EKS-HOS-00326

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00326

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	345.0	1.4E-102	24	274	251

Status

Reviewed

Ensembl Protein

ENSP00000346755

UniProt Accession

Q9P289; B2RAU2; Q3ZB77; Q8NC04; Q9BXC3; Q9BXC4;

Protein Name

Serine/threonine-protein kinase MST4

Protein Synonyms/Alias

Mammalian STE20-like protein kinase 4; MST-4; Mst3 and SOK1-related kinase; STE20-like kinase MST4; Serine/threonine-protein kinase MASK;

Gene Name

MST4

Gene Synonyms/Alias

MST4; MASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000134602	ENSP00000377868	ENST00000394335
ENSG00000134602	ENSP00000377867	ENST00000394334
ENSG00000134602	ENSP00000419702	ENST00000496850
ENSG00000134602	ENSP00000346755	ENST00000354719
ENSG00000134602	ENSP00000418753	ENST00000481105

Organism

Homo sapiens

Functional Description

Mediator of cell growth. Modulates apoptosis.

Protein Length

392

Protein Sequence
(FASTA)

MAHSPVAVQV PGMQNNIADP EELFTKLERI GKGSFGEVFK GIDNRTQQVV AIKIIDLEEA 60

EDEIEDIQQE ITVLSQCDSS YVTKYYGSYL KGSKLWIIME YLGGGSALDL LRAGPFDEFQ 120

IATMLKEILK GLDYLHSEKK IHRDIKAANV LLSEQGDVKL ADFGVAGQLT DTQIKRNTFV 180

GTPFWMAPEV IQQSAYDSKA DIWSLGITAI ELAKGEPPNS DMHPMRVLFL IPKNNPPTLV 240

GDFTKSFKEF IDACLNKDPS FRPTAKELLK HKFIVKNSKK TSYLTELIDR FKRWKAEGHS 300

DDESDSEGSD SESTSRENNT HPEWSFTTVR KKPDPKKVQN GAQDENNASR NQAIEELEKS 360

IAVAEAACPG ITDKMVKKLI EKFQKCSADE SP 392

Nucleotide Sequence
(FASTA)

ATGGCCCACT CGCCGGTGGC TGTCCAAGTG CCTGGGATGC AGAATAACAT AGCTGATCCA 60

GAAGAACTGT TCACAAAATT AGAGCGCATT GGGAAAGGCT CATTTGGGGA AGTTTTCAAA 120

GGAATTGATA ACCGTACCCA GCAAGTCGTT GCTATTAAAA TCATAGACCT TGAGGAAGCC 180

GAAGATGAAA TAGAAGACAT TCAGCAAGAA ATAACTGTCT TGAGTCAATG TGACAGCTCA 240

TATGTAACAA AATACTATGG GTCATATTTA AAGGGGTCTA AATTATGGAT AATAATGGAA 300

TACCTGGGCG GTGGTTCAGC ACTGGATCTT CTTCGAGCTG GTCCATTTGA TGAGTTCCAG 360

ATTGCTACCA TGCTAAAGGA AATTTTAAAA GGTCTGGACT ATCTGCATTC AGAAAAGAAA 420

ATTCACCGAG ACATAAAAGC TGCCAATGTC TTGCTCTCAG AACAAGGAGA TGTTAAACTT 480

GCTGATTTTG GAGTTGCTGG TCAGCTGACA GATACACAGA TTAAAAGAAA TACCTTTGTG 540

GGAACTCCAT TTTGGATGGC TCCTGAAGTT ATTCAACAGT CAGCTTATGA CTCAAAAGCT 600

GACATTTGGT CATTGGGAAT TACTGCTATT GAACTAGCCA AGGGAGAGCC ACCTAACTCC 660

GATATGCATC CAATGAGAGT TCTGTTTCTT ATTCCCAAAA ACAATCCTCC AACTCTTGTT 720

GGAGACTTTA CTAAGTCTTT TAAGGAGTTT ATTGATGCTT GCCTGAACAA AGATCCATCA 780

TTTCGTCCTA CAGCAAAAGA ACTTCTGAAA CACAAATTCA TTGTAAAAAA TTCAAAGAAG 840

ACTTCTTATC TGACTGAACT GATAGATCGT TTTAAGAGAT GGAAGGCAGA AGGACACAGT 900

GATGATGAAT CTGATTCCGA GGGCTCTGAT TCGGAATCTA CCAGCAGGGA AAACAATACT 960

CATCCTGAAT GGAGCTTTAC CACCGTACGA AAGAAGCCTG ATCCAAAGAA AGTACAGAAT 1020

GGGGCACAGG ACGAGAATAA CGCTAGCAGG AATCAGGCGA TTGAAGAACT CGAGAAAAGT 1080

ATTGCTGTGG CTGAAGCCGC CTGTCCCGGC ATCACAGATA AAATGGTGAA GAAACTAATT 1140

GAAAAATTTC AAAAGTGTTC AGCAGACGAA TCCCCCTAA 1179

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.ekleelqkeisvlkklkhpniv  59

         ++ le+igkG++g+v+++ +++t+++vaik+i+le+  +++e++q+ei+vl+++++++++

Q: 24    FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAeDEIEDIQQEITVLSQCDSSYVT  83

         7889*******************************99899********************

S: 60    eylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkv  119

         +y++s+lk ++lw++meyl gGs+ dl++     +++E qia++l+e+lk+L+ylHs+k+

Q: 84    KYYGSYLKGSKLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLKEILKGLDYLHSEKK  140

         *****************************...****************************

S: 120   iHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYde  179

         iHrdika+n+Ll+e+g+VkL+dfgva ql++t+ kr+t+vgtp+wmAPEvi+  ++ Yd+

Q: 141   IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ--QSAYDS  198

         ****************************************************..9*****

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclq  239

         kaDiwslGItaiela+gepP +d++p+++l++i+kn+pp+l  +  f+k+fkef+++cl+

Q: 199   KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDACLN  256

         *****************************************777..**************

S: 240   knpekRpsasellkhkFl  257

         k+p++Rp+a+ellkhkF+

Q: 257   KDPSFRPTAKELLKHKFI  274

         *****************7

Domain Sequence
(FASTA)

FTKLERIGKG SFGEVFKGID NRTQQVVAIK IIDLEEAEDE IEDIQQEITV LSQCDSSYVT 60

KYYGSYLKGS KLWIIMEYLG GGSALDLLRA GPFDEFQIAT MLKEILKGLD YLHSEKKIHR 120

DIKAANVLLS EQGDVKLADF GVAGQLTDTQ IKRNTFVGTP FWMAPEVIQQ SAYDSKADIW 180

SLGITAIELA KGEPPNSDMH PMRVLFLIPK NNPPTLVGDF TKSFKEFIDA CLNKDPSFRP 240

TAKELLKHKF I 251

Keyword

3D-structure; Alternative splicing; Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Golgi apparatus; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0000139	; C:Golgi membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006921	; P:cellular component disassembly involved in execution phase of apoptosis
GO:0042981	; P:regulation of apoptotic process

KEGG

hsa:51765

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013