| Tag | Content |
|---|
| EKPD ID | EPS-HOS-00003 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| DSP/aDSP | 193.8 | 6.6E-57 | 62 | 205 | 144 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000256261 |
| UniProt Accession | Q9BV47; D3DSV8; Q9BTW0; |
| Protein Name | Dual specificity protein phosphatase 26 |
| Protein Synonyms/Alias | Dual specificity phosphatase SKRP3; Low-molecular-mass dual-specificity phosphatase 4; DSP-4; LDP-4; Mitogen-activated protein kinase phosphatase 8; MAP kinase phosphatase 8; MKP-8; Novel amplified gene in thyroid anaplastic cancer; |
| Gene Name | DUSP26 |
| Gene Synonyms/Alias | DUSP26; DUSP24, LDP4, MKP8, NATA1, SKRP3; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Inactivates MAPK1 and MAPK3 which leads todephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). |
| Protein Length | 211 |
Protein Sequence
(FASTA) | | MCPGNWLWAS MTFMARFSRS SSRSPVRTRG TLEEMPTVQH PFLNVFELER LLYTGKTACN 60 | | HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR GTPEAYEGLG IRYLGVEAHD 120 | | SPAFDMSIHF QTAADFIHRA LSQPGGKILV HCAVGVSRSA TLVLAYLMLY HHLTLVEAIK 180 | | KVKDHRGIIP NRGFLRQLLA LDRRLRQGLE A 211 |
|
Nucleotide Sequence
(FASTA) | | ATGTGCCCTG GTAACTGGCT TTGGGCTTCT ATGACTTTTA TGGCCCGCTT CTCCCGGAGT 60 | | AGCTCAAGGT CTCCTGTTCG AACTCGAGGG ACCCTGGAGG AGATGCCAAC CGTTCAACAT 120 | | CCTTTCCTCA ATGTCTTCGA GTTGGAGCGG CTCCTCTACA CAGGCAAGAC AGCCTGTAAC 180 | | CATGCCGACG AGGTCTGGCC AGGCCTCTAT CTCGGAGACC AGGACATGGC TAACAACCGC 240 | | CGGGAGCTTC GCCGCCTGGG CATCACGCAC GTCCTCAATG CCTCACACAG CCGGTGGCGA 300 | | GGCACGCCCG AGGCCTATGA GGGGCTGGGC ATCCGCTACC TGGGTGTTGA GGCCCACGAC 360 | | TCGCCAGCCT TTGACATGAG CATCCACTTC CAGACGGCTG CCGACTTCAT CCACCGGGCG 420 | | CTGAGCCAGC CAGGAGGGAA GATCCTGGTG CATTGTGCTG TGGGCGTGAG CCGATCCGCC 480 | | ACCCTGGTAC TGGCCTACCT CATGCTGTAC CACCACCTTA CCCTCGTGGA GGCCATCAAG 540 | | AAAGTCAAAG ACCACCGAGG CATCATCCCC AACCGGGGCT TCCTGAGGCA GCTCCTGGCC 600 | | CTGGACCGCA GGCTGCGGCA GGGTCTGGAA GCATGA 636 |
|
| Domain Profile | S: 2 vteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvd 61 | +e++pglylgdq++a++rreL++lgit+v+nas+s+++ ++Pe+++ gi+y++++++ | Q: 62 ADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWR--GTPEAYEGLGIRYLGVEAH 119 | 799************************************..******************* |
| S: 62 Dsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAi 120 | Ds+++d++ +f++aa+fi++a +++ggk+lvHCa+GvsRSatlvlaYLm +++l+l++Ai | Q: 120 DSPAFDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAI 179 | *********************9999*********************************** |
| S: 121 eavkrkrpsiepnegfleQLlelekkl 147 | ++vk++r i+pn+gfl+QLl+l+++l | Q: 180 KKVKDHR-GIIPNRGFLRQLLALDRRL 205 | *******.9***************997 |
|
Domain Sequence
(FASTA) | | ADEVWPGLYL GDQDMANNRR ELRRLGITHV LNASHSRWRG TPEAYEGLGI RYLGVEAHDS 60 | | PAFDMSIHFQ TAADFIHRAL SQPGGKILVH CAVGVSRSAT LVLAYLMLYH HLTLVEAIKK 120 | | VKDHRGIIPN RGFLRQLLAL DRRL 144 |
|
| Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Golgi apparatus; Hydrolase; Nucleus; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |