EKS-HOS-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/RIO	341.2	1.3E-101	181	397	217

Status

Reviewed

Ensembl Protein

ENSP00000369162

UniProt Accession

Q9BRS2; B2RB28; Q8NDC8; Q96NV9;

Protein Name

Serine/threonine-protein kinase RIO1

Protein Synonyms/Alias

RIO kinase 1;

Gene Name

RIOK1

Gene Synonyms/Alias

RIOK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000124784	ENSP00000369162	ENST00000379834
ENSG00000124784	ENSP00000418263	ENST00000475351

Organism

Homo sapiens

Functional Description

Protein Length

568

Protein Sequence
(FASTA)

MDYRRLLMSR VVPGQFDDAD SSDSENRDLK TVKEKDDILF EDLQDNVNEN GEGEIEDEEE 60

EGYDDDDDDW DWDEGVGKLA KGYVWNGGSN PQANRQTSDS SSAKMSTPAD KVLRKFENKI 120

NLDKLNVTDS VINKVTEKSR QKEADMYRIK DKADRATVEQ VLDPRTRMIL FKMLTRGIIT 180

EINGCISTGK EANVYHASTA NGESRAIKIY KTSILVFKDR DKYVSGEFRF RHGYCKGNPR 240

KMVKTWAEKE MRNLIRLNTA EIPCPEPIML RSHVLVMSFI GKDDMPAPLL KNVQLSESKA 300

RELYLQVIQY MRRMYQDARL VHADLSEFNM LYHGGGVYII DVSQSVEHDH PHALEFLRKD 360

CANVNDFFMR HSVAVMTVRE LFEFVTDPSI THENMDAYLS KAMEIASQRT KEERSSQDHV 420

DEEVFKRAYI PRTLNEVKNY ERDMDIIMKL KEEDMAMNAQ QDNILYQTVT GLKKDLSGVQ 480

KVPALLENQV EERTCSDSED IGSSECSDTD SEEQGDHARP KKHTTDPDID KKERKKMVKE 540

AQREKRKNKI PKHVKKRKEK TAKTKKGK 568

Nucleotide Sequence
(FASTA)

ATGGACTACC GGCGGCTTCT CATGAGCCGG GTGGTCCCCG GGCAATTCGA CGACGCGGAC 60

TCCTCTGACA GTGAAAACAG AGACTTGAAG ACAGTCAAAG AGAAGGATGA CATTCTGTTT 120

GAAGACCTTC AAGACAATGT GAATGAGAAT GGTGAAGGTG AAATAGAAGA TGAGGAGGAG 180

GAGGGTTATG ACGATGATGA TGATGACTGG GACTGGGATG AAGGAGTTGG AAAACTCGCC 240

AAGGGTTATG TCTGGAATGG AGGAAGCAAC CCACAGGCAA ATCGACAGAC CTCCGACAGC 300

AGTTCAGCCA AAATGTCTAC TCCAGCAGAC AAGGTCTTAC GGAAATTTGA GAATAAAATT 360

AATTTAGATA AGCTAAATGT TACTGATTCC GTCATAAATA AAGTCACCGA AAAGTCTAGA 420

CAAAAGGAAG CAGATATGTA TCGCATCAAA GATAAGGCAG ACAGAGCAAC TGTAGAACAG 480

GTGTTGGATC CCAGAACAAG AATGATTTTA TTCAAGATGT TGACTAGAGG AATCATAACA 540

GAGATAAATG GCTGCATTAG CACAGGAAAA GAAGCTAATG TATACCATGC TAGCACAGCA 600

AATGGAGAGA GCAGAGCAAT CAAAATTTAT AAAACTTCTA TTTTGGTGTT CAAAGATCGG 660

GATAAATATG TAAGTGGAGA ATTCAGATTT CGTCATGGCT ATTGTAAAGG AAACCCTAGG 720

AAAATGGTGA AAACTTGGGC AGAAAAAGAA ATGAGGAACT TAATCAGGCT AAACACAGCA 780

GAGATACCAT GTCCAGAACC AATAATGCTA AGAAGTCATG TTCTTGTCAT GAGTTTCATC 840

GGTAAAGATG ACATGCCTGC ACCACTCTTG AAAAATGTCC AGTTATCAGA ATCCAAGGCT 900

CGGGAGTTGT ACCTGCAGGT CATTCAGTAC ATGAGAAGAA TGTATCAGGA TGCCAGACTT 960

GTCCATGCAG ATCTCAGTGA ATTTAACATG CTGTACCACG GTGGAGGCGT GTATATCATT 1020

GACGTGTCTC AGTCCGTGGA GCACGACCAC CCACATGCCT TGGAGTTCTT GAGAAAGGAT 1080

TGCGCCAACG TCAATGATTT CTTTATGAGG CACAGTGTTG CTGTCATGAC TGTGCGGGAG 1140

CTCTTTGAAT TTGTCACAGA TCCATCCATT ACACATGAGA ACATGGATGC TTATCTCTCA 1200

AAGGCCATGG AAATAGCATC TCAAAGGACC AAGGAAGAAC GGTCTAGCCA AGATCATGTG 1260

GATGAAGAGG TGTTTAAGCG AGCATATATT CCTAGAACCT TGAATGAAGT GAAAAATTAT 1320

GAGAGGGATA TGGACATAAT TATGAAATTG AAGGAAGAGG ACATGGCCAT GAATGCCCAA 1380

CAAGATAATA TTCTATACCA GACTGTTACA GGATTGAAGA AAGATTTGTC AGGAGTTCAG 1440

AAGGTCCCTG CACTCCTAGA AAATCAAGTG GAGGAAAGGA CTTGTTCTGA TTCAGAAGAT 1500

ATTGGAAGCT CTGAGTGCTC TGACACAGAC TCTGAAGAGC AGGGAGACCA TGCCCGCCCC 1560

AAGAAACACA CCACGGACCC TGACATTGAT AAAAAAGAAA GAAAAAAGAT GGTCAAGGAA 1620

GCCCAGAGAG AGAAAAGAAA AAACAAAATT CCTAAACATG TGAAAAAAAG AAAGGAGAAG 1680

ACAGCCAAGA CGAAAAAAGG CAAATAG 1707

Domain Profile

S: 2     svgntigvgkesdvykvsekngeeraiKiyktsllvlknrdkYvdgefrfkksrskanpr  61

         +++++i++gke++vy++s++nge+raiKiykts+lv+k+rdkYv+gefrf+++++k npr

Q: 181   EINGCISTGKEANVYHASTANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPR  240

         699*********************************************************

S: 62    klsrlwAeKEfrnlkrlyekgvpvPepidlkrhvlvmeligrdgypapklkdvklkeeei  121

         k++++wAeKE+rnl+rl+++++p+Pepi+l++hvlvm++ig+d++pap lk+v+l+e+++

Q: 241   KMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKA  300

         ************************************************************

S: 122   kelYsdllalivklynegrLvHaDlsEfnilleddklvliDvsqsveieHpdaleflrrD  181

         +elY +++++++++y+++rLvHaDlsEfn+l++ +++++iDvsqsve++Hp+aleflr+D

Q: 301   RELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEFLRKD  360

         ************************************************************

S: 182   vknvkefFkkklvydvlrerelfelvsasgltkekead  219

         ++nv++fF++++v +v+++relfe+v++ ++t+e+++

Q: 361   CANVNDFFMRHSV-AVMTVRELFEFVTDPSITHENMDA  397

         *************.*********************985

Domain Sequence
(FASTA)

EINGCISTGK EANVYHASTA NGESRAIKIY KTSILVFKDR DKYVSGEFRF RHGYCKGNPR 60

KMVKTWAEKE MRNLIRLNTA EIPCPEPIML RSHVLVMSFI GKDDMPAPLL KNVQLSESKA 120

RELYLQVIQY MRRMYQDARL VHADLSEFNM LYHGGGVYII DVSQSVEHDH PHALEFLRKD 180

CANVNDFFMR HSVAVMTVRE LFEFVTDPSI THENMDA 217

Keyword

ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>