EKS-HOS-00340

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00340

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	316.2	8.4E-94	27	277	251

Status

Reviewed

Ensembl Protein

ENSP00000376317

UniProt Accession

Q9H2K8; Q658N1; Q8IUM4; Q9HC79; Q9NZM9; Q9UHG7;

Protein Name

Serine/threonine-protein kinase TAO3

Protein Synonyms/Alias

Cutaneous T-cell lymphoma-associated antigen HD-CL-09; CTCL-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; Kinase from chicken homolog A; hKFC-A; Thousand and one amino acid protein 3;

Gene Name

TAOK3

Gene Synonyms/Alias

TAOK3; DPK, JIK, KDS, MAP3K18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000135090	ENSP00000438766	ENST00000539872
ENSG00000135090	ENSP00000416374	ENST00000419821
ENSG00000135090	ENSP00000376317	ENST00000392533
ENSG00000135090	ENSP00000443834	ENST00000537952
ENSG00000135090	ENSP00000444057	ENST00000541878
ENSG00000135090	ENSP00000442541	ENST00000541786
ENSG00000135090	ENSP00000443465	ENST00000535570
ENSG00000135090	ENSP00000443487	ENST00000540561
ENSG00000135090	ENSP00000439620	ENST00000537822
ENSG00000135090	ENSP00000438820	ENST00000541186
ENSG00000135090	ENSP00000440315	ENST00000542902
ENSG00000135090	ENSP00000441932	ENST00000536979
ENSG00000135090	ENSP00000437389	ENST00000538601
ENSG00000135090	ENSP00000441071	ENST00000542532

Organism

Homo sapiens

Functional Description

Serine/threonine-protein kinase that acts as a regulatorof the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).

Protein Length

898

Protein Sequence
(FASTA)

MRKGVLKDPE IADLFYKDDP EELFIGLHEI GHGSFGAVYF ATNAHTSEVV AIKKMSYSGK 60

QTHEKWQDIL KEVKFLRQLK HPNTIEYKGC YLKEHTAWLV MEYCLGSASD LLEVHKKPLQ 120

EVEIAAITHG ALHGLAYLHS HALIHRDIKA GNILLTEPGQ VKLADFGSAS MASPANSFVG 180

TPYWMAPEVI LAMDEGQYDG KVDIWSLGIT CIELAERKPP LFNMNAMSAL YHIAQNDSPT 240

LQSNEWTDSF RRFVDYCLQK IPQERPTSAE LLRHDFVRRD RPLRVLIDLI QRTKDAVREL 300

DNLQYRKMKK ILFQETRNGP LNESQEDEED SEHGTSLNRE MDSLGSNHSI PSMSVSTGSQ 360

SSSVNSMQEV MDESSSELVM MHDDESTINS SSSVVHKKDH VFIRDEAGHG DPRPEPRPTQ 420

SVQSQALHYR NRERFATIKS ASLVTRQIHE HEQENELREQ MSGYKRMRRQ HQKQLIALEN 480

KLKAEMDEHR LKLQKEVETH ANNSSIELEK LAKKQVAIIE KEAKVAAADE KKFQQQILAQ 540

QKKDLTTFLE SQKKQYKICK EKIKEEMNED HSTPKKEKQE RISKHKENLQ HTQAEEEAHL 600

LTQQRLYYDK NCRFFKRKIM IKRHEVEQQN IREELNKKRT QKEMEHAMLI RHDESTRELE 660

YRQLHTLQKL RMDLIRLQHQ TELENQLEYN KRRERELHRK HVMELRQQPK NLKAMEMQIK 720

KQFQDTCKVQ TKQYKALKNH QLEVTPKNEH KTILKTLKDE QTRKLAILAE QYEQSINEMM 780

ASQALRLDEA QEAECQALRL QLQQEMELLN AYQSKIKMQT EAQHERELQK LEQRVSLRRA 840

HLEQKIEEEL AALQKERSER IKNLLERQER EIETFDMESL RMGFGNLVTL DFPKEDYR 898

Nucleotide Sequence
(FASTA)

ATGCGTAAAG GGGTGCTGAA GGACCCAGAG ATTGCCGATC TATTCTACAA AGATGATCCT 60

GAGGAACTTT TTATTGGTTT GCATGAAATT GGACATGGAA GTTTTGGAGC AGTTTATTTT 120

GCTACAAATG CTCACACCAG TGAGGTGGTG GCAATTAAGA AGATGTCCTA TAGTGGGAAG 180

CAGACCCATG AGAAATGGCA AGATATTCTT AAGGAAGTTA AATTTTTACG ACAATTGAAG 240

CATCCTAATA CTATTGAGTA CAAAGGCTGT TACTTGAAAG AACACACTGC TTGGTTGGTG 300

ATGGAATATT GCTTAGGCTC AGCCTCTGAT TTATTAGAAG TTCATAAAAA ACCACTTCAG 360

GAAGTGGAGA TCGCTGCCAT TACTCATGGA GCCTTGCATG GACTAGCCTA CCTACATTCT 420

CATGCATTGA TTCATAGGGA TATTAAAGCA GGAAATATTC TTCTAACAGA GCCAGGTCAG 480

GTAAAACTAG CTGATTTTGG ATCTGCTTCA ATGGCTTCTC CTGCCAACTC CTTCGTGGGC 540

ACACCTTACT GGATGGCTCC AGAGGTGATC TTAGCTATGG ATGAAGGACA GTATGATGGG 600

AAAGTTGATA TTTGGTCACT TGGCATCACT TGTATTGAAT TGGCGGAACG GAAGCCGCCC 660

CTTTTCAACA TGAATGCAAT GAGTGCCTTA TATCACATTG CCCAGAATGA CTCCCCAACG 720

TTACAGTCTA ATGAATGGAC AGACTCCTTT AGGAGATTTG TTGATTACTG CTTGCAGAAA 780

ATACCTCAGG AAAGGCCAAC ATCAGCAGAA CTATTAAGGC ATGACTTTGT TCGACGAGAC 840

CGGCCACTAC GTGTCCTCAT TGACCTCATA CAGAGGACAA AAGATGCAGT TCGTGAGCTA 900

GATAACCTAC AGTACCGAAA AATGAAAAAA ATACTTTTCC AAGAGACACG GAATGGACCC 960

TTGAATGAGT CACAGGAGGA TGAGGAAGAC AGTGAACATG GAACCAGCCT GAACAGGGAA 1020

ATGGACAGCC TGGGCAGCAA CCATTCCATT CCAAGCATGT CCGTGAGCAC AGGCAGCCAG 1080

AGCAGCAGTG TGAACAGCAT GCAGGAAGTC ATGGACGAGA GCAGTTCCGA ACTTGTCATG 1140

ATGCACGATG ACGAAAGCAC AATCAATTCC AGCTCCTCCG TCGTGCATAA GAAAGATCAT 1200

GTATTCATAA GGGATGAGGC GGGCCACGGC GATCCCAGGC CTGAGCCGCG GCCTACCCAG 1260

TCAGTTCAGA GCCAGGCCCT CCACTACCGG AACAGAGAGC GCTTTGCCAC GATCAAATCA 1320

GCATCTTTGG TTACACGACA GATCCATGAG CATGAGCAGG AGAACGAGTT GCGGGAACAG 1380

ATGTCAGGTT ATAAGCGGAT GCGGCGCCAG CACCAGAAGC AGCTGATCGC CCTGGAGAAC 1440

AAGCTGAAGG CTGAGATGGA CGAGCACCGC CTCAAGCTAC AGAAGGAGGT GGAGACGCAT 1500

GCCAACAACT CGTCCATCGA GCTGGAGAAG CTGGCCAAGA AGCAAGTGGC TATCATAGAA 1560

AAGGAGGCAA AGGTAGCTGC AGCAGATGAG AAGAAGTTCC AGCAACAGAT CTTGGCCCAG 1620

CAGAAGAAAG ATTTGACAAC TTTCTTAGAA AGTCAGAAGA AGCAGTATAA GATTTGTAAG 1680

GAAAAAATAA AAGAGGAAAT GAATGAGGAC CATAGCACAC CCAAGAAAGA GAAGCAAGAG 1740

CGGATCTCCA AACATAAAGA GAACTTGCAG CACACACAGG CTGAAGAGGA AGCCCACCTT 1800

CTCACTCAAC AGAGACTGTA CTACGACAAA AATTGTCGTT TCTTCAAGCG GAAAATAATG 1860

ATCAAGCGGC ACGAGGTGGA GCAGCAGAAC ATTCGGGAGG AACTAAATAA AAAGAGGACC 1920

CAGAAGGAGA TGGAGCATGC CATGCTAATC CGGCACGACG AGTCCACCCG AGAGCTAGAG 1980

TACAGGCAGC TGCACACGTT ACAGAAGCTA CGCATGGATC TGATCCGTTT ACAGCACCAG 2040

ACGGAACTGG AAAACCAGCT GGAGTACAAT AAGAGGCGAG AAAGAGAACT GCACAGAAAG 2100

CATGTCATGG AACTTCGGCA ACAGCCAAAA AACTTAAAGG CCATGGAAAT GCAAATTAAA 2160

AAACAGTTTC AGGACACTTG CAAAGTACAG ACCAAACAGT ATAAAGCACT CAAGAATCAC 2220

CAGTTGGAAG TTACTCCAAA GAATGAGCAC AAAACAATCT TAAAGACACT GAAAGATGAG 2280

CAGACAAGAA AACTTGCCAT TTTGGCAGAG CAGTATGAAC AGAGTATAAA TGAAATGATG 2340

GCCTCTCAAG CGTTACGGCT AGATGAGGCT CAAGAAGCAG AATGCCAGGC CTTGAGGCTA 2400

CAGCTCCAGC AGGAAATGGA GCTGCTCAAC GCCTACCAGA GCAAAATCAA GATGCAAACA 2460

GAGGCACAAC ATGAACGTGA GCTCCAGAAG CTAGAGCAGA GAGTGTCTCT GCGCAGAGCA 2520

CACCTTGAGC AGAAGATTGA AGAGGAGCTG GCTGCCCTTC AGAAGGAACG CAGCGAGAGA 2580

ATAAAGAACC TATTGGAAAG GCAAGAGCGA GAGATTGAAA CTTTTGACAT GGAGAGCCTC 2640

AGAATGGGAT TTGGGAATTT GGTTACATTA GATTTTCCTA AGGAGGACTA CAGATGA 2697

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekq...ekleelqkeisvlkklkhpnive  60

         l+eig+G++g+vy a++ +t+e+vaikk++++ +   ek++++ ke+++l++lkhpn +e

Q: 27    LHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKqthEKWQDILKEVKFLRQLKHPNTIE  86

         689****************************988899***********************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y +++lke++ wlvmey+  Gs+sdl++ ++k++l+E +ia+i++++l++L+ylHs+  i

Q: 87    YKGCYLKEHTAWLVMEYCL-GSASDLLE-VHKKPLQEVEIAAITHGALHGLAYLHSHALI  144

         ******************7.********.*******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdika+niLlte g+VkL+dfg+a+  +      +++vgtpywmAPEvi ++ e +Yd

Q: 145   HRDIKAGNILLTEPGQVKLADFGSASMASP----ANSFVGTPYWMAPEVILAMdEGQYDG  200

         ***********************9998888....69**************9887999***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclq  239

         k+DiwslGIt+ielae++pP++++++++al++i++n++p+l+s+ +++++f++fv+ clq

Q: 201   KVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSN-EWTDSFRRFVDYCLQ  259

         *****************************************888.***************

S: 240   knpekRpsasellkhkFl  257

         k p++Rp+++ell+h F+

Q: 260   KIPQERPTSAELLRHDFV  277

         ****************97

Domain Sequence
(FASTA)

LHEIGHGSFG AVYFATNAHT SEVVAIKKMS YSGKQTHEKW QDILKEVKFL RQLKHPNTIE 60

YKGCYLKEHT AWLVMEYCLG SASDLLEVHK KPLQEVEIAA ITHGALHGLA YLHSHALIHR 120

DIKAGNILLT EPGQVKLADF GSASMASPAN SFVGTPYWMA PEVILAMDEG QYDGKVDIWS 180

LGITCIELAE RKPPLFNMNA MSALYHIAQN DSPTLQSNEW TDSFRRFVDY CLQKIPQERP 240

TSAELLRHDF V 251

Keyword

ATP-binding; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; DNA damage; DNA repair; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004860	; F:protein kinase inhibitor activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006281	; P:DNA repair
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0000165	; P:MAPK cascade
GO:0046329	; P:negative regulation of JNK cascade
GO:0046330	; P:positive regulation of JNK cascade
GO:0043507	; P:positive regulation of JUN kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

hsa:51347

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013