EKS-HOS-00140

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00140

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/ABC1	327.0	6.5E-97	307	613	307

Status

Reviewed

Ensembl Protein

ENSP00000072869

UniProt Accession

Q7Z695; Q96CN6; Q9Y6T5;

Protein Name

Uncharacterized aarF domain-containing protein kinase 2

Protein Synonyms/Alias

Gene Name

ADCK2

Gene Synonyms/Alias

ADCK2; AARF;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000133597	ENSP00000072869	ENST00000072869
ENSG00000133597	ENSP00000417367	ENST00000483369
ENSG00000133597	ENSP00000420512	ENST00000476491
ENSG00000133597	ENSP00000420288	ENST00000473512

Organism

Homo sapiens

Functional Description

The function of this protein is not yet clear. It is notknown if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Protein Length

626

Protein Sequence
(FASTA)

MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV VSLCGDVGEG 60

APDVLSRRRV RCSGAAGAGP AESLPRAGPL GGVFLHLRLW LRAGALLVKF FPLLLLYPLT 120

YLAPSVSTLW LHLLLKATET SGPTYIKLGQ WASTRRDLFS EAFCAQFSKL HVRVTPHPWT 180

HTERFLRQAF GDDWGSILSF ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP 240

FSHTGAVGGL RELFGYLGNG RKPPENLADQ SFLERLLLPK ADLVGSNAGV SRAQVPGHQP 300

EATNLISVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGVLPG IKWLSLPEIV EEFEKLMVQQ 360

IDLRYEAQNL EHFQVNFRNV KAVKFPTPLR PFVTREVLVE TYEESVPVSS YQQAGIPVDL 420

KRKIARLGIN MLLKMIFVDN FVHADLHPGN ILVQGANGLS SSQEAQLQQA DICDTLVVAV 480

PSSLCPLRLV LLDAGIVAEL QAPDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE 540

GFKTEMAMLV TQARKNTITL EKLHVSSLLS SVFKLLMTHK VKLESNFASI VFAIMVLEGL 600

GRSLDPKLDI LEAARPFLLT GPVCPP 626

Nucleotide Sequence
(FASTA)

ATGGTGGCGC CCTGGCGCGT CTCCGTCAGG GTTTGCCTGT CGCACCTGAG GTGCTTCGAG 60

CTCAGACAGG GACTCAGCCT CCTGAGGCCC TCCGAGTGCC CTCGCGATGC CAGGCTCTGC 120

TGGCTTCTGC TGGGCACTTT GCCCAAGGTC GTCTCCCTGT GCGGGGACGT GGGTGAGGGG 180

GCCCCTGACG TTCTGAGTCG GCGAAGGGTC CGCTGCAGCG GGGCGGCTGG CGCGGGGCCC 240

GCGGAGAGCC TCCCCCGAGC GGGACCTCTG GGCGGCGTCT TCCTGCATCT CCGCCTCTGG 300

CTTCGCGCCG GCGCTCTGTT GGTGAAATTC TTCCCCCTCC TACTCCTCTA CCCCCTCACC 360

TACCTGGCTC CCAGCGTCTC CACCCTCTGG CTCCACCTGC TTCTGAAAGC CACCGAGACC 420

TCAGGCCCAA CCTACATCAA ACTGGGCCAG TGGGCCAGCA CCCGGCGCGA TCTGTTTTCG 480

GAGGCTTTCT GTGCCCAATT TTCCAAGCTG CATGTCCGAG TGACGCCCCA CCCGTGGACT 540

CACACTGAGC GCTTCCTTCG GCAGGCTTTT GGGGATGACT GGGGGAGCAT CCTCTCTTTT 600

GAGAACCGGG AACCTGTGGG CTCAGGCTGC GTGGCCCAGG TGTACAAAGC ATACGCCAAC 660

ACTGCCTTCC TGGAGACTGA CAGCGTCCAG AGACTTGGCA GGGCCTCCTG TCTGCCGCCC 720

TTCTCACATA CTGGGGCAGT CGGTGGGCTG AGAGAGCTCT TTGGATACCT TGGAAATGGC 780

CGGAAACCTC CAGAAAATCT CGCAGACCAG TCGTTTCTAG AAAGGCTGCT CCTCCCTAAA 840

GCTGACCTGG TTGGATCAAA TGCAGGGGTG TCTCGGGCTC AGGTCCCTGG CCACCAACCT 900

GAGGCCACCA ACCTCATCTC CGTGGCAGTG AAAGTGTTGC ACCCTGGCCT GCTCGCTCAG 960

GTGCATATGG ACCTGCTGCT GATGAAGATT GGCAGCCGAG TCCTGGGAGT TTTGCCAGGC 1020

ATCAAGTGGC TTAGCTTGCC TGAGATTGTG GAGGAATTTG AGAAGCTGAT GGTCCAACAG 1080

ATTGACCTGC GTTACGAAGC TCAGAATCTA GAACACTTCC AGGTCAACTT CCGGAATGTG 1140

AAAGCCGTCA AGTTCCCCAC CCCTCTGCGC CCCTTTGTCA CCAGAGAAGT CTTGGTGGAA 1200

ACGTATGAAG AGAGTGTGCC TGTGTCCAGT TACCAGCAGG CAGGAATTCC CGTGGACTTG 1260

AAAAGGAAGA TTGCACGGCT GGGGATCAAC ATGCTCCTGA AGATGATATT TGTGGATAAC 1320

TTTGTCCATG CAGACCTTCA CCCTGGAAAC ATCCTGGTTC AGGGTGCCAA CGGCCTGTCC 1380

TCGAGTCAGG AGGCGCAGCT GCAGCAGGCG GACATCTGTG ACACTCTGGT GGTGGCCGTG 1440

CCATCTTCCC TCTGCCCGCT GCGACTGGTG CTGCTGGATG CTGGCATTGT GGCGGAGCTG 1500

CAGGCCCCTG ACCTGAGGAA TTTCCGGGCA GTTTTCATGG CTGTGGTGAT GGGGCAGGGC 1560

CAGAGAGTGG CTGAGCTGAT CCTGCATCAT GCCCGGGCCA GCGAGTGCAG GGACGTGGAG 1620

GGGTTCAAAA CCGAGATGGC CATGCTGGTG ACCCAGGCCA GGAAGAACAC CATCACCCTG 1680

GAGAAGCTTC ATGTGTCCAG CCTTCTCTCT AGTGTCTTTA AGTTGCTGAT GACTCACAAG 1740

GTAAAGCTTG AGAGCAACTT TGCCTCCATT GTGTTTGCCA TCATGGTGTT GGAGGGGCTT 1800

GGCCGCTCAC TGGACCCCAA ACTGGACATC CTGGAGGCAG CGAGGCCCTT CCTCCTCACG 1860

GGCCCAGTGT GCCCCCCGTG A 1881

Domain Profile

S: 23    eVAVKvqypgvkesidsDlktlelllkvlevlf..kdlklewlvdelkkeLaleldferE  80

         +VAVKv++pg+ +++++Dl +++++++vl+vl+  k+l+l+++v+e++k +++++d+++E

Q: 307   SVAVKVLHPGLLAQVHMDLLLMKIGSRVLGVLPgiKWLSLPEIVEEFEKLMVQQIDLRYE  366

         7***********************************************************

S: 81    arnaekfrkllkkfkalkvPkvleelstkrvLtmelvegvpvddleyiessqilrneiae  140

         a+n+e+f+ +++++ka+k+P++l++++t++vL+++++e+vpv+++++++++++l+++ia+

Q: 367   AQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPVSSYQQAGIPVDLKRKIAR  426

         ************************************************************

S: 141   kliklllkeifvdnfvhtDphpgNvlvq.....ksskegkle..................  177

          +i++llk+ifvdnfvh+D+hpgN+lvq     +ss+e++l+

Q: 427   LGINMLLKMIFVDNFVHADLHPGNILVQganglSSSQEAQLQqadicdtlvvavpsslcp  486

         ****************************99999999999999******************

S: 178   ..lvLLDfGlsrelsekfrrlyikllkavvdrDrkkvkkksqrlaeltgeeaklladalv  235

           lvLLD+G+++el+++++r+++++++avv       ++++qr+ael++++a+++++++v

Q: 487   lrLVLLDAGIVAELQAPDLRNFRAVFMAVV-------MGQGQRVAELILHHARASECRDV  539

         ***************************999.......***********************

S: 236   ervltlgeafasqarkeveeleklaverlessllkllmevlvklprevllilktidllrg  295

         e+++t+++++++qark++++lekl+v++l ss++kllm+++vkl++++++i+++i++l+g

Q: 540   EGFKTEMAMLVTQARKNTITLEKLHVSSLLSSVFKLLMTHKVKLESNFASIVFAIMVLEG  599

         ************************************************************

S: 296   ieeaLkakldilel  309

         ++++L++kldile+

Q: 600   LGRSLDPKLDILEA  613

         **********9886

Domain Sequence
(FASTA)

SVAVKVLHPG LLAQVHMDLL LMKIGSRVLG VLPGIKWLSL PEIVEEFEKL MVQQIDLRYE 60

AQNLEHFQVN FRNVKAVKFP TPLRPFVTRE VLVETYEESV PVSSYQQAGI PVDLKRKIAR 120

LGINMLLKMI FVDNFVHADL HPGNILVQGA NGLSSSQEAQ LQQADICDTL VVAVPSSLCP 180

LRLVLLDAGI VAELQAPDLR NFRAVFMAVV MGQGQRVAEL ILHHARASEC RDVEGFKTEM 240

AMLVTQARKN TITLEKLHVS SLLSSVFKLL MTHKVKLESN FASIVFAIMV LEGLGRSLDP 300

KLDILEA 307

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>