EKS-HOS-00511

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00511

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/BRD	N/A	N/A	N/A	N/A	N/A

Status

Reviewed

Ensembl Protein

ENSP00000387822

UniProt Accession

Q58F21; A6NF68; B7Z811; B7Z890; B7ZAX7; D3DT32; O14789; Q05DQ4; Q6P5T1; Q7Z4A6; Q8IWI6;

Protein Name

Bromodomain testis-specific protein

Protein Synonyms/Alias

Cancer/testis antigen 9; CT9; RING3-like protein;

Gene Name

BRDT

Gene Synonyms/Alias

BRDT;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000137948	ENSP00000446599	ENST00000552654
ENSG00000137948	ENSP00000400199	ENST00000355011
ENSG00000137948	ENSP00000408138	ENST00000457265
ENSG00000137948	ENSP00000414349	ENST00000450792
ENSG00000137948	ENSP00000416714	ENST00000440509
ENSG00000137948	ENSP00000408625	ENST00000449584
ENSG00000137948	ENSP00000447394	ENST00000548992
ENSG00000137948	ENSP00000387822	ENST00000399546
ENSG00000137948	ENSP00000354568	ENST00000362005
ENSG00000137948	ENSP00000400002	ENST00000427104
ENSG00000137948	ENSP00000396351	ENST00000423434
ENSG00000137948	ENSP00000384051	ENST00000402388
ENSG00000137948	ENSP00000404969	ENST00000426141
ENSG00000137948	ENSP00000378038	ENST00000394530
ENSG00000137948	ENSP00000359416	ENST00000370389
ENSG00000137948	ENSP00000410587	ENST00000448194

Organism

Homo sapiens

Functional Description

Testis-specific chromatin protein that specificallybinds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.

Protein Length

947

Protein Sequence
(FASTA)

MSLPSRQTAI IVNPPPPEYI NTKKNGRLTN QLQYLQKVVL KDLWKHSFSW PFQRPVDAVK 60

LQLPDYYTII KNPMDLNTIK KRLENKYYAK ASECIEDFNT MFSNCYLYNK PGDDIVLMAQ 120

ALEKLFMQKL SQMPQEEQVV GVKERIKKGT QQNIAVSSAK EKSSPSATEK VFKQQEIPSV 180

FPKTSISPLN VVQGASVNSS SQTAAQVTKG VKRKADTTTP ATSAVKASSE FSPTFTEKSV 240

ALPPIKENMP KNVLPDSQQQ YNVVKTVKVT EQLRHCSEIL KEMLAKKHFS YAWPFYNPVD 300

VNALGLHNYY DVVKNPMDLG TIKEKMDNQE YKDAYKFAAD VRLMFMNCYK YNPPDHEVVT 360

MARMLQDVFE THFSKIPIEP VESMPLCYIK TDITETTGRE NTNEASSEGN SSDDSEDERV 420

KRLAKLQEQL KAVHQQLQVL SQVPFRKLNK KKEKSKKEKK KEKVNNSNEN PRKMCEQMRL 480

KEKSKRNQPK KRKQQFIGLK SEDEDNAKPM NYDEKRQLSL NINKLPGDKL GRVVHIIQSR 540

EPSLSNSNPD EIEIDFETLK ASTLRELEKY VSACLRKRPL KPPAKKIMMS KEELHSQKKQ 600

ELEKRLLDVN NQLNSRKRQT KSDKTQPSKA VENVSRLSES SSSSSSSSES ESSSSDLSSS 660

DSSDSESEMF PKFTEVKPND SPSKENVKKM KNECIPPEGR TGVTQIGYCV QDTTSANTTL 720

VHQTTPSHVM PPNHHQLAFN YQELEHLQTV KNISPLQILP PSGDSEQLSN GITVMHPSGD 780

SDTTMLESEC QAPVQKDIKI KNADSWKSLG KPVKPSGVMK SSDELFNQFR KAAIEKEVKA 840

RTQELIRKHL EQNTKELKAS QENQRDLGNG LTVESFSNKI QNKCSGEEQK EHQQSSEAQD 900

KSKLWLLKDR DLARQKEQER RRREAMVGTI DMTLQSDIMT MFENNFD 947

Nucleotide Sequence
(FASTA)

ATGTCTCTGC CAAGTCGACA AACAGCTATT ATTGTTAACC CTCCTCCACC AGAATATATA 60

AATACTAAGA AAAATGGGCG ATTGACAAAT CAACTTCAGT ATCTACAAAA AGTTGTCCTA 120

AAGGATTTAT GGAAGCATAG TTTTTCATGG CCCTTTCAAC GTCCTGTGGA TGCTGTGAAA 180

CTACAGTTGC CTGATTATTA TACCATTATA AAAAACCCAA TGGATTTAAA TACAATTAAG 240

AAGCGCTTGG AGAATAAATA TTATGCGAAG GCTTCAGAAT GTATAGAAGA CTTCAATACA 300

ATGTTCTCAA ATTGTTATTT ATATAACAAG CCTGGAGATG ACATTGTTCT TATGGCACAA 360

GCTCTAGAGA AGCTGTTTAT GCAGAAATTA TCTCAGATGC CACAAGAAGA GCAAGTTGTG 420

GGTGTTAAGG AAAGAATCAA GAAAGGCACT CAACAGAATA TAGCTGTTTC TTCTGCTAAA 480

GAAAAATCAT CACCCAGCGC AACAGAAAAA GTATTTAAGC AGCAAGAAAT TCCTTCTGTA 540

TTTCCTAAGA CATCTATTTC TCCCTTGAAC GTGGTACAGG GAGCTTCAGT CAACTCCAGT 600

TCACAAACTG CGGCCCAAGT TACAAAAGGT GTGAAGAGGA AAGCAGATAC AACAACTCCT 660

GCAACTTCAG CAGTTAAAGC AAGTAGTGAA TTTTCTCCAA CATTCACAGA AAAATCAGTG 720

GCACTGCCAC CTATAAAAGA AAATATGCCA AAGAATGTTT TGCCAGATTC TCAGCAACAA 780

TATAATGTTG TGAAGACTGT TAAAGTAACT GAACAATTAA GGCACTGTAG TGAGATTCTT 840

AAAGAAATGC TTGCAAAGAA ACATTTTTCA TATGCATGGC CCTTTTATAA TCCTGTTGAC 900

GTTAATGCTT TGGGACTCCA TAACTACTAT GACGTTGTCA AAAATCCGAT GGATCTTGGA 960

ACTATTAAGG AGAAAATGGA TAACCAAGAA TATAAGGATG CATACAAATT TGCGGCAGAT 1020

GTTAGATTAA TGTTCATGAA TTGCTACAAG TACAATCCTC CAGATCACGA AGTTGTGACA 1080

ATGGCAAGAA TGCTTCAGGA TGTTTTCGAA ACGCATTTTT CAAAGATCCC GATTGAACCT 1140

GTTGAGAGTA TGCCTTTATG TTACATCAAA ACAGATATCA CAGAAACCAC TGGTAGAGAG 1200

AACACTAATG AAGCCTCCTC TGAAGGGAAC TCTTCTGATG ATTCTGAAGA TGAGCGAGTT 1260

AAGCGTCTTG CAAAGCTTCA GGAGCAGCTT AAAGCTGTAC ATCAACAGCT CCAGGTTTTG 1320

TCCCAAGTAC CTTTCCGTAA GCTAAATAAA AAGAAAGAGA AGTCTAAAAA GGAAAAGAAA 1380

AAAGAAAAGG TTAATAACAG CAATGAAAAT CCAAGAAAAA TGTGTGAGCA AATGAGGCTA 1440

AAGGAAAAGT CCAAGAGAAA TCAGCCAAAG AAAAGGAAAC AACAGTTCAT TGGTCTAAAA 1500

TCTGAAGATG AAGATAATGC TAAACCTATG AACTATGATG AGAAAAGGCA GTTAAGTCTG 1560

AATATAAACA AACTCCCTGG AGATAAACTT GGGCGAGTAG TTCACATAAT ACAATCAAGA 1620

GAGCCTTCTC TGAGCAATTC CAATCCTGAT GAGATAGAGA TAGACTTTGA AACACTGAAA 1680

GCATCAACAC TAAGAGAATT AGAAAAATAT GTTTCGGCAT GTCTAAGAAA GAGACCATTA 1740

AAACCTCCTG CTAAGAAAAT AATGATGTCC AAAGAAGAAC TTCACTCACA GAAAAAACAG 1800

GAATTGGAAA AGCGGTTACT GGATGTTAAT AATCAGTTAA ATTCTAGAAA ACGTCAAACA 1860

AAATCTGATA AAACGCAACC ATCCAAAGCT GTTGAAAATG TTTCCCGACT GAGTGAGAGC 1920

AGCAGCAGCA GCAGCAGCTC ATCAGAGTCT GAAAGTAGCA GCAGTGACTT AAGCTCTTCA 1980

GACAGCAGTG ATTCTGAATC AGAAATGTTC CCTAAGTTTA CAGAAGTAAA ACCAAATGAT 2040

TCTCCTTCTA AAGAGAATGT AAAGAAAATG AAGAATGAAT GCATACCGCC TGAAGGAAGA 2100

ACAGGCGTCA CACAGATAGG ATATTGTGTG CAAGACACAA CCTCTGCCAA TACTACCCTT 2160

GTTCATCAGA CCACACCTTC ACATGTAATG CCACCAAATC ACCACCAATT AGCATTTAAT 2220

TATCAAGAAT TAGAACATTT ACAGACTGTG AAAAACATTT CACCTTTACA AATTCTGCCT 2280

CCCTCAGGTG ATTCTGAACA GCTCTCAAAT GGCATAACTG TGATGCATCC ATCTGGTGAT 2340

AGTGACACAA CGATGTTAGA ATCTGAATGT CAAGCTCCTG TACAGAAGGA TATAAAGATT 2400

AAGAATGCAG ATTCATGGAA AAGTTTAGGC AAACCAGTGA AACCATCAGG TGTAATGAAA 2460

TCCTCAGATG AGCTCTTCAA CCAATTTAGA AAAGCAGCCA TAGAAAAGGA AGTAAAAGCT 2520

CGGACACAGG AACTCATACG GAAGCATTTG GAACAAAATA CAAAGGAACT AAAAGCATCT 2580

CAAGAAAATC AGAGGGATCT TGGGAATGGA TTGACTGTAG AATCTTTTTC AAATAAAATA 2640

CAAAACAAGT GCTCTGGAGA AGAGCAGAAA GAACATCAGC AGTCATCAGA AGCTCAAGAT 2700

AAATCCAAAC TCTGGCTTCT CAAAGACCGT GATTTAGCAA GGCAGAAAGA ACAAGAGAGG 2760

AGGAGGAGAG AAGCAATGGT GGGTACCATT GATATGACCC TTCAAAGTGA CATTATGACA 2820

ATGTTTGAAA ACAACTTTGA TTAA 2844

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

3D-structure; Activator; Alternative splicing; Bromodomain; Chromatin regulator; Coiled coil; Complete proteome; Differentiation; Meiosis; mRNA processing; mRNA splicing; Nucleus; Polymorphism; Reference proteome; Repeat; Spermatogenesis; Transcription; Transcription regulation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0070577	; F:histone acetyl-lysine binding
GO:0003713	; F:transcription coactivator activity
GO:0030154	; P:cell differentiation
GO:0006338	; P:chromatin remodeling
GO:0001207	; P:histone displacement
GO:0007141	; P:male meiosis I
GO:0006397	; P:mRNA processing
GO:0051039	; P:positive regulation of transcription during meiosis
GO:0043484	; P:regulation of RNA splicing
GO:0008380	; P:RNA splicing
GO:0007283	; P:spermatogenesis
GO:0006351	; P:transcription, DNA-dependent

KEGG

hsa:676

;

InterPros

IPR001487	; Bromodomain.
IPR018359	; Bromodomain_CS.

Pfam

PF00439

; Bromodomain; 2.

SMARTs

SM00297

; BROMO; 2.

Prosites

PS00633	; BROMODOMAIN_1; 2.
PS50014	; BROMODOMAIN_2; 2.
PS51525	; NET; 1.

Prints

PR00503

; BROMODOMAIN.

Created Date

20-Feb-2013