EKS-HOS-00495
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00495
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/RSKL315.23.6E-93634844211
StatusReviewed
Ensembl ProteinENSP00000442306
UniProt AccessionQ96S38; B3KVM4; D3DTA4; Q8TDD3; Q9NSF4; Q9UL66;
Protein NameRibosomal protein S6 kinase delta-1
Protein Synonyms/Alias S6K-delta-1; 52 kDa ribosomal protein S6 kinase; Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein; SPHK1-binding protein;
Gene NameRPS6KC1
Gene Synonyms/Alias RPS6KC1; RPK118;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000136643ENSP00000439282ENST00000543354
ENSG00000136643ENSP00000442306ENST00000543470
ENSG00000136643ENSP00000355926ENST00000366959
ENSG00000136643ENSP00000355927ENST00000366960
OrganismHomo sapiens
Functional DescriptionMay be involved in transmitting sphingosine-1 phosphate(SPP)-mediated signaling into the cell.
Protein Length854
Protein Sequence
(FASTA)
MASNQNSPIR TFGLNLSSDS SALGAVASDS EQSKTEEERE SRSLFPGSLK PKLGKRDYLE 60
KAGELIKLAL KKEEEDDYEA ASDFYRKGVD LLLEGVQGES SPTRREAVKR RTAEYLMRAE 120
SISSLYGKPQ LDDVSQVLLV MDTRTEQTFI LKGLRKSSEY SRNRKTIIPR CVPNMVCLHK 180
YIISEESVFL VLQHAEGGKL WSYISKFLNR SPEESFDIKE VKKPTLAKVH LQQPTSSPQD 240
SSSFESRGSD GGSMLKALPL KSSLTPSSQD DSNQEDDGQD SSPKWPDSGS SSEEECTTSY 300
LTLCNEYGQE KIEPGSLNEE PFMKTEGNGV DTKAIKSFPA HLAADSDSPS TQLRAHELKF 360
FPNDDPEAVS SPRTSDSLSR SKNSPMEFFR IDSKDSASEL LGLDFGEKLY SLKSEPLKPF 420
FTLPDGDSAS RSFNTSESKV EFKAQDTISR GSDDSVPVIS FKDAAFDDVS GTDEGRPDLL 480
VNLPGELEST REAAAMGPTK FTQTNIGIIE NKLLEAPDVL CLRLSTEQCQ AHEEKGIEEL 540
SDPSGPKSYS ITEKHYAQED PRMLFVAAVD HSSSGDMSLL PSSDPKFQGL GVVESAVTAN 600
NTEESLFRIC SPLSGANEYI ASTDTLKTEE VLLFTDQTDD LAKEEPTSLF QRDSETKGES 660
GLVLEGDKEI HQIFEDLDKK LALASRFYIP EGCIQRWAAE MVVALDALHR EGIVCRDLNP 720
NNILLNDRGH IQLTYFSRWS EVEDSCDSDA IERMYCAPEV GAITEETEAC DWWSLGAVLF 780
ELLTGKTLVE CHPAGINTHT TLNMPECVSE EARSLIQQLL QFNPLERLGA GVAGVEDIKS 840
HPFFTPVDWA ELMR 854
Nucleotide Sequence
(FASTA)
ATGGCTTCCA ATCAAAATTC TCCCATTAGA ACTTTTGGTC TCAATCTTTC TTCGGATTCT 60
TCAGCACTAG GGGCTGTTGC TTCTGACAGT GAACAGAGCA AAACAGAAGA AGAACGGGAA 120
AGTCGTAGCC TCTTTCCTGG CAGTTTAAAG CCGAAGCTTG GCAAGAGAGA TTATTTGGAG 180
AAAGCAGGAG AATTAATAAA GCTGGCTTTA AAAAAGGAAG AAGAAGACGA CTATGAAGCT 240
GCTTCTGATT TTTATAGGAA GGGAGTTGAT TTACTCCTAG AAGGTGTTCA AGGAGAGTCA 300
AGCCCTACCC GTCGAGAAGC TGTGAAGAGA AGAACAGCCG AGTACCTCAT GCGGGCAGAA 360
AGTATCTCTA GTCTTTATGG GAAACCTCAG CTTGATGATG TATCTCAGGT TTTACTTGTA 420
ATGGACACAA GGACAGAACA GACTTTCATT TTAAAAGGTC TAAGGAAAAG CAGTGAATAC 480
AGCAGGAACA GAAAGACCAT CATCCCCCGC TGTGTGCCCA ACATGGTGTG TCTGCATAAG 540
TACATCATCT CTGAGGAGTC AGTATTTCTT GTGCTGCAGC ATGCGGAAGG TGGCAAACTG 600
TGGTCATATA TCAGTAAATT TCTAAACAGA AGTCCTGAAG AAAGCTTTGA CATCAAGGAA 660
GTGAAAAAAC CTACACTTGC AAAAGTTCAC CTGCAGCAGC CAACTTCTAG TCCTCAGGAC 720
AGCAGTAGCT TTGAATCCAG AGGAAGTGAT GGTGGAAGCA TGCTTAAAGC TCTGCCTTTG 780
AAGAGTAGTC TTACTCCAAG TTCTCAAGAT GACAGCAACC AGGAAGATGA TGGCCAAGAT 840
AGCTCTCCAA AGTGGCCAGA TTCTGGTTCA AGTTCAGAAG AAGAATGTAC TACTAGTTAT 900
TTAACATTAT GCAATGAATA TGGGCAAGAA AAGATTGAAC CAGGGTCTTT GAATGAGGAG 960
CCCTTCATGA AGACTGAAGG GAATGGTGTT GATACAAAAG CTATTAAAAG CTTCCCAGCA 1020
CACCTTGCTG CTGACAGTGA CAGCCCCAGC ACACAGCTGA GAGCTCACGA GCTGAAGTTC 1080
TTCCCCAACG ATGACCCAGA AGCAGTTAGT TCTCCAAGAA CATCAGATTC CCTCAGTAGA 1140
TCAAAAAATA GCCCCATGGA ATTCTTTAGG ATAGACAGTA AGGATAGCGC AAGTGAACTC 1200
CTGGGACTTG ACTTTGGAGA AAAATTGTAT AGTCTAAAAT CAGAACCTTT GAAACCATTC 1260
TTTACTCTTC CAGATGGAGA CAGTGCTTCT AGGAGTTTTA ATACTAGTGA AAGCAAGGTA 1320
GAGTTTAAAG CTCAGGACAC CATTAGCAGG GGCTCAGATG ACTCAGTGCC AGTTATTTCA 1380
TTTAAAGATG CTGCTTTTGA TGATGTCAGT GGTACTGATG AAGGAAGACC TGATCTTCTT 1440
GTAAATTTAC CTGGTGAATT GGAGTCAACA AGAGAAGCTG CAGCAATGGG ACCTACTAAG 1500
TTTACACAAA CTAATATAGG GATAATAGAA AATAAACTCT TGGAAGCCCC TGATGTTTTA 1560
TGCCTCAGGC TTAGTACTGA ACAATGCCAA GCACATGAGG AGAAAGGCAT AGAGGAACTG 1620
AGTGATCCCT CTGGGCCCAA ATCCTATAGT ATAACAGAGA AACACTATGC ACAGGAGGAT 1680
CCCAGGATGT TATTTGTAGC AGCTGTTGAT CATAGTAGTT CAGGAGATAT GTCTTTGTTA 1740
CCCAGCTCAG ATCCTAAGTT TCAAGGACTT GGAGTGGTTG AGTCAGCAGT AACTGCAAAC 1800
AACACAGAAG AAAGCTTATT CCGTATTTGT AGTCCACTCT CAGGTGCTAA TGAATATATT 1860
GCAAGCACAG ACACTTTAAA AACAGAAGAA GTATTGCTGT TTACAGATCA GACTGATGAT 1920
TTGGCTAAAG AGGAACCAAC TTCTTTATTC CAGAGAGACT CTGAGACTAA GGGTGAAAGT 1980
GGTTTAGTGC TAGAAGGAGA CAAGGAAATA CATCAGATTT TTGAGGACCT TGATAAAAAA 2040
TTAGCACTAG CCTCCAGGTT TTACATCCCA GAGGGCTGCA TTCAAAGATG GGCAGCTGAA 2100
ATGGTGGTAG CCCTTGATGC TTTACATAGA GAGGGAATTG TGTGCCGCGA TTTGAACCCA 2160
AACAACATCT TATTGAATGA TAGAGGACAC ATTCAGCTAA CGTATTTTAG CAGGTGGAGT 2220
GAGGTTGAAG ATTCCTGTGA CAGCGATGCC ATAGAGAGAA TGTACTGTGC CCCAGAGGTT 2280
GGAGCAATCA CTGAAGAAAC TGAAGCCTGT GATTGGTGGA GTTTGGGTGC TGTCCTCTTT 2340
GAACTTCTCA CTGGCAAGAC TCTGGTTGAA TGCCATCCAG CAGGAATAAA TACTCACACT 2400
ACTTTGAACA TGCCAGAATG TGTCTCTGAA GAGGCTCGCT CACTCATTCA ACAGCTCTTG 2460
CAGTTCAATC CTCTGGAACG ACTTGGTGCT GGAGTTGCTG GTGTTGAAGA TATCAAATCT 2520
CATCCATTTT TTACCCCTGT GGATTGGGCA GAACTGATGA GATGA 2565
Domain Profile
S: 130   rtesllllvgeeptsrsqreaeeesearvklefssdkskaprGnrirregqnsspssske  189
          t+++++l++eepts++qr++e+++e+  +le++                        ke
Q: 634   FTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGD------------------------KE  669
         48999***************************99........................99
S: 190   iklvsedadkslealsrgldkalqsvdkalslrravwslpEelikqWaaelvvaleaLHe  249
         i++++ed+dk+l+++sr                   +++pE++i++Waae+vval+aLH+
Q: 670   IHQIFEDLDKKLALASR-------------------FYIPEGCIQRWAAEMVVALDALHR  710
         *****************...................************************
S: 250   egvlirDlnadniLldskGhllltYfgrwsevekscrreavdnlysAPEvgaiselteas  309
         eg+++rDln++niLl+++Gh++ltYf+rwseve+sc+++a++++y+APEvgai+e+tea+
Q: 711   EGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEAC  770
         ************************************************************
S: 310   DwWslGalLyelLtGkalaeahPsgiqahtelqlPevvSeeAkdLleeLLqfePalRlGa  369
         DwWslGa+L+elLtGk+l+e+hP+gi++ht+l++Pe+vSeeA++L+++LLqf+P +RlGa
Q: 771   DWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGA  830
         ************************************************************
S: 370   GeagvdelkaHPFF  383
         G+agv+++k+HPFF
Q: 831   GVAGVEDIKSHPFF  844
         *************9
Domain Sequence
(FASTA)
FTDQTDDLAK EEPTSLFQRD SETKGESGLV LEGDKEIHQI FEDLDKKLAL ASRFYIPEGC 60
IQRWAAEMVV ALDALHREGI VCRDLNPNNI LLNDRGHIQL TYFSRWSEVE DSCDSDAIER 120
MYCAPEVGAI TEETEACDWW SLGAVLFELL TGKTLVECHP AGINTHTTLN MPECVSEEAR 180
SLIQQLLQFN PLERLGAGVA GVEDIKSHPF F 211
KeywordATP-binding; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00454
EKS-ANC-00476
EKS-BOT-00487
EKS-CAJ-00496
EKS-CAF-00486
EKS-CAP-00518
EKS-CII-00251
EKS-CIS-00201
EKS-DAR-00911
EKS-EQC-00473
EKS-FEC-00465
EKS-GAG-00404
EKS-GAA-00594
EKS-GOG-00477
EKS-ICT-00465
EKS-LAC-00499
EKS-LOA-00493
EKS-MAM-00437
EKS-MOD-00479
EKS-MUM-00518
EKS-MUP-00478
EKS-MYL-00479
EKS-NOL-00441
EKS-ORN-00619
EKS-ORA-00425
EKS-ORC-00460
EKS-ORL-00565
EKS-OTG-00495
EKS-PAT-00457
EKS-PES-00427
EKS-POA-00473
EKS-RAN-00501
EKS-SAH-00456
EKS-SUS-00429
EKS-TAG-00553
EKS-TAS-00071
EKS-TEN-00615
EKS-TUT-00189
EKS-VIP-00095
EKS-XET-00639
EKS-XIM-00550
Gene Ontology
GO:0005769; C:early endosome
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0035091; F:phosphatidylinositol binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007165; P:signal transduction
KEGG
hsa:26750;
InterPros
IPR011009; Kinase-like_dom.
IPR007330; MIT.
IPR001683; Phox.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF04212; MIT; 1.
PF00069; Pkinase; 1.
PF00787; PX; 1.
SMARTs
SM00745; MIT; 1.
SM00312; PX; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
PS50195; PX; 1.
Prints
Created Date20-Feb-2013