCCTC GATAGAGGAA ATGAGAAAGG TTGTTTGTGA CCAGAAGTTT 1080
CGACCAAGTA TCCCAAACCA GTGGCAAAGT TGTGAAGCAC TCCGAGTCAT GGGGAGAATA 1140
ATGCGTGAGT GTTGGTATGC CAACGGAGCG GCCCGCCTAA CTGCTCTTCG TATTAAGAAG 1200
ACTATATCTC AACTTTGTGT CAAAGAAGAC TGCAAAGCCT AA 1242
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia
Q: 115   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  174
         5789********************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         ad+k+++++t+l+lv+eyhe+gsL+dyL+r++++v  +++lals+asGlahLH+eivgt+
Q: 175   ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQ  234
         ************************************************************
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180
         g  KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE
Q: 235   G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPE  292
         *..*********************************************************
S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240
         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem
Q: 293   MLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSIEEM  351
         **********************************9.************************
S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         ++vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++
Q: 352   RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  402
         ************************************************986
Domain Sequence
(FASTA)
IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60
ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NIVTVAGMIK LALSIASGLA HLHMEIVGTQ 120
GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSILNT IDIPQNPKVG TKRYMAPEML 180
DDTMNVNIFE SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSIEEMRKV 240
VCDQKFRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288
KeywordAlternative splicing; Apoptosis; ATP-binding; Complete proteome; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00260
EKS-BOT-00278
EKS-CAJ-00283
EKS-CAF-00284
EKS-CAP-00313
EKS-EQC-00270
EKS-FEC-00263
EKS-GOG-00277
EKS-ICT-00262
EKS-LOA-00289
EKS-MAM-00280
EKS-MOD-00273
EKS-MUM-00308
EKS-MUP-00273
EKS-MYL-00281
EKS-NOL-00255
EKS-ORC-00263
EKS-OTG-00284
EKS-PAT-00262
EKS-PTV-00039
EKS-RAN-00292
EKS-SUS-00245
EKS-TAG-00293
EKS-TAS-00018
EKS-TUT-00036
EKS-VIP-00015
Gene Ontology
GO:0048179; C:activin receptor complex
GO:0016361; F:activin receptor activity, type I
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0038100; F:nodal binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0030154; P:cell differentiation
GO:0019915; P:lipid storage
GO:1901383; P:negative regulation of chorionic trophoblast cell proliferation
GO:0046676; P:negative regulation of insulin secretion
GO:1901164; P:negative regulation of trophoblast cell migration
GO:0038092; P:nodal signaling pathway
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002021; P:response to dietary excess
GO:0009749; P:response to glucose stimulus
GO:0032868; P:response to insulin stimulus
KEGG
hsa:130399;
InterPros
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013