Tag | Content |
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EKPD ID | EKS-HOS-00283 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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TKL/STKR | 453.9 | 1.1E-135 | 115 | 402 | 288 |
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Status | Reviewed |
Ensembl Protein | ENSP00000335178 |
UniProt Accession | Q8NER5; Q4ZFZ8; Q86UL1; Q86UL2; Q8TBG2; |
Protein Name | Activin receptor type-1C |
Protein Synonyms/Alias | Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7; |
Gene Name | ACVR1C |
Gene Synonyms/Alias | ACVR1C; ALK7; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Serine/threonine protein kinase which forms a receptorcomplex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. |
Protein Length | 413 |
Protein Sequence (FASTA) | MTRALCSALR QALLLLAAAA ELSPGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVI 60 | KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TGLPLLVQRT IARTIVLQEI 120 | VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL GFIAADNKDN 180 | GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMIKLALSIA SGLAHLHMEI VGTQGKPAIA 240 | HRDIKSKNIL VKKCETCAIA DLGLAVKHDS ILNTIDIPQN PKVGTKRYMA PEMLDDTMNV 300 | NIFESFKRAD IYSVGLVYWE IARRCSVGGI VEEYQLPYYD MVPSDPSIEE MRKVVCDQKF 360 | RPSIPNQWQS CEALRVMGRI MRECWYANGA ARLTALRIKK TISQLCVKED CKA 413 |
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Nucleotide Sequence (FASTA) | ATGACCCGGG CGCTCTGCTC AGCGCTCCGC CAGGCTCTCC TGCTGCTCGC AGCGGCCGCC 60 | GAGCTCTCGC CAGGACTGAA GTGTGTATGT CTTTTGTGTG ATTCTTCAAA CTTCACCTGC 120 | CAAACAGAAG GAGCATGTTG GGCATCAGTC ATGCTAACCA ATGGAAAAGA GCAGGTGATC 180 | AAATCCTGTG TCTCCCTTCC AGAACTGAAT GCTCAAGTCT TCTGTCATAG TTCCAACAAT 240 | GTTACCAAAA CCGAATGCTG CTTCACAGAT TTTTGCAACA ACATAACACT GCACCTTCCA 300 | ACAGGTCTAC CTCTGTTGGT TCAAAGGACA ATTGCAAGGA CGATTGTGCT TCAGGAAATA 360 | GTAGGAAAAG GTAGATTTGG TGAGGTGTGG CATGGAAGAT GGTGTGGGGA AGATGTGGCT 420 | GTGAAAATAT TCTCCTCCAG AGATGAAAGA TCTTGGTTTC GTGAGGCAGA AATTTACCAG 480 | ACGGTCATGC TGCGACATGA AAACATCCTT GGTTTCATTG CTGCTGACAA CAAAGATAAT 540 | GGAACTTGGA CTCAACTTTG GCTGGTATCT GAATATCATG AACAGGGCTC CTTATATGAC 600 | TATTTGAATA GAAATATAGT GACCGTGGCT GGAATGATCA AGCTGGCGCT CTCAATTGCT 660 | AGTGGTCTGG CACACCTTCA TATGGAGATT GTTGGTACAC AAGGTAAACC TGCTATTGCT 720 | CATCGAGACA TAAAATCAAA GAATATCTTA GTGAAAAAGT GTGAAACTTG TGCCATAGCG 780 | GACTTAGGGT TGGCTGTGAA GCATGATTCA ATACTGAACA CTATCGACAT ACCTCAGAAT 840 | CCTAAAGTGG GAACCAAGAG GTATATGGCT CCTGAAATGC TTGATGATAC AATGAATGTG 900 | AATATCTTTG AGTCCTTCAA ACGAGCTGAC ATCTATTCTG TTGGTCTGGT TTACTGGGAA 960 | ATAGCCCGGA GGTGTTCAGT CGGAGGAATT GTTGAGGAGT ACCAATTGCC TTATTATGAC 1020 | ATGGTGCCTT CAGATCCCTC GATAGAGGAA ATGAGAAAGG TTGTTTGTGA CCAGAAGTTT 1080 | CGACCAAGTA TCCCAAACCA GTGGCAAAGT TGTGAAGCAC TCCGAGTCAT GGGGAGAATA 1140 | ATGCGTGAGT GTTGGTATGC CAACGGAGCG GCCCGCCTAA CTGCTCTTCG TATTAAGAAG 1200 | ACTATATCTC AACTTTGTGT CAAAGAAGAC TGCAAAGCCT AA 1242 |
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Domain Profile | S: 1 lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia 60 | + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia | Q: 115 IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA 174 | 5789******************************************************** |
| S: 61 adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk 120 | ad+k+++++t+l+lv+eyhe+gsL+dyL+r++++v +++lals+asGlahLH+eivgt+ | Q: 175 ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQ 234 | ************************************************************ |
| S: 121 gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE 180 | g KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++ +++d+ +n +vGtkRYmaPE | Q: 235 G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPE 292 | *..********************************************************* |
| S: 181 vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem 240 | +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+ +++veey+lp++++v+sdPs+eem | Q: 293 MLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSIEEM 351 | **********************************9.************************ |
| S: 241 kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl 291 | ++vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++ | Q: 352 RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI 402 | ************************************************986 |
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Domain Sequence (FASTA) | IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60 | ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NIVTVAGMIK LALSIASGLA HLHMEIVGTQ 120 | GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSILNT IDIPQNPKVG TKRYMAPEML 180 | DDTMNVNIFE SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSIEEMRKV 240 | VCDQKFRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288 |
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Keyword | Alternative splicing; Apoptosis; ATP-binding; Complete proteome; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |