| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00489 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/CAMK1 | 441.5 | 5.0E-132 | 20 | 276 | 257 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000256460 |
| UniProt Accession | Q14012; Q3KPF6; |
| Protein Name | Calcium/calmodulin-dependent protein kinase type 1 |
| Protein Synonyms/Alias | CaM kinase I; CaM-KI; CaM kinase I alpha; CaMKI-alpha; |
| Gene Name | CAMK1 |
| Gene Synonyms/Alias | CAMK1; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser- 498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen- stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9, SYN1/synapsin I and SYNII/synapsin II. |
| Protein Length | 370 |
Protein Sequence
(FASTA) | | MLGAVEGPRW KQAEDIRDIY DFRDVLGTGA FSEVILAEDK RTQKLVAIKC IAKEALEGKE 60 | | GSMENEIAVL HKIKHPNIVA LDDIYESGGH LYLIMQLVSG GELFDRIVEK GFYTERDASR 120 | | LIFQVLDAVK YLHDLGIVHR DLKPENLLYY SLDEDSKIMI SDFGLSKMED PGSVLSTACG 180 | | TPGYVAPEVL AQKPYSKAVD CWSIGVIAYI LLCGYPPFYD ENDAKLFEQI LKAEYEFDSP 240 | | YWDDISDSAK DFIRHLMEKD PEKRFTCEQA LQHPWIAGDT ALDKNIHQSV SEQIKKNFAK 300 | | SKWKQAFNAT AVVRHMRKLQ LGTSQEGQGQ TASHGELLTP VAGGPAAGCC CRDCCVEPGT 360 | | ELSPTLPHQL 370 |
|
Nucleotide Sequence
(FASTA) | | ATGCTGGGGG CAGTGGAAGG CCCCAGGTGG AAGCAGGCGG AGGACATTAG AGACATCTAC 60 | | GACTTCCGAG ATGTTCTGGG CACGGGGGCC TTCTCGGAGG TGATCCTGGC AGAAGATAAG 120 | | AGGACGCAGA AGCTGGTGGC CATCAAATGC ATTGCCAAGG AGGCCCTGGA GGGCAAGGAA 180 | | GGCAGCATGG AGAATGAGAT TGCTGTCCTG CACAAGATCA AGCACCCCAA CATTGTAGCC 240 | | CTGGATGACA TCTATGAGAG TGGGGGCCAC CTCTACCTCA TCATGCAGCT GGTGTCGGGT 300 | | GGGGAGCTCT TTGACCGTAT TGTGGAAAAA GGCTTCTACA CGGAGCGGGA CGCCAGCCGC 360 | | CTCATCTTCC AGGTGCTGGA TGCTGTGAAA TACCTGCATG ACCTGGGCAT TGTACACCGG 420 | | GATCTCAAGC CAGAGAATCT GCTGTACTAC AGCCTGGATG AAGACTCCAA AATCATGATC 480 | | TCCGACTTTG GCCTCTCCAA GATGGAGGAC CCGGGCAGTG TGCTCTCCAC CGCCTGTGGA 540 | | ACTCCGGGAT ACGTGGCCCC TGAAGTCCTG GCCCAGAAGC CCTACAGCAA GGCTGTGGAT 600 | | TGCTGGTCCA TAGGTGTCAT CGCCTACATC TTGCTCTGCG GTTACCCTCC CTTCTATGAC 660 | | GAGAATGATG CCAAACTCTT TGAACAGATT TTGAAGGCCG AGTACGAGTT TGACTCTCCT 720 | | TACTGGGACG ACATCTCTGA CTCTGCCAAA GATTTCATCC GGCACTTGAT GGAGAAGGAC 780 | | CCAGAGAAAA GATTCACCTG TGAGCAGGCC TTGCAGCACC CATGGATTGC AGGAGATACA 840 | | GCTCTAGATA AGAATATCCA CCAGTCGGTG AGTGAGCAGA TCAAGAAGAA CTTTGCCAAG 900 | | AGCAAGTGGA AGCAAGCCTT CAATGCCACG GCTGTGGTGC GGCACATGAG GAAACTGCAG 960 | | CTGGGCACCA GCCAGGAGGG GCAGGGGCAG ACGGCGAGCC ATGGGGAGCT GCTGACACCA 1020 | | GTGGCTGGGG GGCCGGCAGC TGGCTGTTGC TGTCGAGACT GCTGCGTGGA GCCGGGCACA 1080 | | GAACTGTCCC CCACACTGCC CCACCAGCTC TAG 1113 |
|
| Domain Profile | S: 1 yklkeklGeGafsevlkakekktqkavaikvikkkalkgkeesveneiavlkklkhpniv 60 | y++++ lG+Gafsev++a++k+tqk vaik+i+k+al+gke s+eneiavl+k+khpniv | Q: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79 | 899********************************************************* |
| S: 61 alkdiyesksklylvlelvtGGelfdrivekgvytekdasevikqvleavkylhelgivh 120 | al+diyes +lyl+++lv+GGelfdrivekg+yte+das++i qvl+avkylh+lgivh | Q: 80 ALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVH 139 | ************************************************************ |
| S: 121 rdlkPenllylskeedskikiadfGlskleeke.llktacGtvgyvapevlkqkkyskkv 179 | rdlkPenlly+s +edski+i+dfGlsk+e+ + +l+tacGt+gyvapevl+qk+ysk+v | Q: 140 RDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGsVLSTACGTPGYVAPEVLAQKPYSKAV 199 | ********************************99************************** |
| S: 180 dvWsiGvityillcGyppfydekeekllekilkgeyefesPyWdeisesakdfikkllel 239 | d+WsiGvi+yillcGyppfyde+++kl+e+ilk+eyef+sPyWd+is+sakdfi++l+e+ | Q: 200 DCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEK 259 | ************************************************************ |
| S: 240 dpekrytieqaledpWi 256 | dpekr+t+eqal++pWi | Q: 260 DPEKRFTCEQALQHPWI 276 | ****************8 |
|
Domain Sequence
(FASTA) | | YDFRDVLGTG AFSEVILAED KRTQKLVAIK CIAKEALEGK EGSMENEIAV LHKIKHPNIV 60 | | ALDDIYESGG HLYLIMQLVS GGELFDRIVE KGFYTERDAS RLIFQVLDAV KYLHDLGIVH 120 | | RDLKPENLLY YSLDEDSKIM ISDFGLSKME DPGSVLSTAC GTPGYVAPEV LAQKPYSKAV 180 | | DCWSIGVIAY ILLCGYPPFY DENDAKLFEQ ILKAEYEFDS PYWDDISDSA KDFIRHLMEK 240 | | DPEKRFTCEQ ALQHPWI 257 |
|
| Keyword | Allosteric enzyme; ATP-binding; Calmodulin-binding; Cell cycle; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Kinase; Neurogenesis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
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| Created Date | 20-Feb-2013 |