| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00491 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/CAMK1 | 420.2 | 1.5E-125 | 15 | 270 | 256 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000340586 |
| UniProt Accession | Q6P2M8; B4DJR8; B4E1A6; B7WPG0; D3DWU7; Q8N4R0; |
| Protein Name | Calcium/calmodulin-dependent protein kinase type 1B |
| Protein Synonyms/Alias | CaM kinase I beta; CaM kinase IB; CaM-KI beta; CaMKI-beta; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase; |
| Gene Name | PNCK |
| Gene Synonyms/Alias | PNCK; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Calcium/calmodulin-dependent protein kinase belonging toa proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity). |
| Protein Length | 343 |
Protein Sequence
(FASTA) | | MLLLKKHTED ISSVYEIRER LGSGAFSEVV LAQERGSAHL VALKCIPKKA LRGKEALVEN 60 | | EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD RIMERGSYTE KDASHLVGQV 120 | | LGAVSYLHSL GIVHRDLKPE NLLYATPFED SKIMVSDFGL SKIQAGNMLG TACGTPGYVA 180 | | PELLEQKPYG KAVDVWALGV ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS 240 | | ESAKDFIRHL LERDPQKRFT CQQALRHLWI SGDTAFDRDI LGSVSEQIRK NFARTHWKRA 300 | | FNATSFLRHI RKLGQIPEGE GASEQGMARH SHSGLRAGQP PKW 343 |
|
Nucleotide Sequence
(FASTA) | | ATGCTGCTGC TGAAGAAACA CACGGAGGAC ATCAGCAGCG TCTACGAGAT CCGCGAGAGG 60 | | CTCGGCTCGG GTGCCTTCTC CGAGGTGGTG CTGGCCCAGG AGCGGGGCTC CGCACACCTC 120 | | GTGGCCCTCA AGTGCATCCC CAAGAAGGCC CTCCGGGGCA AGGAGGCCCT GGTGGAGAAC 180 | | GAGATCGCAG TGCTCCGTAG GATCAGTCAC CCCAACATCG TCGCTCTGGA GGATGTCCAC 240 | | GAGAGCCCTT CCCACCTCTA CCTGGCCATG GAACTGGTGA CGGGTGGCGA GCTGTTTGAC 300 | | CGCATCATGG AGCGCGGCTC CTACACAGAG AAGGATGCCA GCCATCTGGT GGGTCAGGTC 360 | | CTTGGCGCCG TCTCCTACCT GCACAGCCTG GGGATCGTGC ACCGGGACCT CAAGCCCGAA 420 | | AACCTCCTGT ATGCCACGCC CTTTGAGGAC TCGAAGATCA TGGTCTCTGA CTTTGGACTC 480 | | TCCAAAATCC AGGCTGGGAA CATGCTAGGC ACCGCCTGTG GGACCCCTGG ATATGTGGCC 540 | | CCAGAGCTCT TGGAGCAGAA ACCCTACGGG AAGGCCGTAG ATGTGTGGGC CCTGGGCGTC 600 | | ATCTCCTACA TCCTGCTGTG TGGGTACCCC CCCTTCTACG ACGAGAGCGA CCCTGAGCTC 660 | | TTCAGCCAGA TCCTGAGGGC CAGCTATGAG TTTGACTCTC CTTTCTGGGA TGACATCTCA 720 | | GAATCAGCCA AAGACTTCAT CCGGCACCTT CTGGAGCGAG ACCCCCAGAA GAGGTTCACC 780 | | TGCCAACAGG CCTTGCGGCA CCTTTGGATC TCTGGGGACA CAGCCTTCGA CAGGGACATC 840 | | TTAGGCTCTG TCAGTGAGCA GATCCGGAAG AACTTTGCTC GGACACACTG GAAGCGAGCC 900 | | TTCAATGCCA CCTCGTTCCT GCGCCACATC CGGAAGCTGG GGCAGATCCC AGAGGGCGAG 960 | | GGGGCCTCTG AGCAGGGCAT GGCCCGCCAC AGCCACTCAG GCCTCCGTGC TGGCCAGCCC 1020 | | CCCAAGTGGT GA 1032 |
|
| Domain Profile | S: 1 yklkeklGeGafsevlkakekktqkavaikvikkkalkgkeesveneiavlkklkhpniv 60 | y+++e+lG+Gafsev++a+e+ +++ va+k+i kkal+gke+ veneiavl++++hpniv | Q: 15 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIV 74 | 899********************************************************* |
| S: 61 alkdiyesksklylvlelvtGGelfdrivekgvytekdasevikqvleavkylhelgivh 120 | al+d++es+s+lyl +elvtGGelfdri+e+g+ytekdas+++ qvl av+ylh+lgivh | Q: 75 ALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVH 134 | ************************************************************ |
| S: 121 rdlkPenllylskeedskikiadfGlskleekellktacGtvgyvapevlkqkkyskkvd 180 | rdlkPenlly+++ edski+++dfGlsk++ ++l tacGt+gyvape+l+qk+y+k+vd | Q: 135 RDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVD 194 | ************************************************************ |
| S: 181 vWsiGvityillcGyppfydekeekllekilkgeyefesPyWdeisesakdfikklleld 240 | vW++Gvi+yillcGyppfyde++ +l+++il+++yef+sP+Wd+isesakdfi++lle+d | Q: 195 VWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERD 254 | ************************************************************ |
| S: 241 pekrytieqaledpWi 256 | p+kr+t++qal++ Wi | Q: 255 PQKRFTCQQALRHLWI 270 | ***************8 |
|
Domain Sequence
(FASTA) | | YEIRERLGSG AFSEVVLAQE RGSAHLVALK CIPKKALRGK EALVENEIAV LRRISHPNIV 60 | | ALEDVHESPS HLYLAMELVT GGELFDRIME RGSYTEKDAS HLVGQVLGAV SYLHSLGIVH 120 | | RDLKPENLLY ATPFEDSKIM VSDFGLSKIQ AGNMLGTACG TPGYVAPELL EQKPYGKAVD 180 | | VWALGVISYI LLCGYPPFYD ESDPELFSQI LRASYEFDSP FWDDISESAK DFIRHLLERD 240 | | PQKRFTCQQA LRHLWI 256 |
|
| Keyword | Alternative splicing; ATP-binding; Calcium; Calmodulin-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |