EKS-HOS-00172
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00172
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKG499.49.0E-15033291259
StatusReviewed
Ensembl ProteinENSP00000439967
UniProt AccessionQ13237; O00125; O60916;
Protein NamecGMP-dependent protein kinase 2
Protein Synonyms/Alias cGK 2; cGK2; cGMP-dependent protein kinase II; cGKII;
Gene NamePRKG2
Gene Synonyms/Alias PRKG2; PRKGR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000138669ENSP00000389038ENST00000418486
ENSG00000138669ENSP00000439967ENST00000545647
ENSG00000138669ENSP00000264399ENST00000264399
ENSG00000138669ENSP00000378945ENST00000395578
OrganismHomo sapiens
Functional Description
Protein Length342
Protein Sequence
(FASTA)
MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 60
MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 120
ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 180
IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGVDQMMTYN 240
LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK 300
ARSLPSPLQR ELKGPIDHSY FDKYPPEKGM PPDELSGWDK DF 342
Nucleotide Sequence
(FASTA)
ATGTCTAACT GGAAGCTGTC CAAAGCACTC TCTCTGGAAA TGATTCAGCT GAAGGAGAAG 60
GTGGCCAGAT TTTCCTCATC ATCCCCATTC CAGAACCTTG AGATTATTGC AACACTGGGC 120
GTTGGTGGGT TCGGAAGAGT TGAGCTTGTT AAAGTAAAAA ATGAGAATGT TGCTTTTGCT 180
ATGAAGTGTA TAAGGAAGAA GCACATAGTT GACACCAAGC AGCAGGAGCA TGTCTACTCA 240
GAGAAGAGGA TCCTAGAGGA GCTGTGCTCT CCATTCATTG TGAAATTATA TCGTACTTTC 300
AAGGACAATA AGTATGTATA CATGCTTCTG GAGGCCTGCT TAGGTGGGGA GCTCTGGAGT 360
ATATTAAGGG ACAGAGGCAG CTTTGATGAA CCCACCTCCA AATTCTGCGT TGCTTGTGTG 420
ACAGAAGCAT TTGATTACCT GCATCGACTA GGTATTATCT ACAGAGACTT GAAACCAGAA 480
AACTTAATTC TAGATGCTGA GGGTTACCTT AAATTGGTTG ACTTTGGATT TGCGAAGAAA 540
ATAGGGTCTG GACAGAAAAC ATGGACATTC TGTGGGACTC CAGAATATGT AGCTCCTGAA 600
GTCATTCTCA ACAAGGGACA TGACTTCAGT GTGGATTTCT GGTCACTGGG AATTCTAGTG 660
TATGAGCTCC TAACGGGCAA CCCACCCTTT TCTGGGGTTG ACCAAATGAT GACCTACAAT 720
TTGATTCTCA AAGGAATTGA AAAAATGGAT TTTCCCAGGA AGATAACACG ACGACCTGAG 780
GATTTGATTC GGAGGCTTTG CAGGCAAAAT CCAACAGAAA GGCTGGGAAA TCTGAAGAAT 840
GGAATAAATG ACATTAAGAA ACACAGGTGG TTAAATGGTT TTAATTGGGA GGGACTGAAA 900
GCACGGAGCC TTCCATCACC TTTGCAAAGA GAGCTCAAGG GACCCATAGA TCACAGCTAC 960
TTTGACAAAT ATCCTCCTGA AAAGGGAATG CCTCCAGATG AGCTATCAGG CTGGGATAAA 1020
GACTTCTGA 1029
Domain Profile
S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60
         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+
Q: 33    LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  91
         689******************9.999**********************************
S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120
         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +
Q: 92    FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  151
         ************************************************************
S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180
         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv
Q: 152   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  211
         ************************************************************
S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240
         d+w+lgilvyelltg+ppfsgvd+++tynlilkgi+k+++prkit+++edli++lcr+np
Q: 212   DFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  271
         ************************************************************
S: 241   aerlgylkggikdikkhkwf  260
         +erlg+lk+gi+dikkh+w+
Q: 272   TERLGNLKNGINDIKKHRWL  291
         *******************7
Domain Sequence
(FASTA)
LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60
IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120
IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180
FWSLGILVYE LLTGNPPFSG VDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240
ERLGNLKNGI NDIKKHRWL 259
KeywordATP-binding; Cell membrane; cGMP; cGMP-binding; Complete proteome; Kinase; Lipoprotein; Membrane; Myristate; Nitration; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>
EKS-AIM-00158
EKS-BOT-00166
EKS-CAJ-00170
EKS-CAF-00173
EKS-CAP-00165
EKS-EQC-00165
EKS-FEC-00155
EKS-GAM-00085
EKS-GAA-00197
EKS-GOG-00165
EKS-LOA-00165
EKS-MAM-00164
EKS-MOD-00165
EKS-MUM-00171
EKS-MUP-00170
EKS-MYL-00174
EKS-NOL-00159
EKS-ORA-00147
EKS-ORC-00153
EKS-ORL-00192
EKS-OTG-00172
EKS-PAT-00157
EKS-PEM-00088
EKS-POA-00162
EKS-RAN-00162
EKS-SAH-00159
EKS-SUS-00145
EKS-TEN-00208
EKS-VIP-00079
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0005829; C:cytosol
GO:0005524; F:ATP binding
GO:0030553; F:cGMP binding
GO:0004692; F:cGMP-dependent protein kinase activity
GO:0004672; F:protein kinase activity
GO:0007596; P:blood coagulation
GO:0046209; P:nitric oxide metabolic process
GO:0050999; P:regulation of nitric-oxide synthase activity
GO:0007165; P:signal transduction
GO:0044281; P:small molecule metabolic process
KEGG
hsa:5593;
InterPros
IPR000961; AGC-kinase_C.
IPR016232; cGMP-dependent_protein_kinase.
IPR002374; cGMP_dep_kinase.
IPR018490; cNMP-bd-like.
IPR018488; cNMP-bd_CS.
IPR000595; cNMP-bd_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014710; RmlC-like_jellyroll.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00027; cNMP_binding; 2.
PF00069; Pkinase; 1.
SMARTs
SM00100; cNMP; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00888; CNMP_BINDING_1; 2.
PS00889; CNMP_BINDING_2; 2.
PS50042; CNMP_BINDING_3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00104; CGMPKINASE.
Created Date20-Feb-2013