| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00238 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| STE/STE7 | 336.5 | 5.8E-100 | 132 | 383 | 252 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000346493 |
| UniProt Accession | Q13163; B4DE43; Q92961; Q92962; |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 5 |
| Protein Synonyms/Alias | MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5; |
| Gene Name | MAP2K5 |
| Gene Synonyms/Alias | MAP2K5; MEK5, MKK5, PRKMK5; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Acts as a scaffold for the formation of a ternaryMAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. |
| Protein Length | 412 |
Protein Sequence
(FASTA) | | MMEGHFPQSD VIGQVLPEAT TTAFEYEDED GDRITVRSDE EMKAMLSYYY STVMEQQVNG 60 | | QLIEPLQIFP RACKPPGERN IHGLKVNTRA GPSQHSSPAV SDSLPSNSLK KSSAELKKIL 120 | | ANGQMNEQDI RYRDTLGHGN GGTVYKAYHV PSGKILAVKV ILLDITLELQ KQIMSELEIL 180 | | YKCDSSYIIG FYGAFFVENR ISICTEFMDG GSLDVYRKMP EHVLGRIAVA VVKGLTYLWS 240 | | LKILHRDVKP SNMLVNTRGQ VKLCDFGVST QLVNSIAKTY VGTNAYMAPE RISGEQYGIH 300 | | SDVWSLGISF MELALGRFPY PQIQKNQGSL MPLQLLQCIV DEDSPVLPVG EFSEPFVHFI 360 | | TQCMRKQPKE RPAPEELMGH PFIVQFNDGN AAVVSMWVCR ALEERRSQQG PP 412 |
|
Nucleotide Sequence
(FASTA) | | ATGATGGAGG GTCACTTTCC CCAGAGCGAT GTGATAGGCC AGGTTCTGCC TGAAGCAACA 60 | | ACTACAGCAT TTGAATATGA AGATGAAGAT GGTGATCGAA TTACAGTGAG AAGTGATGAG 120 | | GAAATGAAGG CAATGCTGTC ATATTATTAT TCCACAGTAA TGGAACAGCA AGTAAATGGA 180 | | CAGTTAATAG AGCCTCTGCA GATATTTCCA AGAGCCTGCA AGCCTCCTGG GGAACGGAAC 240 | | ATACATGGCC TGAAGGTGAA TACTCGGGCC GGACCCTCTC AACACAGCAG CCCAGCAGTC 300 | | TCAGATTCAC TTCCAAGCAA TAGCTTAAAG AAGTCTTCTG CTGAACTGAA AAAAATACTA 360 | | GCCAATGGCC AGATGAATGA ACAAGACATA CGATATCGGG ACACTCTTGG TCATGGCAAC 420 | | GGAGGCACAG TCTACAAAGC ATATCATGTC CCGAGTGGGA AAATATTAGC TGTAAAGGTC 480 | | ATACTACTAG ATATTACACT GGAACTTCAG AAGCAAATTA TGTCTGAATT GGAAATTCTT 540 | | TATAAGTGCG ATTCATCATA TATCATTGGA TTTTATGGAG CATTTTTTGT AGAAAACAGG 600 | | ATTTCAATAT GTACAGAATT CATGGATGGG GGATCTTTGG ATGTATATAG GAAAATGCCA 660 | | GAACATGTCC TTGGAAGAAT TGCAGTAGCA GTTGTTAAAG GCCTTACTTA TTTGTGGAGT 720 | | TTAAAGATTT TACATAGAGA CGTGAAGCCC TCCAATATGC TAGTAAACAC AAGAGGACAG 780 | | GTTAAGCTGT GTGATTTTGG AGTTAGCACT CAGCTGGTGA ATTCTATAGC CAAGACGTAT 840 | | GTTGGAACAA ATGCTTATAT GGCGCCTGAA AGGATTTCAG GGGAGCAGTA TGGAATTCAT 900 | | TCTGATGTCT GGAGCTTAGG AATCTCTTTT ATGGAGCTTG CTCTTGGGAG GTTTCCATAT 960 | | CCTCAGATTC AGAAAAACCA GGGATCTTTA ATGCCTCTCC AGCTTCTGCA GTGCATTGTT 1020 | | GATGAGGATT CGCCCGTCCT TCCAGTTGGA GAGTTCTCGG AGCCATTTGT ACATTTCATC 1080 | | ACTCAGTGTA TGCGAAAACA GCCAAAAGAA AGGCCAGCAC CTGAAGAATT GATGGGCCAC 1140 | | CCGTTCATCG TGCAGTTCAA TGATGGAAAT GCCGCCGTGG TGTCCATGTG GGTGTGCCGG 1200 | | GCGCTGGAGG AGAGGCGGAG CCAGCAGGGG CCCCCGTGA 1239 |
|
| Domain Profile | S: 3 kleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivk 62 | ++lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++ | Q: 132 YRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIG 190 | 5679************************************************.******* |
| S: 63 fyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkekl 122 | fyGaf+ e+++sic+e+mdg+sld v++k +pe+vlg+iavavvk+l+yl+ +l | Q: 191 FYGAFFVENRISICTEFMDGGSLD-VYRK-------MPEHVLGRIAVAVVKGLTYLW-SL 241 | ************************.6886.......8********************.78 |
| S: 123 kiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvk 182 | ki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++ | Q: 242 KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIH 300 | *****************************************************.****** |
| S: 183 sdvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqefv 236 | sdvWslG++++ela gr+py++ ++ +l+ll++iv+e++p+lp efse f++f+ | Q: 301 SDVWSLGISFMELALGRFPYPQIQKnqgslmPLQLLQCIVDEDSPVLPVGEFSEPFVHFI 360 | ***********************9999********************************* |
| S: 237 skClkkdekeRpklkellkhafi 259 | ++C++k++keRp +el+ h+fi | Q: 361 TQCMRKQPKERPAPEELMGHPFI 383 | **********************7 |
|
Domain Sequence
(FASTA) | | YRDTLGHGNG GTVYKAYHVP SGKILAVKVI LLDITLELQK QIMSELEILY KCDSSYIIGF 60 | | YGAFFVENRI SICTEFMDGG SLDVYRKMPE HVLGRIAVAV VKGLTYLWSL KILHRDVKPS 120 | | NMLVNTRGQV KLCDFGVSTQ LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM 180 | | ELALGRFPYP QIQKNQGSLM PLQLLQCIVD EDSPVLPVGE FSEPFVHFIT QCMRKQPKER 240 | | PAPEELMGHP FI 252 |
|
| Keyword | 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | | GO:0005829 | ; C:cytosol | | GO:0005634 | ; C:nucleus | | GO:0005819 | ; C:spindle | | GO:0005524 | ; F:ATP binding | | GO:0004707 | ; F:MAP kinase activity | | GO:0046872 | ; F:metal ion binding | | GO:0004672 | ; F:protein kinase activity | | GO:0004713 | ; F:protein tyrosine kinase activity | | GO:0000187 | ; P:activation of MAPK activity | | GO:0071363 | ; P:cellular response to growth factor stimulus | | GO:0071499 | ; P:cellular response to laminar fluid shear stress | | GO:0070375 | ; P:ERK5 cascade | | GO:0007507 | ; P:heart development | | GO:0043066 | ; P:negative regulation of apoptotic process | | GO:0090051 | ; P:negative regulation of cell migration involved in sprouting angiogenesis | | GO:2000342 | ; P:negative regulation of chemokine (C-X-C motif) ligand 2 production | | GO:0043154 | ; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | | GO:0034115 | ; P:negative regulation of heterotypic cell-cell adhesion | | GO:0045415 | ; P:negative regulation of interleukin-8 biosynthetic process | | GO:0032088 | ; P:negative regulation of NF-kappaB transcription factor activity | | GO:0060761 | ; P:negative regulation of response to cytokine stimulus | | GO:0000122 | ; P:negative regulation of transcription from RNA polymerase II promoter | | GO:0048011 | ; P:nerve growth factor receptor signaling pathway | | GO:0030307 | ; P:positive regulation of cell growth | | GO:0050679 | ; P:positive regulation of epithelial cell proliferation | | GO:0045944 | ; P:positive regulation of transcription from RNA polymerase II promoter |
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| Created Date | 20-Feb-2013 |