EKS-HOS-00292
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00292
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR333.55.2E-99204505302
StatusReviewed
Ensembl ProteinENSP00000257863
UniProt AccessionQ16671; A0AVE1; B9EGB7; F8W1D2; Q13762;
Protein NameAnti-Muellerian hormone type-2 receptor
Protein Synonyms/Alias Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII;
Gene NameAMHR2
Gene Synonyms/Alias AMHR2; AMHR, MISR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000135409ENSP00000446661ENST00000550311
ENSG00000135409ENSP00000369117ENST00000379791
ENSG00000135409ENSP00000257863ENST00000257863
ENSG00000135409ENSP00000455338ENST00000550839
OrganismHomo sapiens
Functional DescriptionOn ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Protein Length573
Protein Sequence
(FASTA)
MLGSLGLWAL LPTAVEAPPN RRTCVFFEAP GVRGSTKTLG ELLDTGTELP RAIRCLYSRC 60
CFGIWNLTQD RAQVEMQGCR DSDEPGCESL HCDPSPRAHP SPGSTLFTCS CGTDFCNANY 120
SHLPPPGSPG TPGSQGPQAA PGESIWMALV LLGLFLLLLL LLGSIILALL QRKNYRVRGE 180
PVPEPRPDSG RDWSVELQEL PELCFSQVIR EGGHAVVWAG QLQGKLVAIK AFPPRSVAQF 240
QAERALYELP GLQHDHIVRF ITASRGGPGR LLSGPLLVLE LHPKGSLCHY LTQYTSDWGS 300
SLRMALSLAQ GLAFLHEERW QNGQYKPGIA HRDLSSQNVL IREDGSCAIG DLGLALVLPG 360
LTQPPAWTPT QPQGPAAIME AGTQRYMAPE LLDKTLDLQD WGMALRRADI YSLALLLWEI 420
LSRCPDLRPD SSPPPFQLAY EAELGNTPTS DELWALAVQE RRRPYIPSTW RCFATDPDGL 480
RELLEDCWDA DPEARLTAEC VQQRLAALAH PQESHPFPES CPRGCPPLCP EDCTSIPAPT 540
ILPCRPQRSA CHFSVQQGPC SRNPQPACTL SPV 573
Nucleotide Sequence
(FASTA)
ATGCTAGGGT CTTTGGGGCT TTGGGCATTA CTTCCCACAG CTGTGGAAGC ACCCCCAAAC 60
AGGCGAACCT GTGTGTTCTT TGAGGCCCCT GGAGTGCGGG GAAGCACAAA GACACTGGGA 120
GAGCTGCTAG ATACAGGCAC AGAGCTCCCC AGAGCTATCC GCTGCCTCTA CAGCCGCTGC 180
TGCTTTGGGA TCTGGAACCT GACCCAAGAC CGGGCACAGG TGGAAATGCA AGGATGCCGA 240
GACAGTGATG AGCCAGGCTG TGAGTCCCTC CACTGTGACC CAAGTCCCCG AGCCCACCCC 300
AGCCCTGGCT CCACTCTCTT CACCTGCTCC TGTGGCACTG ACTTCTGCAA TGCCAATTAC 360
AGCCATCTGC CTCCTCCAGG GAGCCCTGGG ACTCCTGGCT CCCAGGGTCC CCAGGCTGCC 420
CCAGGTGAGT CCATCTGGAT GGCACTGGTG CTGCTGGGGC TGTTCCTCCT CCTCCTGCTG 480
CTGCTGGGCA GCATCATCTT GGCCCTGCTA CAGCGAAAGA ACTACAGAGT GCGAGGTGAG 540
CCAGTGCCAG AGCCAAGGCC AGACTCAGGC AGGGACTGGA GTGTGGAGCT GCAGGAGCTG 600
CCTGAGCTGT GTTTCTCCCA GGTAATCCGG GAAGGAGGTC ATGCAGTGGT TTGGGCCGGG 660
CAGCTGCAAG GAAAACTGGT TGCCATCAAG GCCTTCCCAC CGAGGTCTGT GGCTCAGTTC 720
CAAGCTGAGA GAGCATTGTA CGAACTTCCA GGCCTACAGC ACGACCACAT TGTCCGATTT 780
ATCACTGCCA GCCGGGGGGG TCCTGGCCGC CTGCTCTCTG GGCCCCTGCT GGTACTGGAA 840
CTGCATCCCA AGGGCTCCCT GTGCCACTAC TTGACCCAGT ACACCAGTGA CTGGGGAAGT 900
TCCCTGCGGA TGGCACTGTC CCTGGCCCAG GGCCTGGCAT TTCTCCATGA GGAGCGCTGG 960
CAGAATGGCC AATATAAACC AGGTATTGCC CACCGAGATC TGAGCAGCCA GAATGTGCTC 1020
ATTCGGGAAG ATGGATCGTG TGCCATTGGA GACCTGGGCC TTGCCTTGGT GCTCCCTGGC 1080
CTCACTCAGC CCCCTGCCTG GACCCCTACT CAACCACAAG GCCCAGCTGC CATCATGGAA 1140
GCTGGCACCC AGAGGTACAT GGCACCAGAG CTCTTGGACA AGACTCTGGA CCTACAGGAT 1200
TGGGGCATGG CCCTCCGACG AGCTGATATT TACTCTTTGG CTCTGCTCCT GTGGGAGATA 1260
CTGAGCCGCT GCCCAGATTT GAGGCCTGAC AGCAGTCCAC CACCCTTCCA ACTGGCCTAT 1320
GAGGCAGAAC TGGGCAATAC CCCTACCTCT GATGAGCTAT GGGCCTTGGC AGTGCAGGAG 1380
AGGAGGCGTC CCTACATCCC ATCCACCTGG CGCTGCTTTG CCACAGACCC TGATGGGCTG 1440
AGGGAGCTCC TAGAAGACTG TTGGGATGCA GACCCAGAAG CACGGCTGAC AGCTGAGTGT 1500
GTACAGCAGC GCCTGGCTGC CTTGGCCCAT CCTCAAGAGA GCCACCCCTT TCCAGAGAGC 1560
TGTCCACGTG GCTGCCCACC TCTCTGCCCA GAAGACTGTA CTTCAATTCC TGCCCCTACC 1620
ATCCTCCCCT GTAGGCCTCA GCGGAGTGCC TGCCACTTCA GCGTTCAGCA AGGCCCTTGT 1680
TCCAGGAATC CTCAGCCTGC CTGTACCCTT TCTCCTGTGT AA 1722
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
          ++++i++G ++ Vw+++l+g+ vA+K+f+ ++ a++++E+++y+++ l+h++i++fi+a
Q: 204   CFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITA  263
         57899*******************************************************
S: 62    dk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
          +    ++l+  llv+e+h+kgsL++yL+++t+d+ ++lr+alsla+Gla+LHee ++++
Q: 264   SRgGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEE-RWQN  322
         **889999***********************************************.8999
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee........ldlaansqvG  172
         g++Kp iaHRDl+s+N+l+++d++c+i+DlGLal l   ++         +  aa++++G
Q: 323   GQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPpawtptqpQGPAAIMEAG  382
         **********************************87776666688888888899******
S: 173   tkRYmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfee  229
         t+RYmaPE+l+++l+l+d+  a++raD+Ysl+L+lWE++sRc +  +d++ ++++l++e+
Q: 383   TQRYMAPELLDKTLDLQDWGmALRRADIYSLALLLWEILSRCPDlrPDSSPPPFQLAYEA  442
         *******************99***********************999*************
S: 230   vvgsdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvk  288
         ++g++P+ +e++++ v+++ rP ip++w++ + + + l++lle+cWdadpeaRlta++v+
Q: 443   ELGNTPTSDELWALAVQERRRPYIPSTWRCFAtDPDGLRELLEDCWDADPEARLTAECVQ  502
         ******************************98789*************************
S: 289   krl  291
         +rl
Q: 503   QRL  505
         986
Domain Sequence
(FASTA)
CFSQVIREGG HAVVWAGQLQ GKLVAIKAFP PRSVAQFQAE RALYELPGLQ HDHIVRFITA 60
SRGGPGRLLS GPLLVLELHP KGSLCHYLTQ YTSDWGSSLR MALSLAQGLA FLHEERWQNG 120
QYKPGIAHRD LSSQNVLIRE DGSCAIGDLG LALVLPGLTQ PPAWTPTQPQ GPAAIMEAGT 180
QRYMAPELLD KTLDLQDWGM ALRRADIYSL ALLLWEILSR CPDLRPDSSP PPFQLAYEAE 240
LGNTPTSDEL WALAVQERRR PYIPSTWRCF ATDPDGLREL LEDCWDADPE ARLTAECVQQ 300
RL 302
KeywordAlternative splicing; ATP-binding; Complete proteome; Disease mutation; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Pseudohermaphroditism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00268
EKS-ANC-00275
EKS-BOT-00286
EKS-CAJ-00292
EKS-CAF-00292
EKS-CAP-00321
EKS-EQC-00278
EKS-FEC-00272
EKS-GOG-00285
EKS-ICT-00271
EKS-LOA-00296
EKS-MAM-00288
EKS-MAE-00019
EKS-MIM-00022
EKS-MUM-00317
EKS-MUP-00282
EKS-MYL-00288
EKS-NOL-00264
EKS-ORC-00268
EKS-OTG-00292
EKS-PAT-00271
EKS-POA-00278
EKS-PTV-00042
EKS-RAN-00302
EKS-SAH-00268
EKS-SUS-00251
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0042562; F:hormone binding
GO:0046872; F:metal ion binding
GO:0004872; F:receptor activity
GO:0005026; F:transforming growth factor beta receptor activity, type II
GO:0001880; P:Mullerian duct regression
GO:0007165; P:signal transduction
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
hsa:269;
InterPros
IPR000472; Activin_rcpt.
IPR015771; Anti-muellerian_hrmn_rcpt_II.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
Prints
Created Date20-Feb-2013