EKS-HOS-00380

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00380

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	388.7	5.3E-116	231	480	250

Status

Reviewed

Ensembl Protein

ENSP00000217188

UniProt Accession

Q9H3Y6;

Protein Name

Tyrosine-protein kinase Srms

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS; C20orf148;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000125508	ENSP00000217188	ENST00000217188

Organism

Homo sapiens

Functional Description

May be involved in proliferation or differentiation ofkeratinocytes in the skin (By similarity).

Protein Length

488

Protein Sequence
(FASTA)

MEPFLRRRLA FLSFFWDKIW PAGGEPDHGT PGSLDPNTDP VPTLPAEPCS PFPQLFLALY 60

DFTARCGGEL SVRRGDRLCA LEEGGGYIFA RRLSGQPSAG LVPITHVAKA SPETLSDQPW 120

YFSGVSRTQA QQLLLSPPNE PGAFLIRPSE SSLGGYSLSV RAQAKVCHYR VSMAADGSLY 180

LQKGRLFPGL EELLTYYKAN WKLIQNPLLQ PCMPQKAPRQ DVWERPHSEF ALGRKLGEGY 240

FGEVWEGLWL GSLPVAIKVI KSANMKLTDL AKEIQTLKGL RHERLIRLHA VCSGGEPVYI 300

VTELMRKGNL QAFLGTPEGR ALRLPPLLGF ACQVAEGMSY LEEQRVVHRD LAARNVLVDD 360

GLACKVADFG LARLLKDDIY SPSSSSKIPV KWTAPEAANY RVFSQKSDVW SFGVLLHEVF 420

TYGQCPYEGM TNHETLQQIM RGYRLPRPAA CPAEVYVLML ECWRSSPEER PSFATLREKL 480

HAIHRCHP 488

Nucleotide Sequence
(FASTA)

ATGGAGCCGT TCCTCAGGAG GCGGCTGGCC TTCCTGTCCT TCTTCTGGGA CAAGATCTGG 60

CCGGCGGGCG GCGAGCCGGA CCATGGCACC CCCGGGTCCC TGGACCCCAA CACTGACCCA 120

GTGCCCACGC TCCCCGCCGA GCCTTGCAGC CCCTTCCCTC AGCTCTTCCT TGCGCTCTAT 180

GACTTCACGG CGCGGTGTGG CGGGGAGCTG AGTGTCCGCC GCGGGGACAG GCTCTGTGCC 240

CTCGAAGAGG GGGGCGGCTA CATCTTCGCA CGCAGGCTTT CGGGCCAGCC CAGCGCCGGG 300

CTCGTGCCCA TCACCCACGT GGCCAAGGCT TCTCCTGAGA CGCTCTCAGA CCAACCCTGG 360

TACTTTAGCG GGGTCAGTCG GACCCAGGCA CAGCAGCTGC TCCTCTCCCC ACCCAACGAA 420

CCAGGGGCCT TCCTCATCCG GCCCAGCGAG AGCAGCCTCG GGGGCTACTC ACTGTCAGTC 480

CGGGCCCAGG CCAAGGTCTG CCACTACCGG GTCTCCATGG CAGCTGATGG CAGCCTCTAC 540

CTGCAGAAGG GACGGCTCTT TCCCGGCCTG GAGGAGCTGC TCACCTACTA CAAGGCCAAC 600

TGGAAGCTGA TCCAGAACCC CCTGCTGCAG CCCTGCATGC CCCAGAAGGC CCCGAGGCAG 660

GACGTGTGGG AGCGGCCACA CTCCGAATTC GCCCTTGGGA GGAAGCTGGG TGAAGGCTAC 720

TTTGGGGAGG TGTGGGAAGG CCTGTGGCTG GGCTCCCTGC CCGTGGCGAT CAAGGTCATC 780

AAGTCAGCCA ACATGAAGCT CACTGACCTC GCCAAGGAGA TCCAGACACT GAAGGGCCTG 840

CGGCACGAGC GGCTCATCCG GCTGCACGCA GTGTGCTCGG GCGGGGAGCC TGTGTACATC 900

GTCACGGAAC TCATGCGCAA GGGGAACCTG CAGGCCTTCC TGGGCACCCC CGAGGGCCGG 960

GCCCTGCGTC TGCCGCCACT CCTGGGCTTT GCCTGCCAGG TGGCTGAGGG CATGAGCTAC 1020

CTGGAGGAGC AGCGCGTTGT GCACCGGGAC TTGGCCGCCC GGAACGTGCT CGTGGACGAC 1080

GGCCTGGCCT GCAAGGTGGC TGACTTCGGC CTGGCCCGGC TGCTCAAGGA CGACATCTAC 1140

TCCCCGAGCA GCAGCTCCAA GATCCCGGTC AAGTGGACAG CGCCTGAGGC GGCCAATTAT 1200

CGTGTCTTCT CCCAGAAGTC AGACGTCTGG TCCTTCGGCG TCCTGCTGCA CGAGGTTTTC 1260

ACCTATGGCC AGTGTCCCTA TGAAGGGATG ACCAACCACG AGACGCTGCA GCAGATCATG 1320

CGAGGGTACC GGCTGCCGCG CCCGGCTGCC TGCCCGGCGG AGGTCTACGT GCTCATGCTG 1380

GAGTGCTGGA GGAGCAGCCC CGAGGAACGG CCCTCCTTCG CCACGCTGCG GGAGAAGCTG 1440

CACGCCATCC ACAGATGCCA CCCCTGA 1467

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

          l +klGeG+fGevw+g+w gs++va+k++k+++++ +++ +e+q+lk lrhe+l++l+a

Q: 231   ALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHA  290

         5789********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s +eP+yivtelm+kG+l++fl + eg++l+lp l+ +a+qvaeGm+ylee++++hrd

Q: 291   VCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRD  350

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarnvlv++ l++kvadfGlarl++dd+y++++++k+P+kWtaPea+++++f++ksdvW

Q: 351   LAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVW  410

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfG+ll+e++t+G++Py+Gmtn+e+l+q+ rgyrlprp++cp+e+y l+lecw+++peer

Q: 411   SFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEER  470

         ************************************************************

S: 242   Ptfetlqevl  251

         P+f tl+e+l

Q: 471   PSFATLREKL  480

         ******9876

Domain Sequence
(FASTA)

ALGRKLGEGY FGEVWEGLWL GSLPVAIKVI KSANMKLTDL AKEIQTLKGL RHERLIRLHA 60

VCSGGEPVYI VTELMRKGNL QAFLGTPEGR ALRLPPLLGF ACQVAEGMSY LEEQRVVHRD 120

LAARNVLVDD GLACKVADFG LARLLKDDIY SPSSSSKIPV KWTAPEAANY RVFSQKSDVW 180

SFGVLLHEVF TYGQCPYEGM TNHETLQQIM RGYRLPRPAA CPAEVYVLML ECWRSSPEER 240

PSFATLREKL 250

Keyword

Acetylation; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity

KEGG

hsa:6725

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013