EKS-HOS-00314
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00314
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/Alpha111.82.1E-3116711819149
StatusReviewed
Ensembl ProteinENSP00000258888
UniProt AccessionQ96L96; Q9P2L6;
Protein NameAlpha-protein kinase 3
Protein Synonyms/Alias Muscle alpha-protein kinase;
Gene NameALPK3
Gene Synonyms/Alias ALPK3; KIAA1330, MAK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000136383ENSP00000258888ENST00000258888
OrganismHomo sapiens
Functional DescriptionKinase that recognizes phosphorylation sites in whichthe surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation (By similarity).
Protein Length1907
Protein Sequence
(FASTA)
MEVAWLVYVL GQQPLARQGE GQSRLVPGRG LVLWLPGLPR SSPSWPAVDL APLAPARPRG 60
PLICHTGHEQ AGREPGPGSS TKGPVLHDQD TRCAFLPRPP GPLQTRRYCR HQGRQGSGLG 120
AGPGAGTWAP APPGVSKPRC PGRARPGEGQ QQVTTARPPA INRGARQPRA GAAAAGRGPG 180
AGAWRTGEAA ASAGPAVGEG GAMGSRRAPS RGWGAGGRSG AGGDGEDDGP VWIPSPASRS 240
YLLSVRPETS LSSNRLSHPS SGRSTFCSII AQLTEETQPL FETTLKSRSV SEDSDVRFTC 300
IVTGYPEPEV TWYKDDTELD RYCGLPKYEI THQGNRHTLQ LYRCREEDAA IYQASAQNSK 360
GIVSCSGVLE VGTMTEYKIH QRWFAKLKRK AAAKLREIEQ SWKHEKAVPG EVDTLRKLSP 420
DRFQRKRRLS GAQAPGPSVP TREPEGGTLA AWQEGETETA QHSGLGLINS FASGEVTTNG 480
EAAPENGEDG EHGLLTYICD AMELGPQRAL KEESGAKKKK KDEESKQGLR KPELEKAAQS 540
RRSSENCIPS SDEPDSCGTQ GPVGVEQVQT QPRGRAARGP GSSGTDSTRK PASAVGTPDK 600
AQKAPGPGPG QEVYFSLKDM YLENTQAVRP LGEEGPQTLS VRAPGESPKG KAPLRARSEG 660
VPGAPGQPTH SLTPQPTRPF NRKRFAPPKP KGEATTDSKP ISSLSQAPEC GAQSLGKAPP 720
QASVQVPTPP ARRRHGTRDS TLQGQAGHRT PGEVLECQTT TAPTMSASSS SDVASIGVST 780
SGSQGIIEPM DMETQEDGRT SANQRTGSKK NVQADGKIQV DGRTRGDGTQ TAQRTRADRK 840
TQVDAGTQES KRPQSDRSAQ KGMMTQGRAE TQLETTQAGE KIQEDRKAQA DKGTQEDRRM 900
QGEKGMQGEK GTQSEGSAPT AMEGQSEQEV ATSLGPPSRT PKLPPTAGPR APLNIECFVQ 960
TPEGSCFPKK PGCLPRSEEA VVTASRNHEQ TVLGPLSGNL MLPAQPPHEG SVEQVGGERC 1020
RGPQSSGPVE AKQEDSPFQC PKEERPGGVP CMDQGGCPLA GLSQEVPTMP SLPGTGLTAS 1080
PKAGPCSTPT SQHGSTATFL PSEDQVLMSS APTLHLGLGT PTQSHPPETM ATSSEGACAQ 1140
VPDVEGRTPG PRSCDPGLID SLKNYLLLLL KLSSTETSGA GGESQVGAAT GGLVPSATLT 1200
PTVEVAGLSP RTSRRILERV ENNHLVQSAQ TLLLSPCTSR RLTGLLDREV QAGRQALAAA 1260
RGSWGPGPSS LTVPAIVVDE EDPGLASEGA SEGEGEVSPE GPGLLGASQE SSMAGRLGEA 1320
GGQAAPGQGP SAESIAQEPS QEEKFPGEAL TGLPAATPEE LALGARRKRF LPKVRAAGDG 1380
EATTPEERES PTVSPRGPRK SLVPGSPGTP GRERRSPTQG RKASMLEVPR AEEELAAGDL 1440
GPSPKAGGLD TEVALDEGKQ ETLAKPRKAK DLLKAPQVIR KIRVEQFPDA SGSLKLWCQF 1500
FNILSDSVLT WAKDQRPVGE VGRSAGDEGP AALAIVQASP VDCGVYRCTI HNEHGSASTD 1560
FCLSPEVLSG FISREEGEVG EEIEMTPMVF AKGLADSGCW GDKLFGRLVS EELRGGGYGC 1620
GLRKASQAKV IYGLEPIFES GRTCIIKVSS LLVFGPSSET SLVGRNYDVT IQGCKIQNMS 1680
REYCKIFAAE ARAAPGFGEV PEIIPLYLIY RPANNIPYAT LEEDLGKPLE SYCSREWGCA 1740
EAPTASGSSE AMQKCQTFQH WLYQWTNGSF LVTDLAGVDW KMTDVQIATK LRGYQGLKES 1800
CFPALLDRFA SSHQCNAYCE LLGLTPLKGP EAAHPQAKAK GSKSPSAGRK GSQLSPQPQK 1860
KGLPSPQGTR KSAPSSKATP QASEPVTTQL LGQPPTQEEG SKAQGMR 1907
Nucleotide Sequence
(FASTA)
ATGGAGGTGG CTTGGCTTGT CTATGTGCTG GGCCAACAGC CACTGGCGAG GCAAGGCGAG 60
GGTCAGTCAC GGCTGGTGCC AGGAAGAGGG CTGGTTCTTT GGCTCCCTGG TCTCCCGCGG 120
TCTAGCCCAA GCTGGCCAGC GGTTGACCTG GCTCCCCTGG CCCCGGCCAG GCCTCGTGGA 180
CCCCTCATAT GCCACACGGG ACATGAGCAG GCCGGCCGGG AGCCGGGTCC CGGGAGCTCC 240
ACGAAGGGGC CTGTCCTCCA TGACCAGGAC ACCCGCTGCG CCTTCCTCCC GAGGCCTCCC 300
GGGCCTCTCC AGACGCGGCG CTACTGCAGA CACCAGGGCC GCCAAGGGAG CGGACTCGGA 360
GCCGGCCCTG GGGCGGGCAC ATGGGCCCCG GCGCCCCCCG GCGTCTCCAA GCCGCGCTGC 420
CCGGGTCGGG CCAGGCCAGG GGAGGGACAG CAGCAGGTGA CGACGGCCCG GCCACCGGCT 480
ATAAATAGGG GCGCGCGTCA GCCGCGGGCG GGAGCGGCGG CGGCGGGCAG GGGCCCGGGG 540
GCCGGGGCCT GGAGGACAGG CGAGGCAGCG GCGAGTGCGG GGCCGGCGGT CGGGGAGGGC 600
GGTGCCATGG GGTCGCGGAG GGCCCCCAGC CGGGGCTGGG GCGCGGGTGG GCGGTCGGGG 660
GCGGGGGGCG ACGGTGAGGA CGACGGCCCC GTGTGGATCC CCAGCCCAGC CAGCCGGAGC 720
TACCTGCTCA GCGTGCGGCC CGAGACCAGC TTATCAAGCA ACCGGTTGTC TCACCCCAGC 780
TCTGGAAGGA GCACCTTCTG CTCCATCATT GCTCAGCTCA CAGAGGAGAC CCAGCCGCTA 840
TTTGAGACCA CGCTCAAGTC CCGGTCTGTG TCCGAGGACA GCGACGTCAG GTTCACCTGC 900
ATCGTCACAG GATACCCAGA GCCAGAGGTG ACCTGGTACA AGGATGATAC GGAGCTGGAC 960
CGCTACTGTG GCTTGCCAAA ATATGAGATC ACTCATCAGG GCAACCGCCA CACACTGCAG 1020
CTGTACAGGT GTCGAGAAGA AGATGCCGCC ATCTACCAGG CCTCTGCCCA GAACAGCAAG 1080
GGCATTGTGT CCTGCTCAGG GGTCCTGGAG GTGGGCACCA TGACTGAGTA CAAGATCCAC 1140
CAGCGCTGGT TCGCCAAGTT GAAGCGCAAG GCTGCGGCAA AGCTGCGCGA GATCGAGCAG 1200
AGCTGGAAGC ACGAGAAGGC GGTGCCTGGG GAGGTCGACA CTCTGCGCAA GCTCAGCCCC 1260
GACCGCTTCC AGCGAAAGCG GCGATTGAGC GGGGCTCAAG CGCCGGGCCC CTCGGTCCCT 1320
ACCAGGGAGC CTGAGGGTGG GACCCTGGCG GCTTGGCAGG AGGGAGAGAC TGAGACTGCT 1380
CAGCACTCAG GTTTGGGCCT GATCAACAGT TTTGCTTCTG GAGAAGTGAC CACCAACGGG 1440
GAGGCTGCCC CCGAGAATGG AGAGGACGGA GAGCATGGCT TGCTGACATA CATCTGTGAC 1500
GCCATGGAGC TGGGGCCTCA GAGAGCCCTC AAAGAGGAGA GTGGGGCCAA GAAGAAAAAG 1560
AAAGATGAGG AATCCAAGCA AGGCCTGCGG AAGCCAGAGT TAGAGAAGGC AGCCCAAAGC 1620
CGCCGTTCTT CAGAAAACTG CATCCCCAGC TCAGACGAGC CTGACTCCTG TGGGACTCAG 1680
GGGCCCGTGG GCGTGGAGCA GGTTCAGACC CAGCCCAGAG GCAGGGCTGC ACGGGGGCCT 1740
GGGTCCTCTG GCACAGATAG TACCAGGAAG CCAGCCTCTG CTGTGGGCAC TCCAGACAAG 1800
GCCCAGAAGG CCCCTGGCCC AGGCCCAGGC CAGGAAGTGT ATTTCTCCTT GAAGGACATG 1860
TACCTGGAGA ACACCCAGGC AGTCAGGCCT CTTGGGGAAG AGGGACCCCA GACCCTGAGT 1920
GTCCGGGCGC CTGGGGAGAG TCCCAAGGGG AAGGCACCCC TCAGGGCTAG AAGCGAGGGG 1980
GTGCCTGGCG CTCCTGGCCA GCCCACACAC TCCTTGACCC CCCAGCCGAC TAGGCCTTTC 2040
AACAGAAAGA GATTTGCCCC TCCAAAGCCC AAAGGAGAGG CCACCACTGA CAGCAAGCCC 2100
ATTTCTTCTC TGAGTCAAGC TCCAGAATGC GGGGCCCAGA GCTTAGGAAA GGCCCCACCT 2160
CAGGCCTCTG TGCAGGTGCC GACGCCCCCT GCCCGGCGGA GACATGGCAC CCGGGACAGC 2220
ACGTTGCAGG GGCAAGCAGG CCACAGGACT CCAGGAGAGG TCCTGGAATG CCAGACAACC 2280
ACGGCTCCTA CCATGTCGGC CAGCAGCAGC TCTGATGTAG CCTCCATTGG GGTTAGCACT 2340
TCCGGAAGTC AAGGTATCAT TGAACCCATG GATATGGAAA CCCAGGAGGA TGGGAGAACA 2400
TCTGCTAACC AGAGAACTGG AAGCAAGAAG AATGTGCAGG CAGATGGGAA GATACAAGTG 2460
GATGGAAGGA CCAGGGGAGA TGGAACACAG ACAGCCCAGA GGACACGTGC AGATAGGAAG 2520
ACGCAGGTGG ATGCTGGGAC ACAAGAAAGC AAGAGGCCAC AGTCAGACAG GAGTGCACAG 2580
AAGGGCATGA TGACACAGGG AAGGGCAGAG ACACAGCTAG AAACAACACA GGCAGGTGAG 2640
AAGATACAGG AAGACAGGAA GGCCCAGGCA GATAAGGGCA CACAGGAAGA CAGAAGGATG 2700
CAGGGAGAGA AGGGGATGCA GGGAGAGAAG GGGACGCAGT CAGAGGGGAG CGCGCCCACA 2760
GCCATGGAAG GTCAGTCTGA GCAAGAGGTG GCAACCAGCC TCGGCCCACC ATCCAGAACC 2820
CCCAAACTCC CACCTACAGC GGGTCCTAGA GCTCCTCTGA ATATTGAATG TTTTGTACAG 2880
ACCCCAGAAG GGTCTTGTTT CCCAAAAAAA CCTGGTTGCC TGCCCAGATC TGAGGAGGCA 2940
GTAGTAACAG CCTCCAGGAA CCATGAGCAA ACTGTGCTGG GTCCCCTGTC AGGGAACCTC 3000
ATGCTCCCAG CACAGCCGCC CCATGAGGGG AGTGTGGAGC AGGTGGGAGG AGAGAGATGC 3060
CGAGGGCCAC AGTCATCAGG CCCAGTCGAG GCCAAGCAGG AGGACAGCCC GTTCCAGTGC 3120
CCCAAGGAGG AGCGGCCAGG GGGAGTGCCG TGTATGGATC AGGGTGGCTG TCCTCTAGCT 3180
GGCCTGAGCC AGGAGGTACC CACGATGCCT TCTCTTCCTG GAACTGGGCT GACAGCTAGC 3240
CCAAAGGCGG GGCCGTGTAG CACCCCGACT TCTCAGCACG GGAGCACAGC CACCTTCCTG 3300
CCCTCTGAGG ATCAGGTCCT GATGAGTTCT GCCCCAACAC TGCACCTGGG GCTGGGGACC 3360
CCCACTCAGA GTCACCCACC AGAAACCATG GCCACCAGCA GTGAGGGGGC CTGCGCCCAG 3420
GTACCAGATG TGGAGGGGCG GACCCCAGGT CCCCGGAGCT GTGACCCTGG CCTCATAGAT 3480
TCCCTGAAGA ACTACCTGCT TCTGCTGCTG AAGCTGTCCA GCACAGAGAC AAGTGGAGCA 3540
GGGGGAGAGT CCCAGGTGGG GGCAGCCACC GGAGGTCTGG TGCCCTCAGC CACTCTGACA 3600
CCCACTGTGG AAGTGGCTGG GCTTAGTCCC CGGACATCGA GGCGCATCCT GGAGCGTGTG 3660
GAGAACAACC ACCTGGTGCA GAGTGCACAG ACCCTGCTGC TGAGCCCCTG TACCTCCCGC 3720
CGCCTCACCG GCCTCCTGGA CCGTGAGGTG CAGGCTGGCC GCCAGGCCCT TGCTGCTGCC 3780
CGAGGCTCCT GGGGTCCTGG TCCCAGCTCC CTCACTGTCC CTGCCATTGT GGTAGACGAG 3840
GAGGACCCTG GGCTGGCCTC AGAAGGAGCC AGTGAGGGTG AAGGAGAGGT TTCCCCTGAG 3900
GGGCCTGGCC TCCTGGGGGC CTCTCAGGAG AGCAGCATGG CTGGTCGACT GGGGGAGGCG 3960
GGTGGGCAGG CAGCCCCTGG ACAGGGGCCC TCAGCAGAGA GCATAGCCCA GGAGCCCTCC 4020
CAAGAGGAGA AGTTCCCAGG GGAGGCTCTG ACAGGTCTCC CGGCAGCTAC ACCTGAGGAA 4080
CTGGCTCTAG GGGCCCGGAG GAAGAGATTT CTCCCTAAGG TCAGAGCAGC AGGAGACGGG 4140
GAGGCAACCA CACCTGAAGA AAGGGAGAGC CCCACGGTTT CCCCCCGGGG GCCCAGGAAA 4200
AGCCTGGTGC CTGGGTCCCC AGGGACTCCA GGGCGGGAGA GACGCTCCCC TACGCAGGGC 4260
AGAAAGGCGA GCATGCTGGA GGTGCCTCGG GCAGAGGAGG AGCTGGCGGC AGGAGACCTG 4320
GGCCCCAGCC CCAAGGCCGG CGGTCTGGAC ACAGAGGTGG CCCTGGATGA AGGCAAGCAG 4380
GAGACACTGG CCAAGCCCAG GAAAGCCAAA GACCTGCTGA AAGCCCCACA GGTGATCCGG 4440
AAGATTCGGG TGGAGCAGTT TCCTGATGCC TCCGGTAGCC TGAAGCTGTG GTGCCAGTTT 4500
TTCAACATTC TTAGTGACTC AGTCTTGACA TGGGCCAAGG ATCAGCGCCC AGTGGGCGAG 4560
GTGGGCAGGA GCGCAGGGGA TGAGGGGCCG GCGGCCTTGG CCATCGTGCA GGCCTCCCCC 4620
GTAGACTGCG GTGTGTATCG GTGCACCATC CACAATGAGC ACGGCTCGGC CTCCACCGAC 4680
TTCTGCCTCA GCCCTGAGGT GTTGTCAGGA TTCATCTCCA GAGAAGAAGG TGAAGTTGGA 4740
GAAGAGATTG AGATGACCCC TATGGTGTTT GCTAAGGGTC TGGCTGACTC TGGCTGCTGG 4800
GGGGACAAGC TCTTTGGGCG ACTGGTAAGC GAGGAGCTCC GAGGGGGTGG ATATGGGTGT 4860
GGCCTTCGGA AGGCCTCCCA GGCCAAGGTC ATCTACGGGC TGGAACCCAT CTTCGAGTCG 4920
GGCCGCACGT GCATCATCAA GGTGTCCAGC CTGCTTGTGT TTGGGCCCAG CAGTGAGACT 4980
TCTCTTGTGG GCAGAAACTA CGACGTCACC ATCCAGGGGT GCAAGATCCA GAACATGAGT 5040
CGGGAGTACT GCAAAATCTT CGCAGCAGAA GCCCGGGCCG CGCCTGGCTT TGGGGAGGTG 5100
CCTGAGATCA TCCCACTGTA TCTGATCTAC CGGCCTGCAA ACAATATCCC ATATGCTACC 5160
CTGGAGGAAG ACCTGGGCAA GCCCCTGGAG TCTTACTGTT CTCGGGAATG GGGCTGTGCT 5220
GAGGCTCCGA CAGCATCTGG CAGCTCTGAG GCCATGCAGA AATGCCAGAC CTTCCAACAC 5280
TGGCTGTATC AGTGGACAAA TGGCAGCTTC CTTGTCACAG ACTTGGCAGG GGTTGACTGG 5340
AAGATGACTG ATGTGCAGAT TGCTACCAAA CTCCGAGGAT ACCAGGGCCT CAAGGAAAGC 5400
TGCTTCCCTG CCCTGCTGGA CCGGTTCGCC TCCTCCCACC AGTGCAATGC CTACTGTGAG 5460
CTGCTGGGGC TGACACCTCT CAAGGGCCCG GAGGCGGCCC ACCCCCAAGC CAAAGCCAAA 5520
GGCTCTAAGA GTCCATCTGC TGGCAGGAAA GGCTCCCAGC TGAGTCCTCA GCCCCAGAAG 5580
AAAGGCCTCC CTAGTCCTCA GGGCACCCGG AAGAGTGCTC CAAGTTCCAA GGCCACCCCT 5640
CAGGCCTCAG AGCCAGTCAC CACTCAGTTG TTGGGACAGC CTCCCACCCA AGAGGAGGGC 5700
TCCAAGGCCC AGGGCATGCG GTAG 5724
Domain Profile
S: 65    lrdverqraaqklvtefn..qvkPkkivyiprlievfLkdrtskn.qlltvEeyllGefv  121
         ++  + q  ++++ + f       +   ++p++i++ L++r+ +n +++t+Ee l     
Q: 1671  IQGCKIQNMSREYCKIFAaeARAAPGFGEVPEIIPLYLIYRPANNiPYATLEEDLGKPLE  1730
         55666777777777777754334456789**************************99999
S: 122   Kynnnngdei.....krenkleelmlafsHftyeytngellVvDlqGvgeklTDpqiatk  176
          y +++            +++ +++++f+H++y++tng++lV+Dl+Gv++k+TD+qiatk
Q: 1731  SYCSREWGCAeaptaSGSSEAMQKCQTFQHWLYQWTNGSFLVTDLAGVDWKMTDVQIATK  1790
         99999864334344467899****************************************
S: 177   srgtkfgkanlgeraiknFfakhhCNeiC  205
          rg++++k++++ +++++F+++h+CN++C
Q: 1791  LRGYQGLKESCFPALLDRFASSHQCNAYC  1819
         *****************************
Domain Sequence
(FASTA)
IQGCKIQNMS REYCKIFAAE ARAAPGFGEV PEIIPLYLIY RPANNIPYAT LEEDLGKPLE 60
SYCSREWGCA EAPTASGSSE AMQKCQTFQH WLYQWTNGSF LVTDLAGVDW KMTDVQIATK 120
LRGYQGLKES CFPALLDRFA SSHQCNAYC 149
KeywordComplete proteome; Developmental protein; Disulfide bond; Immunoglobulin domain; Kinase; Nucleus; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00287
EKS-ANC-00299
EKS-BOT-00307
EKS-CAJ-00311
EKS-CAF-00312
EKS-CAP-00340
EKS-DAR-00658
EKS-EQC-00299
EKS-FEC-00294
EKS-GAM-00192
EKS-GAG-00259
EKS-GAA-00379
EKS-GOG-00302
EKS-ICT-00289
EKS-LAC-00320
EKS-LOA-00316
EKS-MAM-00310
EKS-MEG-00247
EKS-MOD-00302
EKS-MUM-00337
EKS-MUP-00304
EKS-NOL-00283
EKS-ORN-00397
EKS-ORC-00290
EKS-ORL-00369
EKS-OTG-00315
EKS-PAT-00290
EKS-POA-00299
EKS-RAN-00322
EKS-SAH-00286
EKS-TAR-00401
EKS-TEN-00397
EKS-XET-00379
EKS-XIM-00389
Gene Ontology
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007507; P:heart development
KEGG
hsa:57538;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR004166; MHCK_EF2_kinase.
Pfam
PF02816; Alpha_kinase; 1.
PF07679; I-set; 1.
SMARTs
SM00811; Alpha_kinase; 1.
SM00408; IGc2; 1.
Prosites
PS51158; ALPHA_KINASE; 1.
PS50835; IG_LIKE; 2.
Prints
Created Date20-Feb-2013