EPS-HOS-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	238.3	5.8E-70	112	388	277

Status

Reviewed

Ensembl Protein

ENSP00000254654

UniProt Accession

Q9H0C8; B3KM39;

Protein Name

Integrin-linked kinase-associated serine/threonine phosphatase 2C

Protein Synonyms/Alias

ILKAP;

Gene Name

ILKAP

Gene Synonyms/Alias

ILKAP;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000132323	ENSP00000395301	ENST00000457149
ENSG00000132323	ENSP00000406254	ENST00000450411
ENSG00000132323	ENSP00000254654	ENST00000254654

Organism

Homo sapiens

Functional Description

Protein phosphatase that may play a role in regulationof cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

Protein Length

392

Protein Sequence
(FASTA)

MDLFGDLPEP ERSPRPAAGK EAQKGPLLFD DLPPASSTDS GSGGPLLFDD LPPASSGDSG 60

SLATSISQMV KTEGKGAKRK TSEEEKNGSE ELVEKKVCKA SSVIFGLKGY VAERKGEREE 120

MQDAHVILND ITEECRPPSS LITRVSYFAV FDGHGGIRAS KFAAQNLHQN LIRKFPKGDV 180

ISVEKTVKRC LLDTFKHTDE EFLKQASSQK PAWKDGSTAT CVLAVDNILY IANLGDSRAI 240

LCRYNEESQK HAALSLSKEH NPTQYEERMR IQKAGGNVRD GRVLGVLEVS RSIGDGQYKR 300

CGVTSVPDIR RCQLTPNDRF ILLACDGLFK VFTPEEAVNF ILSCLEDEKI QTREGKSAAD 360

ARYEAACNRL ANKAVQRGSA DNVTVMVVRI GH 392

Nucleotide Sequence
(FASTA)

ATGGACCTCT TCGGGGACCT GCCGGAGCCC GAGCGCTCGC CGCGCCCGGC TGCCGGGAAA 60

GAAGCTCAGA AAGGACCCCT GCTCTTTGAT GACCTCCCTC CGGCCAGCAG TACTGACTCA 120

GGATCAGGGG GACCTTTGCT TTTTGATGAT CTCCCACCCG CTAGCAGTGG CGATTCAGGT 180

TCTCTTGCCA CATCAATATC CCAGATGGTA AAGACTGAAG GGAAAGGAGC AAAGAGAAAA 240

ACCTCCGAGG AAGAGAAGAA TGGCAGTGAA GAGCTTGTGG AAAAGAAAGT TTGTAAAGCC 300

TCTTCGGTGA TCTTTGGTCT GAAGGGCTAT GTGGCTGAGC GGAAGGGTGA GAGGGAGGAG 360

ATGCAGGATG CCCACGTCAT CCTGAACGAC ATCACCGAGG AGTGTAGGCC CCCATCGTCC 420

CTCATTACTC GGGTTTCATA TTTTGCTGTT TTTGATGGAC ATGGAGGAAT TCGAGCCTCA 480

AAATTTGCTG CACAGAATTT GCATCAAAAC TTAATCAGAA AATTTCCTAA AGGAGATGTA 540

ATCAGTGTAG AGAAAACCGT GAAGAGATGC CTTTTGGACA CTTTCAAGCA TACTGATGAA 600

GAGTTCCTTA AACAAGCTTC CAGCCAGAAG CCTGCCTGGA AAGATGGGTC CACTGCCACG 660

TGTGTTCTGG CTGTAGACAA CATTCTTTAT ATTGCCAACC TCGGAGATAG TCGGGCAATC 720

TTGTGTCGTT ATAATGAGGA GAGTCAAAAA CATGCAGCCT TAAGCCTCAG CAAAGAGCAT 780

AATCCAACTC AGTATGAAGA GCGGATGAGG ATACAGAAGG CTGGAGGAAA CGTCAGGGAT 840

GGGCGTGTTT TGGGCGTGCT AGAGGTGTCA CGCTCCATTG GGGACGGGCA GTACAAGCGC 900

TGCGGTGTCA CCTCTGTGCC CGACATCAGA CGCTGCCAGC TGACCCCCAA TGACAGGTTC 960

ATTTTGTTGG CCTGTGATGG GCTCTTCAAG GTCTTTACCC CAGAAGAAGC CGTGAACTTC 1020

ATCTTGTCCT GTCTCGAGGA TGAAAAGATC CAGACCCGGG AAGGGAAGTC CGCAGCCGAC 1080

GCCCGCTACG AAGCAGCCTG CAACAGGCTG GCCAACAAGG CGGTGCAGCG GGGCTCGGCC 1140

GACAACGTCA CTGTGATGGT GGTGCGGATA GGGCACTGA 1179

Domain Profile

S: 6     vsvngrrnemedavtsspnflkspekkdr....laffgvyDGhggsevakfcseklheil  61

         ++ +g+r+em+da+ + +++ +++   +     +++f+v+DGhgg +++kf++++lh+ l

Q: 112   AERKGEREEMQDAHVILNDITEECRPPSSlitrVSYFAVFDGHGGIRASKFAAQNLHQNL  171

         567899**************9998887778899***************************

S: 62    aeele..sseseerkvkkalakaFlstdeelkvleeksldidk..sGstavvalikdskl  117

          +++   +  s e+ vk++l ++F++tdee+  l+++s+++ +   Gsta+++l  d+ l

Q: 172   IRKFPkgDVISVEKTVKRCLLDTFKHTDEEF--LKQASSQKPAwkDGSTATCVLAVDNIL  229

         ***9977788999******************..666666655577***************

S: 118   yvanvGdSravLcr.ngk.....avelssdHkpsredEleRieeaggsvilkdgaRvlGv  171

         y+an+GdSra+Lcr n++     a++ls++H+p++ +E+ Ri++agg+v +    RvlGv

Q: 230   YIANLGDSRAILCRyNEEsqkhaALSLSKEHNPTQYEERMRIQKAGGNVRDG---RVLGV  286

         **************7666799*****************************99...*****

S: 172   LavsRalGdlylk.pyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle  230

         L+vsR++Gd+++k   vt+ P++  ++lt++d+f+ La+DGl++v+++eeav+++ ++le

Q: 287   LEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLE  346

         *************555********************************************

S: 231   ............kkeaeqeaakkLvklalargskdnvsaivv  260

                      +++ ++a+++L++ a++rgs dnv+++vv

Q: 347   dekiqtregksaADARYEAACNRLANKAVQRGSADNVTVMVV  388

         ************9*************************9997

Domain Sequence
(FASTA)

AERKGEREEM QDAHVILNDI TEECRPPSSL ITRVSYFAVF DGHGGIRASK FAAQNLHQNL 60

IRKFPKGDVI SVEKTVKRCL LDTFKHTDEE FLKQASSQKP AWKDGSTATC VLAVDNILYI 120

ANLGDSRAIL CRYNEESQKH AALSLSKEHN PTQYEERMRI QKAGGNVRDG RVLGVLEVSR 180

SIGDGQYKRC GVTSVPDIRR CQLTPNDRFI LLACDGLFKV FTPEEAVNFI LSCLEDEKIQ 240

TREGKSAADA RYEAACNRLA NKAVQRGSAD NVTVMVV 277

Keyword

Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0045786	; P:negative regulation of cell cycle
GO:0006470	; P:protein dephosphorylation
GO:0007090	; P:regulation of S phase of mitotic cell cycle

KEGG

hsa:80895

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013