EKS-HOS-00213

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00213

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	521.1	2.7E-156	4	287	284

Status

Reviewed

Ensembl Protein

ENSP00000412365

UniProt Accession

Q92772; B2R695;

Protein Name

Cyclin-dependent kinase-like 2

Protein Synonyms/Alias

Protein kinase p56 KKIAMRE; Serine/threonine-protein kinase KKIAMRE;

Gene Name

CDKL2

Gene Synonyms/Alias

CDKL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000138769	ENSP00000412365	ENST00000429927
ENSG00000138769	ENSP00000422666	ENST00000506234
ENSG00000138769	ENSP00000306340	ENST00000307465

Organism

Homo sapiens

Functional Description

Protein Length

493

Protein Sequence
(FASTA)

MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QVVQKYLFQI INGIGFCHSH 120

NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 180

KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFN KNPVFAGVRL 240

PEIKEREPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL 300

QLKVQKDARN VSLSKKSQNR KKEKEKDDSL VEERKTLVVQ DTNADPKIKD YKLFKIKGSK 360

IDGEKAEKGN RASNASCLHD SRTSHNKIVP STSLKDCSNV SVDHTRNPSV AIPPLTHNLS 420

AVAPSINSGM GTETIPIQGY RVDEKTKKCS IPFVKPNRHS PSGIYNINVT TLVSGPPLSD 480

DSGADLPQME HQH 493

Nucleotide Sequence
(FASTA)

ATGGAAAAAT ATGAAAACCT GGGTTTGGTT GGAGAAGGGA GTTATGGAAT GGTGATGAAG 60

TGTAGGAATA AAGATACTGG AAGAATTGTG GCCATAAAGA AGTTCTTAGA AAGTGACGAT 120

GACAAAATGG TTAAAAAGAT TGCAATGCGA GAAATCAAGT TACTAAAGCA ACTTAGGCAT 180

GAAAACTTGG TGAATCTCTT GGAAGTGTGT AAGAAAAAAA AACGATGGTA CCTAGTCTTT 240

GAATTTGTTG ACCACACAAT TCTTGATGAC TTGGAGCTCT TTCCAAATGG ACTAGACTAC 300

CAAGTAGTTC AAAAGTATTT GTTTCAGATT ATTAATGGAA TTGGATTTTG TCACAGTCAC 360

AATATCATAC ACAGAGATAT AAAGCCAGAG AATATATTAG TCTCCCAGTC TGGCGTTGTC 420

AAGCTATGCG ATTTTGGATT TGCGCGAACA TTGGCAGCTC CTGGGGAGGT TTATACTGAT 480

TATGTGGCAA CCCGATGGTA CAGAGCTCCA GAACTATTGG TTGGTGATGT CAAGTATGGC 540

AAGGCTGTTG ATGTGTGGGC CATTGGTTGT CTGGTAACTG AAATGTTCAT GGGGGAACCC 600

CTATTTCCTG GAGATTCTGA TATTGATCAG CTATATCATA TTATGATGTG TTTAGGTAAT 660

CTAATTCCAA GGCATCAGGA GCTTTTTAAT AAAAATCCTG TGTTTGCTGG AGTAAGGTTG 720

CCTGAAATCA AGGAAAGAGA ACCTCTTGAA AGACGCTATC CTAAGCTCTC TGAAGTGGTG 780

ATAGATTTAG CAAAGAAATG CTTACATATT GACCCCGACA AAAGACCCTT CTGTGCTGAG 840

CTCCTACACC ATGATTTCTT TCAAATGGAT GGATTTGCTG AGAGGTTTTC CCAAGAACTA 900

CAGTTAAAAG TACAGAAAGA TGCCAGAAAT GTTTCTTTAT CTAAAAAATC CCAAAACAGA 960

AAGAAGGAAA AAGAAAAAGA TGATTCCTTA GTTGAAGAAA GAAAAACACT TGTGGTACAG 1020

GATACCAATG CTGATCCCAA AATTAAGGAT TATAAACTAT TTAAAATAAA AGGCTCAAAA 1080

ATTGATGGAG AAAAAGCTGA AAAAGGCAAT AGAGCTTCAA ATGCCAGCTG TCTCCATGAC 1140

AGTAGGACAA GCCACAACAA AATAGTGCCT TCAACAAGCC TCAAAGACTG CAGCAATGTC 1200

AGCGTGGACC ACACAAGGAA TCCAAGCGTG GCAATTCCCC CACTTACACA CAATCTTTCT 1260

GCAGTTGCTC CCAGCATTAA TTCTGGAATG GGGACTGAGA CTATACCAAT TCAGGGTTAC 1320

AGAGTGGATG AGAAAACTAA GAAGTGTTCT ATTCCATTTG TTAAACCGAA CAGACATTCC 1380

CCATCAGGCA TTTATAACAT TAATGTGACC ACATTAGTAT CAGGACCTCC CCTGTCAGAT 1440

GATTCAGGGG CTGATTTGCC TCAAATGGAA CACCAGCACT GA 1482

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG+v+kcrnkdtg+ivaikkfles+ddk+vkkia+reikllkql+henl

Q: 4     YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+t+ld+le +pnG+++++v+k+l+qi+++i fch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sgvvklcdfGfar+laapg+vytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGcl++e+++Geplfpg+sd+dqly+i+++lG+liprhq++f+kn+vfaGv+lpe+

Q: 184   DVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEI  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++e+le++ypkl+ev++dl+kkcl++dp++r +c+ell+h++f

Q: 244   KEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF  287

         ******************************************98

Domain Sequence
(FASTA)

YENLGLVGEG SYGMVMKCRN KDTGRIVAIK KFLESDDDKM VKKIAMREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DHTILDDLEL FPNGLDYQVV QKYLFQIING IGFCHSHNII 120

HRDIKPENIL VSQSGVVKLC DFGFARTLAA PGEVYTDYVA TRWYRAPELL VGDVKYGKAV 180

DVWAIGCLVT EMFMGEPLFP GDSDIDQLYH IMMCLGNLIP RHQELFNKNP VFAGVRLPEI 240

KEREPLERRY PKLSEVVIDL AKKCLHIDPD KRPFCAELLH HDFF 284

Keyword

3D-structure; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0004672	; F:protein kinase activity
GO:0007049	; P:cell cycle
GO:0007548	; P:sex differentiation
GO:0007165	; P:signal transduction

KEGG

hsa:8999

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013